HIPHOP chemogenomics database

YHL044W_p

Putative integral membrane protein, member of DUP240 gene family; green fluorescent protein (GFP)-fusion protein localizes to the plasma membrane in a punctate pattern

Zygosity: Homozygous strain

fixedexpanded
Profile for YHL044W / YHL044W

Click on Significant Values for Screen Details

Top fitness defect scores for YHL044W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2367	9070478	6.64	135.4 µM	4.37E-13	cell wall	7	1.56E-11
2	SGTC_138	0850-0259	5.56	40.9 µM	1.05E-9	cell wall	122	1.31E-8
3	SGTC_3311	9131146	5.46	2.9 µM	2.07E-9	cell wall	72	2.37E-8
4	SGTC_2293	7624732	4.83	200.0 µM	9.85E-8		10	6.74E-7
5	SGTC_101	0490-5701	4.66	117.5 µM	2.63E-7		6	1.58E-6
6	SGTC_514	4466-0038	4.53	2.6 nM	5.36E-7	cell wall	127	2.93E-6
7	SGTC_1596	piperlongumine	4.53	63.0 µM	5.39E-7		4	2.94E-6
8	SGTC_2412	st077135	4.32	33.4 µM	1.65E-6		16	7.76E-6
9	SGTC_2523	spermine	4.23	47.7 µM	2.68E-6	calcium & mitochondrial duress	27	1.18E-5
10	SGTC_1464	k208-0027	4.21	110.0 µM	2.97E-6		21	1.30E-5
11	SGTC_3350	9150499	4.16	3.6 µM	3.76E-6	cell wall	48	1.59E-5
12	SGTC_511	blebbistatin	4.15	171.0 µM	3.99E-6	DNA intercalators	19	1.67E-5
13	SGTC_2584	androsterone	4.15	48.7 µM	4.06E-6	cell wall	122	1.70E-5
14	SGTC_951	1171-0579	4.06	82.7 µM	6.05E-6	cell wall	75	2.40E-5
15	SGTC_1068	loratadine	4.02	26.9 µM	7.47E-6		20	2.89E-5
16	SGTC_3075	9116269	4.02	49.5 µM	7.72E-6		20	2.97E-5
17	SGTC_1454	4239-0054	3.99	42.6 µM	8.82E-6		36	3.33E-5
18	SGTC_1601	4'-hydroxyflavanone	3.81	55.5 µM	2.05E-5	RPP1 & pyrimidine depletion	34	6.94E-5
19	SGTC_690	glyoxal	3.78	20.3 µM	2.37E-5		90	7.88E-5
20	SGTC_1334	1486-0610	3.77	236.0 µM	2.45E-5	60S ribosome export	22	8.09E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.237	3.70E-44	YLL032C	YLL032C	hom	Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene
0.222	1.01E-38	YML117W	NAB6	hom	Putative RNA-binding protein that associates with mRNAs encoding cell wall proteins in high-throughput studies; deletion mutants display increased sensitivity to some cell wall disrupting agents; expression negatively regulated by cAMP
0.221	2.43E-38	YDL066W	IDP1	hom	Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes
0.215	1.98E-36	YJL073W	JEM1	hom	DnaJ-like chaperone required for nuclear membrane fusion during mating, localizes to the ER membrane; exhibits genetic interactions with KAR2
0.215	2.00E-36	YJR142W_p	YJR142W_p	hom	Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member
0.214	4.19E-36	YOL003C	PFA4	hom	Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
0.209	2.29E-34	YMR124W_p	YMR124W_p	hom	Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization
0.203	1.27E-32	YPL115C	BEM3	hom	Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly
0.198	4.21E-31	YGR056W	RSC1	hom	Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; contains two essential bromodomains, a bromo-adjacent homology (BAH) domain, and an AT hook
0.195	3.65E-30	YJL099W	CHS6	hom	Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication
0.194	7.66E-30	YBR023C	CHS3	hom	Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan
0.194	1.04E-29	YMR036C	MIH1	hom	Protein tyrosine phosphatase involved in cell cycle control; regulates the phosphorylation state of Cdc28p; homolog of S. pombe cdc25
0.189	2.30E-28	YBR020W	GAL1	hom	Galactokinase; phosphorylates alpha-D-galactose to alpha-D-galactose-1-phosphate in the first step of galactose catabolism; expression regulated by Gal4p; GAL1 has a paralog, GAL3, that arose from the whole genome duplication
0.184	4.87E-27	YNR040W_p	YNR040W_p	hom	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.184	6.69E-27	YBL085W	BOI1	hom	Protein implicated in polar growth; functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI1 has a paralog, BOI2, that arose from the whole genome duplication