YHR040W / BCD1

Essential protein required for the accumulation of box C/D snoRNA

Zygosity: Heterozygous strain
fixedexpanded
Profile for YHR040W / BCD1

Click on Significant Values for Screen Details ID:SGTC_18|Compound:0111-0177|FD-Score:-2.94|P-value:4.54E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:2.79|P-value:6.90E-4 ID:SGTC_72|Compound:0744-0168|FD-Score:2.70|P-value:9.90E-4 ID:SGTC_292|Compound:k038-0015|FD-Score:5.86|P-value:1.14E-11 ID:SGTC_418|Compound:lividomycin a|FD-Score:3.95|P-value:3.26E-6 ID:SGTC_790|Compound:1575-0012|FD-Score:3.01|P-value:2.87E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:-2.78|P-value:8.59E-4 ID:SGTC_965|Compound:1291-5240|FD-Score:-3.21|P-value:1.44E-4 ID:SGTC_968|Compound:1309-0633|FD-Score:2.85|P-value:5.49E-4 ID:SGTC_1001|Compound:4048-4355|FD-Score:3.02|P-value:2.73E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:7.11|P-value:2.59E-16 ID:SGTC_1450|Compound:4112-4260|FD-Score:2.85|P-value:5.48E-4 ID:SGTC_1491|Compound:4138-0063|FD-Score:3.53|P-value:2.67E-5 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:2.86|P-value:5.24E-4 ID:SGTC_1682|Compound:st012968|FD-Score:-2.98|P-value:3.83E-4 ID:SGTC_1761|Compound:st044296|FD-Score:2.98|P-value:3.26E-4 ID:SGTC_1762|Compound:st045503|FD-Score:3.11|P-value:1.85E-4 ID:SGTC_1764|Compound:st044502|FD-Score:3.83|P-value:6.05E-6 ID:SGTC_1919|Compound:st067113|FD-Score:3.33|P-value:7.01E-5 ID:SGTC_2368|Compound:9071271|FD-Score:-5.29|P-value:9.93E-10 ID:SGTC_2430|Compound:5571206|FD-Score:4.05|P-value:1.83E-6 ID:SGTC_2618|Compound:avocadyne|FD-Score:-2.86|P-value:6.21E-4 ID:SGTC_2832|Compound:7992762|FD-Score:-3.04|P-value:2.99E-4 ID:SGTC_2971|Compound:9092186|FD-Score:-3.22|P-value:1.36E-4 ID:SGTC_2973|Compound:9094665|FD-Score:3.16|P-value:1.48E-4 ID:SGTC_2990|Compound:9074105|FD-Score:-3.08|P-value:2.50E-4 ID:SGTC_18|Compound:0111-0177|FD-Score:-2.94|P-value:4.54E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:2.79|P-value:6.90E-4 ID:SGTC_72|Compound:0744-0168|FD-Score:2.70|P-value:9.90E-4 ID:SGTC_292|Compound:k038-0015|FD-Score:5.86|P-value:1.14E-11 ID:SGTC_418|Compound:lividomycin a|FD-Score:3.95|P-value:3.26E-6 ID:SGTC_790|Compound:1575-0012|FD-Score:3.01|P-value:2.87E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:-2.78|P-value:8.59E-4 ID:SGTC_965|Compound:1291-5240|FD-Score:-3.21|P-value:1.44E-4 ID:SGTC_968|Compound:1309-0633|FD-Score:2.85|P-value:5.49E-4 ID:SGTC_1001|Compound:4048-4355|FD-Score:3.02|P-value:2.73E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:7.11|P-value:2.59E-16 ID:SGTC_1450|Compound:4112-4260|FD-Score:2.85|P-value:5.48E-4 ID:SGTC_1491|Compound:4138-0063|FD-Score:3.53|P-value:2.67E-5 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:2.86|P-value:5.24E-4 ID:SGTC_1682|Compound:st012968|FD-Score:-2.98|P-value:3.83E-4 ID:SGTC_1761|Compound:st044296|FD-Score:2.98|P-value:3.26E-4 ID:SGTC_1762|Compound:st045503|FD-Score:3.11|P-value:1.85E-4 ID:SGTC_1764|Compound:st044502|FD-Score:3.83|P-value:6.05E-6 ID:SGTC_1919|Compound:st067113|FD-Score:3.33|P-value:7.01E-5 ID:SGTC_2368|Compound:9071271|FD-Score:-5.29|P-value:9.93E-10 ID:SGTC_2430|Compound:5571206|FD-Score:4.05|P-value:1.83E-6 ID:SGTC_2618|Compound:avocadyne|FD-Score:-2.86|P-value:6.21E-4 ID:SGTC_2832|Compound:7992762|FD-Score:-3.04|P-value:2.99E-4 ID:SGTC_2971|Compound:9092186|FD-Score:-3.22|P-value:1.36E-4 ID:SGTC_2973|Compound:9094665|FD-Score:3.16|P-value:1.48E-4 ID:SGTC_2990|Compound:9074105|FD-Score:-3.08|P-value:2.50E-4

Top fitness defect scores for YHR040W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1132 3456-3614 7.11 2.5 µM 2.59E-16 tubulin folding & SWR complex 1 5.75E-13 1.35
2 SGTC_292 k038-0015 5.86 474.0 µM 1.14E-11 1 2.29E-9 1.57
3 SGTC_2430 5571206 4.05 200.0 µM 1.83E-6 20 2.53E-5 0.25
4 SGTC_418 lividomycin a 3.95 100.0 µM 3.26E-6 2 3.96E-5 0.45
5 SGTC_1764 st044502 3.83 93.5 µM 6.05E-6 4 6.41E-5 0.07
6 SGTC_1491 4138-0063 3.53 26.5 µM 2.67E-5 5 2.04E-4 0.35
7 SGTC_1919 st067113 3.33 52.3 µM 7.01E-5 TSC3-RPN4 17 4.33E-4 0.19
8 SGTC_2973 9094665 3.16 18.0 µM 1.48E-4 NEO1 25 7.79E-4 0.00
9 SGTC_1762 st045503 3.11 25.5 µM 1.85E-4 7 9.26E-4 0.10
10 SGTC_1001 4048-4355 3.02 44.4 µM 2.73E-4 copper-dependent oxidative stress 21 0.00126 0.03
11 SGTC_790 1575-0012 3.01 79.1 µM 2.87E-4 TSC3-RPN4 15 0.00131 0.05
12 SGTC_1761 st044296 2.98 37.0 µM 3.26E-4 15 0.00144 0.12
13 SGTC_1585 2',4'-dihydroxychalcone 2.86 10.4 µM 5.24E-4 22 0.00209 0.06
14 SGTC_1450 4112-4260 2.85 37.6 µM 5.48E-4 calcium & mitochondrial duress 17 0.00217 0.08
15 SGTC_968 1309-0633 2.85 340.0 µM 5.49E-4 16 0.00217 0.16
16 SGTC_65 0798-0905 2.79 35.0 µM 6.90E-4 calcium & mitochondrial duress 28 0.00260 0.03
17 SGTC_72 0744-0168 2.70 198.4 µM 9.90E-4 RPP1 & pyrimidine depletion 29 0.00344 0.10
18 SGTC_852 0418-0143 2.70 439.0 µM 0.00100 calcium & mitochondrial duress 32 0.00348 0.08
19 SGTC_1125 tnp00248 2.70 1.3 µM 0.00101 30 0.00350 0.01
20 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 2.70 19.1 µM 0.00101 17 0.00350 0.04

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.194 7.09E-30 YDL242W_d YDL242W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.144 4.34E-17 YLR247C IRC20 hom Putative helicase; localizes to the mitochondrion and the nucleus; YLR247C is not an essential gene; null mutant displays increased levels of spontaneous Rad52p foci
0.144 5.22E-17 YOR285W RDL1 hom Protein of unknown function containing a rhodanese-like domain; localized to the mitochondrial outer membrane; protein abundance increases in response to DNA replication stress
0.141 2.68E-16 YGR041W BUD9 hom Protein involved in bud-site selection; mutant has increased aneuploidy tolerance; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the distal pole
0.124 4.65E-13 YGL252C RTG2 hom Sensor of mitochondrial dysfunction; regulates the subcellular location of Rtg1p and Rtg3p, transcriptional activators of the retrograde (RTG) and TOR pathways; Rtg2p is inhibited by the phosphorylated form of Mks1p
0.123 7.23E-13 YER007W PAC2 hom Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl
0.121 1.78E-12 YGL140C_p YGL140C_p hom Putative protein of unknown function; non-essential gene; contains multiple predicted transmembrane domains
0.121 2.34E-12 YLR273C PIG1 hom Putative targeting subunit for the type-1 protein phosphatase Glc7p that tethers it to the Gsy2p glycogen synthase
0.117 9.99E-12 YPL241C CIN2 hom GTPase-activating protein (GAP) for Cin4p; tubulin folding factor C involved in beta-tubulin (Tub2p) folding; mutants display increased chromosome loss and benomyl sensitivity; deletion complemented by human GAP, retinitis pigmentosa 2
0.111 1.33E-10 YDR003W RCR2 hom Vacuolar protein; presumably functions within the endosomal-vacuolar trafficking pathway, affecting events that determine whether plasma membrane proteins are degraded or routed to the plasma membrane; RCR2 has a paralog, RCR1, that arose from the whole genome duplication
0.110 1.65E-10 YNL263C YIF1 het Integral membrane protein required for the fusion of ER-derived COPII transport vesicles with the Golgi; interacts with Yip1p and Yos1p; localizes to the Golgi, the ER, and COPII vesicles; homolog of human YIPF3
0.109 2.85E-10 YOR098C NUP1 het FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; possible karyopherin release factor that accelerates release of karyopherin-cargo complexes after transport across NPC; both NUP1 and NUP60 are homologous to human NUP153
0.107 5.03E-10 YGL226C-A OST5 hom Zeta subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins
0.107 5.26E-10 YLR216C CPR6 hom Peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity; protein abundance increases in response to DNA replication stress
0.104 1.50E-9 YBR153W RIB7 het Diaminohydroxyphoshoribosylaminopyrimidine deaminase; catalyzes the second step of the riboflavin biosynthesis pathway