HIPHOP chemogenomics database

YHR007C-A_p

Putative protein of unknown function; identified by expression profiling and mass spectrometry

Zygosity: Homozygous strain

fixedexpanded
Profile for YHR007C-A / YHR007C-A

Click on Significant Values for Screen Details

Top fitness defect scores for YHR007C-A deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_1691	st019933	5.21	84.6 µM	2.24E-9		4	9.23E-8
2	SGTC_2701	st077767	4.67	14.7 µM	7.48E-8		24	1.50E-6
3	SGTC_522	1273-0010	4.48	11.6 µM	2.29E-7	60S ribosome export	14	3.67E-6
4	SGTC_3203	9113543	4.41	49.5 µM	3.44E-7		22	5.07E-6
5	SGTC_1673	st016611	4.06	27.3 µM	2.43E-6		40	2.41E-5
6	SGTC_3235	9132602	3.85	49.5 µM	7.48E-6		27	5.92E-5
7	SGTC_2787	5284540	3.85	71.4 µM	7.55E-6		24	5.96E-5
8	SGTC_2094	5332512	3.75	191.7 µM	1.26E-5		30	9.00E-5
9	SGTC_666	0272-0154	3.72	136.0 µM	1.47E-5	cell wall	66	1.02E-4
10	SGTC_1680	diphenhydramine	3.64	100.0 µM	2.11E-5	NEO1	38	1.36E-4
11	SGTC_1688	st021091	3.63	57.6 µM	2.20E-5		9	1.40E-4
12	SGTC_1306	1185-0270	3.60	9.0 µM	2.59E-5	Golgi	59	1.60E-4
13	SGTC_1248	0469-0687	3.56	58.6 µM	3.14E-5		41	1.86E-4
14	SGTC_1457	k015-0032	3.56	57.3 µM	3.14E-5		49	1.86E-4
15	SGTC_1607	st000305	3.49	50.6 µM	4.39E-5		28	2.44E-4
16	SGTC_2564	betulinic acid	3.42	100.0 µM	5.94E-5		51	3.10E-4
17	SGTC_2681	menadione	3.40	3.2 µM	6.69E-5	superoxide	42	3.41E-4
18	SGTC_358	0075-0058	3.30	9.4 µM	1.01E-4		100	4.76E-4
19	SGTC_1794	st048918	3.18	76.9 µM	1.78E-4		22	7.49E-4
20	SGTC_154	3389-1638	3.17	511.1 µM	1.84E-4		53	7.68E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.138	1.22E-15	YHL032C	GUT1	hom	Glycerol kinase, converts glycerol to glycerol-3-phosphate; glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p; derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p
0.113	4.45E-11	YHL010C	ETP1	hom	Putative protein of unknown function that is required for growth on ethanol; contains a zinc finger region and has homology to human BRAP2, which is a cytoplasmic protein that binds nuclear localization sequences
0.093	6.10E-8	YOL086W-A	MHF1	hom	Component of the heterotetrameric MHF histone-fold complex; in humans the MMF complex interacts with both DNA and Mph1p ortholog FANCM, a Fanconi anemia complementation group protein, to stabilize and remodel blocked replication forks and repair damaged DNA; mhf1 srs2 double mutants are MMS hypersensitive; ortholog of human centromere constitutive-associated network (CCAN) subunit CENP-S, also known as MHF1
0.091	1.19E-7	YMR140W	SIP5	hom	Protein of unknown function; interacts with both the Reg1p/Glc7p phosphatase and the Snf1p kinase; forms cytoplasmic foci upon DNA replication stress
0.089	2.29E-7	YHL007C	STE20	hom	Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family; involved in pheromone response, pseudohyphal/invasive growth, vacuole inheritance, down-regulation of sterol uptake; GBB motif binds Ste4p
0.087	4.56E-7	YPR182W	SMX3	het	Core Sm protein Sm F; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm F
0.087	4.80E-7	YDL133C-A	RPL41B	hom	Ribosomal 60S subunit protein L41B; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41, no bacterial homolog; RPL41B has a paralog, RPL41A, that arose from the whole genome duplication
0.082	1.77E-6	YLR183C	TOS4	hom	Putative transcription factor, contains Forkhead Associated domain; found associated with chromatin; target of SBF transcription factor; expression is periodic and peaks in G1; relative distribution to the nucleus increases upon DNA replication stress; TOS4 has a paralog, PLM2, that arose from the whole genome duplication
0.080	3.82E-6	YKR047W_d	YKR047W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NAP1
0.079	4.98E-6	YHL003C	LAG1	hom	Ceramide synthase component; involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p; forms ER foci upon DNA replication stress
0.078	5.62E-6	YFL048C	EMP47	hom	Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport
0.074	2.01E-5	YLR390W-A	CCW14	hom	Covalently linked cell wall glycoprotein, present in the inner layer of the cell wall
0.073	2.09E-5	YER158C_p	YER158C_p	hom	Protein of unknown function; potentially phosphorylated by Cdc28p; YER158C has a paralog, AFR1, that arose from the whole genome duplication
0.073	2.62E-5	YML029W	USA1	hom	Scaffold subunit of the Hrd1p ubiquitin ligase that also promotes ligase oligomerization; involved in ER-associated protein degradation (ERAD); interacts with the U1 snRNP-specific protein, Snp1p
0.072	2.81E-5	YFL017C	GNA1	het	Evolutionarily conserved glucosamine-6-phosphate acetyltransferase required for multiple cell cycle events including passage through START, DNA synthesis, and mitosis; involved in UDP-N-acetylglucosamine synthesis, forms GlcNAc6P from AcCoA