HIPHOP chemogenomics database
YHR040W / BCD1 
Essential protein required for the accumulation of box C/D snoRNA
Zygosity: Heterozygous strain
fixedexpanded
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Top fitness defect scores for YHR040W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.194 | 7.09E-30 | YDL242W_d | YDL242W_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
| 0.144 | 4.34E-17 | YLR247C | IRC20 | hom | Putative helicase; localizes to the mitochondrion and the nucleus; YLR247C is not an essential gene; null mutant displays increased levels of spontaneous Rad52p foci |
| 0.144 | 5.22E-17 | YOR285W | RDL1 | hom | Protein of unknown function containing a rhodanese-like domain; localized to the mitochondrial outer membrane; protein abundance increases in response to DNA replication stress |
| 0.141 | 2.68E-16 | YGR041W | BUD9 | hom | Protein involved in bud-site selection; mutant has increased aneuploidy tolerance; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the distal pole |
| 0.124 | 4.65E-13 | YGL252C | RTG2 | hom | Sensor of mitochondrial dysfunction; regulates the subcellular location of Rtg1p and Rtg3p, transcriptional activators of the retrograde (RTG) and TOR pathways; Rtg2p is inhibited by the phosphorylated form of Mks1p |
| 0.123 | 7.23E-13 | YER007W | PAC2 | hom | Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl |
| 0.121 | 1.78E-12 | YGL140C_p | YGL140C_p | hom | Putative protein of unknown function; non-essential gene; contains multiple predicted transmembrane domains |
| 0.121 | 2.34E-12 | YLR273C | PIG1 | hom | Putative targeting subunit for the type-1 protein phosphatase Glc7p that tethers it to the Gsy2p glycogen synthase |
| 0.117 | 9.99E-12 | YPL241C | CIN2 | hom | GTPase-activating protein (GAP) for Cin4p; tubulin folding factor C involved in beta-tubulin (Tub2p) folding; mutants display increased chromosome loss and benomyl sensitivity; deletion complemented by human GAP, retinitis pigmentosa 2 |
| 0.111 | 1.33E-10 | YDR003W | RCR2 | hom | Vacuolar protein; presumably functions within the endosomal-vacuolar trafficking pathway, affecting events that determine whether plasma membrane proteins are degraded or routed to the plasma membrane; RCR2 has a paralog, RCR1, that arose from the whole genome duplication |
| 0.110 | 1.65E-10 | YNL263C | YIF1 | het | Integral membrane protein required for the fusion of ER-derived COPII transport vesicles with the Golgi; interacts with Yip1p and Yos1p; localizes to the Golgi, the ER, and COPII vesicles; homolog of human YIPF3 |
| 0.109 | 2.85E-10 | YOR098C | NUP1 | het | FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; possible karyopherin release factor that accelerates release of karyopherin-cargo complexes after transport across NPC; both NUP1 and NUP60 are homologous to human NUP153 |
| 0.107 | 5.03E-10 | YGL226C-A | OST5 | hom | Zeta subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins |
| 0.107 | 5.26E-10 | YLR216C | CPR6 | hom | Peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity; protein abundance increases in response to DNA replication stress |
| 0.104 | 1.50E-9 | YBR153W | RIB7 | het | Diaminohydroxyphoshoribosylaminopyrimidine deaminase; catalyzes the second step of the riboflavin biosynthesis pathway |