YHR050W-A_p

Protein of unknown function; identified by expression profiling and mass spectrometry

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR050W-A / YHR050W-A

Click on Significant Values for Screen Details ID:SGTC_177|Compound:1327-0068|FD-Score:-3.22|P-value:5.00E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:29.50|P-value:5.03E-198 ID:SGTC_275|Compound:trichlorophene|FD-Score:3.63|P-value:1.19E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:3.51|P-value:1.94E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:7.83|P-value:9.39E-16 ID:SGTC_425|Compound:3825-7017|FD-Score:-5.02|P-value:1.54E-7 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:4.41|P-value:3.87E-6 ID:SGTC_597|Compound:k018-0003|FD-Score:3.29|P-value:4.36E-4 ID:SGTC_771|Compound:0250-0039|FD-Score:3.10|P-value:8.44E-4 ID:SGTC_1087|Compound:pterostilbene|FD-Score:3.94|P-value:3.34E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.77|P-value:6.05E-5 ID:SGTC_1635|Compound:st007035|FD-Score:14.70|P-value:1.12E-50 ID:SGTC_1885|Compound:st057546|FD-Score:-3.30|P-value:3.73E-4 ID:SGTC_1902|Compound:st060212|FD-Score:-3.04|P-value:9.60E-4 ID:SGTC_1905|Compound:st060207|FD-Score:4.01|P-value:2.42E-5 ID:SGTC_2018|Compound:5133068|FD-Score:3.12|P-value:8.02E-4 ID:SGTC_2060|Compound:5238662|FD-Score:-3.97|P-value:2.54E-5 ID:SGTC_2098|Compound:5376439|FD-Score:3.68|P-value:9.91E-5 ID:SGTC_2100|Compound:5377183|FD-Score:3.33|P-value:3.73E-4 ID:SGTC_2292|Compound:7671323|FD-Score:-8.10|P-value:8.25E-17 ID:SGTC_2293|Compound:7624732|FD-Score:-3.93|P-value:3.01E-5 ID:SGTC_2302|Compound:7771753|FD-Score:-3.95|P-value:2.76E-5 ID:SGTC_2400|Compound:5203494|FD-Score:-3.12|P-value:7.30E-4 ID:SGTC_2508|Compound:celastrol|FD-Score:-3.32|P-value:3.46E-4 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:3.22|P-value:5.68E-4 ID:SGTC_2956|Compound:9076196|FD-Score:3.36|P-value:3.30E-4 ID:SGTC_2972|Compound:9093619|FD-Score:-3.63|P-value:1.08E-4 ID:SGTC_2999|Compound:9069765|FD-Score:-3.14|P-value:6.82E-4 ID:SGTC_3229|Compound:9132204|FD-Score:3.21|P-value:5.87E-4 ID:SGTC_177|Compound:1327-0068|FD-Score:-3.22|P-value:5.00E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:29.50|P-value:5.03E-198 ID:SGTC_275|Compound:trichlorophene|FD-Score:3.63|P-value:1.19E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:3.51|P-value:1.94E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:7.83|P-value:9.39E-16 ID:SGTC_425|Compound:3825-7017|FD-Score:-5.02|P-value:1.54E-7 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:4.41|P-value:3.87E-6 ID:SGTC_597|Compound:k018-0003|FD-Score:3.29|P-value:4.36E-4 ID:SGTC_771|Compound:0250-0039|FD-Score:3.10|P-value:8.44E-4 ID:SGTC_1087|Compound:pterostilbene|FD-Score:3.94|P-value:3.34E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.77|P-value:6.05E-5 ID:SGTC_1635|Compound:st007035|FD-Score:14.70|P-value:1.12E-50 ID:SGTC_1885|Compound:st057546|FD-Score:-3.30|P-value:3.73E-4 ID:SGTC_1902|Compound:st060212|FD-Score:-3.04|P-value:9.60E-4 ID:SGTC_1905|Compound:st060207|FD-Score:4.01|P-value:2.42E-5 ID:SGTC_2018|Compound:5133068|FD-Score:3.12|P-value:8.02E-4 ID:SGTC_2060|Compound:5238662|FD-Score:-3.97|P-value:2.54E-5 ID:SGTC_2098|Compound:5376439|FD-Score:3.68|P-value:9.91E-5 ID:SGTC_2100|Compound:5377183|FD-Score:3.33|P-value:3.73E-4 ID:SGTC_2292|Compound:7671323|FD-Score:-8.10|P-value:8.25E-17 ID:SGTC_2293|Compound:7624732|FD-Score:-3.93|P-value:3.01E-5 ID:SGTC_2302|Compound:7771753|FD-Score:-3.95|P-value:2.76E-5 ID:SGTC_2400|Compound:5203494|FD-Score:-3.12|P-value:7.30E-4 ID:SGTC_2508|Compound:celastrol|FD-Score:-3.32|P-value:3.46E-4 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:3.22|P-value:5.68E-4 ID:SGTC_2956|Compound:9076196|FD-Score:3.36|P-value:3.30E-4 ID:SGTC_2972|Compound:9093619|FD-Score:-3.63|P-value:1.08E-4 ID:SGTC_2999|Compound:9069765|FD-Score:-3.14|P-value:6.82E-4 ID:SGTC_3229|Compound:9132204|FD-Score:3.21|P-value:5.87E-4

Top fitness defect scores for YHR050W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 29.50 5.3 µM 5.03E-198 15 6.23E-192
2 SGTC_1635 st007035 14.70 42.4 µM 1.12E-50 41 3.31E-49
3 SGTC_421 streptovitacin 7.83 30.0 mM 9.39E-16 2 2.35E-15
4 SGTC_473 2-arachidonoylglycerol 4.41 10.0 µM 3.87E-6 17 5.08E-6
5 SGTC_1905 st060207 4.01 84.5 µM 2.42E-5 9 3.01E-5
6 SGTC_1087 pterostilbene 3.94 9.1 µM 3.34E-5 25 4.12E-5
7 SGTC_2098 5376439 3.68 882.5 nM 9.91E-5 16 1.19E-4
8 SGTC_275 trichlorophene 3.63 5.7 µM 1.19E-4 mitochondrial stress 244 1.41E-4
9 SGTC_364 0083-0097 3.51 67.7 µM 1.94E-4 41 2.28E-4
10 SGTC_2956 9076196 3.36 2.5 µM 3.30E-4 42 3.83E-4
11 SGTC_2100 5377183 3.33 190.0 µM 3.73E-4 60S ribosome export 31 4.32E-4
12 SGTC_597 k018-0003 3.29 82.8 µM 4.36E-4 RNA pol III & RNase P/MRP 27 5.03E-4
13 SGTC_2697 mebhydrolin 3.22 72.4 µM 5.68E-4 NEO1 103 6.50E-4
14 SGTC_3229 9132204 3.21 49.5 µM 5.87E-4 11 6.72E-4
15 SGTC_2018 5133068 3.12 143.0 µM 8.02E-4 64 9.10E-4
16 SGTC_771 0250-0039 3.10 27.3 µM 8.44E-4 36 9.56E-4
17 SGTC_2379 9035213 3.02 200.0 µM 0.00112 56 0.00126
18 SGTC_2833 9001315 3.01 45.5 µM 0.00115 amide catabolism 101 0.00129
19 SGTC_386 1509-0011 2.99 3.1 µM 0.00123 199 0.00138
20 SGTC_2490 carminic acid 2.89 95.4 µM 0.00172 32 0.00191

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.741 0 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.707 0 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.671 0 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.647 0 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.647 0 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.630 0 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.626 0 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.625 0 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.620 0 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.620 0 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.603 0 YKL087C CYT2 hom Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1
0.597 4.94E-323 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.595 3.80E-320 YOR065W CYT1 hom Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
0.579 8.53E-300 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.577 1.25E-297 YER141W COX15 hom Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase