YHR003C

Protein of unknown function, localized to the mitochondrial outer membrane

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR003C / YHR003C

Click on Significant Values for Screen Details ID:SGTC_130|Compound:0136-0219|FD-Score:3.76|P-value:3.14E-6 ID:SGTC_414|Compound:piperonyl butoxide|FD-Score:-2.63|P-value:8.62E-4 ID:SGTC_681|Compound:1642-0006|FD-Score:-2.69|P-value:6.53E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-6.37|P-value:1.26E-14 ID:SGTC_789|Compound:1309-1135|FD-Score:-2.92|P-value:2.48E-4 ID:SGTC_836|Compound:0330-0104|FD-Score:-2.87|P-value:3.10E-4 ID:SGTC_900|Compound:1112-0045|FD-Score:-2.85|P-value:3.39E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.71|P-value:9.10E-9 ID:SGTC_1122|Compound:capsaicin|FD-Score:-3.25|P-value:5.08E-5 ID:SGTC_1165|Compound:k072-0275|FD-Score:-3.42|P-value:2.24E-5 ID:SGTC_1181|Compound:1222-0449|FD-Score:3.36|P-value:2.78E-5 ID:SGTC_1290|Compound:0986-0249|FD-Score:-2.64|P-value:8.21E-4 ID:SGTC_2043|Compound:5101342|FD-Score:-2.91|P-value:2.61E-4 ID:SGTC_2103|Compound:5378138|FD-Score:2.88|P-value:2.73E-4 ID:SGTC_2123|Compound:5259487|FD-Score:3.18|P-value:6.57E-5 ID:SGTC_2154|Compound:5570129|FD-Score:-2.69|P-value:6.51E-4 ID:SGTC_2357|Compound:9067248|FD-Score:-2.76|P-value:5.02E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-2.86|P-value:3.25E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:3.83|P-value:2.09E-6 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:-2.82|P-value:3.79E-4 ID:SGTC_2587|Compound:piperic acid|FD-Score:-2.86|P-value:3.23E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:-2.67|P-value:7.19E-4 ID:SGTC_2694|Compound:st077685|FD-Score:-4.13|P-value:3.90E-7 ID:SGTC_2750|Compound:bromebric acid|FD-Score:4.41|P-value:6.03E-8 ID:SGTC_2804|Compound:7954240|FD-Score:3.74|P-value:3.58E-6 ID:SGTC_2812|Compound:7970281|FD-Score:3.44|P-value:1.85E-5 ID:SGTC_2813|Compound:7971799|FD-Score:-3.04|P-value:1.44E-4 ID:SGTC_2815|Compound:7968870|FD-Score:-2.83|P-value:3.69E-4 ID:SGTC_2874|Compound:9043904|FD-Score:2.83|P-value:3.44E-4 ID:SGTC_2918|Compound:7977171|FD-Score:3.75|P-value:3.41E-6 ID:SGTC_2919|Compound:7978188|FD-Score:2.87|P-value:2.86E-4 ID:SGTC_3048|Compound:9093155|FD-Score:2.77|P-value:4.44E-4 ID:SGTC_3064|Compound:1327-0027|FD-Score:2.85|P-value:3.04E-4 ID:SGTC_3094|Compound:9117742|FD-Score:-3.61|P-value:7.88E-6 ID:SGTC_130|Compound:0136-0219|FD-Score:3.76|P-value:3.14E-6 ID:SGTC_414|Compound:piperonyl butoxide|FD-Score:-2.63|P-value:8.62E-4 ID:SGTC_681|Compound:1642-0006|FD-Score:-2.69|P-value:6.53E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-6.37|P-value:1.26E-14 ID:SGTC_789|Compound:1309-1135|FD-Score:-2.92|P-value:2.48E-4 ID:SGTC_836|Compound:0330-0104|FD-Score:-2.87|P-value:3.10E-4 ID:SGTC_900|Compound:1112-0045|FD-Score:-2.85|P-value:3.39E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.71|P-value:9.10E-9 ID:SGTC_1122|Compound:capsaicin|FD-Score:-3.25|P-value:5.08E-5 ID:SGTC_1165|Compound:k072-0275|FD-Score:-3.42|P-value:2.24E-5 ID:SGTC_1181|Compound:1222-0449|FD-Score:3.36|P-value:2.78E-5 ID:SGTC_1290|Compound:0986-0249|FD-Score:-2.64|P-value:8.21E-4 ID:SGTC_2043|Compound:5101342|FD-Score:-2.91|P-value:2.61E-4 ID:SGTC_2103|Compound:5378138|FD-Score:2.88|P-value:2.73E-4 ID:SGTC_2123|Compound:5259487|FD-Score:3.18|P-value:6.57E-5 ID:SGTC_2154|Compound:5570129|FD-Score:-2.69|P-value:6.51E-4 ID:SGTC_2357|Compound:9067248|FD-Score:-2.76|P-value:5.02E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-2.86|P-value:3.25E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:3.83|P-value:2.09E-6 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:-2.82|P-value:3.79E-4 ID:SGTC_2587|Compound:piperic acid|FD-Score:-2.86|P-value:3.23E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:-2.67|P-value:7.19E-4 ID:SGTC_2694|Compound:st077685|FD-Score:-4.13|P-value:3.90E-7 ID:SGTC_2750|Compound:bromebric acid|FD-Score:4.41|P-value:6.03E-8 ID:SGTC_2804|Compound:7954240|FD-Score:3.74|P-value:3.58E-6 ID:SGTC_2812|Compound:7970281|FD-Score:3.44|P-value:1.85E-5 ID:SGTC_2813|Compound:7971799|FD-Score:-3.04|P-value:1.44E-4 ID:SGTC_2815|Compound:7968870|FD-Score:-2.83|P-value:3.69E-4 ID:SGTC_2874|Compound:9043904|FD-Score:2.83|P-value:3.44E-4 ID:SGTC_2918|Compound:7977171|FD-Score:3.75|P-value:3.41E-6 ID:SGTC_2919|Compound:7978188|FD-Score:2.87|P-value:2.86E-4 ID:SGTC_3048|Compound:9093155|FD-Score:2.77|P-value:4.44E-4 ID:SGTC_3064|Compound:1327-0027|FD-Score:2.85|P-value:3.04E-4 ID:SGTC_3094|Compound:9117742|FD-Score:-3.61|P-value:7.88E-6

Top fitness defect scores for YHR003C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2750 bromebric acid 4.41 70.2 µM 6.03E-8 18 5.14E-6
2 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 3.83 63.6 µM 2.09E-6 48 6.29E-5
3 SGTC_130 0136-0219 3.76 337.7 µM 3.14E-6 25 8.37E-5
4 SGTC_2918 7977171 3.75 22.1 µM 3.41E-6 34 8.89E-5
5 SGTC_2804 7954240 3.74 19.5 µM 3.58E-6 41 9.20E-5
6 SGTC_2812 7970281 3.44 58.4 µM 1.85E-5 55 2.95E-4
7 SGTC_1181 1222-0449 3.36 220.0 µM 2.78E-5 45 3.93E-4
8 SGTC_2123 5259487 3.18 200.0 µM 6.57E-5 40 7.25E-4
9 SGTC_2103 5378138 2.88 10.0 µM 2.73E-4 69 0.00200
10 SGTC_2919 7978188 2.87 46.4 µM 2.86E-4 80 0.00206
11 SGTC_3064 1327-0027 2.85 10.0 µM 3.04E-4 28 0.00216
12 SGTC_2874 9043904 2.83 71.4 µM 3.44E-4 54 0.00236
13 SGTC_3048 9093155 2.77 49.5 µM 4.44E-4 32 0.00283
14 SGTC_1138 3761-0006 2.55 1.0 µM 0.00109 54 0.00536
15 SGTC_538 2922-0838 2.54 53.3 µM 0.00116 Golgi 142 0.00561
16 SGTC_3230 9131665 2.53 49.5 µM 0.00117 18 0.00567
17 SGTC_112 phenothiazine 2.51 287.2 µM 0.00128 unfolded protein response 84 0.00602
18 SGTC_3086 9117350 2.48 49.5 µM 0.00142 42 0.00651
19 SGTC_916 4466-0038 2.47 42.0 nM 0.00149 cell wall 213 0.00672
20 SGTC_2107 5363541 2.46 170.2 µM 0.00158 102 0.00702

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.314 8.06E-78 YBR118W TEF2 hom Translational elongation factor EF-1 alpha; also encoded by TEF1; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes; may also have a role in tRNA re-export from the nucleus; TEF2 has a paralog, TEF1, that arose from the whole genome duplication
0.286 2.29E-64 YOL141W PPM2 hom AdoMet-dependent tRNA methyltransferase also involved in methoxycarbonylation; required for the synthesis of wybutosine (yW), a modified guanosine found at the 3'-position adjacent to the anticodon of phe-tRNA; similarity to Ppm1p
0.286 3.52E-64 YER064C VHR2 hom Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.265 5.89E-55 YKL179C COY1 hom Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function
0.261 2.66E-53 YMR210W YMR210W hom Putative acyltransferase with similarity to Eeb1p and Eht1p, has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification
0.255 4.56E-51 YKL140W TGL1 hom Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes
0.249 1.33E-48 YKL220C FRE2 hom Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels
0.248 2.78E-48 YLR205C HMX1 hom ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants
0.246 1.68E-47 YEL004W YEA4 hom Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter required for cell wall chitin synthesis; localized to the ER
0.244 8.38E-47 YEL049W PAU2 hom Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
0.243 2.52E-46 YMR147W_p YMR147W_p hom Putative protein of unknown function
0.241 9.80E-46 YLR267W_p BOP2_p hom Protein of unknown function
0.238 1.33E-44 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.238 2.15E-44 YOR087W YVC1 hom Vacuolar cation channel, mediates release of Ca(2+) from the vacuole in response to hyperosmotic shock
0.235 1.86E-43 YOR298C-A MBF1 hom Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress