YHR059W / FYV4

Protein of unknown function, required for survival upon exposure to K1 killer toxin

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR059W / FYV4

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:-4.27|P-value:9.16E-6 ID:SGTC_104|Compound:0074-0074|FD-Score:3.66|P-value:9.10E-5 ID:SGTC_108|Compound:0509-0257|FD-Score:5.57|P-value:6.72E-9 ID:SGTC_174|Compound:3553-0389|FD-Score:4.50|P-value:2.11E-6 ID:SGTC_180|Compound:1486-1293|FD-Score:4.27|P-value:6.48E-6 ID:SGTC_342|Compound:k048-0088|FD-Score:-3.17|P-value:7.47E-4 ID:SGTC_355|Compound:1311-2252|FD-Score:4.84|P-value:3.81E-7 ID:SGTC_541|Compound:4513-1321|FD-Score:3.19|P-value:5.49E-4 ID:SGTC_630|Compound:4356-0227|FD-Score:3.79|P-value:5.19E-5 ID:SGTC_637|Compound:1181-0519|FD-Score:3.85|P-value:4.08E-5 ID:SGTC_664|Compound:1222-0054|FD-Score:3.81|P-value:4.89E-5 ID:SGTC_702|Compound:1488-0190|FD-Score:-3.44|P-value:2.84E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:4.13|P-value:1.23E-5 ID:SGTC_889|Compound:0919-1524|FD-Score:3.19|P-value:5.33E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:-3.33|P-value:4.22E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:3.79|P-value:5.20E-5 ID:SGTC_1454|Compound:4239-0054|FD-Score:4.20|P-value:8.67E-6 ID:SGTC_1516|Compound:st013856|FD-Score:4.31|P-value:5.24E-6 ID:SGTC_1543|Compound:azetidyl-2-carboxylic acid|FD-Score:3.56|P-value:1.34E-4 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:3.68|P-value:8.29E-5 ID:SGTC_1687|Compound:st020778|FD-Score:3.14|P-value:6.47E-4 ID:SGTC_1761|Compound:st044296|FD-Score:7.29|P-value:5.79E-14 ID:SGTC_1876|Compound:myriocin|FD-Score:6.28|P-value:8.02E-11 ID:SGTC_2299|Compound:7976368|FD-Score:4.08|P-value:1.52E-5 ID:SGTC_2370|Compound:9071495|FD-Score:3.02|P-value:9.77E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:-3.10|P-value:9.49E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:4.21|P-value:8.28E-6 ID:SGTC_2706|Compound:st078239|FD-Score:4.20|P-value:8.82E-6 ID:SGTC_2802|Compound:7925815|FD-Score:3.35|P-value:3.06E-4 ID:SGTC_2846|Compound:9008642|FD-Score:-3.17|P-value:7.41E-4 ID:SGTC_2858|Compound:9025781|FD-Score:3.37|P-value:2.84E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.97|P-value:3.38E-5 ID:SGTC_3052|Compound:9092717|FD-Score:3.96|P-value:2.53E-5 ID:SGTC_3140|Compound:9094243|FD-Score:3.91|P-value:3.19E-5 ID:SGTC_3152|Compound:9099253|FD-Score:-4.08|P-value:2.06E-5 ID:SGTC_3221|Compound:9128209|FD-Score:3.56|P-value:1.35E-4 ID:SGTC_3251|Compound:9135047|FD-Score:3.37|P-value:2.82E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.27|P-value:9.16E-6 ID:SGTC_104|Compound:0074-0074|FD-Score:3.66|P-value:9.10E-5 ID:SGTC_108|Compound:0509-0257|FD-Score:5.57|P-value:6.72E-9 ID:SGTC_174|Compound:3553-0389|FD-Score:4.50|P-value:2.11E-6 ID:SGTC_180|Compound:1486-1293|FD-Score:4.27|P-value:6.48E-6 ID:SGTC_342|Compound:k048-0088|FD-Score:-3.17|P-value:7.47E-4 ID:SGTC_355|Compound:1311-2252|FD-Score:4.84|P-value:3.81E-7 ID:SGTC_541|Compound:4513-1321|FD-Score:3.19|P-value:5.49E-4 ID:SGTC_630|Compound:4356-0227|FD-Score:3.79|P-value:5.19E-5 ID:SGTC_637|Compound:1181-0519|FD-Score:3.85|P-value:4.08E-5 ID:SGTC_664|Compound:1222-0054|FD-Score:3.81|P-value:4.89E-5 ID:SGTC_702|Compound:1488-0190|FD-Score:-3.44|P-value:2.84E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:4.13|P-value:1.23E-5 ID:SGTC_889|Compound:0919-1524|FD-Score:3.19|P-value:5.33E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:-3.33|P-value:4.22E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:3.79|P-value:5.20E-5 ID:SGTC_1454|Compound:4239-0054|FD-Score:4.20|P-value:8.67E-6 ID:SGTC_1516|Compound:st013856|FD-Score:4.31|P-value:5.24E-6 ID:SGTC_1543|Compound:azetidyl-2-carboxylic acid|FD-Score:3.56|P-value:1.34E-4 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:3.68|P-value:8.29E-5 ID:SGTC_1687|Compound:st020778|FD-Score:3.14|P-value:6.47E-4 ID:SGTC_1761|Compound:st044296|FD-Score:7.29|P-value:5.79E-14 ID:SGTC_1876|Compound:myriocin|FD-Score:6.28|P-value:8.02E-11 ID:SGTC_2299|Compound:7976368|FD-Score:4.08|P-value:1.52E-5 ID:SGTC_2370|Compound:9071495|FD-Score:3.02|P-value:9.77E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:-3.10|P-value:9.49E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:4.21|P-value:8.28E-6 ID:SGTC_2706|Compound:st078239|FD-Score:4.20|P-value:8.82E-6 ID:SGTC_2802|Compound:7925815|FD-Score:3.35|P-value:3.06E-4 ID:SGTC_2846|Compound:9008642|FD-Score:-3.17|P-value:7.41E-4 ID:SGTC_2858|Compound:9025781|FD-Score:3.37|P-value:2.84E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.97|P-value:3.38E-5 ID:SGTC_3052|Compound:9092717|FD-Score:3.96|P-value:2.53E-5 ID:SGTC_3140|Compound:9094243|FD-Score:3.91|P-value:3.19E-5 ID:SGTC_3152|Compound:9099253|FD-Score:-4.08|P-value:2.06E-5 ID:SGTC_3221|Compound:9128209|FD-Score:3.56|P-value:1.35E-4 ID:SGTC_3251|Compound:9135047|FD-Score:3.37|P-value:2.82E-4

Top fitness defect scores for YHR059W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1761 st044296 7.29 37.0 µM 5.79E-14 1 1.56E-13
2 SGTC_1876 myriocin 6.28 605.0 nM 8.02E-11 13 1.74E-10
3 SGTC_108 0509-0257 5.57 621.1 µM 6.72E-9 16 1.27E-8
4 SGTC_355 1311-2252 4.84 105.0 µM 3.81E-7 6 6.35E-7
5 SGTC_174 3553-0389 4.50 74.3 µM 2.11E-6 13 3.33E-6
6 SGTC_1516 st013856 4.31 110.0 µM 5.24E-6 8 8.02E-6
7 SGTC_180 1486-1293 4.27 102.8 µM 6.48E-6 35 9.86E-6
8 SGTC_2613 3',4'-dimethoxydalbergione 4.21 24.6 µM 8.28E-6 16 1.25E-5
9 SGTC_1454 4239-0054 4.20 42.6 µM 8.67E-6 26 1.31E-5
10 SGTC_2706 st078239 4.20 82.5 µM 8.82E-6 6 1.33E-5
11 SGTC_800 3448-7362 4.13 155.0 µM 1.23E-5 translation 146 1.83E-5
12 SGTC_2299 7976368 4.08 114.9 µM 1.52E-5 29 2.25E-5
13 SGTC_3052 9092717 3.96 49.5 µM 2.53E-5 27 3.68E-5
14 SGTC_3140 9094243 3.91 49.5 µM 3.19E-5 25 4.61E-5
15 SGTC_637 1181-0519 3.85 7.3 µM 4.08E-5 fatty acid desaturase (OLE1) 111 5.85E-5
16 SGTC_664 1222-0054 3.81 14.9 µM 4.89E-5 sphingolipid biosynthesis & PDR1 40 6.96E-5
17 SGTC_630 4356-0227 3.79 183.0 µM 5.19E-5 12 7.38E-5
18 SGTC_948 3448-0295 3.79 75.3 µM 5.20E-5 31 7.40E-5
19 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 3.68 19.1 µM 8.29E-5 25 1.16E-4
20 SGTC_104 0074-0074 3.66 591.0 µM 9.10E-5 9 1.27E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.230 1.35E-41 YGR212W SLI1 hom N-acetyltransferase, confers resistance to the sphingolipid biosynthesis inhibitor myriocin (ISP-1) by converting it into N-acetyl-myriocin, co-operates with Ypk1p in mediating resistance to myriocin
0.159 1.58E-20 YHR041C SRB2 hom Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; general transcription factor involved in telomere maintenance
0.156 7.93E-20 YOL050C_d YOL050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified gene GAL11; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
0.155 1.56E-19 YMR296C LCB1 het Component of serine palmitoyltransferase, responsible along with Lcb2p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine
0.131 2.33E-14 YEL044W IES6 hom Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions; human ortholog INO80C is a member of the human INO80 complex; implicated in DNA repair based on genetic interactions with RAD52 epistasis genes
0.127 1.47E-13 YLR101C_d YLR101C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified, essential ORF ERG27/YLR100W
0.124 6.36E-13 YDR392W SPT3 hom Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters
0.123 7.83E-13 YDR071C PAA1 hom Polyamine acetyltransferase; acetylates polyamines (e.g. putrescine, spermidine, spermine) and also aralkylamines (e.g. tryptamine, phenylethylamine); may be involved in transcription and/or DNA replication
0.122 1.53E-12 YGR104C SRB5 hom Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; required for proper termination of transcription for some genes; involved in telomere maintenance
0.115 2.80E-11 YPL254W HFI1 hom Adaptor protein required for structural integrity of the SAGA complex, a histone acetyltransferase-coactivator complex that is involved in global regulation of gene expression through acetylation and transcription functions
0.113 4.80E-11 YLR055C SPT8 hom Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters
0.109 2.47E-10 YBR125C PTC4 hom Cytoplasmic type 2C protein phosphatase (PP2C); identified as a high-copy number suppressor of cnb1 mpk1 synthetic lethality; overexpression decreases high-osmolarity induced Hog1p phosphorylation and kinase activity
0.103 2.21E-9 YGR213C RTA1 hom Protein involved in 7-aminocholesterol resistance; has seven potential membrane-spanning regions; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-translocating exporter (LTE) family of protein
0.093 6.18E-8 YHR205W SCH9 hom AGC family protein kinase; functional ortholog of mammalian S6 kinase; phosphorylated by Tor1p and required for TORC1-mediated regulation of ribosome biogenesis, translation initiation, and entry into G0 phase; involved in transactivation of osmostress-responsive genes; regulates G1 progression, cAPK activity and nitrogen activation of the FGM pathway; integrates nutrient signals and stress signals from sphingolipids to regulate lifespan
0.093 6.99E-8 YGL025C PGD1 hom Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for basal and activated transcription; direct target of Cyc8p-Tup1p transcriptional corepressor