| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|
| 0.129 |
7.24E-14 |
YLR452C |
SST2 |
hom |
GTPase-activating protein for Gpa1p, regulates desensitization to alpha factor pheromone; also required to prevent receptor-independent signaling of the mating pathway; member of the RGS (regulator of G-protein signaling) family |
| 0.116 |
1.72E-11 |
YOL066C |
RIB2 |
het |
Bifunctional enzyme with DRAP deaminase and tRNA:pseudouridine synthase activity; the deaminase catalyzes the third step in riboflavin biosynthesis and the synthase catalyzes formation of pseudouridine at position 32 in cytoplasmic tRNAs |
| 0.105 |
8.84E-10 |
YDR281C |
PHM6 |
hom |
Protein of unknown function, expression is regulated by phosphate levels |
| 0.099 |
1.08E-8 |
YJL137C |
GLG2 |
hom |
Glycogenin glucosyltransferase; self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin; GLG2 has a paralog, GLG1, that arose from the whole genome duplication |
| 0.098 |
1.36E-8 |
YIR021W-A_p |
YIR021W-A_p |
hom |
Putative protein of unknown function; identified by expression profiling and mass spectrometry |
| 0.095 |
3.87E-8 |
YNL187W |
SWT21 |
hom |
Protein involved in mRNA splicing; contains a consensus nuclear export signal (NES) sequence similar to the consensus sequence recognized by Crm1p; interacts genetically with Prp40p and Tgs1p; contains WD40 repeats |
| 0.093 |
7.05E-8 |
YNR011C |
PRP2 |
het |
RNA-dependent ATPase in the DEAH-box family, required for activation of the spliceosome before the first transesterification step in RNA splicing; orthologous to human protein DHX16 |
| 0.093 |
7.13E-8 |
YHR040W |
BCD1 |
het |
Essential protein required for the accumulation of box C/D snoRNA |
| 0.086 |
5.42E-7 |
YMR101C |
SRT1 |
hom |
Cis-prenyltransferase involved in synthesis of long-chain dolichols (19-22 isoprene units; as opposed to Rer2p which synthesizes shorter-chain dolichols); localizes to lipid bodies; transcription is induced during stationary phase |
| 0.086 |
6.69E-7 |
YDR119W_p |
VBA4_p |
hom |
Protein of unknown function with proposed role as a basic amino acid permease based on phylogeny; GFP-fusion protein localizes to vacuolar membrane; physical interaction with Atg27p suggests a possible role in autophagy; non-essential gene |
| 0.085 |
7.11E-7 |
YIL039W |
TED1 |
hom |
Conserved phosphoesterase domain-containing protein that acts together with Emp24p/Erv25p in cargo exit from the ER; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) |
| 0.084 |
1.02E-6 |
YER016W |
BIM1 |
hom |
Microtubule-binding protein that together with Kar9p makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally |
| 0.083 |
1.50E-6 |
YGL015C_p |
YGL015C_p |
hom |
Putative protein of unknown function; null mutants accumulate cargo in the Golgi |
| 0.082 |
1.91E-6 |
YDL131W |
LYS21 |
hom |
Homocitrate synthase isozyme; catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; LYS21 has a paralog, LYS20, that arose from the whole genome duplication |
| 0.082 |
1.93E-6 |
YPL184C |
MRN1 |
hom |
RNA-binding protein that may be involved in translational regulation; binds specific categories of mRNAs, including those that contain upstream open reading frames (uORFs) and internal ribosome entry sites (IRES); interacts genetically with chromatin remodelers and splicing factors, linking chromatin state, splicing and as a result mRNA maturation |
