Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; has a potential role in the secretory pathway
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YHR057C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.110 | 1.59E-10 | YMR008C | PLB1 | hom | Phospholipase B (lysophospholipase) involved in lipid metabolism, required for deacylation of phosphatidylcholine and phosphatidylethanolamine but not phosphatidylinositol |
0.093 | 6.71E-8 | YNL262W | POL2 | het | Catalytic subunit of DNA polymerase (II) epsilon, a chromosomal DNA replication polymerase that exhibits processivity and proofreading exonuclease activity; also involved in DNA synthesis during DNA repair; interacts extensively with Mrc1p |
0.090 | 1.93E-7 | YJL048C | UBX6 | hom | UBX (ubiquitin regulatory X) domain-containing protein; interacts with Cdc48p, transcription is repressed when cells are grown in media containing inositol and choline; UBX6 has a paralog, UBX7, that arose from the whole genome duplication |
0.084 | 9.97E-7 | YOR087W | YVC1 | hom | Vacuolar cation channel, mediates release of Ca(2+) from the vacuole in response to hyperosmotic shock |
0.082 | 1.89E-6 | YIL083C | CAB2 | het | Probable phosphopantothenoylcysteine synthetase (PPCS), which catalyzes the second step of coenzyme A biosynthesis from pantothenate; null mutant lethality is complemented by E. coli coaBC (encoding a bifunctional enzyme with PPCS activity) |
0.081 | 2.82E-6 | YDR147W | EKI1 | hom | Ethanolamine kinase; primarily responsible for phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; exhibits some choline kinase activity, thus contributing to phosphatidylcholine synthesis via the CDP-choline pathway; EKI1 has a paralog, CKI1, that arose from the whole genome duplication |
0.079 | 4.97E-6 | YNL155W | YNL155W | hom | Protein of unknown function; contains a DHHC domain and an AN1-type zinc finger; predicted to have thiol-disulfide oxidoreductase active site; transcriptionally regulated by Rpn4p along with proteasome subunit genes; putative ortholog of human AIRAP, which stimulates proteasome activity in response to arsenic; protein abundance increases in response to DNA replication stress |
0.079 | 5.24E-6 | YMR118C_p | SHH3_p | hom | Putative mitochondrial inner membrane protein of unknown function; although similar to Sdh3p, Shh3p is not a stoichiometric subunit of either succinate dehydrogenase or of the TIM22 translocase |
0.076 | 1.11E-5 | YIL003W | CFD1 | het | Highly conserved, iron-sulfur cluster binding protein localized in the cytoplasm; forms a complex with Nbp35p that is involved in iron-sulfur protein assembly in the cytosol |
0.076 | 1.18E-5 | YPL074W | YTA6 | hom | Putative ATPase of the CDC48/PAS1/SEC18 (AAA) family; localized to the cortex of mother cells but not to daughter cells; relocalizes from cytoplasm to plasma membrane foci upon DNA replication stress |
0.075 | 1.31E-5 | YNL286W | CUS2 | hom | Protein that binds to U2 snRNA and Prp11p, may be involved in U2 snRNA folding; contains two RNA recognition motifs (RRMs) |
0.075 | 1.49E-5 | YKL070W_p | YKL070W_p | hom | Putative protein of unknown function; expression induced in cells treated with mycotoxins patulin or citrinin; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies |
0.074 | 1.69E-5 | YPL175W | SPT14 | het | UDP-GlcNAc-binding and catalytic subunit of the enzyme that mediates the first step in glycosylphosphatidylinositol (GPI) biosynthesis, mutations cause defects in transcription and in biogenesis of cell wall proteins |
0.073 | 2.14E-5 | YOR046C | DBP5 | het | Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family; involved in mRNA export from the nucleus; involved in translation termination; ATP/ADP cycling is regulated by Gle1p and Nup159p |
0.073 | 2.53E-5 | YMR155W_p | YMR155W_p | hom | Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen |