YHR049W / FSH1

Putative serine hydrolase that localizes to both the nucleus and cytoplasm; sequence is similar to S. cerevisiae Fsh2p and Fsh3p and the human candidate tumor suppressor OVCA2

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR049W / FSH1

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:-2.98|P-value:5.06E-4 ID:SGTC_233|Compound:rapamycin|FD-Score:-3.25|P-value:1.73E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:2.85|P-value:7.08E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:3.13|P-value:2.31E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:3.60|P-value:2.75E-5 ID:SGTC_516|Compound:3992-2719|FD-Score:-3.56|P-value:4.31E-5 ID:SGTC_557|Compound:1315-0110|FD-Score:3.29|P-value:1.16E-4 ID:SGTC_628|Compound:1636-0253|FD-Score:-2.94|P-value:6.01E-4 ID:SGTC_630|Compound:4356-0227|FD-Score:-3.75|P-value:1.77E-5 ID:SGTC_697|Compound:0508-1955|FD-Score:3.14|P-value:2.16E-4 ID:SGTC_777|Compound:1315-0167|FD-Score:2.82|P-value:7.96E-4 ID:SGTC_843|Compound:0310-0051|FD-Score:-3.60|P-value:3.60E-5 ID:SGTC_851|Compound:0394-0702|FD-Score:-3.07|P-value:3.61E-4 ID:SGTC_941|Compound:3237-0776|FD-Score:2.82|P-value:7.78E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:3.08|P-value:2.84E-4 ID:SGTC_995|Compound:3931-2021|FD-Score:4.50|P-value:2.46E-7 ID:SGTC_1007|Compound:4101-0031|FD-Score:4.43|P-value:3.75E-7 ID:SGTC_1217|Compound:1183-1422|FD-Score:3.82|P-value:9.69E-6 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:2.87|P-value:6.55E-4 ID:SGTC_1345|Compound:1488-0192|FD-Score:3.28|P-value:1.19E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:3.31|P-value:1.06E-4 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:2.89|P-value:5.97E-4 ID:SGTC_1633|Compound:st005664|FD-Score:-2.98|P-value:5.23E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:4.22|P-value:1.17E-6 ID:SGTC_1727|Compound:st034309|FD-Score:2.97|P-value:4.34E-4 ID:SGTC_1751|Compound:st044839|FD-Score:4.20|P-value:1.33E-6 ID:SGTC_1759|Compound:st043059|FD-Score:3.26|P-value:1.32E-4 ID:SGTC_1779|Compound:st039427|FD-Score:2.93|P-value:5.14E-4 ID:SGTC_1792|Compound:st045773|FD-Score:5.47|P-value:4.98E-10 ID:SGTC_1923|Compound:st058458|FD-Score:5.55|P-value:2.98E-10 ID:SGTC_1930|Compound:st074634|FD-Score:2.94|P-value:4.94E-4 ID:SGTC_1934|Compound:st074720|FD-Score:-3.79|P-value:1.46E-5 ID:SGTC_1937|Compound:st074714|FD-Score:-3.63|P-value:3.15E-5 ID:SGTC_2068|Compound:5226020|FD-Score:2.84|P-value:7.34E-4 ID:SGTC_2074|Compound:5212007|FD-Score:6.39|P-value:5.10E-13 ID:SGTC_2091|Compound:4-phenylthiadiazole|FD-Score:-2.87|P-value:7.73E-4 ID:SGTC_2151|Compound:5563267|FD-Score:2.90|P-value:5.68E-4 ID:SGTC_2167|Compound:5876490|FD-Score:4.17|P-value:1.54E-6 ID:SGTC_2179|Compound:6298986|FD-Score:3.18|P-value:1.81E-4 ID:SGTC_2278|Compound:7948257|FD-Score:2.88|P-value:6.29E-4 ID:SGTC_2324|Compound:6149169|FD-Score:4.35|P-value:5.75E-7 ID:SGTC_2533|Compound:agelasine|FD-Score:4.88|P-value:2.49E-8 ID:SGTC_2587|Compound:piperic acid|FD-Score:-4.15|P-value:2.27E-6 ID:SGTC_2648|Compound:atorvastatin|FD-Score:3.35|P-value:8.76E-5 ID:SGTC_2685|Compound:mycophenolic acid|FD-Score:2.86|P-value:6.83E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-2.98|P-value:5.06E-4 ID:SGTC_233|Compound:rapamycin|FD-Score:-3.25|P-value:1.73E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:2.85|P-value:7.08E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:3.13|P-value:2.31E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:3.60|P-value:2.75E-5 ID:SGTC_516|Compound:3992-2719|FD-Score:-3.56|P-value:4.31E-5 ID:SGTC_557|Compound:1315-0110|FD-Score:3.29|P-value:1.16E-4 ID:SGTC_628|Compound:1636-0253|FD-Score:-2.94|P-value:6.01E-4 ID:SGTC_630|Compound:4356-0227|FD-Score:-3.75|P-value:1.77E-5 ID:SGTC_697|Compound:0508-1955|FD-Score:3.14|P-value:2.16E-4 ID:SGTC_777|Compound:1315-0167|FD-Score:2.82|P-value:7.96E-4 ID:SGTC_843|Compound:0310-0051|FD-Score:-3.60|P-value:3.60E-5 ID:SGTC_851|Compound:0394-0702|FD-Score:-3.07|P-value:3.61E-4 ID:SGTC_941|Compound:3237-0776|FD-Score:2.82|P-value:7.78E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:3.08|P-value:2.84E-4 ID:SGTC_995|Compound:3931-2021|FD-Score:4.50|P-value:2.46E-7 ID:SGTC_1007|Compound:4101-0031|FD-Score:4.43|P-value:3.75E-7 ID:SGTC_1217|Compound:1183-1422|FD-Score:3.82|P-value:9.69E-6 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:2.87|P-value:6.55E-4 ID:SGTC_1345|Compound:1488-0192|FD-Score:3.28|P-value:1.19E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:3.31|P-value:1.06E-4 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:2.89|P-value:5.97E-4 ID:SGTC_1633|Compound:st005664|FD-Score:-2.98|P-value:5.23E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:4.22|P-value:1.17E-6 ID:SGTC_1727|Compound:st034309|FD-Score:2.97|P-value:4.34E-4 ID:SGTC_1751|Compound:st044839|FD-Score:4.20|P-value:1.33E-6 ID:SGTC_1759|Compound:st043059|FD-Score:3.26|P-value:1.32E-4 ID:SGTC_1779|Compound:st039427|FD-Score:2.93|P-value:5.14E-4 ID:SGTC_1792|Compound:st045773|FD-Score:5.47|P-value:4.98E-10 ID:SGTC_1923|Compound:st058458|FD-Score:5.55|P-value:2.98E-10 ID:SGTC_1930|Compound:st074634|FD-Score:2.94|P-value:4.94E-4 ID:SGTC_1934|Compound:st074720|FD-Score:-3.79|P-value:1.46E-5 ID:SGTC_1937|Compound:st074714|FD-Score:-3.63|P-value:3.15E-5 ID:SGTC_2068|Compound:5226020|FD-Score:2.84|P-value:7.34E-4 ID:SGTC_2074|Compound:5212007|FD-Score:6.39|P-value:5.10E-13 ID:SGTC_2091|Compound:4-phenylthiadiazole|FD-Score:-2.87|P-value:7.73E-4 ID:SGTC_2151|Compound:5563267|FD-Score:2.90|P-value:5.68E-4 ID:SGTC_2167|Compound:5876490|FD-Score:4.17|P-value:1.54E-6 ID:SGTC_2179|Compound:6298986|FD-Score:3.18|P-value:1.81E-4 ID:SGTC_2278|Compound:7948257|FD-Score:2.88|P-value:6.29E-4 ID:SGTC_2324|Compound:6149169|FD-Score:4.35|P-value:5.75E-7 ID:SGTC_2533|Compound:agelasine|FD-Score:4.88|P-value:2.49E-8 ID:SGTC_2587|Compound:piperic acid|FD-Score:-4.15|P-value:2.27E-6 ID:SGTC_2648|Compound:atorvastatin|FD-Score:3.35|P-value:8.76E-5 ID:SGTC_2685|Compound:mycophenolic acid|FD-Score:2.86|P-value:6.83E-4

Top fitness defect scores for YHR049W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2074 5212007 6.39 75.4 µM 5.10E-13 1 8.35E-11
2 SGTC_1923 st058458 5.55 19.1 µM 2.98E-10 8 1.46E-8
3 SGTC_1792 st045773 5.47 43.6 µM 4.98E-10 8 2.21E-8
4 SGTC_2533 agelasine 4.88 13.7 µM 2.49E-8 ERG2 28 5.27E-7
5 SGTC_995 3931-2021 4.50 34.6 µM 2.46E-7 RPP1 & pyrimidine depletion 13 3.39E-6
6 SGTC_1007 4101-0031 4.43 70.0 µM 3.75E-7 10 4.77E-6
7 SGTC_2324 6149169 4.35 200.0 µM 5.75E-7 16 6.75E-6
8 SGTC_1718 roemerine 4.22 11.9 µM 1.17E-6 redox potentiating 48 1.20E-5
9 SGTC_1751 st044839 4.20 27.2 µM 1.33E-6 Golgi 9 1.33E-5
10 SGTC_2167 5876490 4.17 200.0 µM 1.54E-6 26 1.50E-5
11 SGTC_1217 1183-1422 3.82 255.0 µM 9.69E-6 13 6.71E-5
12 SGTC_377 3970-0964 3.60 33.1 µM 2.75E-5 58 1.57E-4
13 SGTC_2648 atorvastatin 3.35 78.7 µM 8.76E-5 azole & statin 34 4.02E-4
14 SGTC_1454 4239-0054 3.31 42.6 µM 1.06E-4 58 4.68E-4
15 SGTC_557 1315-0110 3.29 16.2 µM 1.16E-4 Golgi 45 5.06E-4
16 SGTC_1345 1488-0192 3.28 31.4 µM 1.19E-4 36 5.17E-4
17 SGTC_1759 st043059 3.26 70.0 µM 1.32E-4 amide catabolism 50 5.61E-4
18 SGTC_2179 6298986 3.18 200.0 µM 1.81E-4 heme requiring 38 7.27E-4
19 SGTC_697 0508-1955 3.14 564.0 µM 2.16E-4 71 8.38E-4
20 SGTC_294 k038-0071 3.13 157.0 µM 2.31E-4 ubiquinone biosynthesis & proteasome 104 8.87E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.143 9.82E-17 YDR419W RAD30 hom DNA polymerase eta, involved in translesion synthesis during post-replication repair; catalyzes the synthesis of DNA opposite cyclobutane pyrimidine dimers and other lesions; may also have a role in protection against mitochondrial mutagenesis; mutations in human pol eta are responsible for XPV
0.105 1.01E-9 YDR376W ARH1 het Oxidoreductase of the mitochondrial inner membrane, involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability
0.104 1.39E-9 YHR065C RRP3 het Protein involved in rRNA processing; required for maturation of the 35S primary transcript of pre-rRNA and for cleavage leading to mature 18S rRNA; homologous to eIF-4a, which is a DEAD box RNA-dependent ATPase with helicase activity
0.102 3.03E-9 YIL155C GUT2 hom Mitochondrial glycerol-3-phosphate dehydrogenase; expression is repressed by both glucose and cAMP and derepressed by non-fermentable carbon sources in a Snf1p, Rsf1p, Hap2/3/4/5 complex dependent manner
0.101 5.44E-9 YLR107W REX3 hom RNA exonuclease; required for maturation of the RNA component of RNase MRP; functions redundantly with Rnh70p and Rex2p in processing of U5 snRNA and RNase P RNA; member of RNase D family of exonucleases
0.100 5.82E-9 YMR159C ATG16 hom Conserved protein involved in autophagy; interacts with Atg12p-Atg5p conjugates to form Atg12p-Atg5p-Atg16p multimers, which localize to the pre-autophagosomal structure and are required for autophagy; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
0.100 7.37E-9 YJL083W TAX4 hom EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; TAX4 has a paralog, IRS4, that arose from the whole genome duplication
0.095 3.75E-8 YER028C MIG3 hom Transcriptional regulator; partially nonfunctional in S288C strains but has a major role in catabolite repression and ethanol response in some other strains; involved in response to toxic agents; phosphorylation by Snf1p or the Mec1p pathway inactivates Mig3p, allowing induction of damage response genes; MIG3 has a paralog, MIG2, that arose from the whole genome duplication
0.094 4.30E-8 YHR188C GPI16 het Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-Tp homolog
0.094 4.70E-8 YER110C KAP123 hom Karyopherin beta, mediates nuclear import of ribosomal proteins prior to assembly into ribosomes and import of histones H3 and H4; localizes to the nuclear pore, nucleus, and cytoplasm; exhibits genetic interactions with RAI1
0.091 1.16E-7 YGL039W YGL039W hom Oxidoreductase shown to reduce carbonyl compounds to chiral alcohols
0.091 1.30E-7 YIL078W THS1 het Threonyl-tRNA synthetase, essential cytoplasmic protein
0.089 2.14E-7 YDR513W GRX2 hom Cytoplasmic glutaredoxin; thioltransferase, glutathione-dependent disulfide oxidoreductase involved in maintaining redox state of target proteins, also exhibits glutathione peroxidase activity, expression induced in response to stress; GRX2 has a paralog, GRX1, that arose from the whole genome duplication
0.082 1.77E-6 YBR298C MAL31 hom Maltose permease, high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL3 complex locus; member of the 12 transmembrane domain superfamily of sugar transporters; functional in genomic reference strain S288C
0.082 1.88E-6 YNL189W SRP1 het Karyopherin alpha homolog, forms a dimer with karyopherin beta Kap95p to mediate import of nuclear proteins, binds the nuclear localization signal of the substrate during import; may also play a role in regulation of protein degradation