YHR007C-A_p

Putative protein of unknown function; identified by expression profiling and mass spectrometry

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR007C-A / YHR007C-A

Click on Significant Values for Screen Details ID:SGTC_47|Compound:0149-0135|FD-Score:-3.19|P-value:1.67E-4 ID:SGTC_52|Compound:0329-0193|FD-Score:-3.08|P-value:2.61E-4 ID:SGTC_62|Compound:0180-0423|FD-Score:-3.21|P-value:1.47E-4 ID:SGTC_88|Compound:0180-0332|FD-Score:-2.83|P-value:7.17E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:-2.81|P-value:7.62E-4 ID:SGTC_154|Compound:3389-1638|FD-Score:3.17|P-value:1.84E-4 ID:SGTC_208|Compound:k072-0098|FD-Score:3.00|P-value:3.78E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:3.30|P-value:1.01E-4 ID:SGTC_371|Compound:0195-0006|FD-Score:-2.88|P-value:5.77E-4 ID:SGTC_404|Compound:fumagillin|FD-Score:3.16|P-value:1.88E-4 ID:SGTC_472|Compound:calcifediol|FD-Score:-3.98|P-value:3.62E-6 ID:SGTC_522|Compound:1273-0010|FD-Score:4.48|P-value:2.29E-7 ID:SGTC_646|Compound:4092-0839|FD-Score:-3.01|P-value:3.53E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:3.72|P-value:1.47E-5 ID:SGTC_740|Compound:k014-0057|FD-Score:2.95|P-value:4.47E-4 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:-3.13|P-value:2.08E-4 ID:SGTC_1017|Compound:4239-0030|FD-Score:-2.83|P-value:7.18E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:3.56|P-value:3.14E-5 ID:SGTC_1306|Compound:1185-0270|FD-Score:3.60|P-value:2.59E-5 ID:SGTC_1456|Compound:k015-0012|FD-Score:3.02|P-value:3.36E-4 ID:SGTC_1457|Compound:k015-0032|FD-Score:3.56|P-value:3.14E-5 ID:SGTC_1464|Compound:k208-0027|FD-Score:2.80|P-value:8.30E-4 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:-2.93|P-value:4.91E-4 ID:SGTC_1607|Compound:st000305|FD-Score:3.49|P-value:4.39E-5 ID:SGTC_1636|Compound:st007707|FD-Score:2.94|P-value:4.69E-4 ID:SGTC_1673|Compound:st016611|FD-Score:4.06|P-value:2.43E-6 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:3.64|P-value:2.11E-5 ID:SGTC_1682|Compound:st012968|FD-Score:-2.89|P-value:5.60E-4 ID:SGTC_1683|Compound:st010134|FD-Score:-4.61|P-value:1.03E-7 ID:SGTC_1688|Compound:st021091|FD-Score:3.63|P-value:2.20E-5 ID:SGTC_1691|Compound:st019933|FD-Score:5.21|P-value:2.24E-9 ID:SGTC_1703|Compound:st026983|FD-Score:-2.88|P-value:5.77E-4 ID:SGTC_1726|Compound:st035556|FD-Score:-3.78|P-value:1.05E-5 ID:SGTC_1736|Compound:st036774|FD-Score:-2.88|P-value:5.90E-4 ID:SGTC_1737|Compound:st035557|FD-Score:-3.08|P-value:2.64E-4 ID:SGTC_1749|Compound:st037932|FD-Score:3.00|P-value:3.73E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:-2.78|P-value:8.78E-4 ID:SGTC_1794|Compound:st048918|FD-Score:3.18|P-value:1.78E-4 ID:SGTC_1889|Compound:st059080|FD-Score:2.90|P-value:5.55E-4 ID:SGTC_1906|Compound:st060206|FD-Score:2.98|P-value:4.11E-4 ID:SGTC_2020|Compound:4017018|FD-Score:-2.82|P-value:7.47E-4 ID:SGTC_2094|Compound:5332512|FD-Score:3.75|P-value:1.26E-5 ID:SGTC_2258|Compound:7960471|FD-Score:-3.43|P-value:5.46E-5 ID:SGTC_2266|Compound:7929956|FD-Score:-2.95|P-value:4.37E-4 ID:SGTC_2354|Compound:9060492|FD-Score:2.89|P-value:5.76E-4 ID:SGTC_2442|Compound:5158906|FD-Score:-2.97|P-value:4.13E-4 ID:SGTC_2457|Compound:5731572|FD-Score:2.87|P-value:6.25E-4 ID:SGTC_2462|Compound:5162487|FD-Score:3.16|P-value:1.92E-4 ID:SGTC_2464|Compound:5717415|FD-Score:-3.02|P-value:3.28E-4 ID:SGTC_2467|Compound:5474540|FD-Score:-2.79|P-value:8.42E-4 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:2.81|P-value:7.97E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:3.42|P-value:5.94E-5 ID:SGTC_2568|Compound:diosmetin|FD-Score:2.97|P-value:4.26E-4 ID:SGTC_2569|Compound:tetrandrine|FD-Score:3.12|P-value:2.25E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-3.95|P-value:4.32E-6 ID:SGTC_2681|Compound:menadione|FD-Score:3.40|P-value:6.69E-5 ID:SGTC_2701|Compound:st077767|FD-Score:4.67|P-value:7.48E-8 ID:SGTC_2787|Compound:5284540|FD-Score:3.85|P-value:7.55E-6 ID:SGTC_2789|Compound:5281112|FD-Score:3.12|P-value:2.30E-4 ID:SGTC_2840|Compound:9008771|FD-Score:3.08|P-value:2.66E-4 ID:SGTC_3203|Compound:9113543|FD-Score:4.41|P-value:3.44E-7 ID:SGTC_3212|Compound:9128307|FD-Score:3.16|P-value:1.90E-4 ID:SGTC_3235|Compound:9132602|FD-Score:3.85|P-value:7.48E-6 ID:SGTC_3255|Compound:9139072|FD-Score:-2.90|P-value:5.46E-4 ID:SGTC_3274|Compound:9138298|FD-Score:-3.82|P-value:8.23E-6 ID:SGTC_3294|Compound:9122953|FD-Score:2.84|P-value:7.11E-4 ID:SGTC_47|Compound:0149-0135|FD-Score:-3.19|P-value:1.67E-4 ID:SGTC_52|Compound:0329-0193|FD-Score:-3.08|P-value:2.61E-4 ID:SGTC_62|Compound:0180-0423|FD-Score:-3.21|P-value:1.47E-4 ID:SGTC_88|Compound:0180-0332|FD-Score:-2.83|P-value:7.17E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:-2.81|P-value:7.62E-4 ID:SGTC_154|Compound:3389-1638|FD-Score:3.17|P-value:1.84E-4 ID:SGTC_208|Compound:k072-0098|FD-Score:3.00|P-value:3.78E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:3.30|P-value:1.01E-4 ID:SGTC_371|Compound:0195-0006|FD-Score:-2.88|P-value:5.77E-4 ID:SGTC_404|Compound:fumagillin|FD-Score:3.16|P-value:1.88E-4 ID:SGTC_472|Compound:calcifediol|FD-Score:-3.98|P-value:3.62E-6 ID:SGTC_522|Compound:1273-0010|FD-Score:4.48|P-value:2.29E-7 ID:SGTC_646|Compound:4092-0839|FD-Score:-3.01|P-value:3.53E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:3.72|P-value:1.47E-5 ID:SGTC_740|Compound:k014-0057|FD-Score:2.95|P-value:4.47E-4 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:-3.13|P-value:2.08E-4 ID:SGTC_1017|Compound:4239-0030|FD-Score:-2.83|P-value:7.18E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:3.56|P-value:3.14E-5 ID:SGTC_1306|Compound:1185-0270|FD-Score:3.60|P-value:2.59E-5 ID:SGTC_1456|Compound:k015-0012|FD-Score:3.02|P-value:3.36E-4 ID:SGTC_1457|Compound:k015-0032|FD-Score:3.56|P-value:3.14E-5 ID:SGTC_1464|Compound:k208-0027|FD-Score:2.80|P-value:8.30E-4 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:-2.93|P-value:4.91E-4 ID:SGTC_1607|Compound:st000305|FD-Score:3.49|P-value:4.39E-5 ID:SGTC_1636|Compound:st007707|FD-Score:2.94|P-value:4.69E-4 ID:SGTC_1673|Compound:st016611|FD-Score:4.06|P-value:2.43E-6 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:3.64|P-value:2.11E-5 ID:SGTC_1682|Compound:st012968|FD-Score:-2.89|P-value:5.60E-4 ID:SGTC_1683|Compound:st010134|FD-Score:-4.61|P-value:1.03E-7 ID:SGTC_1688|Compound:st021091|FD-Score:3.63|P-value:2.20E-5 ID:SGTC_1691|Compound:st019933|FD-Score:5.21|P-value:2.24E-9 ID:SGTC_1703|Compound:st026983|FD-Score:-2.88|P-value:5.77E-4 ID:SGTC_1726|Compound:st035556|FD-Score:-3.78|P-value:1.05E-5 ID:SGTC_1736|Compound:st036774|FD-Score:-2.88|P-value:5.90E-4 ID:SGTC_1737|Compound:st035557|FD-Score:-3.08|P-value:2.64E-4 ID:SGTC_1749|Compound:st037932|FD-Score:3.00|P-value:3.73E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:-2.78|P-value:8.78E-4 ID:SGTC_1794|Compound:st048918|FD-Score:3.18|P-value:1.78E-4 ID:SGTC_1889|Compound:st059080|FD-Score:2.90|P-value:5.55E-4 ID:SGTC_1906|Compound:st060206|FD-Score:2.98|P-value:4.11E-4 ID:SGTC_2020|Compound:4017018|FD-Score:-2.82|P-value:7.47E-4 ID:SGTC_2094|Compound:5332512|FD-Score:3.75|P-value:1.26E-5 ID:SGTC_2258|Compound:7960471|FD-Score:-3.43|P-value:5.46E-5 ID:SGTC_2266|Compound:7929956|FD-Score:-2.95|P-value:4.37E-4 ID:SGTC_2354|Compound:9060492|FD-Score:2.89|P-value:5.76E-4 ID:SGTC_2442|Compound:5158906|FD-Score:-2.97|P-value:4.13E-4 ID:SGTC_2457|Compound:5731572|FD-Score:2.87|P-value:6.25E-4 ID:SGTC_2462|Compound:5162487|FD-Score:3.16|P-value:1.92E-4 ID:SGTC_2464|Compound:5717415|FD-Score:-3.02|P-value:3.28E-4 ID:SGTC_2467|Compound:5474540|FD-Score:-2.79|P-value:8.42E-4 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:2.81|P-value:7.97E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:3.42|P-value:5.94E-5 ID:SGTC_2568|Compound:diosmetin|FD-Score:2.97|P-value:4.26E-4 ID:SGTC_2569|Compound:tetrandrine|FD-Score:3.12|P-value:2.25E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-3.95|P-value:4.32E-6 ID:SGTC_2681|Compound:menadione|FD-Score:3.40|P-value:6.69E-5 ID:SGTC_2701|Compound:st077767|FD-Score:4.67|P-value:7.48E-8 ID:SGTC_2787|Compound:5284540|FD-Score:3.85|P-value:7.55E-6 ID:SGTC_2789|Compound:5281112|FD-Score:3.12|P-value:2.30E-4 ID:SGTC_2840|Compound:9008771|FD-Score:3.08|P-value:2.66E-4 ID:SGTC_3203|Compound:9113543|FD-Score:4.41|P-value:3.44E-7 ID:SGTC_3212|Compound:9128307|FD-Score:3.16|P-value:1.90E-4 ID:SGTC_3235|Compound:9132602|FD-Score:3.85|P-value:7.48E-6 ID:SGTC_3255|Compound:9139072|FD-Score:-2.90|P-value:5.46E-4 ID:SGTC_3274|Compound:9138298|FD-Score:-3.82|P-value:8.23E-6 ID:SGTC_3294|Compound:9122953|FD-Score:2.84|P-value:7.11E-4

Top fitness defect scores for YHR007C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1691 st019933 5.21 84.6 µM 2.24E-9 4 9.23E-8
2 SGTC_2701 st077767 4.67 14.7 µM 7.48E-8 24 1.50E-6
3 SGTC_522 1273-0010 4.48 11.6 µM 2.29E-7 60S ribosome export 14 3.67E-6
4 SGTC_3203 9113543 4.41 49.5 µM 3.44E-7 22 5.07E-6
5 SGTC_1673 st016611 4.06 27.3 µM 2.43E-6 40 2.41E-5
6 SGTC_3235 9132602 3.85 49.5 µM 7.48E-6 27 5.92E-5
7 SGTC_2787 5284540 3.85 71.4 µM 7.55E-6 24 5.96E-5
8 SGTC_2094 5332512 3.75 191.7 µM 1.26E-5 30 9.00E-5
9 SGTC_666 0272-0154 3.72 136.0 µM 1.47E-5 cell wall 66 1.02E-4
10 SGTC_1680 diphenhydramine 3.64 100.0 µM 2.11E-5 NEO1 38 1.36E-4
11 SGTC_1688 st021091 3.63 57.6 µM 2.20E-5 9 1.40E-4
12 SGTC_1306 1185-0270 3.60 9.0 µM 2.59E-5 Golgi 59 1.60E-4
13 SGTC_1248 0469-0687 3.56 58.6 µM 3.14E-5 41 1.86E-4
14 SGTC_1457 k015-0032 3.56 57.3 µM 3.14E-5 49 1.86E-4
15 SGTC_1607 st000305 3.49 50.6 µM 4.39E-5 28 2.44E-4
16 SGTC_2564 betulinic acid 3.42 100.0 µM 5.94E-5 51 3.10E-4
17 SGTC_2681 menadione 3.40 3.2 µM 6.69E-5 superoxide 42 3.41E-4
18 SGTC_358 0075-0058 3.30 9.4 µM 1.01E-4 100 4.76E-4
19 SGTC_1794 st048918 3.18 76.9 µM 1.78E-4 22 7.49E-4
20 SGTC_154 3389-1638 3.17 511.1 µM 1.84E-4 53 7.68E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.138 1.22E-15 YHL032C GUT1 hom Glycerol kinase, converts glycerol to glycerol-3-phosphate; glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p; derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p
0.113 4.45E-11 YHL010C ETP1 hom Putative protein of unknown function that is required for growth on ethanol; contains a zinc finger region and has homology to human BRAP2, which is a cytoplasmic protein that binds nuclear localization sequences
0.093 6.10E-8 YOL086W-A MHF1 hom Component of the heterotetrameric MHF histone-fold complex; in humans the MMF complex interacts with both DNA and Mph1p ortholog FANCM, a Fanconi anemia complementation group protein, to stabilize and remodel blocked replication forks and repair damaged DNA; mhf1 srs2 double mutants are MMS hypersensitive; ortholog of human centromere constitutive-associated network (CCAN) subunit CENP-S, also known as MHF1
0.091 1.19E-7 YMR140W SIP5 hom Protein of unknown function; interacts with both the Reg1p/Glc7p phosphatase and the Snf1p kinase; forms cytoplasmic foci upon DNA replication stress
0.089 2.29E-7 YHL007C STE20 hom Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family; involved in pheromone response, pseudohyphal/invasive growth, vacuole inheritance, down-regulation of sterol uptake; GBB motif binds Ste4p
0.087 4.56E-7 YPR182W SMX3 het Core Sm protein Sm F; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm F
0.087 4.80E-7 YDL133C-A RPL41B hom Ribosomal 60S subunit protein L41B; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41, no bacterial homolog; RPL41B has a paralog, RPL41A, that arose from the whole genome duplication
0.082 1.77E-6 YLR183C TOS4 hom Putative transcription factor, contains Forkhead Associated domain; found associated with chromatin; target of SBF transcription factor; expression is periodic and peaks in G1; relative distribution to the nucleus increases upon DNA replication stress; TOS4 has a paralog, PLM2, that arose from the whole genome duplication
0.080 3.82E-6 YKR047W_d YKR047W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NAP1
0.079 4.98E-6 YHL003C LAG1 hom Ceramide synthase component; involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p; forms ER foci upon DNA replication stress
0.078 5.62E-6 YFL048C EMP47 hom Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport
0.074 2.01E-5 YLR390W-A CCW14 hom Covalently linked cell wall glycoprotein, present in the inner layer of the cell wall
0.073 2.09E-5 YER158C_p YER158C_p hom Protein of unknown function; potentially phosphorylated by Cdc28p; YER158C has a paralog, AFR1, that arose from the whole genome duplication
0.073 2.62E-5 YML029W USA1 hom Scaffold subunit of the Hrd1p ubiquitin ligase that also promotes ligase oligomerization; involved in ER-associated protein degradation (ERAD); interacts with the U1 snRNP-specific protein, Snp1p
0.072 2.81E-5 YFL017C GNA1 het Evolutionarily conserved glucosamine-6-phosphate acetyltransferase required for multiple cell cycle events including passage through START, DNA synthesis, and mitosis; involved in UDP-N-acetylglucosamine synthesis, forms GlcNAc6P from AcCoA