YHR092C / HXT4

High-affinity glucose transporter; member of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose; HXT4 has a paralog, HXT7, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR092C / HXT4

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:4.77|P-value:1.69E-7 ID:SGTC_103|Compound:0844-0104|FD-Score:-3.09|P-value:8.52E-4 ID:SGTC_179|Compound:1273-0063|FD-Score:3.28|P-value:1.99E-4 ID:SGTC_180|Compound:1486-1293|FD-Score:3.46|P-value:9.58E-5 ID:SGTC_217|Compound:ketoconazole|FD-Score:3.29|P-value:1.88E-4 ID:SGTC_252|Compound:miconazole|FD-Score:2.86|P-value:9.64E-4 ID:SGTC_405|Compound:ebelactone b|FD-Score:4.16|P-value:4.09E-6 ID:SGTC_416|Compound:estradiol valerate|FD-Score:-3.12|P-value:7.57E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:4.45|P-value:9.40E-7 ID:SGTC_637|Compound:1181-0519|FD-Score:2.91|P-value:8.19E-4 ID:SGTC_639|Compound:0833-0042|FD-Score:-3.81|P-value:5.04E-5 ID:SGTC_724|Compound:3910-0327|FD-Score:-3.05|P-value:9.73E-4 ID:SGTC_762|Compound:1165-0429|FD-Score:2.89|P-value:8.81E-4 ID:SGTC_1224|Compound:0823-0416|FD-Score:3.67|P-value:3.82E-5 ID:SGTC_1232|Compound:0279-0259|FD-Score:-4.47|P-value:2.30E-6 ID:SGTC_1250|Compound:0485-0349|FD-Score:3.15|P-value:3.27E-4 ID:SGTC_1273|Compound:0849-0096|FD-Score:2.94|P-value:7.25E-4 ID:SGTC_1394|Compound:3474-0001|FD-Score:3.21|P-value:2.64E-4 ID:SGTC_1408|Compound:3909-7976|FD-Score:3.87|P-value:1.60E-5 ID:SGTC_1435|Compound:4092-0789|FD-Score:3.68|P-value:3.69E-5 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:3.44|P-value:1.03E-4 ID:SGTC_1629|Compound:st005085|FD-Score:3.17|P-value:3.10E-4 ID:SGTC_1635|Compound:st007035|FD-Score:3.15|P-value:3.33E-4 ID:SGTC_1701|Compound:st028638|FD-Score:-3.34|P-value:3.38E-4 ID:SGTC_1712|Compound:st032288|FD-Score:-4.16|P-value:1.02E-5 ID:SGTC_1794|Compound:st048918|FD-Score:3.54|P-value:6.95E-5 ID:SGTC_1873|Compound:rapamycin|FD-Score:3.24|P-value:2.34E-4 ID:SGTC_1897|Compound:st060201|FD-Score:-3.42|P-value:2.52E-4 ID:SGTC_1903|Compound:st060211|FD-Score:2.94|P-value:7.31E-4 ID:SGTC_1948|Compound:st076329|FD-Score:2.93|P-value:7.46E-4 ID:SGTC_1991|Compound:st073000|FD-Score:-3.28|P-value:4.31E-4 ID:SGTC_2009|Compound:4012297|FD-Score:5.43|P-value:3.43E-9 ID:SGTC_2060|Compound:5238662|FD-Score:2.87|P-value:9.39E-4 ID:SGTC_2126|Compound:5251174|FD-Score:3.03|P-value:5.15E-4 ID:SGTC_2248|Compound:tofa|FD-Score:4.83|P-value:1.21E-7 ID:SGTC_2354|Compound:9060492|FD-Score:3.13|P-value:3.52E-4 ID:SGTC_2355|Compound:9061122|FD-Score:4.09|P-value:5.65E-6 ID:SGTC_2414|Compound:st077232|FD-Score:-3.13|P-value:7.48E-4 ID:SGTC_2450|Compound:5739737|FD-Score:4.25|P-value:2.58E-6 ID:SGTC_2581|Compound:avocatin a|FD-Score:-4.02|P-value:2.00E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:8.63|P-value:2.80E-20 ID:SGTC_2600|Compound:tangeritin|FD-Score:-3.41|P-value:2.59E-4 ID:SGTC_2602|Compound:kawain|FD-Score:4.68|P-value:2.76E-7 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:4.50|P-value:7.17E-7 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:4.30|P-value:2.04E-6 ID:SGTC_2739|Compound:tacrine|FD-Score:3.15|P-value:3.28E-4 ID:SGTC_2798|Compound:7813637|FD-Score:5.41|P-value:3.75E-9 ID:SGTC_2799|Compound:7812892|FD-Score:2.86|P-value:9.56E-4 ID:SGTC_2802|Compound:7925815|FD-Score:4.92|P-value:7.12E-8 ID:SGTC_2821|Compound:7996764|FD-Score:4.27|P-value:2.31E-6 ID:SGTC_3027|Compound:9089541|FD-Score:3.38|P-value:1.32E-4 ID:SGTC_3048|Compound:9093155|FD-Score:-3.11|P-value:8.05E-4 ID:SGTC_3054|Compound:9094397|FD-Score:-3.49|P-value:1.87E-4 ID:SGTC_3067|Compound:9117431|FD-Score:3.37|P-value:1.38E-4 ID:SGTC_3110|Compound:9122132|FD-Score:3.17|P-value:3.09E-4 ID:SGTC_3157|Compound:9099274|FD-Score:4.21|P-value:3.15E-6 ID:SGTC_3236|Compound:9132701|FD-Score:2.93|P-value:7.55E-4 ID:SGTC_3242|Compound:9133940|FD-Score:3.24|P-value:2.32E-4 ID:SGTC_3255|Compound:9139072|FD-Score:3.34|P-value:1.59E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:4.77|P-value:1.69E-7 ID:SGTC_103|Compound:0844-0104|FD-Score:-3.09|P-value:8.52E-4 ID:SGTC_179|Compound:1273-0063|FD-Score:3.28|P-value:1.99E-4 ID:SGTC_180|Compound:1486-1293|FD-Score:3.46|P-value:9.58E-5 ID:SGTC_217|Compound:ketoconazole|FD-Score:3.29|P-value:1.88E-4 ID:SGTC_252|Compound:miconazole|FD-Score:2.86|P-value:9.64E-4 ID:SGTC_405|Compound:ebelactone b|FD-Score:4.16|P-value:4.09E-6 ID:SGTC_416|Compound:estradiol valerate|FD-Score:-3.12|P-value:7.57E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:4.45|P-value:9.40E-7 ID:SGTC_637|Compound:1181-0519|FD-Score:2.91|P-value:8.19E-4 ID:SGTC_639|Compound:0833-0042|FD-Score:-3.81|P-value:5.04E-5 ID:SGTC_724|Compound:3910-0327|FD-Score:-3.05|P-value:9.73E-4 ID:SGTC_762|Compound:1165-0429|FD-Score:2.89|P-value:8.81E-4 ID:SGTC_1224|Compound:0823-0416|FD-Score:3.67|P-value:3.82E-5 ID:SGTC_1232|Compound:0279-0259|FD-Score:-4.47|P-value:2.30E-6 ID:SGTC_1250|Compound:0485-0349|FD-Score:3.15|P-value:3.27E-4 ID:SGTC_1273|Compound:0849-0096|FD-Score:2.94|P-value:7.25E-4 ID:SGTC_1394|Compound:3474-0001|FD-Score:3.21|P-value:2.64E-4 ID:SGTC_1408|Compound:3909-7976|FD-Score:3.87|P-value:1.60E-5 ID:SGTC_1435|Compound:4092-0789|FD-Score:3.68|P-value:3.69E-5 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:3.44|P-value:1.03E-4 ID:SGTC_1629|Compound:st005085|FD-Score:3.17|P-value:3.10E-4 ID:SGTC_1635|Compound:st007035|FD-Score:3.15|P-value:3.33E-4 ID:SGTC_1701|Compound:st028638|FD-Score:-3.34|P-value:3.38E-4 ID:SGTC_1712|Compound:st032288|FD-Score:-4.16|P-value:1.02E-5 ID:SGTC_1794|Compound:st048918|FD-Score:3.54|P-value:6.95E-5 ID:SGTC_1873|Compound:rapamycin|FD-Score:3.24|P-value:2.34E-4 ID:SGTC_1897|Compound:st060201|FD-Score:-3.42|P-value:2.52E-4 ID:SGTC_1903|Compound:st060211|FD-Score:2.94|P-value:7.31E-4 ID:SGTC_1948|Compound:st076329|FD-Score:2.93|P-value:7.46E-4 ID:SGTC_1991|Compound:st073000|FD-Score:-3.28|P-value:4.31E-4 ID:SGTC_2009|Compound:4012297|FD-Score:5.43|P-value:3.43E-9 ID:SGTC_2060|Compound:5238662|FD-Score:2.87|P-value:9.39E-4 ID:SGTC_2126|Compound:5251174|FD-Score:3.03|P-value:5.15E-4 ID:SGTC_2248|Compound:tofa|FD-Score:4.83|P-value:1.21E-7 ID:SGTC_2354|Compound:9060492|FD-Score:3.13|P-value:3.52E-4 ID:SGTC_2355|Compound:9061122|FD-Score:4.09|P-value:5.65E-6 ID:SGTC_2414|Compound:st077232|FD-Score:-3.13|P-value:7.48E-4 ID:SGTC_2450|Compound:5739737|FD-Score:4.25|P-value:2.58E-6 ID:SGTC_2581|Compound:avocatin a|FD-Score:-4.02|P-value:2.00E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:8.63|P-value:2.80E-20 ID:SGTC_2600|Compound:tangeritin|FD-Score:-3.41|P-value:2.59E-4 ID:SGTC_2602|Compound:kawain|FD-Score:4.68|P-value:2.76E-7 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:4.50|P-value:7.17E-7 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:4.30|P-value:2.04E-6 ID:SGTC_2739|Compound:tacrine|FD-Score:3.15|P-value:3.28E-4 ID:SGTC_2798|Compound:7813637|FD-Score:5.41|P-value:3.75E-9 ID:SGTC_2799|Compound:7812892|FD-Score:2.86|P-value:9.56E-4 ID:SGTC_2802|Compound:7925815|FD-Score:4.92|P-value:7.12E-8 ID:SGTC_2821|Compound:7996764|FD-Score:4.27|P-value:2.31E-6 ID:SGTC_3027|Compound:9089541|FD-Score:3.38|P-value:1.32E-4 ID:SGTC_3048|Compound:9093155|FD-Score:-3.11|P-value:8.05E-4 ID:SGTC_3054|Compound:9094397|FD-Score:-3.49|P-value:1.87E-4 ID:SGTC_3067|Compound:9117431|FD-Score:3.37|P-value:1.38E-4 ID:SGTC_3110|Compound:9122132|FD-Score:3.17|P-value:3.09E-4 ID:SGTC_3157|Compound:9099274|FD-Score:4.21|P-value:3.15E-6 ID:SGTC_3236|Compound:9132701|FD-Score:2.93|P-value:7.55E-4 ID:SGTC_3242|Compound:9133940|FD-Score:3.24|P-value:2.32E-4 ID:SGTC_3255|Compound:9139072|FD-Score:3.34|P-value:1.59E-4

Top fitness defect scores for YHR092C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2582 agaric acid 8.63 100.0 µM 2.80E-20 redox potentiating 93 3.04E-18
2 SGTC_2009 4012297 5.43 12.1 µM 3.43E-9 cell wall signaling 29 2.84E-8
3 SGTC_2798 7813637 5.41 45.5 µM 3.75E-9 7 3.07E-8
4 SGTC_2802 7925815 4.92 54.5 µM 7.12E-8 20 4.30E-7
5 SGTC_2248 tofa 4.83 1.1 µM 1.21E-7 sphingolipid biosynthesis & PDR1 29 6.95E-7
6 SGTC_58 0957-0393 4.77 9.0 µM 1.69E-7 cell wall 310 9.32E-7
7 SGTC_2602 kawain 4.68 100.0 µM 2.76E-7 12 1.45E-6
8 SGTC_2633 5,7-dihydroxyisoflavone 4.50 100.0 µM 7.17E-7 23 3.40E-6
9 SGTC_607 4491-0986 4.45 66.8 µM 9.40E-7 heme requiring 16 4.34E-6
10 SGTC_2658 polymyxin b sulfate 4.30 77.0 µM 2.04E-6 NEO1 33 8.69E-6
11 SGTC_2821 7996764 4.27 71.4 µM 2.31E-6 28 9.70E-6
12 SGTC_2450 5739737 4.25 12.9 µM 2.58E-6 19 1.07E-5
13 SGTC_3157 9099274 4.21 49.5 µM 3.15E-6 15 1.28E-5
14 SGTC_405 ebelactone b 4.16 50.0 µM 4.09E-6 14 1.62E-5
15 SGTC_2355 9061122 4.09 103.1 µM 5.65E-6 11 2.16E-5
16 SGTC_1408 3909-7976 3.87 48.8 µM 1.60E-5 Golgi 22 5.48E-5
17 SGTC_1435 4092-0789 3.68 56.7 µM 3.69E-5 plasma membrane duress 18 1.16E-4
18 SGTC_1224 0823-0416 3.67 294.0 µM 3.82E-5 16 1.19E-4
19 SGTC_1794 st048918 3.54 76.9 µM 6.95E-5 14 2.03E-4
20 SGTC_180 1486-1293 3.46 102.8 µM 9.58E-5 53 2.70E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.253 3.53E-50 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.230 2.22E-41 YGL178W MPT5 hom mRNA-binding protein of the PUF family; binds to the 3' UTR of specific mRNAs, including those involved in mating type switching, cell wall integrity, chronological lifespan, chromatin modification, and spindle pole body architecture; recruits the CCR4-NOT deadenylase complex to mRNAs along with Dhh1p and Dcp1p to promote deadenylation, decapping, and decay; also interacts with the Caf20p translational initiation repressor, affecting its mRNA target specificity
0.224 2.14E-39 YNL106C INP52 hom Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.203 2.04E-32 YMR109W MYO5 hom One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization
0.195 4.06E-30 YEL007W MIT1 hom Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1
0.189 2.34E-28 YNL105W_d RRT16_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene INP52; identified in a screen for mutants with decreased levels of rDNA transcription
0.188 4.00E-28 YNL027W CRZ1 hom Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress
0.184 5.97E-27 YNL074C MLF3 hom Serine-rich protein of unknown function, predicted to be palmitoylated; overproduction suppresses the growth inhibition caused by exposure to the immunosuppressant leflunomide
0.184 7.25E-27 YHR036W BRL1 het Essential nuclear envelope integral membrane protein identified as a suppressor of a conditional mutation in the major karyopherin, CRM1; homologous to and interacts with Brr6p, a nuclear envelope protein involved in nuclear export
0.183 9.90E-27 YGR196C FYV8 hom Protein of unknown function, required for survival upon exposure to K1 killer toxin
0.181 4.57E-26 YOR049C RSB1 hom Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane
0.180 8.56E-26 YBR082C UBC4 hom Ubiquitin-conjugating enzyme (E2); mediates degradation of abnormal or excess proteins, including calmodulin and histone H3; interacts with many SCF ubiquitin protein ligases; component of the cellular stress response; UBC4 has a paralog, UBC5, that arose from the whole genome duplication
0.180 9.97E-26 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.176 9.31E-25 YBR260C RGD1 hom GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization
0.175 1.89E-24 YML052W SUR7 hom Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants