YHL045W_d

Putative protein of unknown function; not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YHL045W / YHL045W

Click on Significant Values for Screen Details ID:SGTC_33|Compound:0986-0033|FD-Score:-5.89|P-value:6.42E-10 ID:SGTC_44|Compound:0929-0055|FD-Score:-11.60|P-value:4.90E-33 ID:SGTC_145|Compound:3737-0113|FD-Score:-3.23|P-value:4.48E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:-3.35|P-value:2.85E-4 ID:SGTC_203|Compound:k066-0004|FD-Score:-3.16|P-value:5.73E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:3.48|P-value:1.70E-4 ID:SGTC_481|Compound:bay k-8644|FD-Score:3.22|P-value:4.50E-4 ID:SGTC_492|Compound:tmb-8|FD-Score:-3.25|P-value:4.03E-4 ID:SGTC_626|Compound:0214-0009|FD-Score:3.88|P-value:3.18E-5 ID:SGTC_665|Compound:3914-0008|FD-Score:4.69|P-value:6.86E-7 ID:SGTC_667|Compound:1498-1044|FD-Score:3.76|P-value:5.42E-5 ID:SGTC_758|Compound:0868-0029|FD-Score:-14.30|P-value:4.00E-49 ID:SGTC_999|Compound:4022-0066|FD-Score:3.97|P-value:2.15E-5 ID:SGTC_1028|Compound:k015-0029|FD-Score:3.56|P-value:1.20E-4 ID:SGTC_1111|Compound:tnp00062|FD-Score:3.76|P-value:5.26E-5 ID:SGTC_1131|Compound:3454-3128|FD-Score:5.29|P-value:2.50E-8 ID:SGTC_1358|Compound:1509-0022|FD-Score:3.06|P-value:8.03E-4 ID:SGTC_1409|Compound:3909-8004|FD-Score:3.29|P-value:3.46E-4 ID:SGTC_1534|Compound:6-azauridine|FD-Score:4.35|P-value:3.62E-6 ID:SGTC_1780|Compound:st038448|FD-Score:4.47|P-value:2.06E-6 ID:SGTC_1842|Compound:st055362|FD-Score:3.16|P-value:5.66E-4 ID:SGTC_1909|Compound:st060837|FD-Score:4.56|P-value:1.32E-6 ID:SGTC_2070|Compound:5230947|FD-Score:3.21|P-value:4.79E-4 ID:SGTC_2167|Compound:5876490|FD-Score:-3.27|P-value:3.87E-4 ID:SGTC_2437|Compound:5741531|FD-Score:4.16|P-value:9.32E-6 ID:SGTC_2442|Compound:5158906|FD-Score:3.78|P-value:5.00E-5 ID:SGTC_2447|Compound:5741742|FD-Score:-3.32|P-value:3.21E-4 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:3.74|P-value:5.86E-5 ID:SGTC_2754|Compound:granisetron|FD-Score:3.15|P-value:5.92E-4 ID:SGTC_2852|Compound:9023854|FD-Score:4.56|P-value:1.30E-6 ID:SGTC_3044|Compound:9093193|FD-Score:3.52|P-value:1.44E-4 ID:SGTC_3048|Compound:9093155|FD-Score:-3.66|P-value:8.11E-5 ID:SGTC_3060|Compound:1327-0027|FD-Score:-3.28|P-value:3.61E-4 ID:SGTC_3138|Compound:9097216|FD-Score:3.01|P-value:9.62E-4 ID:SGTC_33|Compound:0986-0033|FD-Score:-5.89|P-value:6.42E-10 ID:SGTC_44|Compound:0929-0055|FD-Score:-11.60|P-value:4.90E-33 ID:SGTC_145|Compound:3737-0113|FD-Score:-3.23|P-value:4.48E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:-3.35|P-value:2.85E-4 ID:SGTC_203|Compound:k066-0004|FD-Score:-3.16|P-value:5.73E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:3.48|P-value:1.70E-4 ID:SGTC_481|Compound:bay k-8644|FD-Score:3.22|P-value:4.50E-4 ID:SGTC_492|Compound:tmb-8|FD-Score:-3.25|P-value:4.03E-4 ID:SGTC_626|Compound:0214-0009|FD-Score:3.88|P-value:3.18E-5 ID:SGTC_665|Compound:3914-0008|FD-Score:4.69|P-value:6.86E-7 ID:SGTC_667|Compound:1498-1044|FD-Score:3.76|P-value:5.42E-5 ID:SGTC_758|Compound:0868-0029|FD-Score:-14.30|P-value:4.00E-49 ID:SGTC_999|Compound:4022-0066|FD-Score:3.97|P-value:2.15E-5 ID:SGTC_1028|Compound:k015-0029|FD-Score:3.56|P-value:1.20E-4 ID:SGTC_1111|Compound:tnp00062|FD-Score:3.76|P-value:5.26E-5 ID:SGTC_1131|Compound:3454-3128|FD-Score:5.29|P-value:2.50E-8 ID:SGTC_1358|Compound:1509-0022|FD-Score:3.06|P-value:8.03E-4 ID:SGTC_1409|Compound:3909-8004|FD-Score:3.29|P-value:3.46E-4 ID:SGTC_1534|Compound:6-azauridine|FD-Score:4.35|P-value:3.62E-6 ID:SGTC_1780|Compound:st038448|FD-Score:4.47|P-value:2.06E-6 ID:SGTC_1842|Compound:st055362|FD-Score:3.16|P-value:5.66E-4 ID:SGTC_1909|Compound:st060837|FD-Score:4.56|P-value:1.32E-6 ID:SGTC_2070|Compound:5230947|FD-Score:3.21|P-value:4.79E-4 ID:SGTC_2167|Compound:5876490|FD-Score:-3.27|P-value:3.87E-4 ID:SGTC_2437|Compound:5741531|FD-Score:4.16|P-value:9.32E-6 ID:SGTC_2442|Compound:5158906|FD-Score:3.78|P-value:5.00E-5 ID:SGTC_2447|Compound:5741742|FD-Score:-3.32|P-value:3.21E-4 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:3.74|P-value:5.86E-5 ID:SGTC_2754|Compound:granisetron|FD-Score:3.15|P-value:5.92E-4 ID:SGTC_2852|Compound:9023854|FD-Score:4.56|P-value:1.30E-6 ID:SGTC_3044|Compound:9093193|FD-Score:3.52|P-value:1.44E-4 ID:SGTC_3048|Compound:9093155|FD-Score:-3.66|P-value:8.11E-5 ID:SGTC_3060|Compound:1327-0027|FD-Score:-3.28|P-value:3.61E-4 ID:SGTC_3138|Compound:9097216|FD-Score:3.01|P-value:9.62E-4

Top fitness defect scores for YHL045W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1131 3454-3128 5.29 32.3 µM 2.50E-8 11 6.06E-8
2 SGTC_665 3914-0008 4.69 307.0 µM 6.86E-7 9 1.38E-6
3 SGTC_2852 9023854 4.56 52.0 µM 1.30E-6 20 2.53E-6
4 SGTC_1909 st060837 4.56 51.5 µM 1.32E-6 36 2.56E-6
5 SGTC_1780 st038448 4.47 24.5 µM 2.06E-6 iron homeostasis 6 3.91E-6
6 SGTC_1534 6-azauridine 4.35 81.6 µM 3.62E-6 RNA pol III & RNase P/MRP 15 6.66E-6
7 SGTC_2437 5741531 4.16 144.2 µM 9.32E-6 32 1.63E-5
8 SGTC_999 4022-0066 3.97 22.7 µM 2.15E-5 Golgi 43 3.58E-5
9 SGTC_626 0214-0009 3.88 33.0 µM 3.18E-5 copper-dependent oxidative stress 23 5.19E-5
10 SGTC_2442 5158906 3.78 48.5 µM 5.00E-5 24 7.96E-5
11 SGTC_1111 tnp00062 3.76 510.7 nM 5.26E-5 12 8.35E-5
12 SGTC_667 1498-1044 3.76 59.0 µM 5.42E-5 RPP1 & pyrimidine depletion 23 8.59E-5
13 SGTC_2622 2-methoxyxanthone 3.74 59.9 µM 5.86E-5 23 9.25E-5
14 SGTC_1028 k015-0029 3.56 4.8 µM 1.20E-4 35 1.82E-4
15 SGTC_3044 9093193 3.52 49.5 µM 1.44E-4 43 2.17E-4
16 SGTC_421 streptovitacin 3.48 30.0 mM 1.70E-4 38 2.54E-4
17 SGTC_1409 3909-8004 3.29 61.9 µM 3.46E-4 48 4.96E-4
18 SGTC_481 bay k-8644 3.22 50.0 µM 4.50E-4 51 6.36E-4
19 SGTC_2070 5230947 3.21 200.0 µM 4.79E-4 36 6.75E-4
20 SGTC_1842 st055362 3.16 61.2 µM 5.66E-4 41 7.90E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.374 7.93E-112 YDL155W CLB3 hom B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation; relative distribution to the nucleus increases upon DNA replication stress
0.364 1.67E-105 YPL246C RBD2 hom Possible rhomboid protease, has similarity to eukaryotic rhomboid proteases including Pcp1p
0.344 1.00E-93 YML029W USA1 hom Scaffold subunit of the Hrd1p ubiquitin ligase that also promotes ligase oligomerization; involved in ER-associated protein degradation (ERAD); interacts with the U1 snRNP-specific protein, Snp1p
0.343 1.88E-93 YGL090W LIF1 hom Component of the DNA ligase IV complex that mediates nonhomologous end joining in DNA double-strand break repair; physically interacts with Dnl4p and Nej1p; homologous to mammalian XRCC4 protein
0.316 1.11E-78 YIL009W FAA3 hom Long chain fatty acyl-CoA synthetase, activates imported fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.314 8.51E-78 YLR040C_p YLR040C_p hom Protein of unknown function; localizes to the cell wall; predicted to be a GPI-attached protein; upregulated by Mcm1p-Alpha1p transcription factor; partially overlaps the dubious ORF YLR041W; mRNA identified as translated by ribosome profiling data; YLR040C is not essential
0.301 2.90E-71 YOR271C_p FSF1_p hom Putative protein, predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis
0.301 3.97E-71 YNL123W NMA111 hom Serine protease and general molecular chaperone; involved in response to heat stress and promotion of apoptosis; may contribute to lipid homeostasis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteases
0.294 8.31E-68 YDL022W GPD1 hom NAD-dependent glycerol-3-phosphate dehydrogenase; key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; homolog of Gpd2p; protein abundance increases in response to DNA replication stress; constitutively inactivated via phosphorylation by the protein kinases YPK1 and YPK2, dephosphorylation increases catalytic activity
0.285 6.88E-64 YLR317W_d YLR317W_d het Dubious open reading frame; may be part of a bicistronic transcript with NKP2/YLR315W; overlaps the verified ORF TAD3/YLR316C
0.279 3.85E-61 YGR018C_p YGR018C_p hom Protein of unknown function; mRNA identified as translated by ribosome profiling data; partially overlaps the uncharacterized ORF YGR017W
0.266 2.31E-55 YLR034C SMF3 hom Putative divalent metal ion transporter involved in iron homeostasis; transcriptionally regulated by metal ions; member of the Nramp family of metal transport proteins; protein abundance increases in response to DNA replication stress
0.262 1.35E-53 YML025C YML6 het Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins
0.254 9.58E-51 YNL103W MET4 het Leucine-zipper transcriptional activator, responsible for the regulation of the sulfur amino acid pathway, requires different combinations of the auxiliary factors Cbf1p, Met28p, Met31p and Met32p
0.251 2.32E-49 YLR440C SEC39 het Component of the Dsl1p tethering complex that interacts with ER SNAREs Sec20p and Use1p; proposed to be involved in protein secretion; localizes to the ER and nuclear envelope