YHR036W / BRL1

Essential nuclear envelope integral membrane protein identified as a suppressor of a conditional mutation in the major karyopherin, CRM1; homologous to and interacts with Brr6p, a nuclear envelope protein involved in nuclear export

Zygosity: Heterozygous strain
fixedexpanded
Profile for YHR036W / BRL1

Click on Significant Values for Screen Details ID:SGTC_3|Compound:0833-0587|FD-Score:4.30|P-value:1.94E-4 ID:SGTC_22|Compound:0964-0034|FD-Score:6.62|P-value:2.44E-8 ID:SGTC_32|Compound:0928-0142|FD-Score:4.77|P-value:4.23E-5 ID:SGTC_50|Compound:0929-0078|FD-Score:-4.47|P-value:1.13E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:19.00|P-value:1.85E-55 ID:SGTC_64|Compound:000l-0018|FD-Score:5.48|P-value:3.14E-6 ID:SGTC_78|Compound:0336-0123|FD-Score:-3.99|P-value:4.94E-4 ID:SGTC_81|Compound:0411-0046|FD-Score:5.47|P-value:3.22E-6 ID:SGTC_88|Compound:0180-0332|FD-Score:5.06|P-value:1.53E-5 ID:SGTC_103|Compound:0844-0104|FD-Score:-5.28|P-value:6.64E-6 ID:SGTC_138|Compound:0850-0259|FD-Score:6.20|P-value:1.61E-7 ID:SGTC_163|Compound:1327-0036|FD-Score:6.14|P-value:2.06E-7 ID:SGTC_168|Compound:3970-0862|FD-Score:4.47|P-value:1.16E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:4.83|P-value:3.47E-5 ID:SGTC_195|Compound:4234-0266|FD-Score:4.36|P-value:1.64E-4 ID:SGTC_197|Compound:4544-0043|FD-Score:8.55|P-value:9.09E-13 ID:SGTC_214|Compound:4373-3496|FD-Score:3.80|P-value:8.71E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:6.54|P-value:3.52E-8 ID:SGTC_221|Compound:trifluoperazine|FD-Score:-3.81|P-value:8.39E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:18.20|P-value:3.73E-51 ID:SGTC_248|Compound:streptozotocin|FD-Score:3.92|P-value:6.18E-4 ID:SGTC_257|Compound:daunorubicin|FD-Score:-5.77|P-value:9.80E-7 ID:SGTC_320|Compound:4092-0846|FD-Score:3.89|P-value:6.75E-4 ID:SGTC_326|Compound:k292-0812|FD-Score:3.97|P-value:5.26E-4 ID:SGTC_332|Compound:4112-0506|FD-Score:7.58|P-value:2.02E-10 ID:SGTC_346|Compound:4513-0042|FD-Score:5.45|P-value:3.55E-6 ID:SGTC_360|Compound:0957-0399|FD-Score:4.59|P-value:7.78E-5 ID:SGTC_367|Compound:0335-0881|FD-Score:4.46|P-value:1.16E-4 ID:SGTC_424|Compound:splitomicin|FD-Score:-4.52|P-value:9.64E-5 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:5.06|P-value:1.53E-5 ID:SGTC_525|Compound:k781-2675|FD-Score:7.84|P-value:5.15E-11 ID:SGTC_526|Compound:4469-0568|FD-Score:4.03|P-value:4.41E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:8.12|P-value:1.09E-11 ID:SGTC_580|Compound:1123-0028|FD-Score:4.09|P-value:3.71E-4 ID:SGTC_586|Compound:0957-0265|FD-Score:8.64|P-value:5.12E-13 ID:SGTC_674|Compound:0498-0004|FD-Score:7.53|P-value:2.65E-10 ID:SGTC_794|Compound:k038-0031|FD-Score:3.83|P-value:7.94E-4 ID:SGTC_848|Compound:0368-0089|FD-Score:-3.75|P-value:9.99E-4 ID:SGTC_875|Compound:0709-0210|FD-Score:6.24|P-value:1.34E-7 ID:SGTC_876|Compound:0720-0963|FD-Score:4.77|P-value:4.20E-5 ID:SGTC_951|Compound:1171-0579|FD-Score:6.63|P-value:2.26E-8 ID:SGTC_977|Compound:1348-1378|FD-Score:4.17|P-value:2.94E-4 ID:SGTC_1067|Compound:clotrimazole|FD-Score:4.79|P-value:3.87E-5 ID:SGTC_1133|Compound:3473-0247|FD-Score:5.41|P-value:4.11E-6 ID:SGTC_1161|Compound:k007-0610|FD-Score:-7.04|P-value:3.17E-9 ID:SGTC_1230|Compound:0170-0365|FD-Score:4.80|P-value:3.75E-5 ID:SGTC_1240|Compound:0356-0016|FD-Score:-5.86|P-value:6.78E-7 ID:SGTC_1243|Compound:0416-0003|FD-Score:4.39|P-value:1.50E-4 ID:SGTC_1245|Compound:0418-0076|FD-Score:4.86|P-value:3.13E-5 ID:SGTC_1282|Compound:0886-0010|FD-Score:5.72|P-value:1.22E-6 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:-4.25|P-value:2.26E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:6.72|P-value:1.48E-8 ID:SGTC_1346|Compound:1488-2224|FD-Score:4.61|P-value:7.30E-5 ID:SGTC_1363|Compound:1636-0063|FD-Score:3.94|P-value:5.85E-4 ID:SGTC_1390|Compound:3413-2614|FD-Score:4.75|P-value:4.57E-5 ID:SGTC_1446|Compound:4239-0190|FD-Score:5.23|P-value:8.11E-6 ID:SGTC_1493|Compound:4348-0038|FD-Score:4.61|P-value:7.34E-5 ID:SGTC_1547|Compound:harmine|FD-Score:4.78|P-value:4.10E-5 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:-3.84|P-value:7.66E-4 ID:SGTC_1638|Compound:st008370|FD-Score:4.52|P-value:9.77E-5 ID:SGTC_1652|Compound:st011932|FD-Score:4.02|P-value:4.56E-4 ID:SGTC_1707|Compound:st032323|FD-Score:5.28|P-value:6.74E-6 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:4.58|P-value:7.86E-5 ID:SGTC_1786|Compound:berberine|FD-Score:3.95|P-value:5.68E-4 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:3.78|P-value:9.08E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:15.00|P-value:2.16E-35 ID:SGTC_1962|Compound:st076595|FD-Score:3.80|P-value:8.60E-4 ID:SGTC_2023|Compound:5144124|FD-Score:3.85|P-value:7.56E-4 ID:SGTC_2038|Compound:4100038|FD-Score:5.47|P-value:3.26E-6 ID:SGTC_2149|Compound:5554786|FD-Score:4.80|P-value:3.78E-5 ID:SGTC_2210|Compound:7115885|FD-Score:4.61|P-value:7.33E-5 ID:SGTC_2233|Compound:sulbentine|FD-Score:-4.16|P-value:3.01E-4 ID:SGTC_2248|Compound:tofa|FD-Score:15.90|P-value:1.30E-39 ID:SGTC_2289|Compound:7946404|FD-Score:4.76|P-value:4.32E-5 ID:SGTC_2322|Compound:7413319|FD-Score:4.21|P-value:2.61E-4 ID:SGTC_2456|Compound:5770359|FD-Score:4.25|P-value:2.31E-4 ID:SGTC_2537|Compound:larixol|FD-Score:-4.23|P-value:2.45E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:-3.89|P-value:6.62E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:13.60|P-value:1.56E-29 ID:SGTC_2584|Compound:androsterone|FD-Score:4.67|P-value:5.82E-5 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:3.81|P-value:8.52E-4 ID:SGTC_2628|Compound:lathosterol|FD-Score:5.84|P-value:7.29E-7 ID:SGTC_2651|Compound:1327-0036|FD-Score:13.60|P-value:1.57E-29 ID:SGTC_2662|Compound:daunorubicin|FD-Score:-6.20|P-value:1.56E-7 ID:SGTC_2679|Compound:rapamycin|FD-Score:15.10|P-value:6.04E-36 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-4.49|P-value:1.06E-4 ID:SGTC_2842|Compound:9000675|FD-Score:-4.13|P-value:3.30E-4 ID:SGTC_2896|Compound:9052656|FD-Score:5.87|P-value:6.45E-7 ID:SGTC_2912|Compound:7964298|FD-Score:4.03|P-value:4.47E-4 ID:SGTC_2997|Compound:9067075|FD-Score:4.20|P-value:2.72E-4 ID:SGTC_3060|Compound:1327-0027|FD-Score:4.07|P-value:3.95E-4 ID:SGTC_3143|Compound:9086658|FD-Score:-4.25|P-value:2.30E-4 ID:SGTC_3247|Compound:9135149|FD-Score:4.79|P-value:3.96E-5 ID:SGTC_3|Compound:0833-0587|FD-Score:4.30|P-value:1.94E-4 ID:SGTC_22|Compound:0964-0034|FD-Score:6.62|P-value:2.44E-8 ID:SGTC_32|Compound:0928-0142|FD-Score:4.77|P-value:4.23E-5 ID:SGTC_50|Compound:0929-0078|FD-Score:-4.47|P-value:1.13E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:19.00|P-value:1.85E-55 ID:SGTC_64|Compound:000l-0018|FD-Score:5.48|P-value:3.14E-6 ID:SGTC_78|Compound:0336-0123|FD-Score:-3.99|P-value:4.94E-4 ID:SGTC_81|Compound:0411-0046|FD-Score:5.47|P-value:3.22E-6 ID:SGTC_88|Compound:0180-0332|FD-Score:5.06|P-value:1.53E-5 ID:SGTC_103|Compound:0844-0104|FD-Score:-5.28|P-value:6.64E-6 ID:SGTC_138|Compound:0850-0259|FD-Score:6.20|P-value:1.61E-7 ID:SGTC_163|Compound:1327-0036|FD-Score:6.14|P-value:2.06E-7 ID:SGTC_168|Compound:3970-0862|FD-Score:4.47|P-value:1.16E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:4.83|P-value:3.47E-5 ID:SGTC_195|Compound:4234-0266|FD-Score:4.36|P-value:1.64E-4 ID:SGTC_197|Compound:4544-0043|FD-Score:8.55|P-value:9.09E-13 ID:SGTC_214|Compound:4373-3496|FD-Score:3.80|P-value:8.71E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:6.54|P-value:3.52E-8 ID:SGTC_221|Compound:trifluoperazine|FD-Score:-3.81|P-value:8.39E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:18.20|P-value:3.73E-51 ID:SGTC_248|Compound:streptozotocin|FD-Score:3.92|P-value:6.18E-4 ID:SGTC_257|Compound:daunorubicin|FD-Score:-5.77|P-value:9.80E-7 ID:SGTC_320|Compound:4092-0846|FD-Score:3.89|P-value:6.75E-4 ID:SGTC_326|Compound:k292-0812|FD-Score:3.97|P-value:5.26E-4 ID:SGTC_332|Compound:4112-0506|FD-Score:7.58|P-value:2.02E-10 ID:SGTC_346|Compound:4513-0042|FD-Score:5.45|P-value:3.55E-6 ID:SGTC_360|Compound:0957-0399|FD-Score:4.59|P-value:7.78E-5 ID:SGTC_367|Compound:0335-0881|FD-Score:4.46|P-value:1.16E-4 ID:SGTC_424|Compound:splitomicin|FD-Score:-4.52|P-value:9.64E-5 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:5.06|P-value:1.53E-5 ID:SGTC_525|Compound:k781-2675|FD-Score:7.84|P-value:5.15E-11 ID:SGTC_526|Compound:4469-0568|FD-Score:4.03|P-value:4.41E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:8.12|P-value:1.09E-11 ID:SGTC_580|Compound:1123-0028|FD-Score:4.09|P-value:3.71E-4 ID:SGTC_586|Compound:0957-0265|FD-Score:8.64|P-value:5.12E-13 ID:SGTC_674|Compound:0498-0004|FD-Score:7.53|P-value:2.65E-10 ID:SGTC_794|Compound:k038-0031|FD-Score:3.83|P-value:7.94E-4 ID:SGTC_848|Compound:0368-0089|FD-Score:-3.75|P-value:9.99E-4 ID:SGTC_875|Compound:0709-0210|FD-Score:6.24|P-value:1.34E-7 ID:SGTC_876|Compound:0720-0963|FD-Score:4.77|P-value:4.20E-5 ID:SGTC_951|Compound:1171-0579|FD-Score:6.63|P-value:2.26E-8 ID:SGTC_977|Compound:1348-1378|FD-Score:4.17|P-value:2.94E-4 ID:SGTC_1067|Compound:clotrimazole|FD-Score:4.79|P-value:3.87E-5 ID:SGTC_1133|Compound:3473-0247|FD-Score:5.41|P-value:4.11E-6 ID:SGTC_1161|Compound:k007-0610|FD-Score:-7.04|P-value:3.17E-9 ID:SGTC_1230|Compound:0170-0365|FD-Score:4.80|P-value:3.75E-5 ID:SGTC_1240|Compound:0356-0016|FD-Score:-5.86|P-value:6.78E-7 ID:SGTC_1243|Compound:0416-0003|FD-Score:4.39|P-value:1.50E-4 ID:SGTC_1245|Compound:0418-0076|FD-Score:4.86|P-value:3.13E-5 ID:SGTC_1282|Compound:0886-0010|FD-Score:5.72|P-value:1.22E-6 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:-4.25|P-value:2.26E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:6.72|P-value:1.48E-8 ID:SGTC_1346|Compound:1488-2224|FD-Score:4.61|P-value:7.30E-5 ID:SGTC_1363|Compound:1636-0063|FD-Score:3.94|P-value:5.85E-4 ID:SGTC_1390|Compound:3413-2614|FD-Score:4.75|P-value:4.57E-5 ID:SGTC_1446|Compound:4239-0190|FD-Score:5.23|P-value:8.11E-6 ID:SGTC_1493|Compound:4348-0038|FD-Score:4.61|P-value:7.34E-5 ID:SGTC_1547|Compound:harmine|FD-Score:4.78|P-value:4.10E-5 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:-3.84|P-value:7.66E-4 ID:SGTC_1638|Compound:st008370|FD-Score:4.52|P-value:9.77E-5 ID:SGTC_1652|Compound:st011932|FD-Score:4.02|P-value:4.56E-4 ID:SGTC_1707|Compound:st032323|FD-Score:5.28|P-value:6.74E-6 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:4.58|P-value:7.86E-5 ID:SGTC_1786|Compound:berberine|FD-Score:3.95|P-value:5.68E-4 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:3.78|P-value:9.08E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:15.00|P-value:2.16E-35 ID:SGTC_1962|Compound:st076595|FD-Score:3.80|P-value:8.60E-4 ID:SGTC_2023|Compound:5144124|FD-Score:3.85|P-value:7.56E-4 ID:SGTC_2038|Compound:4100038|FD-Score:5.47|P-value:3.26E-6 ID:SGTC_2149|Compound:5554786|FD-Score:4.80|P-value:3.78E-5 ID:SGTC_2210|Compound:7115885|FD-Score:4.61|P-value:7.33E-5 ID:SGTC_2233|Compound:sulbentine|FD-Score:-4.16|P-value:3.01E-4 ID:SGTC_2248|Compound:tofa|FD-Score:15.90|P-value:1.30E-39 ID:SGTC_2289|Compound:7946404|FD-Score:4.76|P-value:4.32E-5 ID:SGTC_2322|Compound:7413319|FD-Score:4.21|P-value:2.61E-4 ID:SGTC_2456|Compound:5770359|FD-Score:4.25|P-value:2.31E-4 ID:SGTC_2537|Compound:larixol|FD-Score:-4.23|P-value:2.45E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:-3.89|P-value:6.62E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:13.60|P-value:1.56E-29 ID:SGTC_2584|Compound:androsterone|FD-Score:4.67|P-value:5.82E-5 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:3.81|P-value:8.52E-4 ID:SGTC_2628|Compound:lathosterol|FD-Score:5.84|P-value:7.29E-7 ID:SGTC_2651|Compound:1327-0036|FD-Score:13.60|P-value:1.57E-29 ID:SGTC_2662|Compound:daunorubicin|FD-Score:-6.20|P-value:1.56E-7 ID:SGTC_2679|Compound:rapamycin|FD-Score:15.10|P-value:6.04E-36 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-4.49|P-value:1.06E-4 ID:SGTC_2842|Compound:9000675|FD-Score:-4.13|P-value:3.30E-4 ID:SGTC_2896|Compound:9052656|FD-Score:5.87|P-value:6.45E-7 ID:SGTC_2912|Compound:7964298|FD-Score:4.03|P-value:4.47E-4 ID:SGTC_2997|Compound:9067075|FD-Score:4.20|P-value:2.72E-4 ID:SGTC_3060|Compound:1327-0027|FD-Score:4.07|P-value:3.95E-4 ID:SGTC_3143|Compound:9086658|FD-Score:-4.25|P-value:2.30E-4 ID:SGTC_3247|Compound:9135149|FD-Score:4.79|P-value:3.96E-5

Top fitness defect scores for YHR036W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_58 0957-0393 19.00 9.0 µM 1.85E-55 cell wall 1 1.45E-80 5.04
2 SGTC_227 fluconazole 18.20 33.5 µM 3.73E-51 azole & statin 5 3.05E-74 2.26
3 SGTC_2248 tofa 15.90 1.1 µM 1.30E-39 sphingolipid biosynthesis & PDR1 2 2.73E-57 2.47
4 SGTC_2679 rapamycin 15.10 1.0 nM 6.04E-36 3 6.56E-52 3.45
5 SGTC_1844 rapamycin 15.00 4.0 nM 2.16E-35 4 4.26E-51 2.44
6 SGTC_2582 agaric acid 13.60 100.0 µM 1.56E-29 redox potentiating 2 1.69E-42 2.23
7 SGTC_2651 1327-0036 13.60 5.0 µM 1.57E-29 8 1.71E-42 0.77
8 SGTC_586 0957-0265 8.64 8.2 µM 5.12E-13 cell wall 11 2.70E-18 0.14
9 SGTC_197 4544-0043 8.55 41.6 µM 9.09E-13 endomembrane recycling 7 6.26E-18 1.69
10 SGTC_576 1073-0113 8.12 22.7 µM 1.09E-11 redox potentiating 9 2.37E-16 0.62
11 SGTC_525 k781-2675 7.84 26.7 µM 5.15E-11 redox potentiating 8 2.28E-15 0.32
12 SGTC_332 4112-0506 7.58 40.9 µM 2.02E-10 5 1.69E-14 0.27
13 SGTC_674 0498-0004 7.53 451.0 µM 2.65E-10 heme requiring 4 2.49E-14 1.47
14 SGTC_1317 1273-0028 6.72 910.0 nM 1.48E-8 azole & statin 6 8.83E-12 0.81
15 SGTC_951 1171-0579 6.63 82.7 µM 2.26E-8 cell wall 7 1.63E-11 0.64
16 SGTC_22 0964-0034 6.62 14.5 µM 2.44E-8 unfolded protein response 11 1.82E-11 0.01
17 SGTC_217 ketoconazole 6.54 989.0 nM 3.52E-8 ergosterol depletion effects on membrane 5 3.13E-11 1.23
18 SGTC_875 0709-0210 6.24 25.7 µM 1.34E-7 fatty acid desaturase (OLE1) 3 2.20E-10 0.02
19 SGTC_138 0850-0259 6.20 40.9 µM 1.61E-7 cell wall 32 2.86E-10 0.03
20 SGTC_163 1327-0036 6.14 7.5 µM 2.06E-7 31 4.10E-10 0.09

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.597 1.98E-323 YJL054W TIM54 het Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane
0.490 7.68E-202 YKL028W TFA1 het TFIIE large subunit, involved in recruitment of RNA polymerase II to the promoter, activation of TFIIH, and promoter opening
0.292 4.09E-67 YLL043W FPS1 hom Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress
0.287 8.72E-65 YDL147W RPN5 het Subunit of the COP9 signalosome (CSN) and non-ATPase regulatory subunit of the 26S proteasome lid, similar to mammalian p55 subunit and to another S. cerevisiae regulatory subunit, Rpn7p; Rpn5p is an essential protein
0.266 1.35E-55 YLR331C_d JIP3_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
0.265 3.37E-55 YBR091C TIM12 het Essential protein of the inner mitochondrial membrane, peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins
0.265 6.73E-55 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.244 7.24E-47 YOL003C PFA4 hom Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
0.237 3.87E-44 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.233 1.43E-42 YDR172W SUP35 het Translation termination factor eRF3, has a role in mRNA deadenylation and decay; altered protein conformation creates the [PSI(+)] prion that alters translational fidelity and results in a nonsense suppressor phenotype
0.230 1.55E-41 YBR077C SLM4 hom Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; gene exhibits synthetic genetic interaction with MSS4
0.227 1.86E-40 YJR013W GPI14 het Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M
0.225 6.60E-40 YMR211W DML1 het Essential protein involved in mtDNA inheritance, may also function in the partitioning of the mitochondrial organelle or in the segregation of chromosomes, exhibits regions similar to members of a GTPase family
0.224 1.70E-39 YKL203C TOR2 het PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; TOR2 has a paralog, TOR1, that arose from the whole genome duplication
0.221 1.63E-38 YOR236W DFR1 het Dihydrofolate reductase involved in tetrahydrofolate biosynthesis; required for respiratory metabolism