YHR044C / DOG1

2-deoxyglucose-6-phosphate phosphatase; paralogous to DOG2; member of a family of low molecular weight phosphatases; confers 2-deoxyglucose resistance when overexpressed, in vivo substrate has not yet been identified

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR044C / DOG1

Click on Significant Values for Screen Details ID:SGTC_111|Compound:0083-0039|FD-Score:3.40|P-value:8.22E-5 ID:SGTC_182|Compound:3448-4371|FD-Score:2.81|P-value:9.37E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:3.10|P-value:3.01E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:-2.91|P-value:5.79E-4 ID:SGTC_313|Compound:3474-0040|FD-Score:3.14|P-value:2.53E-4 ID:SGTC_338|Compound:4055-0136|FD-Score:2.87|P-value:7.49E-4 ID:SGTC_349|Compound:k015-0014|FD-Score:2.91|P-value:6.32E-4 ID:SGTC_354|Compound:2783-3500|FD-Score:-3.34|P-value:9.55E-5 ID:SGTC_534|Compound:k292-0788|FD-Score:2.95|P-value:5.52E-4 ID:SGTC_558|Compound:k064-0027|FD-Score:3.41|P-value:7.75E-5 ID:SGTC_657|Compound:3534-0529|FD-Score:3.78|P-value:1.40E-5 ID:SGTC_679|Compound:0422-0091|FD-Score:2.85|P-value:8.05E-4 ID:SGTC_686|Compound:1319-0111|FD-Score:3.65|P-value:2.64E-5 ID:SGTC_822|Compound:1487-0950|FD-Score:3.49|P-value:5.54E-5 ID:SGTC_857|Compound:0438-0306|FD-Score:2.90|P-value:6.73E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:3.51|P-value:4.95E-5 ID:SGTC_902|Compound:1120-0002|FD-Score:-4.23|P-value:1.19E-6 ID:SGTC_906|Compound:1165-0455|FD-Score:-3.16|P-value:2.09E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:4.25|P-value:1.23E-6 ID:SGTC_925|Compound:2064-1272|FD-Score:5.17|P-value:4.96E-9 ID:SGTC_927|Compound:2425-1185|FD-Score:3.75|P-value:1.65E-5 ID:SGTC_1053|Compound:3366-3204|FD-Score:2.88|P-value:7.14E-4 ID:SGTC_1063|Compound:disulfiram|FD-Score:-4.15|P-value:1.88E-6 ID:SGTC_1078|Compound:idebenone|FD-Score:3.91|P-value:7.39E-6 ID:SGTC_1081|Compound:sertraline|FD-Score:3.04|P-value:3.83E-4 ID:SGTC_1365|Compound:1672-3266|FD-Score:2.82|P-value:8.85E-4 ID:SGTC_1392|Compound:3455-1037|FD-Score:2.82|P-value:9.01E-4 ID:SGTC_1596|Compound:piperlongumine|FD-Score:3.95|P-value:5.97E-6 ID:SGTC_1626|Compound:st003712|FD-Score:-4.15|P-value:1.90E-6 ID:SGTC_1634|Compound:st006576|FD-Score:2.86|P-value:7.58E-4 ID:SGTC_1637|Compound:st007924|FD-Score:-3.13|P-value:2.36E-4 ID:SGTC_1726|Compound:st035556|FD-Score:2.87|P-value:7.49E-4 ID:SGTC_1735|Compound:st034310|FD-Score:4.01|P-value:4.32E-6 ID:SGTC_1802|Compound:st050112|FD-Score:3.58|P-value:3.70E-5 ID:SGTC_1866|Compound:st057638|FD-Score:4.66|P-value:1.20E-7 ID:SGTC_1909|Compound:st060837|FD-Score:4.47|P-value:3.62E-7 ID:SGTC_1994|Compound:st072947|FD-Score:3.50|P-value:5.35E-5 ID:SGTC_2128|Compound:5255449|FD-Score:-5.61|P-value:1.99E-10 ID:SGTC_2131|Compound:toluylene red|FD-Score:-4.37|P-value:5.43E-7 ID:SGTC_2174|Compound:5790901|FD-Score:3.22|P-value:1.78E-4 ID:SGTC_2368|Compound:9071271|FD-Score:4.00|P-value:4.61E-6 ID:SGTC_2563|Compound:tomatine|FD-Score:3.80|P-value:1.26E-5 ID:SGTC_2640|Compound:pentamidine|FD-Score:3.30|P-value:1.29E-4 ID:SGTC_2665|Compound:lovastatin|FD-Score:2.98|P-value:4.78E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:-3.27|P-value:1.33E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:6.61|P-value:1.08E-13 ID:SGTC_2754|Compound:granisetron|FD-Score:3.33|P-value:1.14E-4 ID:SGTC_2763|Compound:lisinopril|FD-Score:3.10|P-value:3.02E-4 ID:SGTC_2834|Compound:9001755|FD-Score:3.93|P-value:6.48E-6 ID:SGTC_2871|Compound:9038510|FD-Score:2.94|P-value:5.60E-4 ID:SGTC_3002|Compound:9075603|FD-Score:-3.51|P-value:4.60E-5 ID:SGTC_3072|Compound:9116419|FD-Score:-4.70|P-value:7.95E-8 ID:SGTC_3309|Compound:9129340|FD-Score:3.87|P-value:8.92E-6 ID:SGTC_3316|Compound:9136639|FD-Score:4.67|P-value:1.15E-7 ID:SGTC_111|Compound:0083-0039|FD-Score:3.40|P-value:8.22E-5 ID:SGTC_182|Compound:3448-4371|FD-Score:2.81|P-value:9.37E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:3.10|P-value:3.01E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:-2.91|P-value:5.79E-4 ID:SGTC_313|Compound:3474-0040|FD-Score:3.14|P-value:2.53E-4 ID:SGTC_338|Compound:4055-0136|FD-Score:2.87|P-value:7.49E-4 ID:SGTC_349|Compound:k015-0014|FD-Score:2.91|P-value:6.32E-4 ID:SGTC_354|Compound:2783-3500|FD-Score:-3.34|P-value:9.55E-5 ID:SGTC_534|Compound:k292-0788|FD-Score:2.95|P-value:5.52E-4 ID:SGTC_558|Compound:k064-0027|FD-Score:3.41|P-value:7.75E-5 ID:SGTC_657|Compound:3534-0529|FD-Score:3.78|P-value:1.40E-5 ID:SGTC_679|Compound:0422-0091|FD-Score:2.85|P-value:8.05E-4 ID:SGTC_686|Compound:1319-0111|FD-Score:3.65|P-value:2.64E-5 ID:SGTC_822|Compound:1487-0950|FD-Score:3.49|P-value:5.54E-5 ID:SGTC_857|Compound:0438-0306|FD-Score:2.90|P-value:6.73E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:3.51|P-value:4.95E-5 ID:SGTC_902|Compound:1120-0002|FD-Score:-4.23|P-value:1.19E-6 ID:SGTC_906|Compound:1165-0455|FD-Score:-3.16|P-value:2.09E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:4.25|P-value:1.23E-6 ID:SGTC_925|Compound:2064-1272|FD-Score:5.17|P-value:4.96E-9 ID:SGTC_927|Compound:2425-1185|FD-Score:3.75|P-value:1.65E-5 ID:SGTC_1053|Compound:3366-3204|FD-Score:2.88|P-value:7.14E-4 ID:SGTC_1063|Compound:disulfiram|FD-Score:-4.15|P-value:1.88E-6 ID:SGTC_1078|Compound:idebenone|FD-Score:3.91|P-value:7.39E-6 ID:SGTC_1081|Compound:sertraline|FD-Score:3.04|P-value:3.83E-4 ID:SGTC_1365|Compound:1672-3266|FD-Score:2.82|P-value:8.85E-4 ID:SGTC_1392|Compound:3455-1037|FD-Score:2.82|P-value:9.01E-4 ID:SGTC_1596|Compound:piperlongumine|FD-Score:3.95|P-value:5.97E-6 ID:SGTC_1626|Compound:st003712|FD-Score:-4.15|P-value:1.90E-6 ID:SGTC_1634|Compound:st006576|FD-Score:2.86|P-value:7.58E-4 ID:SGTC_1637|Compound:st007924|FD-Score:-3.13|P-value:2.36E-4 ID:SGTC_1726|Compound:st035556|FD-Score:2.87|P-value:7.49E-4 ID:SGTC_1735|Compound:st034310|FD-Score:4.01|P-value:4.32E-6 ID:SGTC_1802|Compound:st050112|FD-Score:3.58|P-value:3.70E-5 ID:SGTC_1866|Compound:st057638|FD-Score:4.66|P-value:1.20E-7 ID:SGTC_1909|Compound:st060837|FD-Score:4.47|P-value:3.62E-7 ID:SGTC_1994|Compound:st072947|FD-Score:3.50|P-value:5.35E-5 ID:SGTC_2128|Compound:5255449|FD-Score:-5.61|P-value:1.99E-10 ID:SGTC_2131|Compound:toluylene red|FD-Score:-4.37|P-value:5.43E-7 ID:SGTC_2174|Compound:5790901|FD-Score:3.22|P-value:1.78E-4 ID:SGTC_2368|Compound:9071271|FD-Score:4.00|P-value:4.61E-6 ID:SGTC_2563|Compound:tomatine|FD-Score:3.80|P-value:1.26E-5 ID:SGTC_2640|Compound:pentamidine|FD-Score:3.30|P-value:1.29E-4 ID:SGTC_2665|Compound:lovastatin|FD-Score:2.98|P-value:4.78E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:-3.27|P-value:1.33E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:6.61|P-value:1.08E-13 ID:SGTC_2754|Compound:granisetron|FD-Score:3.33|P-value:1.14E-4 ID:SGTC_2763|Compound:lisinopril|FD-Score:3.10|P-value:3.02E-4 ID:SGTC_2834|Compound:9001755|FD-Score:3.93|P-value:6.48E-6 ID:SGTC_2871|Compound:9038510|FD-Score:2.94|P-value:5.60E-4 ID:SGTC_3002|Compound:9075603|FD-Score:-3.51|P-value:4.60E-5 ID:SGTC_3072|Compound:9116419|FD-Score:-4.70|P-value:7.95E-8 ID:SGTC_3309|Compound:9129340|FD-Score:3.87|P-value:8.92E-6 ID:SGTC_3316|Compound:9136639|FD-Score:4.67|P-value:1.15E-7

Top fitness defect scores for YHR044C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2753 fluvastatin 6.61 17.1 µM 1.08E-13 azole & statin 6 1.89E-11
2 SGTC_925 2064-1272 5.17 59.6 µM 4.96E-9 7 1.18E-7
3 SGTC_3316 9136639 4.67 10.6 µM 1.15E-7 6 1.54E-6
4 SGTC_1866 st057638 4.66 64.0 µM 1.20E-7 7 1.60E-6
5 SGTC_1909 st060837 4.47 51.5 µM 3.62E-7 39 3.93E-6
6 SGTC_923 1900-2434 4.25 73.3 µM 1.23E-6 RNA processing & uracil transport 27 1.07E-5
7 SGTC_1735 st034310 4.01 56.8 µM 4.32E-6 Golgi 25 2.99E-5
8 SGTC_2368 9071271 4.00 200.0 µM 4.61E-6 32 3.15E-5
9 SGTC_1596 piperlongumine 3.95 63.0 µM 5.97E-6 18 3.90E-5
10 SGTC_2834 9001755 3.93 58.4 µM 6.48E-6 35 4.17E-5
11 SGTC_1078 idebenone 3.91 36.1 µM 7.39E-6 Golgi 45 4.64E-5
12 SGTC_3309 9129340 3.87 25.8 µM 8.92E-6 17 5.42E-5
13 SGTC_2563 tomatine 3.80 8.5 µM 1.26E-5 53 7.22E-5
14 SGTC_657 3534-0529 3.78 86.7 µM 1.40E-5 16 7.86E-5
15 SGTC_927 2425-1185 3.75 123.0 µM 1.65E-5 33 8.99E-5
16 SGTC_686 1319-0111 3.65 510.0 µM 2.64E-5 60S ribosome export 37 1.32E-4
17 SGTC_1802 st050112 3.58 57.9 µM 3.70E-5 17 1.74E-4
18 SGTC_887 0885-0007 3.51 9.6 µM 4.95E-5 endomembrane recycling 53 2.21E-4
19 SGTC_1994 st072947 3.50 40.9 µM 5.35E-5 29 2.35E-4
20 SGTC_822 1487-0950 3.49 154.0 µM 5.54E-5 29 2.42E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.114 3.71E-11 YML075C HMG1 hom HMG-CoA reductase; catalyzes the conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; one of two isozymes; localizes to the nuclear envelope; overproduction induces the formation of karmellae; forms foci at the nuclear periphery upon DNA replication stress
0.105 1.12E-9 YDR476C_p YDR476C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDR476C is not an essential gene
0.103 2.01E-9 YOR066W MSA1 hom Activator of G1-specific transcription factors, MBF and SBF; involved in regulation of the timing of G1-specific gene transcription and cell cycle initiation; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation
0.099 7.72E-9 YJL147C_p YJL147C_p hom Mitochondrial protein of unknown function; homozygous diploid deletion strain has a sporulation defect characterized by elevated dityrosine in the soluble fraction; expression induced by calcium shortage; YJL147W is a non-essential gene
0.082 1.90E-6 YJR096W YJR096W hom Putative xylose and arabinose reductase; member of the aldo-keto reductase (AKR) family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
0.082 2.23E-6 YNL104C LEU4 hom Alpha-isopropylmalate synthase (2-isopropylmalate synthase); the main isozyme responsible for the first step in the leucine biosynthesis pathway; LEU4 has a paralog, LEU9, that arose from the whole genome duplication
0.081 2.63E-6 YOR245C DGA1 hom Diacylglycerol acyltransferase, catalyzes the terminal step of triacylglycerol (TAG) formation, acylates diacylglycerol using acyl-CoA as an acyl donor, localized to lipid particles
0.081 2.80E-6 YEL047C FRD1 hom Soluble fumarate reductase; required with isoenzyme Osm1p for anaerobic growth; may interact with ribosomes, based on co-purification experiments; authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; similar to Arxula adeninovorans fumarate reductase; protein abundance increases in response to DNA replication stress; FRD1 has a paralog, OSM1, that arose from the whole genome duplication
0.079 4.54E-6 YPR077C_d YPR077C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression increased by deletion of NAP1
0.075 1.50E-5 YEL058W PCM1 het Essential N-acetylglucosamine-phosphate mutase; converts GlcNAc-6-P to GlcNAc-1-P, which is a precursor for the biosynthesis of chitin and for the formation of N-glycosylated mannoproteins and glycosylphosphatidylinositol anchors
0.073 2.27E-5 YGR280C PXR1 het Essential protein involved in rRNA and snoRNA maturation; competes with TLC1 RNA for binding to Est2p, suggesting a role in negative regulation of telomerase; human homolog inhibits telomerase; contains a G-patch RNA interacting domain
0.073 2.34E-5 YNL212W VID27 hom Cytoplasmic protein of unknown function; possibly involved in vacuolar protein degradation; not essential for proteasome-dependent degradation of fructose-1,6-bisphosphatase (FBPase); null mutants exhibit normal growth
0.072 2.80E-5 YJR094W-A RPL43B hom Ribosomal 60S subunit protein L43B; homologous to mammalian ribosomal protein L37A, no bacterial homolog; RPL43B has a paralog, RPL43A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.072 3.08E-5 YNR024W MPP6 hom Nuclear exosome-associated RNA binding protein; involved in surveillance of pre-rRNAs and pre-mRNAs, and the degradation of cryptic non-coding RNAs (ncRNA); copurifies with ribosomes
0.071 3.41E-5 YNR032C-A HUB1 hom Ubiquitin-like protein modifier; promotes alternative splicing of SRC1 pre-mRNA; binds non-covalently to the HIND domain of Snu66, may function in modification of Sph1p and Hbt1p, functionally complemented by the human or S. pombe ortholog; mechanism of Hub1p adduct formation not yet clear