YHR001W / OSH7

Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR001W / OSH7

Click on Significant Values for Screen Details ID:SGTC_65|Compound:0798-0905|FD-Score:2.75|P-value:9.80E-4 ID:SGTC_136|Compound:0097-0015|FD-Score:-3.32|P-value:8.99E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:-2.86|P-value:6.28E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:3.29|P-value:1.04E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:-2.89|P-value:5.57E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:3.40|P-value:6.37E-5 ID:SGTC_349|Compound:k015-0014|FD-Score:2.75|P-value:9.85E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:3.70|P-value:1.56E-5 ID:SGTC_356|Compound:1634-0012|FD-Score:3.98|P-value:3.73E-6 ID:SGTC_415|Compound:dibenzyl ketone|FD-Score:2.82|P-value:7.39E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:4.84|P-value:2.57E-8 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.64|P-value:2.10E-5 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:4.31|P-value:5.92E-7 ID:SGTC_552|Compound:k242-0005|FD-Score:-2.87|P-value:5.85E-4 ID:SGTC_721|Compound:1187-1332|FD-Score:-2.83|P-value:7.00E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:6.02|P-value:6.07E-12 ID:SGTC_924|Compound:2046-0044|FD-Score:-2.90|P-value:5.20E-4 ID:SGTC_1015|Compound:4130-4525|FD-Score:3.25|P-value:1.25E-4 ID:SGTC_1025|Compound:k007-0731|FD-Score:3.09|P-value:2.48E-4 ID:SGTC_1186|Compound:1319-0216|FD-Score:3.65|P-value:2.03E-5 ID:SGTC_1193|Compound:1488-0126|FD-Score:-2.77|P-value:8.84E-4 ID:SGTC_1224|Compound:0823-0416|FD-Score:-4.00|P-value:3.18E-6 ID:SGTC_1230|Compound:0170-0365|FD-Score:5.28|P-value:1.32E-9 ID:SGTC_1252|Compound:0493-0875|FD-Score:3.49|P-value:4.20E-5 ID:SGTC_1271|Compound:0832-2808|FD-Score:3.88|P-value:6.17E-6 ID:SGTC_1274|Compound:0865-0114|FD-Score:-4.08|P-value:2.01E-6 ID:SGTC_1302|Compound:1159-0335|FD-Score:-3.19|P-value:1.54E-4 ID:SGTC_1325|Compound:1431-0015|FD-Score:3.03|P-value:3.26E-4 ID:SGTC_1330|Compound:1469-0054|FD-Score:3.72|P-value:1.38E-5 ID:SGTC_1332|Compound:1480-0653|FD-Score:2.88|P-value:5.85E-4 ID:SGTC_1343|Compound:1487-0095|FD-Score:3.49|P-value:4.23E-5 ID:SGTC_1542|Compound:7-hydroxy-3'-methoxyflavone|FD-Score:-3.06|P-value:2.77E-4 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:4.07|P-value:2.30E-6 ID:SGTC_1898|Compound:st060199|FD-Score:-3.47|P-value:4.50E-5 ID:SGTC_1907|Compound:st060210|FD-Score:2.89|P-value:5.65E-4 ID:SGTC_2018|Compound:5133068|FD-Score:-2.75|P-value:9.39E-4 ID:SGTC_2445|Compound:5742597|FD-Score:3.40|P-value:6.49E-5 ID:SGTC_3006|Compound:9075424|FD-Score:-3.74|P-value:1.18E-5 ID:SGTC_3191|Compound:9110352|FD-Score:-2.80|P-value:7.83E-4 ID:SGTC_3303|Compound:9125618|FD-Score:3.75|P-value:1.24E-5 ID:SGTC_65|Compound:0798-0905|FD-Score:2.75|P-value:9.80E-4 ID:SGTC_136|Compound:0097-0015|FD-Score:-3.32|P-value:8.99E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:-2.86|P-value:6.28E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:3.29|P-value:1.04E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:-2.89|P-value:5.57E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:3.40|P-value:6.37E-5 ID:SGTC_349|Compound:k015-0014|FD-Score:2.75|P-value:9.85E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:3.70|P-value:1.56E-5 ID:SGTC_356|Compound:1634-0012|FD-Score:3.98|P-value:3.73E-6 ID:SGTC_415|Compound:dibenzyl ketone|FD-Score:2.82|P-value:7.39E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:4.84|P-value:2.57E-8 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.64|P-value:2.10E-5 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:4.31|P-value:5.92E-7 ID:SGTC_552|Compound:k242-0005|FD-Score:-2.87|P-value:5.85E-4 ID:SGTC_721|Compound:1187-1332|FD-Score:-2.83|P-value:7.00E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:6.02|P-value:6.07E-12 ID:SGTC_924|Compound:2046-0044|FD-Score:-2.90|P-value:5.20E-4 ID:SGTC_1015|Compound:4130-4525|FD-Score:3.25|P-value:1.25E-4 ID:SGTC_1025|Compound:k007-0731|FD-Score:3.09|P-value:2.48E-4 ID:SGTC_1186|Compound:1319-0216|FD-Score:3.65|P-value:2.03E-5 ID:SGTC_1193|Compound:1488-0126|FD-Score:-2.77|P-value:8.84E-4 ID:SGTC_1224|Compound:0823-0416|FD-Score:-4.00|P-value:3.18E-6 ID:SGTC_1230|Compound:0170-0365|FD-Score:5.28|P-value:1.32E-9 ID:SGTC_1252|Compound:0493-0875|FD-Score:3.49|P-value:4.20E-5 ID:SGTC_1271|Compound:0832-2808|FD-Score:3.88|P-value:6.17E-6 ID:SGTC_1274|Compound:0865-0114|FD-Score:-4.08|P-value:2.01E-6 ID:SGTC_1302|Compound:1159-0335|FD-Score:-3.19|P-value:1.54E-4 ID:SGTC_1325|Compound:1431-0015|FD-Score:3.03|P-value:3.26E-4 ID:SGTC_1330|Compound:1469-0054|FD-Score:3.72|P-value:1.38E-5 ID:SGTC_1332|Compound:1480-0653|FD-Score:2.88|P-value:5.85E-4 ID:SGTC_1343|Compound:1487-0095|FD-Score:3.49|P-value:4.23E-5 ID:SGTC_1542|Compound:7-hydroxy-3'-methoxyflavone|FD-Score:-3.06|P-value:2.77E-4 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:4.07|P-value:2.30E-6 ID:SGTC_1898|Compound:st060199|FD-Score:-3.47|P-value:4.50E-5 ID:SGTC_1907|Compound:st060210|FD-Score:2.89|P-value:5.65E-4 ID:SGTC_2018|Compound:5133068|FD-Score:-2.75|P-value:9.39E-4 ID:SGTC_2445|Compound:5742597|FD-Score:3.40|P-value:6.49E-5 ID:SGTC_3006|Compound:9075424|FD-Score:-3.74|P-value:1.18E-5 ID:SGTC_3191|Compound:9110352|FD-Score:-2.80|P-value:7.83E-4 ID:SGTC_3303|Compound:9125618|FD-Score:3.75|P-value:1.24E-5

Top fitness defect scores for YHR001W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_922 1866-0035 6.02 480.0 µM 6.07E-12 excess fatty acid 20 8.88E-10
2 SGTC_1230 0170-0365 5.28 3.8 µM 1.32E-9 endomembrane recycling 32 6.29E-8
3 SGTC_431 k089-0097 4.84 107.0 µM 2.57E-8 iron homeostasis 17 6.64E-7
4 SGTC_457 grayanotoxin iii 4.31 135.0 µM 5.92E-7 50 8.02E-6
5 SGTC_1557 sumaresinolic acid 4.07 42.3 µM 2.30E-6 18 2.36E-5
6 SGTC_356 1634-0012 3.98 32.5 µM 3.73E-6 23 3.47E-5
7 SGTC_1271 0832-2808 3.88 169.0 µM 6.17E-6 13 5.17E-5
8 SGTC_3303 9125618 3.75 40.6 µM 1.24E-5 54 9.00E-5
9 SGTC_1330 1469-0054 3.72 61.8 µM 1.38E-5 iron homeostasis 21 9.81E-5
10 SGTC_352 k048-0007 3.70 5.1 µM 1.56E-5 ERAD & cell cycle 87 1.09E-4
11 SGTC_1186 1319-0216 3.65 26.0 µM 2.03E-5 26 1.33E-4
12 SGTC_453 enantio-paf c16 3.64 10.0 µM 2.10E-5 173 1.37E-4
13 SGTC_1252 0493-0875 3.49 34.8 µM 4.20E-5 45 2.39E-4
14 SGTC_1343 1487-0095 3.49 224.0 µM 4.23E-5 13 2.40E-4
15 SGTC_335 4077-0256 3.40 27.6 µM 6.37E-5 27 3.33E-4
16 SGTC_2445 5742597 3.40 35.6 µM 6.49E-5 57 3.38E-4
17 SGTC_212 3807-4682 3.29 38.8 µM 1.04E-4 tubulin folding & SWR complex 107 4.93E-4
18 SGTC_1015 4130-4525 3.25 82.0 µM 1.25E-4 60S ribosome export 47 5.72E-4
19 SGTC_1025 k007-0731 3.09 70.0 µM 2.48E-4 52 9.85E-4
20 SGTC_1325 1431-0015 3.03 227.0 µM 3.26E-4 Golgi 52 0.00123

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.195 6.07E-30 YDR247W VHS1 hom Cytoplasmic serine/threonine protein kinase; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; homolog of Sks1p
0.173 4.31E-24 YDL128W VCX1 hom Vacuolar membrane antiporter with Ca2+/H+ and K+/H+ exchange activity, involved in control of cytosolic Ca2+ and K+ concentrations; has similarity to sodium/calcium exchangers, including the bovine Na+/Ca2+,K+ antiporter
0.136 2.22E-15 YNL157W IGO1 hom Protein required for initiation of G0 program; prevents degradation of nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway; phosphorylated by Rim15p; GFP protein localizes to the cytoplasm and nucleus; similar to Igo2p
0.122 1.60E-12 YGL081W_p YGL081W_p hom Putative protein of unknown function; non-essential gene; interacts genetically with CHS5, a gene involved in chitin biosynthesis
0.121 1.71E-12 YPL133C RDS2 hom Transcription factor involved in regulating gluconeogenesis and glyoxylate cycle genes; member of the zinc cluster family of proteins; confers resistance to ketoconazole
0.118 7.60E-12 YDR042C_p YDR042C_p hom Putative protein of unknown function; expression is increased in ssu72-ts69 mutant
0.117 1.11E-11 YDR501W PLM2 hom Putative transcription factor, contains Forkhead Associated domain; found associated with chromatin; target of SBF transcription factor; induced in response to DNA damaging agents and deletion of telomerase; PLM2 has a paralog, TOS4, that arose from the whole genome duplication
0.112 7.48E-11 YDR436W PPZ2 hom Serine/threonine protein phosphatase Z, isoform of Ppz1p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance
0.110 1.67E-10 YDR269C_d YDR269C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.108 3.75E-10 YMR134W ERG29 het Protein of unknown function that may be involved in iron metabolism; mutant bm-8 has a growth defect on iron-limited medium that is complemented by overexpression of Yfh1p; shows localization to the ER; highly conserved in ascomycetes
0.107 4.86E-10 YOR047C STD1 hom Protein involved in control of glucose-regulated gene expression; interacts with kinase Snf1p, glucose sensors Snf3p and Rgt2p, TATA-binding Spt15p; regulator of transcription factor Rgt1p; interactions with Pma1p appear to propagate [GAR+]
0.104 1.69E-9 YGL097W SRM1 het Nucleotide exchange factor for Gsp1p, localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; suppressor of the pheromone response pathway; potentially phosphorylated by Cdc28p
0.103 1.94E-9 YBL034C STU1 het Component of the mitotic spindle that binds to interpolar microtubules via its association with beta-tubulin (Tub2p); required for interpolar microtubules to provide an outward force on the spindle poles
0.103 2.29E-9 YOL135C MED7 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
0.103 2.46E-9 YCR012W PGK1 het 3-phosphoglycerate kinase, catalyzes transfer of high-energy phosphoryl groups from the acyl phosphate of 1,3-bisphosphoglycerate to ADP to produce ATP; key enzyme in glycolysis and gluconeogenesis