YHR064C / SSZ1

Hsp70 protein that interacts with Zuo1p (a DnaJ homolog) to form a ribosome-associated complex that binds the ribosome via the Zuo1p subunit; also involved in pleiotropic drug resistance via sequential activation of PDR1 and PDR5; binds ATP

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR064C / SSZ1

Click on Significant Values for Screen Details ID:SGTC_33|Compound:0986-0033|FD-Score:3.17|P-value:6.90E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:5.25|P-value:9.82E-8 ID:SGTC_117|Compound:lucigenin|FD-Score:4.27|P-value:1.03E-5 ID:SGTC_136|Compound:0097-0015|FD-Score:3.33|P-value:4.01E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:3.50|P-value:2.16E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:6.24|P-value:3.75E-10 ID:SGTC_151|Compound:3013-0144|FD-Score:-3.44|P-value:7.62E-4 ID:SGTC_187|Compound:1488-2104|FD-Score:4.03|P-value:2.85E-5 ID:SGTC_197|Compound:4544-0043|FD-Score:6.10|P-value:8.56E-10 ID:SGTC_299|Compound:1273-0059|FD-Score:-4.89|P-value:2.40E-6 ID:SGTC_304|Compound:1310-0298|FD-Score:-3.59|P-value:4.59E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:6.55|P-value:5.27E-11 ID:SGTC_310|Compound:1273-0058|FD-Score:-5.54|P-value:1.04E-7 ID:SGTC_351|Compound:caspofungin|FD-Score:6.87|P-value:6.62E-12 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.31|P-value:3.06E-5 ID:SGTC_467|Compound:ro 31-8220|FD-Score:7.11|P-value:1.29E-12 ID:SGTC_502|Compound:l-744,832|FD-Score:6.60|P-value:3.96E-11 ID:SGTC_513|Compound:4245-1575|FD-Score:-3.55|P-value:5.27E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:7.77|P-value:1.18E-14 ID:SGTC_547|Compound:1120-0019|FD-Score:3.13|P-value:7.99E-4 ID:SGTC_567|Compound:1080-0542|FD-Score:-3.42|P-value:8.00E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.60|P-value:4.46E-4 ID:SGTC_570|Compound:0987-0065|FD-Score:-3.78|P-value:2.30E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:4.83|P-value:8.21E-7 ID:SGTC_625|Compound:k213-0058|FD-Score:4.21|P-value:1.35E-5 ID:SGTC_653|Compound:0203-0016|FD-Score:3.56|P-value:1.78E-4 ID:SGTC_663|Compound:1486-0733|FD-Score:4.05|P-value:2.65E-5 ID:SGTC_664|Compound:1222-0054|FD-Score:3.06|P-value:9.97E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:3.32|P-value:4.18E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:5.54|P-value:2.14E-8 ID:SGTC_800|Compound:3448-7362|FD-Score:4.40|P-value:5.91E-6 ID:SGTC_830|Compound:4076-0286|FD-Score:3.35|P-value:3.70E-4 ID:SGTC_907|Compound:3448-6986|FD-Score:3.53|P-value:1.94E-4 ID:SGTC_917|Compound:harmaline|FD-Score:-4.26|P-value:3.72E-5 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:3.38|P-value:3.31E-4 ID:SGTC_944|Compound:3370-0224|FD-Score:-4.51|P-value:1.34E-5 ID:SGTC_1056|Compound:3448-1962|FD-Score:-3.52|P-value:5.85E-4 ID:SGTC_1120|Compound:ficusin|FD-Score:3.60|P-value:1.51E-4 ID:SGTC_1121|Compound:fusaric acid|FD-Score:4.11|P-value:2.05E-5 ID:SGTC_1160|Compound:4092-0570|FD-Score:3.33|P-value:3.95E-4 ID:SGTC_1194|Compound:1488-0194|FD-Score:3.17|P-value:6.90E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:-4.00|P-value:1.03E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:3.23|P-value:5.73E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:3.11|P-value:8.45E-4 ID:SGTC_1320|Compound:1313-0481|FD-Score:-3.39|P-value:8.85E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:-3.75|P-value:2.60E-4 ID:SGTC_1367|Compound:1812-0510|FD-Score:3.56|P-value:1.74E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.10|P-value:8.65E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:11.60|P-value:5.16E-30 ID:SGTC_1622|Compound:st003707|FD-Score:4.34|P-value:7.63E-6 ID:SGTC_1627|Compound:st003713|FD-Score:6.21|P-value:4.50E-10 ID:SGTC_1690|Compound:st023502|FD-Score:3.69|P-value:1.09E-4 ID:SGTC_1712|Compound:st032288|FD-Score:5.32|P-value:7.00E-8 ID:SGTC_1730|Compound:st033808|FD-Score:5.28|P-value:8.48E-8 ID:SGTC_1784|Compound:st039334|FD-Score:3.18|P-value:6.80E-4 ID:SGTC_1812|Compound:st052057|FD-Score:5.59|P-value:1.63E-8 ID:SGTC_1877|Compound:wortmannin|FD-Score:3.82|P-value:6.54E-5 ID:SGTC_2074|Compound:5212007|FD-Score:-3.60|P-value:4.40E-4 ID:SGTC_2075|Compound:5212009|FD-Score:-4.25|P-value:3.83E-5 ID:SGTC_2102|Compound:5377816|FD-Score:-3.82|P-value:2.01E-4 ID:SGTC_2105|Compound:5350118|FD-Score:3.17|P-value:6.93E-4 ID:SGTC_2165|Compound:5727197|FD-Score:-3.49|P-value:6.33E-4 ID:SGTC_2306|Compound:7482397|FD-Score:-3.48|P-value:6.53E-4 ID:SGTC_2365|Compound:9042475|FD-Score:3.09|P-value:8.98E-4 ID:SGTC_2423|Compound:st077119|FD-Score:3.48|P-value:2.38E-4 ID:SGTC_2431|Compound:5490079|FD-Score:4.24|P-value:1.17E-5 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:4.92|P-value:5.24E-7 ID:SGTC_2568|Compound:diosmetin|FD-Score:-3.99|P-value:1.08E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:5.23|P-value:1.07E-7 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.06|P-value:2.50E-5 ID:SGTC_2737|Compound:bleomycin|FD-Score:6.80|P-value:1.08E-11 ID:SGTC_2794|Compound:7785382|FD-Score:-3.97|P-value:1.17E-4 ID:SGTC_2801|Compound:7907800|FD-Score:3.61|P-value:1.47E-4 ID:SGTC_2825|Compound:7998094|FD-Score:4.91|P-value:5.51E-7 ID:SGTC_2889|Compound:9059656|FD-Score:3.59|P-value:1.55E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-4.34|P-value:2.70E-5 ID:SGTC_2932|Compound:9016711|FD-Score:4.44|P-value:4.93E-6 ID:SGTC_2933|Compound:9026794|FD-Score:3.51|P-value:2.11E-4 ID:SGTC_2940|Compound:9060638|FD-Score:3.21|P-value:5.95E-4 ID:SGTC_3173|Compound:9105693|FD-Score:3.30|P-value:4.45E-4 ID:SGTC_3219|Compound:9131112|FD-Score:-3.95|P-value:1.23E-4 ID:SGTC_33|Compound:0986-0033|FD-Score:3.17|P-value:6.90E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:5.25|P-value:9.82E-8 ID:SGTC_117|Compound:lucigenin|FD-Score:4.27|P-value:1.03E-5 ID:SGTC_136|Compound:0097-0015|FD-Score:3.33|P-value:4.01E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:3.50|P-value:2.16E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:6.24|P-value:3.75E-10 ID:SGTC_151|Compound:3013-0144|FD-Score:-3.44|P-value:7.62E-4 ID:SGTC_187|Compound:1488-2104|FD-Score:4.03|P-value:2.85E-5 ID:SGTC_197|Compound:4544-0043|FD-Score:6.10|P-value:8.56E-10 ID:SGTC_299|Compound:1273-0059|FD-Score:-4.89|P-value:2.40E-6 ID:SGTC_304|Compound:1310-0298|FD-Score:-3.59|P-value:4.59E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:6.55|P-value:5.27E-11 ID:SGTC_310|Compound:1273-0058|FD-Score:-5.54|P-value:1.04E-7 ID:SGTC_351|Compound:caspofungin|FD-Score:6.87|P-value:6.62E-12 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.31|P-value:3.06E-5 ID:SGTC_467|Compound:ro 31-8220|FD-Score:7.11|P-value:1.29E-12 ID:SGTC_502|Compound:l-744,832|FD-Score:6.60|P-value:3.96E-11 ID:SGTC_513|Compound:4245-1575|FD-Score:-3.55|P-value:5.27E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:7.77|P-value:1.18E-14 ID:SGTC_547|Compound:1120-0019|FD-Score:3.13|P-value:7.99E-4 ID:SGTC_567|Compound:1080-0542|FD-Score:-3.42|P-value:8.00E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.60|P-value:4.46E-4 ID:SGTC_570|Compound:0987-0065|FD-Score:-3.78|P-value:2.30E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:4.83|P-value:8.21E-7 ID:SGTC_625|Compound:k213-0058|FD-Score:4.21|P-value:1.35E-5 ID:SGTC_653|Compound:0203-0016|FD-Score:3.56|P-value:1.78E-4 ID:SGTC_663|Compound:1486-0733|FD-Score:4.05|P-value:2.65E-5 ID:SGTC_664|Compound:1222-0054|FD-Score:3.06|P-value:9.97E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:3.32|P-value:4.18E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:5.54|P-value:2.14E-8 ID:SGTC_800|Compound:3448-7362|FD-Score:4.40|P-value:5.91E-6 ID:SGTC_830|Compound:4076-0286|FD-Score:3.35|P-value:3.70E-4 ID:SGTC_907|Compound:3448-6986|FD-Score:3.53|P-value:1.94E-4 ID:SGTC_917|Compound:harmaline|FD-Score:-4.26|P-value:3.72E-5 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:3.38|P-value:3.31E-4 ID:SGTC_944|Compound:3370-0224|FD-Score:-4.51|P-value:1.34E-5 ID:SGTC_1056|Compound:3448-1962|FD-Score:-3.52|P-value:5.85E-4 ID:SGTC_1120|Compound:ficusin|FD-Score:3.60|P-value:1.51E-4 ID:SGTC_1121|Compound:fusaric acid|FD-Score:4.11|P-value:2.05E-5 ID:SGTC_1160|Compound:4092-0570|FD-Score:3.33|P-value:3.95E-4 ID:SGTC_1194|Compound:1488-0194|FD-Score:3.17|P-value:6.90E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:-4.00|P-value:1.03E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:3.23|P-value:5.73E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:3.11|P-value:8.45E-4 ID:SGTC_1320|Compound:1313-0481|FD-Score:-3.39|P-value:8.85E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:-3.75|P-value:2.60E-4 ID:SGTC_1367|Compound:1812-0510|FD-Score:3.56|P-value:1.74E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.10|P-value:8.65E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:11.60|P-value:5.16E-30 ID:SGTC_1622|Compound:st003707|FD-Score:4.34|P-value:7.63E-6 ID:SGTC_1627|Compound:st003713|FD-Score:6.21|P-value:4.50E-10 ID:SGTC_1690|Compound:st023502|FD-Score:3.69|P-value:1.09E-4 ID:SGTC_1712|Compound:st032288|FD-Score:5.32|P-value:7.00E-8 ID:SGTC_1730|Compound:st033808|FD-Score:5.28|P-value:8.48E-8 ID:SGTC_1784|Compound:st039334|FD-Score:3.18|P-value:6.80E-4 ID:SGTC_1812|Compound:st052057|FD-Score:5.59|P-value:1.63E-8 ID:SGTC_1877|Compound:wortmannin|FD-Score:3.82|P-value:6.54E-5 ID:SGTC_2074|Compound:5212007|FD-Score:-3.60|P-value:4.40E-4 ID:SGTC_2075|Compound:5212009|FD-Score:-4.25|P-value:3.83E-5 ID:SGTC_2102|Compound:5377816|FD-Score:-3.82|P-value:2.01E-4 ID:SGTC_2105|Compound:5350118|FD-Score:3.17|P-value:6.93E-4 ID:SGTC_2165|Compound:5727197|FD-Score:-3.49|P-value:6.33E-4 ID:SGTC_2306|Compound:7482397|FD-Score:-3.48|P-value:6.53E-4 ID:SGTC_2365|Compound:9042475|FD-Score:3.09|P-value:8.98E-4 ID:SGTC_2423|Compound:st077119|FD-Score:3.48|P-value:2.38E-4 ID:SGTC_2431|Compound:5490079|FD-Score:4.24|P-value:1.17E-5 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:4.92|P-value:5.24E-7 ID:SGTC_2568|Compound:diosmetin|FD-Score:-3.99|P-value:1.08E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:5.23|P-value:1.07E-7 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.06|P-value:2.50E-5 ID:SGTC_2737|Compound:bleomycin|FD-Score:6.80|P-value:1.08E-11 ID:SGTC_2794|Compound:7785382|FD-Score:-3.97|P-value:1.17E-4 ID:SGTC_2801|Compound:7907800|FD-Score:3.61|P-value:1.47E-4 ID:SGTC_2825|Compound:7998094|FD-Score:4.91|P-value:5.51E-7 ID:SGTC_2889|Compound:9059656|FD-Score:3.59|P-value:1.55E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-4.34|P-value:2.70E-5 ID:SGTC_2932|Compound:9016711|FD-Score:4.44|P-value:4.93E-6 ID:SGTC_2933|Compound:9026794|FD-Score:3.51|P-value:2.11E-4 ID:SGTC_2940|Compound:9060638|FD-Score:3.21|P-value:5.95E-4 ID:SGTC_3173|Compound:9105693|FD-Score:3.30|P-value:4.45E-4 ID:SGTC_3219|Compound:9131112|FD-Score:-3.95|P-value:1.23E-4

Top fitness defect scores for YHR064C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1597 7-benzyloxygramine 11.60 47.5 µM 5.16E-30 calcium & mitochondrial duress 11 2.07E-31
2 SGTC_528 3492-0019 7.77 172.0 µM 1.18E-14 calcium & mitochondrial duress 78 3.97E-15
3 SGTC_467 ro 31-8220 7.11 72.8 µM 1.29E-12 calcium & mitochondrial duress 22 5.66E-13
4 SGTC_351 caspofungin 6.87 25.0 nM 6.62E-12 cell wall 28 3.16E-12
5 SGTC_2737 bleomycin 6.80 30.5 nM 1.08E-11 Golgi 24 5.29E-12
6 SGTC_502 l-744,832 6.60 89.3 µM 3.96E-11 calcium & mitochondrial duress 9 2.08E-11
7 SGTC_309 k408-0051 6.55 1.5 µM 5.27E-11 11 2.81E-11
8 SGTC_149 3970-0822 6.24 46.1 µM 3.75E-10 tubulin folding & SWR complex 35 2.21E-10
9 SGTC_1627 st003713 6.21 25.6 µM 4.50E-10 calcium & mitochondrial duress 29 2.67E-10
10 SGTC_197 4544-0043 6.10 41.6 µM 8.56E-10 endomembrane recycling 14 5.26E-10
11 SGTC_1812 st052057 5.59 4.3 µM 1.63E-8 calcium & mitochondrial duress 8 1.16E-8
12 SGTC_788 1182-0090 5.54 188.0 µM 2.14E-8 endomembrane recycling 42 1.54E-8
13 SGTC_1712 st032288 5.32 53.4 µM 7.00E-8 calcium & mitochondrial duress 102 5.33E-8
14 SGTC_1730 st033808 5.28 45.1 µM 8.48E-8 8 6.52E-8
15 SGTC_65 0798-0905 5.25 35.0 µM 9.82E-8 calcium & mitochondrial duress 46 7.60E-8
16 SGTC_2619 obliquin 5.23 87.9 µM 1.07E-7 cell wall 93 8.35E-8
17 SGTC_2566 crystal violet carbinol 4.92 226.0 nM 5.24E-7 20 4.37E-7
18 SGTC_2825 7998094 4.91 58.4 µM 5.51E-7 fatty acid desaturase (OLE1) 16 4.62E-7
19 SGTC_582 0987-0078 4.83 156.0 µM 8.21E-7 calcium & mitochondrial duress 40 7.00E-7
20 SGTC_2932 9016711 4.44 44.5 µM 4.93E-6 33 4.54E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.434 1.72E-154 YGR285C ZUO1 hom Ribosome-associated chaperone, functions in ribosome biogenesis and, in partnership with Ssz1p and SSb1/2, as a chaperone for nascent polypeptide chains; contains a DnaJ domain and functions as a J-protein partner for Ssb1p and Ssb2p
0.431 6.87E-152 YJL129C TRK1 hom Component of the Trk1p-Trk2p potassium transport system; 180 kDa high affinity potassium transporter; phosphorylated in vivo and interacts physically with the phosphatase Ppz1p, suggesting Trk1p acitivy is regulated by phosphorylation; TRK1 has a paralog, TRK2, that arose from the whole genome duplication
0.418 1.54E-141 YJL165C HAL5 hom Putative protein kinase; overexpression increases sodium and lithium tolerance, whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake, suggesting a role in regulation of Trk1p and/or Trk2p transporters; HAL5 has a paralog, KKQ8, that arose from the whole genome duplication
0.309 3.30E-75 YOL016C CMK2 hom Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to mammalian Cam Kinase II; CMK2 has a paralog, CMK1, that arose from the whole genome duplication
0.303 2.65E-72 YDR475C JIP4 hom Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence
0.292 9.41E-67 YIL105C SLM1 hom Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex; protein abundance increases in response to DNA replication stress; SLM1 has a paralog, SLM2, that arose from the whole genome duplication
0.239 5.82E-45 YPL145C KES1 hom One of seven members of the yeast oxysterol binding protein family; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex; KES1 has a paralog, HES1, that arose from the whole genome duplication
0.239 1.14E-44 YIL154C IMP2' hom Transcriptional activator involved in maintenance of ion homeostasis and protection against DNA damage caused by bleomycin and other oxidants, contains a C-terminal leucine-rich repeat
0.234 4.51E-43 YDL160C DHH1 hom Cytoplasmic DExD/H-box helicase, stimulates mRNA decapping; coordinates distinct steps in mRNA function and decay, interacts with both the decapping and deadenylase complexes, may have a role in mRNA export and translation; C-terminus of Dhh1p interacts with Ngr1p and promotes POR1, but not EDC1 mRNA decay; forms cytoplasmic foci upon DNA replication stress
0.231 1.01E-41 YCR008W SAT4 hom Ser/Thr protein kinase involved in salt tolerance; funtions in regulation of Trk1p-Trk2p potassium transporter; partially redundant with Hal5p; has similarity to Npr1p
0.229 3.82E-41 YBR109C CMD1 het Calmodulin; Ca++ binding protein that regulates Ca++ independent processes (mitosis, bud growth, actin organization, endocytosis, etc.) and Ca++ dependent processes (stress-activated pathways), targets include Nuf1p, Myo2p and calcineurin
0.226 5.82E-40 YDR466W PKH3 hom Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant
0.221 1.65E-38 YHR205W SCH9 hom AGC family protein kinase; functional ortholog of mammalian S6 kinase; phosphorylated by Tor1p and required for TORC1-mediated regulation of ribosome biogenesis, translation initiation, and entry into G0 phase; involved in transactivation of osmostress-responsive genes; regulates G1 progression, cAPK activity and nitrogen activation of the FGM pathway; integrates nutrient signals and stress signals from sphingolipids to regulate lifespan
0.221 2.35E-38 YBL051C PIN4 hom Protein involved in G2/M phase progression and response to DNA damage, interacts with Rad53p; contains an RNA recognition motif, a nuclear localization signal, and several SQ/TQ cluster domains; hyperphosphorylated in response to DNA damage
0.218 2.34E-37 YEL003W GIM4 hom Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it