HIPHOP chemogenomics database
YHR018C / ARG4 
Argininosuccinate lyase, catalyzes the final step in the arginine biosynthesis pathway
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YHR018C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.198 | 4.51E-31 | YOL058W | ARG1 | hom | Arginosuccinate synthetase, catalyzes the formation of L-argininosuccinate from citrulline and L-aspartate in the arginine biosynthesis pathway; potential Cdc28p substrate |
| 0.192 | 3.48E-29 | YOL140W | ARG8 | hom | Acetylornithine aminotransferase, catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine |
| 0.140 | 4.41E-16 | YIL160C | POT1 | hom | 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids |
| 0.137 | 1.60E-15 | YDR205W | MSC2 | hom | Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids |
| 0.131 | 2.11E-14 | YOR303W | CPA1 | hom | Small subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor; translationally regulated by an attenuator peptide encoded by YOR302W within the CPA1 mRNA 5'-leader |
| 0.120 | 3.59E-12 | YOR130C | ORT1 | hom | Ornithine transporter of the mitochondrial inner membrane, exports ornithine from mitochondria as part of arginine biosynthesis; human ortholog is associated with hyperammonaemia-hyperornithinaemia-homocitrullinuria (HHH) syndrome |
| 0.119 | 4.08E-12 | YJL088W | ARG3 | hom | Ornithine carbamoyltransferase (carbamoylphosphate:L-ornithine carbamoyltransferase), catalyzes the sixth step in the biosynthesis of the arginine precursor ornithine |
| 0.109 | 2.52E-10 | YDL189W | RBS1 | hom | Protein of unknown function, identified as a high copy suppressor of psk1 psk2 mutations that confer temperature-sensitivity for galactose utilization; proposed to bind single-stranded nucleic acids via its R3H domain |
| 0.108 | 3.58E-10 | YML057C-A_d | YML057C-A_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene CMP2/YML057W |
| 0.107 | 5.88E-10 | YJR109C | CPA2 | hom | Large subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor |
| 0.105 | 1.06E-9 | YBR120C | CBP6 | hom | Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex |
| 0.103 | 2.49E-9 | YJL071W | ARG2 | hom | Acetylglutamate synthase (glutamate N-acetyltransferase), mitochondrial enzyme that catalyzes the first step in the biosynthesis of the arginine precursor ornithine; forms a complex with Arg5,6p |
| 0.101 | 5.40E-9 | YMR133W | REC114 | hom | Protein involved in early stages of meiotic recombination; possibly involved in the coordination of recombination and meiotic division; mutations lead to premature initiation of the first meiotic division |
| 0.097 | 1.79E-8 | YJR054W | KCH1 | hom | Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate |
| 0.092 | 9.88E-8 | YGL178W | MPT5 | hom | mRNA-binding protein of the PUF family; binds to the 3' UTR of specific mRNAs, including those involved in mating type switching, cell wall integrity, chronological lifespan, chromatin modification, and spindle pole body architecture; recruits the CCR4-NOT deadenylase complex to mRNAs along with Dhh1p and Dcp1p to promote deadenylation, decapping, and decay; also interacts with the Caf20p translational initiation repressor, affecting its mRNA target specificity |