YHR021W-A_p / ECM12

Putative protein of unknown function; may contribute to cell wall biosynthesis, mutants display zymolyase hypersensitivity

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR021W-A / ECM12

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:4.27|P-value:4.12E-6 ID:SGTC_260|Compound:nsc-65238|FD-Score:3.30|P-value:2.87E-4 ID:SGTC_298|Compound:1391-0729|FD-Score:3.04|P-value:7.41E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:3.16|P-value:4.71E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:3.26|P-value:3.25E-4 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:3.22|P-value:3.87E-4 ID:SGTC_521|Compound:r062-0005|FD-Score:2.96|P-value:9.92E-4 ID:SGTC_541|Compound:4513-1321|FD-Score:3.07|P-value:6.59E-4 ID:SGTC_638|Compound:3970-0837|FD-Score:3.41|P-value:1.81E-4 ID:SGTC_664|Compound:1222-0054|FD-Score:5.28|P-value:1.68E-8 ID:SGTC_803|Compound:4488-1585|FD-Score:-2.98|P-value:8.86E-4 ID:SGTC_810|Compound:3825-7150|FD-Score:3.53|P-value:1.11E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:4.27|P-value:4.00E-6 ID:SGTC_1486|Compound:3970-0793|FD-Score:3.29|P-value:2.90E-4 ID:SGTC_1626|Compound:st003712|FD-Score:6.84|P-value:4.17E-13 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:-3.49|P-value:1.29E-4 ID:SGTC_1636|Compound:st007707|FD-Score:-3.57|P-value:9.21E-5 ID:SGTC_1638|Compound:st008370|FD-Score:-3.46|P-value:1.45E-4 ID:SGTC_2105|Compound:5350118|FD-Score:3.38|P-value:2.07E-4 ID:SGTC_2394|Compound:5221648|FD-Score:3.04|P-value:7.51E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:6.33|P-value:1.85E-11 ID:SGTC_2652|Compound:actinonin|FD-Score:3.00|P-value:8.67E-4 ID:SGTC_2659|Compound:sanguinarine|FD-Score:-3.21|P-value:3.87E-4 ID:SGTC_2786|Compound:7743617|FD-Score:3.63|P-value:7.33E-5 ID:SGTC_2990|Compound:9074105|FD-Score:3.07|P-value:6.78E-4 ID:SGTC_2999|Compound:9069765|FD-Score:-4.50|P-value:1.24E-6 ID:SGTC_3290|Compound:9121031|FD-Score:2.98|P-value:9.14E-4 ID:SGTC_3345|Compound:9148410|FD-Score:3.21|P-value:4.02E-4 ID:SGTC_6|Compound:0844-0013|FD-Score:4.27|P-value:4.12E-6 ID:SGTC_260|Compound:nsc-65238|FD-Score:3.30|P-value:2.87E-4 ID:SGTC_298|Compound:1391-0729|FD-Score:3.04|P-value:7.41E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:3.16|P-value:4.71E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:3.26|P-value:3.25E-4 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:3.22|P-value:3.87E-4 ID:SGTC_521|Compound:r062-0005|FD-Score:2.96|P-value:9.92E-4 ID:SGTC_541|Compound:4513-1321|FD-Score:3.07|P-value:6.59E-4 ID:SGTC_638|Compound:3970-0837|FD-Score:3.41|P-value:1.81E-4 ID:SGTC_664|Compound:1222-0054|FD-Score:5.28|P-value:1.68E-8 ID:SGTC_803|Compound:4488-1585|FD-Score:-2.98|P-value:8.86E-4 ID:SGTC_810|Compound:3825-7150|FD-Score:3.53|P-value:1.11E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:4.27|P-value:4.00E-6 ID:SGTC_1486|Compound:3970-0793|FD-Score:3.29|P-value:2.90E-4 ID:SGTC_1626|Compound:st003712|FD-Score:6.84|P-value:4.17E-13 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:-3.49|P-value:1.29E-4 ID:SGTC_1636|Compound:st007707|FD-Score:-3.57|P-value:9.21E-5 ID:SGTC_1638|Compound:st008370|FD-Score:-3.46|P-value:1.45E-4 ID:SGTC_2105|Compound:5350118|FD-Score:3.38|P-value:2.07E-4 ID:SGTC_2394|Compound:5221648|FD-Score:3.04|P-value:7.51E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:6.33|P-value:1.85E-11 ID:SGTC_2652|Compound:actinonin|FD-Score:3.00|P-value:8.67E-4 ID:SGTC_2659|Compound:sanguinarine|FD-Score:-3.21|P-value:3.87E-4 ID:SGTC_2786|Compound:7743617|FD-Score:3.63|P-value:7.33E-5 ID:SGTC_2990|Compound:9074105|FD-Score:3.07|P-value:6.78E-4 ID:SGTC_2999|Compound:9069765|FD-Score:-4.50|P-value:1.24E-6 ID:SGTC_3290|Compound:9121031|FD-Score:2.98|P-value:9.14E-4 ID:SGTC_3345|Compound:9148410|FD-Score:3.21|P-value:4.02E-4

Top fitness defect scores for YHR021W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1626 st003712 6.84 1.8 µM 4.17E-13 5 3.89E-12
2 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 6.33 3.7 µM 1.85E-11 10 1.25E-10
3 SGTC_664 1222-0054 5.28 14.9 µM 1.68E-8 sphingolipid biosynthesis & PDR1 22 6.42E-8
4 SGTC_1130 3454-2858 4.27 15.9 µM 4.00E-6 NEO1 69 9.71E-6
5 SGTC_6 0844-0013 4.27 19.8 µM 4.12E-6 66 9.98E-6
6 SGTC_2786 7743617 3.63 45.5 µM 7.33E-5 37 1.40E-4
7 SGTC_810 3825-7150 3.53 143.0 µM 1.11E-4 60S ribosome export 15 2.05E-4
8 SGTC_638 3970-0837 3.41 4.1 µM 1.81E-4 61 3.22E-4
9 SGTC_2105 5350118 3.38 200.0 µM 2.07E-4 46 3.65E-4
10 SGTC_260 nsc-65238 3.30 4.0 µM 2.87E-4 endomembrane recycling 32 4.91E-4
11 SGTC_1486 3970-0793 3.29 4.5 µM 2.90E-4 19 4.96E-4
12 SGTC_374 0880-0231 3.26 82.3 µM 3.25E-4 iron homeostasis 55 5.51E-4
13 SGTC_392 N-ethylmaleimide 3.22 8.3 µM 3.87E-4 RNA pol III & RNase P/MRP 35 6.48E-4
14 SGTC_3345 9148410 3.21 3.6 µM 4.02E-4 26 6.70E-4
15 SGTC_363 0455-0021 3.16 3.1 µM 4.71E-4 azole & statin 112 7.76E-4
16 SGTC_541 4513-1321 3.07 94.0 µM 6.59E-4 58 0.00106
17 SGTC_2990 9074105 3.07 71.4 µM 6.78E-4 33 0.00109
18 SGTC_298 1391-0729 3.04 10.0 µM 7.41E-4 calcium & mitochondrial duress 38 0.00118
19 SGTC_2394 5221648 3.04 200.0 µM 7.51E-4 65 0.00119
20 SGTC_2652 actinonin 3.00 100.0 µM 8.67E-4 22 0.00136

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.165 7.96E-22 YOR155C ISN1 hom Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase, catalyzes the breakdown of IMP to inosine, does not show similarity to known 5'-nucleotidases from other organisms
0.164 1.20E-21 YPL004C LSP1 hom Primary component of eisosomes, which are large immobile patch structures at the cell cortex associated with endocytosis, along with Pil1p and Sur7p; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways; member of the BAR domain family
0.161 7.12E-21 YDL049C KNH1 hom Protein with similarity to Kre9p, which is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant; required for propionic acid resistance
0.157 5.76E-20 YLR101C_d YLR101C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified, essential ORF ERG27/YLR100W
0.157 5.79E-20 YLR288C MEC3 hom DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1
0.157 7.30E-20 YNL242W ATG2 hom Peripheral membrane protein required for autophagic vesicle formation; also required for vesicle formation during pexophagy and the cytoplasm-to-vaucole targeting (Cvt) pathway; involved in Atg9p cycling between the phagophore assembly site and mitochondria; forms cytoplasmic foci upon DNA replication stress
0.154 2.60E-19 YER067C-A_d YER067C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER067W
0.153 3.82E-19 YDL018C ERP3 hom Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport
0.152 7.39E-19 YFL046W_p FMP32_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.152 8.73E-19 YNL218W MGS1 hom Protein with DNA-dependent ATPase and ssDNA annealing activities; involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP); forms nuclear foci upon DNA replication stress
0.151 1.46E-18 YKR009C FOX2 hom Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities
0.150 1.97E-18 YKR069W MET1 hom S-adenosyl-L-methionine uroporphyrinogen III transmethylase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis
0.148 7.65E-18 YKR025W RPC37 het RNA polymerase III subunit C37
0.146 1.48E-17 YMR191W SPG5 hom Protein required for proteasome assembly during quiescence; binds to base of the proteasome regulartory particle; required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
0.144 4.90E-17 YOR059C YOR059C hom Lipid particle protein of unknown function; contains a putative lipase serine active site; induced by transcription factor Rpn4p; protein abundance increases in response to DNA replication stress