YHL044W_p

Putative integral membrane protein, member of DUP240 gene family; green fluorescent protein (GFP)-fusion protein localizes to the plasma membrane in a punctate pattern

Zygosity: Homozygous strain
fixedexpanded
Profile for YHL044W / YHL044W

Click on Significant Values for Screen Details ID:SGTC_69|Compound:0096-0274|FD-Score:3.06|P-value:4.98E-4 ID:SGTC_101|Compound:0490-5701|FD-Score:4.66|P-value:2.63E-7 ID:SGTC_138|Compound:0850-0259|FD-Score:5.56|P-value:1.05E-9 ID:SGTC_176|Compound:1486-1328|FD-Score:-2.95|P-value:7.44E-4 ID:SGTC_405|Compound:ebelactone b|FD-Score:3.36|P-value:1.46E-4 ID:SGTC_511|Compound:blebbistatin|FD-Score:4.15|P-value:3.99E-6 ID:SGTC_514|Compound:4466-0038|FD-Score:4.53|P-value:5.36E-7 ID:SGTC_541|Compound:4513-1321|FD-Score:3.23|P-value:2.53E-4 ID:SGTC_598|Compound:3937-0236|FD-Score:3.21|P-value:2.78E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:2.99|P-value:6.54E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:3.78|P-value:2.37E-5 ID:SGTC_715|Compound:0868-0130|FD-Score:3.46|P-value:9.60E-5 ID:SGTC_925|Compound:2064-1272|FD-Score:-3.13|P-value:3.81E-4 ID:SGTC_936|Compound:3005-4620|FD-Score:3.24|P-value:2.46E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:4.06|P-value:6.05E-6 ID:SGTC_989|Compound:1501-0895|FD-Score:2.99|P-value:6.41E-4 ID:SGTC_1032|Compound:k061-1018|FD-Score:3.30|P-value:1.89E-4 ID:SGTC_1068|Compound:loratadine|FD-Score:4.02|P-value:7.47E-6 ID:SGTC_1134|Compound:3477-0009|FD-Score:3.37|P-value:1.44E-4 ID:SGTC_1169|Compound:aniline yellow|FD-Score:3.15|P-value:3.44E-4 ID:SGTC_1254|Compound:0550-0035|FD-Score:3.15|P-value:3.55E-4 ID:SGTC_1334|Compound:1486-0610|FD-Score:3.77|P-value:2.45E-5 ID:SGTC_1454|Compound:4239-0054|FD-Score:3.99|P-value:8.82E-6 ID:SGTC_1464|Compound:k208-0027|FD-Score:4.21|P-value:2.97E-6 ID:SGTC_1596|Compound:piperlongumine|FD-Score:4.53|P-value:5.39E-7 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:3.81|P-value:2.05E-5 ID:SGTC_1689|Compound:st020265|FD-Score:3.00|P-value:6.24E-4 ID:SGTC_1707|Compound:st032323|FD-Score:3.14|P-value:3.56E-4 ID:SGTC_1727|Compound:st034309|FD-Score:2.97|P-value:6.98E-4 ID:SGTC_1989|Compound:st071868|FD-Score:2.88|P-value:9.62E-4 ID:SGTC_1992|Compound:st073643|FD-Score:3.13|P-value:3.76E-4 ID:SGTC_2003|Compound:4023581|FD-Score:3.57|P-value:6.21E-5 ID:SGTC_2097|Compound:5376186|FD-Score:-3.81|P-value:2.05E-5 ID:SGTC_2171|Compound:5739187|FD-Score:3.45|P-value:1.04E-4 ID:SGTC_2177|Compound:5811945|FD-Score:3.42|P-value:1.14E-4 ID:SGTC_2194|Compound:5927483|FD-Score:3.52|P-value:7.56E-5 ID:SGTC_2293|Compound:7624732|FD-Score:4.83|P-value:9.85E-8 ID:SGTC_2299|Compound:7976368|FD-Score:-3.82|P-value:1.97E-5 ID:SGTC_2302|Compound:7771753|FD-Score:3.23|P-value:2.57E-4 ID:SGTC_2367|Compound:9070478|FD-Score:6.64|P-value:4.37E-13 ID:SGTC_2411|Compound:st077133|FD-Score:3.41|P-value:1.21E-4 ID:SGTC_2412|Compound:st077135|FD-Score:4.32|P-value:1.65E-6 ID:SGTC_2445|Compound:5742597|FD-Score:-2.96|P-value:7.20E-4 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:3.53|P-value:7.30E-5 ID:SGTC_2523|Compound:spermine|FD-Score:4.23|P-value:2.68E-6 ID:SGTC_2584|Compound:androsterone|FD-Score:4.15|P-value:4.06E-6 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:-3.10|P-value:4.26E-4 ID:SGTC_2718|Compound:lomofungin|FD-Score:-2.93|P-value:8.01E-4 ID:SGTC_2806|Compound:7952793|FD-Score:3.54|P-value:7.04E-5 ID:SGTC_2858|Compound:9025781|FD-Score:3.37|P-value:1.40E-4 ID:SGTC_3028|Compound:9087778|FD-Score:3.00|P-value:6.11E-4 ID:SGTC_3049|Compound:9092223|FD-Score:2.98|P-value:6.81E-4 ID:SGTC_3074|Compound:9116018|FD-Score:3.35|P-value:1.54E-4 ID:SGTC_3075|Compound:9116269|FD-Score:4.02|P-value:7.72E-6 ID:SGTC_3100|Compound:9120536|FD-Score:-3.18|P-value:3.10E-4 ID:SGTC_3108|Compound:9121785|FD-Score:2.88|P-value:9.67E-4 ID:SGTC_3153|Compound:9100258|FD-Score:3.15|P-value:3.53E-4 ID:SGTC_3171|Compound:9103192|FD-Score:3.17|P-value:3.21E-4 ID:SGTC_3311|Compound:9131146|FD-Score:5.46|P-value:2.07E-9 ID:SGTC_3321|Compound:9137793|FD-Score:2.96|P-value:7.20E-4 ID:SGTC_3350|Compound:9150499|FD-Score:4.16|P-value:3.76E-6 ID:SGTC_69|Compound:0096-0274|FD-Score:3.06|P-value:4.98E-4 ID:SGTC_101|Compound:0490-5701|FD-Score:4.66|P-value:2.63E-7 ID:SGTC_138|Compound:0850-0259|FD-Score:5.56|P-value:1.05E-9 ID:SGTC_176|Compound:1486-1328|FD-Score:-2.95|P-value:7.44E-4 ID:SGTC_405|Compound:ebelactone b|FD-Score:3.36|P-value:1.46E-4 ID:SGTC_511|Compound:blebbistatin|FD-Score:4.15|P-value:3.99E-6 ID:SGTC_514|Compound:4466-0038|FD-Score:4.53|P-value:5.36E-7 ID:SGTC_541|Compound:4513-1321|FD-Score:3.23|P-value:2.53E-4 ID:SGTC_598|Compound:3937-0236|FD-Score:3.21|P-value:2.78E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:2.99|P-value:6.54E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:3.78|P-value:2.37E-5 ID:SGTC_715|Compound:0868-0130|FD-Score:3.46|P-value:9.60E-5 ID:SGTC_925|Compound:2064-1272|FD-Score:-3.13|P-value:3.81E-4 ID:SGTC_936|Compound:3005-4620|FD-Score:3.24|P-value:2.46E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:4.06|P-value:6.05E-6 ID:SGTC_989|Compound:1501-0895|FD-Score:2.99|P-value:6.41E-4 ID:SGTC_1032|Compound:k061-1018|FD-Score:3.30|P-value:1.89E-4 ID:SGTC_1068|Compound:loratadine|FD-Score:4.02|P-value:7.47E-6 ID:SGTC_1134|Compound:3477-0009|FD-Score:3.37|P-value:1.44E-4 ID:SGTC_1169|Compound:aniline yellow|FD-Score:3.15|P-value:3.44E-4 ID:SGTC_1254|Compound:0550-0035|FD-Score:3.15|P-value:3.55E-4 ID:SGTC_1334|Compound:1486-0610|FD-Score:3.77|P-value:2.45E-5 ID:SGTC_1454|Compound:4239-0054|FD-Score:3.99|P-value:8.82E-6 ID:SGTC_1464|Compound:k208-0027|FD-Score:4.21|P-value:2.97E-6 ID:SGTC_1596|Compound:piperlongumine|FD-Score:4.53|P-value:5.39E-7 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:3.81|P-value:2.05E-5 ID:SGTC_1689|Compound:st020265|FD-Score:3.00|P-value:6.24E-4 ID:SGTC_1707|Compound:st032323|FD-Score:3.14|P-value:3.56E-4 ID:SGTC_1727|Compound:st034309|FD-Score:2.97|P-value:6.98E-4 ID:SGTC_1989|Compound:st071868|FD-Score:2.88|P-value:9.62E-4 ID:SGTC_1992|Compound:st073643|FD-Score:3.13|P-value:3.76E-4 ID:SGTC_2003|Compound:4023581|FD-Score:3.57|P-value:6.21E-5 ID:SGTC_2097|Compound:5376186|FD-Score:-3.81|P-value:2.05E-5 ID:SGTC_2171|Compound:5739187|FD-Score:3.45|P-value:1.04E-4 ID:SGTC_2177|Compound:5811945|FD-Score:3.42|P-value:1.14E-4 ID:SGTC_2194|Compound:5927483|FD-Score:3.52|P-value:7.56E-5 ID:SGTC_2293|Compound:7624732|FD-Score:4.83|P-value:9.85E-8 ID:SGTC_2299|Compound:7976368|FD-Score:-3.82|P-value:1.97E-5 ID:SGTC_2302|Compound:7771753|FD-Score:3.23|P-value:2.57E-4 ID:SGTC_2367|Compound:9070478|FD-Score:6.64|P-value:4.37E-13 ID:SGTC_2411|Compound:st077133|FD-Score:3.41|P-value:1.21E-4 ID:SGTC_2412|Compound:st077135|FD-Score:4.32|P-value:1.65E-6 ID:SGTC_2445|Compound:5742597|FD-Score:-2.96|P-value:7.20E-4 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:3.53|P-value:7.30E-5 ID:SGTC_2523|Compound:spermine|FD-Score:4.23|P-value:2.68E-6 ID:SGTC_2584|Compound:androsterone|FD-Score:4.15|P-value:4.06E-6 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:-3.10|P-value:4.26E-4 ID:SGTC_2718|Compound:lomofungin|FD-Score:-2.93|P-value:8.01E-4 ID:SGTC_2806|Compound:7952793|FD-Score:3.54|P-value:7.04E-5 ID:SGTC_2858|Compound:9025781|FD-Score:3.37|P-value:1.40E-4 ID:SGTC_3028|Compound:9087778|FD-Score:3.00|P-value:6.11E-4 ID:SGTC_3049|Compound:9092223|FD-Score:2.98|P-value:6.81E-4 ID:SGTC_3074|Compound:9116018|FD-Score:3.35|P-value:1.54E-4 ID:SGTC_3075|Compound:9116269|FD-Score:4.02|P-value:7.72E-6 ID:SGTC_3100|Compound:9120536|FD-Score:-3.18|P-value:3.10E-4 ID:SGTC_3108|Compound:9121785|FD-Score:2.88|P-value:9.67E-4 ID:SGTC_3153|Compound:9100258|FD-Score:3.15|P-value:3.53E-4 ID:SGTC_3171|Compound:9103192|FD-Score:3.17|P-value:3.21E-4 ID:SGTC_3311|Compound:9131146|FD-Score:5.46|P-value:2.07E-9 ID:SGTC_3321|Compound:9137793|FD-Score:2.96|P-value:7.20E-4 ID:SGTC_3350|Compound:9150499|FD-Score:4.16|P-value:3.76E-6

Top fitness defect scores for YHL044W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2367 9070478 6.64 135.4 µM 4.37E-13 cell wall 7 1.56E-11
2 SGTC_138 0850-0259 5.56 40.9 µM 1.05E-9 cell wall 122 1.31E-8
3 SGTC_3311 9131146 5.46 2.9 µM 2.07E-9 cell wall 72 2.37E-8
4 SGTC_2293 7624732 4.83 200.0 µM 9.85E-8 10 6.74E-7
5 SGTC_101 0490-5701 4.66 117.5 µM 2.63E-7 6 1.58E-6
6 SGTC_514 4466-0038 4.53 2.6 nM 5.36E-7 cell wall 127 2.93E-6
7 SGTC_1596 piperlongumine 4.53 63.0 µM 5.39E-7 4 2.94E-6
8 SGTC_2412 st077135 4.32 33.4 µM 1.65E-6 16 7.76E-6
9 SGTC_2523 spermine 4.23 47.7 µM 2.68E-6 calcium & mitochondrial duress 27 1.18E-5
10 SGTC_1464 k208-0027 4.21 110.0 µM 2.97E-6 21 1.30E-5
11 SGTC_3350 9150499 4.16 3.6 µM 3.76E-6 cell wall 48 1.59E-5
12 SGTC_511 blebbistatin 4.15 171.0 µM 3.99E-6 DNA intercalators 19 1.67E-5
13 SGTC_2584 androsterone 4.15 48.7 µM 4.06E-6 cell wall 122 1.70E-5
14 SGTC_951 1171-0579 4.06 82.7 µM 6.05E-6 cell wall 75 2.40E-5
15 SGTC_1068 loratadine 4.02 26.9 µM 7.47E-6 20 2.89E-5
16 SGTC_3075 9116269 4.02 49.5 µM 7.72E-6 20 2.97E-5
17 SGTC_1454 4239-0054 3.99 42.6 µM 8.82E-6 36 3.33E-5
18 SGTC_1601 4'-hydroxyflavanone 3.81 55.5 µM 2.05E-5 RPP1 & pyrimidine depletion 34 6.94E-5
19 SGTC_690 glyoxal 3.78 20.3 µM 2.37E-5 90 7.88E-5
20 SGTC_1334 1486-0610 3.77 236.0 µM 2.45E-5 60S ribosome export 22 8.09E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.237 3.70E-44 YLL032C YLL032C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene
0.222 1.01E-38 YML117W NAB6 hom Putative RNA-binding protein that associates with mRNAs encoding cell wall proteins in high-throughput studies; deletion mutants display increased sensitivity to some cell wall disrupting agents; expression negatively regulated by cAMP
0.221 2.43E-38 YDL066W IDP1 hom Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes
0.215 1.98E-36 YJL073W JEM1 hom DnaJ-like chaperone required for nuclear membrane fusion during mating, localizes to the ER membrane; exhibits genetic interactions with KAR2
0.215 2.00E-36 YJR142W_p YJR142W_p hom Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member
0.214 4.19E-36 YOL003C PFA4 hom Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
0.209 2.29E-34 YMR124W_p YMR124W_p hom Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization
0.203 1.27E-32 YPL115C BEM3 hom Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly
0.198 4.21E-31 YGR056W RSC1 hom Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; contains two essential bromodomains, a bromo-adjacent homology (BAH) domain, and an AT hook
0.195 3.65E-30 YJL099W CHS6 hom Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication
0.194 7.66E-30 YBR023C CHS3 hom Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan
0.194 1.04E-29 YMR036C MIH1 hom Protein tyrosine phosphatase involved in cell cycle control; regulates the phosphorylation state of Cdc28p; homolog of S. pombe cdc25
0.189 2.30E-28 YBR020W GAL1 hom Galactokinase; phosphorylates alpha-D-galactose to alpha-D-galactose-1-phosphate in the first step of galactose catabolism; expression regulated by Gal4p; GAL1 has a paralog, GAL3, that arose from the whole genome duplication
0.184 4.87E-27 YNR040W_p YNR040W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.184 6.69E-27 YBL085W BOI1 hom Protein implicated in polar growth; functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI1 has a paralog, BOI2, that arose from the whole genome duplication