YHR078W_p

High osmolarity-regulated gene of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR078W / YHR078W

Click on Significant Values for Screen Details ID:SGTC_9|Compound:0092-0002|FD-Score:-3.07|P-value:7.18E-4 ID:SGTC_92|Compound:0063-0024|FD-Score:-3.61|P-value:8.95E-5 ID:SGTC_99|Compound:0109-0120|FD-Score:-3.02|P-value:8.59E-4 ID:SGTC_441|Compound:propafenone|FD-Score:-3.54|P-value:1.17E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:4.71|P-value:4.31E-7 ID:SGTC_633|Compound:0437-0093|FD-Score:-3.48|P-value:1.51E-4 ID:SGTC_654|Compound:1124-0271|FD-Score:3.70|P-value:5.65E-5 ID:SGTC_741|Compound:4582-0002|FD-Score:-3.47|P-value:1.57E-4 ID:SGTC_991|Compound:3996-0057|FD-Score:3.09|P-value:6.28E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.86|P-value:2.83E-5 ID:SGTC_1191|Compound:1487-1166|FD-Score:4.05|P-value:1.16E-5 ID:SGTC_1423|Compound:4048-0112|FD-Score:3.06|P-value:6.96E-4 ID:SGTC_1632|Compound:st005650|FD-Score:-3.52|P-value:1.30E-4 ID:SGTC_1781|Compound:st038725|FD-Score:-3.37|P-value:2.31E-4 ID:SGTC_1783|Compound:st039459|FD-Score:3.39|P-value:1.96E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:4.87|P-value:1.90E-7 ID:SGTC_1961|Compound:st076550|FD-Score:4.87|P-value:1.87E-7 ID:SGTC_1968|Compound:st069590|FD-Score:3.28|P-value:3.10E-4 ID:SGTC_1969|Compound:st069479|FD-Score:4.08|P-value:1.03E-5 ID:SGTC_1972|Compound:st070201|FD-Score:4.26|P-value:4.30E-6 ID:SGTC_2063|Compound:5246145|FD-Score:3.50|P-value:1.29E-4 ID:SGTC_2149|Compound:5554786|FD-Score:3.87|P-value:2.68E-5 ID:SGTC_2167|Compound:5876490|FD-Score:3.91|P-value:2.18E-5 ID:SGTC_2384|Compound:9036245|FD-Score:3.43|P-value:1.68E-4 ID:SGTC_2421|Compound:5690543|FD-Score:3.52|P-value:1.19E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:3.58|P-value:9.13E-5 ID:SGTC_2774|Compound:tamoxifen|FD-Score:3.12|P-value:5.63E-4 ID:SGTC_2856|Compound:9022925|FD-Score:3.09|P-value:6.27E-4 ID:SGTC_2969|Compound:9091408|FD-Score:-3.00|P-value:9.18E-4 ID:SGTC_2990|Compound:9074105|FD-Score:-4.35|P-value:3.12E-6 ID:SGTC_2994|Compound:9053520|FD-Score:3.01|P-value:8.36E-4 ID:SGTC_2997|Compound:9067075|FD-Score:4.32|P-value:3.25E-6 ID:SGTC_3221|Compound:9128209|FD-Score:-3.12|P-value:6.01E-4 ID:SGTC_9|Compound:0092-0002|FD-Score:-3.07|P-value:7.18E-4 ID:SGTC_92|Compound:0063-0024|FD-Score:-3.61|P-value:8.95E-5 ID:SGTC_99|Compound:0109-0120|FD-Score:-3.02|P-value:8.59E-4 ID:SGTC_441|Compound:propafenone|FD-Score:-3.54|P-value:1.17E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:4.71|P-value:4.31E-7 ID:SGTC_633|Compound:0437-0093|FD-Score:-3.48|P-value:1.51E-4 ID:SGTC_654|Compound:1124-0271|FD-Score:3.70|P-value:5.65E-5 ID:SGTC_741|Compound:4582-0002|FD-Score:-3.47|P-value:1.57E-4 ID:SGTC_991|Compound:3996-0057|FD-Score:3.09|P-value:6.28E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.86|P-value:2.83E-5 ID:SGTC_1191|Compound:1487-1166|FD-Score:4.05|P-value:1.16E-5 ID:SGTC_1423|Compound:4048-0112|FD-Score:3.06|P-value:6.96E-4 ID:SGTC_1632|Compound:st005650|FD-Score:-3.52|P-value:1.30E-4 ID:SGTC_1781|Compound:st038725|FD-Score:-3.37|P-value:2.31E-4 ID:SGTC_1783|Compound:st039459|FD-Score:3.39|P-value:1.96E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:4.87|P-value:1.90E-7 ID:SGTC_1961|Compound:st076550|FD-Score:4.87|P-value:1.87E-7 ID:SGTC_1968|Compound:st069590|FD-Score:3.28|P-value:3.10E-4 ID:SGTC_1969|Compound:st069479|FD-Score:4.08|P-value:1.03E-5 ID:SGTC_1972|Compound:st070201|FD-Score:4.26|P-value:4.30E-6 ID:SGTC_2063|Compound:5246145|FD-Score:3.50|P-value:1.29E-4 ID:SGTC_2149|Compound:5554786|FD-Score:3.87|P-value:2.68E-5 ID:SGTC_2167|Compound:5876490|FD-Score:3.91|P-value:2.18E-5 ID:SGTC_2384|Compound:9036245|FD-Score:3.43|P-value:1.68E-4 ID:SGTC_2421|Compound:5690543|FD-Score:3.52|P-value:1.19E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:3.58|P-value:9.13E-5 ID:SGTC_2774|Compound:tamoxifen|FD-Score:3.12|P-value:5.63E-4 ID:SGTC_2856|Compound:9022925|FD-Score:3.09|P-value:6.27E-4 ID:SGTC_2969|Compound:9091408|FD-Score:-3.00|P-value:9.18E-4 ID:SGTC_2990|Compound:9074105|FD-Score:-4.35|P-value:3.12E-6 ID:SGTC_2994|Compound:9053520|FD-Score:3.01|P-value:8.36E-4 ID:SGTC_2997|Compound:9067075|FD-Score:4.32|P-value:3.25E-6 ID:SGTC_3221|Compound:9128209|FD-Score:-3.12|P-value:6.01E-4

Top fitness defect scores for YHR078W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1961 st076550 4.87 68.7 µM 1.87E-7 7 5.61E-7
2 SGTC_1785 bathophenanthroline 4.87 24.0 µM 1.90E-7 heme requiring 21 5.69E-7
3 SGTC_625 k213-0058 4.71 121.0 µM 4.31E-7 translation 67 1.21E-6
4 SGTC_2997 9067075 4.32 71.4 µM 3.25E-6 unfolded protein response 45 7.82E-6
5 SGTC_1972 st070201 4.26 17.4 µM 4.30E-6 21 1.01E-5
6 SGTC_1969 st069479 4.08 40.1 µM 1.03E-5 10 2.27E-5
7 SGTC_1191 1487-1166 4.05 10.6 µM 1.16E-5 azole & statin 30 2.53E-5
8 SGTC_2167 5876490 3.91 200.0 µM 2.18E-5 32 4.53E-5
9 SGTC_2149 5554786 3.87 194.8 µM 2.68E-5 cell wall signaling 43 5.48E-5
10 SGTC_1132 3456-3614 3.86 2.5 µM 2.83E-5 tubulin folding & SWR complex 53 5.77E-5
11 SGTC_654 1124-0271 3.70 80.9 µM 5.65E-5 29 1.09E-4
12 SGTC_2758 dehydroepiandrosterone 3.58 69.3 µM 9.13E-5 53 1.70E-4
13 SGTC_2421 5690543 3.52 90.7 µM 1.19E-4 28 2.17E-4
14 SGTC_2063 5246145 3.50 200.0 µM 1.29E-4 36 2.34E-4
15 SGTC_2384 9036245 3.43 200.0 µM 1.68E-4 47 3.00E-4
16 SGTC_1783 st039459 3.39 87.5 µM 1.96E-4 Golgi 37 3.46E-4
17 SGTC_1968 st069590 3.28 43.6 µM 3.10E-4 30 5.27E-4
18 SGTC_2774 tamoxifen 3.12 10.9 µM 5.63E-4 42 9.15E-4
19 SGTC_2856 9022925 3.09 19.5 µM 6.27E-4 64 0.00101
20 SGTC_991 3996-0057 3.09 64.7 µM 6.28E-4 46 0.00101

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.129 7.24E-14 YLR452C SST2 hom GTPase-activating protein for Gpa1p, regulates desensitization to alpha factor pheromone; also required to prevent receptor-independent signaling of the mating pathway; member of the RGS (regulator of G-protein signaling) family
0.116 1.72E-11 YOL066C RIB2 het Bifunctional enzyme with DRAP deaminase and tRNA:pseudouridine synthase activity; the deaminase catalyzes the third step in riboflavin biosynthesis and the synthase catalyzes formation of pseudouridine at position 32 in cytoplasmic tRNAs
0.105 8.84E-10 YDR281C PHM6 hom Protein of unknown function, expression is regulated by phosphate levels
0.099 1.08E-8 YJL137C GLG2 hom Glycogenin glucosyltransferase; self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin; GLG2 has a paralog, GLG1, that arose from the whole genome duplication
0.098 1.36E-8 YIR021W-A_p YIR021W-A_p hom Putative protein of unknown function; identified by expression profiling and mass spectrometry
0.095 3.87E-8 YNL187W SWT21 hom Protein involved in mRNA splicing; contains a consensus nuclear export signal (NES) sequence similar to the consensus sequence recognized by Crm1p; interacts genetically with Prp40p and Tgs1p; contains WD40 repeats
0.093 7.05E-8 YNR011C PRP2 het RNA-dependent ATPase in the DEAH-box family, required for activation of the spliceosome before the first transesterification step in RNA splicing; orthologous to human protein DHX16
0.093 7.13E-8 YHR040W BCD1 het Essential protein required for the accumulation of box C/D snoRNA
0.086 5.42E-7 YMR101C SRT1 hom Cis-prenyltransferase involved in synthesis of long-chain dolichols (19-22 isoprene units; as opposed to Rer2p which synthesizes shorter-chain dolichols); localizes to lipid bodies; transcription is induced during stationary phase
0.086 6.69E-7 YDR119W_p VBA4_p hom Protein of unknown function with proposed role as a basic amino acid permease based on phylogeny; GFP-fusion protein localizes to vacuolar membrane; physical interaction with Atg27p suggests a possible role in autophagy; non-essential gene
0.085 7.11E-7 YIL039W TED1 hom Conserved phosphoesterase domain-containing protein that acts together with Emp24p/Erv25p in cargo exit from the ER; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
0.084 1.02E-6 YER016W BIM1 hom Microtubule-binding protein that together with Kar9p makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally
0.083 1.50E-6 YGL015C_p YGL015C_p hom Putative protein of unknown function; null mutants accumulate cargo in the Golgi
0.082 1.91E-6 YDL131W LYS21 hom Homocitrate synthase isozyme; catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; LYS21 has a paralog, LYS20, that arose from the whole genome duplication
0.082 1.93E-6 YPL184C MRN1 hom RNA-binding protein that may be involved in translational regulation; binds specific categories of mRNAs, including those that contain upstream open reading frames (uORFs) and internal ribosome entry sites (IRES); interacts genetically with chromatin remodelers and splicing factors, linking chromatin state, splicing and as a result mRNA maturation