HIPHOP chemogenomics database

YHR034C / PIH1

Component of the conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1); R2TP complex interacts with Hsp90 (Hsp82p and Hsc82p) to mediate assembly large protein complexes such as box C/D snoRNPs and RNA polymerase II

Zygosity: Homozygous strain

fixedexpanded
Profile for YHR034C / PIH1

Click on Significant Values for Screen Details

Top fitness defect scores for YHR034C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_696	1560-0013	6.95	611.0 µM	3.64E-10		3	1.78E-12
2	SGTC_177	1327-0068	6.60	8.4 µM	2.43E-9		20	1.99E-11
3	SGTC_625	k213-0058	6.46	121.0 µM	5.09E-9	translation	27	5.10E-11
4	SGTC_1129	3453-1384	5.99	223.0 µM	5.44E-8		11	1.04E-9
5	SGTC_1910	st062352	5.25	60.4 µM	1.63E-6		9	7.76E-8
6	SGTC_3242	9133940	4.98	49.5 µM	4.88E-6		2	3.11E-7
7	SGTC_573	3702-0553	4.96	84.7 µM	5.31E-6		4	3.46E-7
8	SGTC_2651	1327-0036	4.88	5.0 µM	7.42E-6		115	5.28E-7
9	SGTC_2430	5571206	4.82	200.0 µM	9.34E-6		36	7.08E-7
10	SGTC_636	0kpi-0074	4.81	126.0 µM	9.97E-6		10	7.68E-7
11	SGTC_708	3448-5400	4.74	146.0 µM	1.30E-5		23	1.08E-6
12	SGTC_2875	9039966	4.69	71.4 µM	1.58E-5		5	1.37E-6
13	SGTC_59	0330-0160	4.58	1.3 µM	2.42E-5		82	2.36E-6
14	SGTC_28	pentachloropyridine N-oxide	4.56	1.6 µM	2.59E-5	TSC3-RPN4	42	2.58E-6
15	SGTC_18	0111-0177	4.49	500.0 nM	3.40E-5		45	3.63E-6
16	SGTC_2601	securinine	4.38	100.0 µM	5.09E-5		21	6.03E-6
17	SGTC_2917	7979103	4.37	53.8 µM	5.17E-5		18	6.15E-6
18	SGTC_2603	homopterocarpin	4.33	100.0 µM	6.04E-5		22	7.49E-6
19	SGTC_163	1327-0036	4.27	7.5 µM	7.51E-5		91	9.85E-6
20	SGTC_1768	st044301	4.26	37.2 µM	7.84E-5		13	1.04E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.155	1.75E-19	YKR057W	RPS21A	hom	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21A has a paralog, RPS21B, that arose from the whole genome duplication
0.152	1.14E-18	YCR053W	THR4	hom	Threonine synthase, conserved protein that catalyzes formation of threonine from O-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway
0.136	2.44E-15	YIL052C	RPL34B	hom	Ribosomal 60S subunit protein L34B; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34B has a paralog, RPL34A, that arose from the whole genome duplication
0.136	3.18E-15	YHR025W	THR1	hom	Homoserine kinase, conserved protein required for threonine biosynthesis; expression is regulated by the GCN4-mediated general amino acid control pathway
0.134	7.85E-15	YJR139C	HOM6	hom	Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase), dimeric enzyme that catalyzes the third step in the common pathway for methionine and threonine biosynthesis; enzyme has nucleotide-binding, dimerization and catalytic regions
0.130	4.07E-14	YFL037W	TUB2	het	Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria
0.129	6.73E-14	YIR008C	PRI1	het	Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
0.122	1.33E-12	YBR068C	BAP2	hom	High-affinity leucine permease; functions as a branched-chain amino acid permease involved in uptake of leucine, isoleucine and valine; contains 12 predicted transmembrane domains; BAP2 has a paralog, BAP3, that arose from the whole genome duplication
0.118	5.97E-12	YKL143W	LTV1	hom	Component of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; required for ribosomal small subunit export from nucleus; required for growth at low temperature
0.117	1.16E-11	YER107C	GLE2	hom	RNA export factor associated with the nuclear pore complex (NPC); associates with NUP116p; required for polyadenylated RNA export but not for protein import; homologous to S. pombe Rae1p and human RAE1
0.117	1.18E-11	YBR191W	RPL21A	hom	Ribosomal 60S subunit protein L21A; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21A has a paralog, RPL21B, that arose from the whole genome duplication
0.115	2.36E-11	YDR417C_d	YDR417C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RPL12B/YDR418W
0.113	5.04E-11	YER052C	HOM3	hom	Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.113	5.38E-11	YJR007W	SUI2	het	Alpha subunit of the translation initiation factor eIF2; eIF2 is involved in identification of the start codon; phosphorylation of Ser51 is required for regulation of translation by inhibiting the exchange of GDP for GTP; protein abundance increases in response to DNA replication stress
0.113	6.36E-11	YJR013W	GPI14	het	Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M