YHL042W_p

Putative protein of unknown function; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins

Zygosity: Homozygous strain
fixedexpanded
Profile for YHL042W / YHL042W

Click on Significant Values for Screen Details ID:SGTC_345|Compound:1362-0200|FD-Score:-3.24|P-value:9.00E-4 ID:SGTC_424|Compound:splitomicin|FD-Score:-3.69|P-value:1.78E-4 ID:SGTC_944|Compound:3370-0224|FD-Score:-3.21|P-value:9.67E-4 ID:SGTC_949|Compound:1165-0505|FD-Score:-3.46|P-value:4.11E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:-3.56|P-value:2.93E-4 ID:SGTC_1293|Compound:1000-1278|FD-Score:3.12|P-value:7.73E-4 ID:SGTC_1363|Compound:1636-0063|FD-Score:3.70|P-value:9.01E-5 ID:SGTC_1376|Compound:2910-0861|FD-Score:-3.60|P-value:2.49E-4 ID:SGTC_1396|Compound:3511-0007|FD-Score:5.12|P-value:1.29E-7 ID:SGTC_1424|Compound:4048-1941|FD-Score:3.21|P-value:5.67E-4 ID:SGTC_1934|Compound:st074720|FD-Score:3.16|P-value:6.67E-4 ID:SGTC_1984|Compound:st072354|FD-Score:-3.65|P-value:2.05E-4 ID:SGTC_2104|Compound:5389443|FD-Score:-3.25|P-value:8.63E-4 ID:SGTC_2121|Compound:5257820|FD-Score:-3.36|P-value:5.88E-4 ID:SGTC_2138|Compound:5575593|FD-Score:-3.90|P-value:7.90E-5 ID:SGTC_2164|Compound:5685496|FD-Score:3.37|P-value:3.20E-4 ID:SGTC_2174|Compound:5790901|FD-Score:3.94|P-value:3.41E-5 ID:SGTC_2175|Compound:5807670|FD-Score:5.33|P-value:4.25E-8 ID:SGTC_2405|Compound:ticlatone|FD-Score:4.25|P-value:9.25E-6 ID:SGTC_2411|Compound:st077133|FD-Score:3.61|P-value:1.29E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:3.13|P-value:7.51E-4 ID:SGTC_2556|Compound:citropten|FD-Score:3.07|P-value:9.19E-4 ID:SGTC_2823|Compound:7987624|FD-Score:-3.35|P-value:6.10E-4 ID:SGTC_2839|Compound:9003951|FD-Score:-3.39|P-value:5.39E-4 ID:SGTC_2909|Compound:7941780|FD-Score:-4.71|P-value:2.31E-6 ID:SGTC_2911|Compound:7942208|FD-Score:5.11|P-value:1.37E-7 ID:SGTC_2913|Compound:7966556|FD-Score:3.18|P-value:6.28E-4 ID:SGTC_2924|Compound:9010168|FD-Score:3.13|P-value:7.38E-4 ID:SGTC_2927|Compound:9011802|FD-Score:3.32|P-value:3.84E-4 ID:SGTC_2933|Compound:9026794|FD-Score:3.45|P-value:2.38E-4 ID:SGTC_2936|Compound:9038235|FD-Score:3.52|P-value:1.82E-4 ID:SGTC_2949|Compound:9072542|FD-Score:3.92|P-value:3.81E-5 ID:SGTC_3127|Compound:9126946|FD-Score:3.73|P-value:8.03E-5 ID:SGTC_3190|Compound:9110366|FD-Score:-5.65|P-value:1.81E-8 ID:SGTC_3196|Compound:9111891|FD-Score:-4.25|P-value:1.87E-5 ID:SGTC_345|Compound:1362-0200|FD-Score:-3.24|P-value:9.00E-4 ID:SGTC_424|Compound:splitomicin|FD-Score:-3.69|P-value:1.78E-4 ID:SGTC_944|Compound:3370-0224|FD-Score:-3.21|P-value:9.67E-4 ID:SGTC_949|Compound:1165-0505|FD-Score:-3.46|P-value:4.11E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:-3.56|P-value:2.93E-4 ID:SGTC_1293|Compound:1000-1278|FD-Score:3.12|P-value:7.73E-4 ID:SGTC_1363|Compound:1636-0063|FD-Score:3.70|P-value:9.01E-5 ID:SGTC_1376|Compound:2910-0861|FD-Score:-3.60|P-value:2.49E-4 ID:SGTC_1396|Compound:3511-0007|FD-Score:5.12|P-value:1.29E-7 ID:SGTC_1424|Compound:4048-1941|FD-Score:3.21|P-value:5.67E-4 ID:SGTC_1934|Compound:st074720|FD-Score:3.16|P-value:6.67E-4 ID:SGTC_1984|Compound:st072354|FD-Score:-3.65|P-value:2.05E-4 ID:SGTC_2104|Compound:5389443|FD-Score:-3.25|P-value:8.63E-4 ID:SGTC_2121|Compound:5257820|FD-Score:-3.36|P-value:5.88E-4 ID:SGTC_2138|Compound:5575593|FD-Score:-3.90|P-value:7.90E-5 ID:SGTC_2164|Compound:5685496|FD-Score:3.37|P-value:3.20E-4 ID:SGTC_2174|Compound:5790901|FD-Score:3.94|P-value:3.41E-5 ID:SGTC_2175|Compound:5807670|FD-Score:5.33|P-value:4.25E-8 ID:SGTC_2405|Compound:ticlatone|FD-Score:4.25|P-value:9.25E-6 ID:SGTC_2411|Compound:st077133|FD-Score:3.61|P-value:1.29E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:3.13|P-value:7.51E-4 ID:SGTC_2556|Compound:citropten|FD-Score:3.07|P-value:9.19E-4 ID:SGTC_2823|Compound:7987624|FD-Score:-3.35|P-value:6.10E-4 ID:SGTC_2839|Compound:9003951|FD-Score:-3.39|P-value:5.39E-4 ID:SGTC_2909|Compound:7941780|FD-Score:-4.71|P-value:2.31E-6 ID:SGTC_2911|Compound:7942208|FD-Score:5.11|P-value:1.37E-7 ID:SGTC_2913|Compound:7966556|FD-Score:3.18|P-value:6.28E-4 ID:SGTC_2924|Compound:9010168|FD-Score:3.13|P-value:7.38E-4 ID:SGTC_2927|Compound:9011802|FD-Score:3.32|P-value:3.84E-4 ID:SGTC_2933|Compound:9026794|FD-Score:3.45|P-value:2.38E-4 ID:SGTC_2936|Compound:9038235|FD-Score:3.52|P-value:1.82E-4 ID:SGTC_2949|Compound:9072542|FD-Score:3.92|P-value:3.81E-5 ID:SGTC_3127|Compound:9126946|FD-Score:3.73|P-value:8.03E-5 ID:SGTC_3190|Compound:9110366|FD-Score:-5.65|P-value:1.81E-8 ID:SGTC_3196|Compound:9111891|FD-Score:-4.25|P-value:1.87E-5

Top fitness defect scores for YHL042W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2175 5807670 5.33 165.3 µM 4.25E-8 9 4.86E-8
2 SGTC_1396 3511-0007 5.12 98.6 µM 1.29E-7 mitochondrial processes 5 1.49E-7
3 SGTC_2911 7942208 5.11 15.6 µM 1.37E-7 mitochondrial response to ROS 4 1.58E-7
4 SGTC_2405 ticlatone 4.25 3.5 µM 9.25E-6 61 1.08E-5
5 SGTC_2174 5790901 3.94 200.0 µM 3.41E-5 tubulin folding & SWR complex 36 4.01E-5
6 SGTC_2949 9072542 3.92 2.2 µM 3.81E-5 TSC3-RPN4 38 4.49E-5
7 SGTC_3127 9126946 3.73 49.5 µM 8.03E-5 ERG2 22 9.46E-5
8 SGTC_1363 1636-0063 3.70 10.4 µM 9.01E-5 Golgi 37 1.06E-4
9 SGTC_2411 st077133 3.61 39.9 µM 1.29E-4 RNA pol III & RNase P/MRP 40 1.52E-4
10 SGTC_2936 9038235 3.52 15.6 µM 1.82E-4 36 2.14E-4
11 SGTC_2933 9026794 3.45 32.5 µM 2.38E-4 43 2.80E-4
12 SGTC_2164 5685496 3.37 200.0 µM 3.20E-4 36 3.76E-4
13 SGTC_2927 9011802 3.32 47.9 µM 3.84E-4 46 4.53E-4
14 SGTC_1424 4048-1941 3.21 275.0 µM 5.67E-4 54 6.68E-4
15 SGTC_2913 7966556 3.18 36.6 µM 6.28E-4 60S ribosome export 39 7.39E-4
16 SGTC_1934 st074720 3.16 32.6 µM 6.67E-4 98 7.84E-4
17 SGTC_2924 9010168 3.13 62.8 µM 7.38E-4 cell wall signaling 75 8.68E-4
18 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 3.13 54.6 µM 7.51E-4 RPP1 & pyrimidine depletion 61 8.83E-4
19 SGTC_1293 1000-1278 3.12 195.0 µM 7.73E-4 45 9.10E-4
20 SGTC_2556 citropten 3.07 84.6 µM 9.19E-4 77 0.00108

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.160 1.16E-20 YOR282W_d YOR282W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps essential, verified gene PLP2/YOR281C
0.110 1.86E-10 YGR121C MEP1 hom Ammonium permease; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation
0.105 9.32E-10 YGR134W CAF130 hom Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation
0.099 7.95E-9 YGL256W ADH4 hom Alcohol dehydrogenase isoenzyme type IV, dimeric enzyme demonstrated to be zinc-dependent despite sequence similarity to iron-activated alcohol dehydrogenases; transcription is induced in response to zinc deficiency
0.098 1.20E-8 YGR223C HSV2 hom Phosphatidylinositol 3,5-bisphosphate-binding protein, plays a role in micronucleophagy; belongs to the PROPPIN family of proteins; predicted to fold as a seven-bladed beta-propeller; displays punctate cytoplasmic localization
0.090 1.88E-7 YHR193C EGD2 hom Alpha subunit of the heteromeric nascent polypeptide-associated complex (NAC) involved in protein sorting and translocation, associated with cytoplasmic ribosomes
0.089 2.15E-7 YBR217W ATG12 hom Conserved ubiquitin-like modifier involved in autophagy and the Cvt pathway; conjugated to Atg5p to form a complex involved in Atg8p lipidation; Atg12p-Atg5p also forms a complex with Atg16p that is required for autophagosome formation
0.089 2.52E-7 YER074W RPS24A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S24, no bacterial homolog; RPS24A has a paralog, RPS24B, that arose from the whole genome duplication
0.083 1.68E-6 YLR078C BOS1 het v-SNARE (vesicle specific SNAP receptor), localized to the endoplasmic reticulum membrane and necessary for vesicular transport from the ER to the Golgi
0.083 1.70E-6 YCR001W_d YCR001W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR001W is not an essential gene
0.081 2.37E-6 YHR029C YHI9 hom Protein of unknown function; null mutant is defective in unfolded protein response; possibly involved in a membrane regulation metabolic pathway; member of the PhzF superfamily, though most likely not involved in phenazine production
0.080 3.98E-6 YJL210W PEX2 hom RING-finger peroxin and E3 ubiquitin ligase, peroxisomal membrane protein with a C-terminal zinc-binding RING domain, forms translocation subcomplex with Pex10p and Pex12p which functions in peroxisomal matrix protein import
0.078 6.28E-6 YLR077W FMP25 hom Mitochondrial inner membrane protein required for an early step in assembly of respiratory complex III (cytochrome bc1 complex); mRNA is targeted to mitochondria
0.077 7.55E-6 YDL104C QRI7 hom Highly conserved mitochondrial protein, essential for t6A modification of mitochondrial tRNAs that decode ANN codons; similar to Kae1p and E. coli YgjD, both of which are also required for tRNA t6A modification
0.074 1.63E-5 YPL140C MKK2 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk1p; MKK2 has a paralog, MKK1, that arose from the whole genome duplication