YHR093W_d / AHT1

Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; multicopy suppressor of glucose transport defects, likely due to the presence of an HXT4 regulatory element in the region

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR093W / AHT1

Click on Significant Values for Screen Details ID:SGTC_394|Compound:menadione|FD-Score:3.21|P-value:5.33E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:4.16|P-value:1.16E-5 ID:SGTC_430|Compound:0958-0115|FD-Score:-7.58|P-value:8.35E-15 ID:SGTC_431|Compound:k089-0097|FD-Score:-3.06|P-value:9.95E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:3.78|P-value:6.05E-5 ID:SGTC_816|Compound:0325-0417|FD-Score:-3.08|P-value:9.24E-4 ID:SGTC_819|Compound:1013-0258|FD-Score:-3.21|P-value:5.98E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:3.22|P-value:5.32E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:-6.70|P-value:5.82E-12 ID:SGTC_1036|Compound:k216-0215|FD-Score:3.81|P-value:5.41E-5 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:4.81|P-value:4.92E-7 ID:SGTC_1120|Compound:ficusin|FD-Score:3.65|P-value:1.02E-4 ID:SGTC_1198|Compound:1612-1005|FD-Score:3.43|P-value:2.41E-4 ID:SGTC_1283|Compound:0922-0125|FD-Score:3.55|P-value:1.53E-4 ID:SGTC_1285|Compound:0929-0069|FD-Score:4.04|P-value:2.02E-5 ID:SGTC_1291|Compound:0993-0025|FD-Score:5.18|P-value:6.80E-8 ID:SGTC_1360|Compound:1598-0022|FD-Score:3.13|P-value:7.26E-4 ID:SGTC_1364|Compound:1653-0028|FD-Score:-3.97|P-value:2.98E-5 ID:SGTC_1428|Compound:4049-0204|FD-Score:3.34|P-value:3.36E-4 ID:SGTC_1506|Compound:4226-2149|FD-Score:3.35|P-value:3.28E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:6.28|P-value:8.76E-11 ID:SGTC_1762|Compound:st045503|FD-Score:-3.34|P-value:3.62E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-4.83|P-value:5.16E-7 ID:SGTC_1936|Compound:st074407|FD-Score:-3.19|P-value:6.33E-4 ID:SGTC_2057|Compound:5236571|FD-Score:-3.07|P-value:9.71E-4 ID:SGTC_2059|Compound:5238311|FD-Score:3.35|P-value:3.29E-4 ID:SGTC_2138|Compound:5575593|FD-Score:3.20|P-value:5.71E-4 ID:SGTC_2140|Compound:5586273|FD-Score:-3.45|P-value:2.40E-4 ID:SGTC_2146|Compound:5545642|FD-Score:-4.19|P-value:1.13E-5 ID:SGTC_2158|Compound:5657123|FD-Score:4.95|P-value:2.47E-7 ID:SGTC_2439|Compound:5492030|FD-Score:3.60|P-value:1.25E-4 ID:SGTC_2451|Compound:5856223|FD-Score:-4.03|P-value:2.34E-5 ID:SGTC_2461|Compound:5755302|FD-Score:3.48|P-value:1.98E-4 ID:SGTC_2629|Compound:bisabolol|FD-Score:3.52|P-value:1.67E-4 ID:SGTC_2806|Compound:7952793|FD-Score:4.83|P-value:4.61E-7 ID:SGTC_2924|Compound:9010168|FD-Score:3.04|P-value:9.88E-4 ID:SGTC_2930|Compound:9013230|FD-Score:3.07|P-value:8.90E-4 ID:SGTC_3045|Compound:9092950|FD-Score:3.14|P-value:6.88E-4 ID:SGTC_3049|Compound:9092223|FD-Score:4.30|P-value:6.07E-6 ID:SGTC_3147|Compound:9097027|FD-Score:3.81|P-value:5.32E-5 ID:SGTC_3158|Compound:9100007|FD-Score:-3.12|P-value:8.04E-4 ID:SGTC_3217|Compound:9129673|FD-Score:-3.39|P-value:3.07E-4 ID:SGTC_3231|Compound:9132313|FD-Score:-3.57|P-value:1.52E-4 ID:SGTC_3238|Compound:9133470|FD-Score:-4.75|P-value:7.79E-7 ID:SGTC_3248|Compound:9135562|FD-Score:-4.03|P-value:2.29E-5 ID:SGTC_394|Compound:menadione|FD-Score:3.21|P-value:5.33E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:4.16|P-value:1.16E-5 ID:SGTC_430|Compound:0958-0115|FD-Score:-7.58|P-value:8.35E-15 ID:SGTC_431|Compound:k089-0097|FD-Score:-3.06|P-value:9.95E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:3.78|P-value:6.05E-5 ID:SGTC_816|Compound:0325-0417|FD-Score:-3.08|P-value:9.24E-4 ID:SGTC_819|Compound:1013-0258|FD-Score:-3.21|P-value:5.98E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:3.22|P-value:5.32E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:-6.70|P-value:5.82E-12 ID:SGTC_1036|Compound:k216-0215|FD-Score:3.81|P-value:5.41E-5 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:4.81|P-value:4.92E-7 ID:SGTC_1120|Compound:ficusin|FD-Score:3.65|P-value:1.02E-4 ID:SGTC_1198|Compound:1612-1005|FD-Score:3.43|P-value:2.41E-4 ID:SGTC_1283|Compound:0922-0125|FD-Score:3.55|P-value:1.53E-4 ID:SGTC_1285|Compound:0929-0069|FD-Score:4.04|P-value:2.02E-5 ID:SGTC_1291|Compound:0993-0025|FD-Score:5.18|P-value:6.80E-8 ID:SGTC_1360|Compound:1598-0022|FD-Score:3.13|P-value:7.26E-4 ID:SGTC_1364|Compound:1653-0028|FD-Score:-3.97|P-value:2.98E-5 ID:SGTC_1428|Compound:4049-0204|FD-Score:3.34|P-value:3.36E-4 ID:SGTC_1506|Compound:4226-2149|FD-Score:3.35|P-value:3.28E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:6.28|P-value:8.76E-11 ID:SGTC_1762|Compound:st045503|FD-Score:-3.34|P-value:3.62E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-4.83|P-value:5.16E-7 ID:SGTC_1936|Compound:st074407|FD-Score:-3.19|P-value:6.33E-4 ID:SGTC_2057|Compound:5236571|FD-Score:-3.07|P-value:9.71E-4 ID:SGTC_2059|Compound:5238311|FD-Score:3.35|P-value:3.29E-4 ID:SGTC_2138|Compound:5575593|FD-Score:3.20|P-value:5.71E-4 ID:SGTC_2140|Compound:5586273|FD-Score:-3.45|P-value:2.40E-4 ID:SGTC_2146|Compound:5545642|FD-Score:-4.19|P-value:1.13E-5 ID:SGTC_2158|Compound:5657123|FD-Score:4.95|P-value:2.47E-7 ID:SGTC_2439|Compound:5492030|FD-Score:3.60|P-value:1.25E-4 ID:SGTC_2451|Compound:5856223|FD-Score:-4.03|P-value:2.34E-5 ID:SGTC_2461|Compound:5755302|FD-Score:3.48|P-value:1.98E-4 ID:SGTC_2629|Compound:bisabolol|FD-Score:3.52|P-value:1.67E-4 ID:SGTC_2806|Compound:7952793|FD-Score:4.83|P-value:4.61E-7 ID:SGTC_2924|Compound:9010168|FD-Score:3.04|P-value:9.88E-4 ID:SGTC_2930|Compound:9013230|FD-Score:3.07|P-value:8.90E-4 ID:SGTC_3045|Compound:9092950|FD-Score:3.14|P-value:6.88E-4 ID:SGTC_3049|Compound:9092223|FD-Score:4.30|P-value:6.07E-6 ID:SGTC_3147|Compound:9097027|FD-Score:3.81|P-value:5.32E-5 ID:SGTC_3158|Compound:9100007|FD-Score:-3.12|P-value:8.04E-4 ID:SGTC_3217|Compound:9129673|FD-Score:-3.39|P-value:3.07E-4 ID:SGTC_3231|Compound:9132313|FD-Score:-3.57|P-value:1.52E-4 ID:SGTC_3238|Compound:9133470|FD-Score:-4.75|P-value:7.79E-7 ID:SGTC_3248|Compound:9135562|FD-Score:-4.03|P-value:2.29E-5

Top fitness defect scores for YHR093W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1510 1123-0200 6.28 71.5 µM 8.76E-11 14 1.69E-10
2 SGTC_1291 0993-0025 5.18 5.8 µM 6.80E-8 3 1.08E-7
3 SGTC_2158 5657123 4.95 3.6 µM 2.47E-7 2 3.78E-7
4 SGTC_2806 7952793 4.83 58.4 µM 4.61E-7 8 6.93E-7
5 SGTC_1071 trifluoperazine 4.81 6.3 µM 4.92E-7 13 7.39E-7
6 SGTC_3049 9092223 4.30 49.5 µM 6.07E-6 14 8.47E-6
7 SGTC_421 streptovitacin 4.16 30.0 mM 1.16E-5 18 1.59E-5
8 SGTC_1285 0929-0069 4.04 65.5 µM 2.02E-5 12 2.72E-5
9 SGTC_3147 9097027 3.81 49.5 µM 5.32E-5 28 6.97E-5
10 SGTC_1036 k216-0215 3.81 33.5 µM 5.41E-5 mitochondrial response to ROS 57 7.08E-5
11 SGTC_674 0498-0004 3.78 451.0 µM 6.05E-5 heme requiring 26 7.89E-5
12 SGTC_1120 ficusin 3.65 1.8 µM 1.02E-4 35 1.31E-4
13 SGTC_2439 5492030 3.60 7.2 µM 1.25E-4 20 1.60E-4
14 SGTC_1283 0922-0125 3.55 16.4 µM 1.53E-4 36 1.95E-4
15 SGTC_2629 bisabolol 3.52 100.0 µM 1.67E-4 32 2.12E-4
16 SGTC_2461 5755302 3.48 26.1 µM 1.98E-4 52 2.49E-4
17 SGTC_1198 1612-1005 3.43 86.7 µM 2.41E-4 25 3.02E-4
18 SGTC_1506 4226-2149 3.35 212.0 µM 3.28E-4 57 4.07E-4
19 SGTC_2059 5238311 3.35 157.0 µM 3.29E-4 46 4.08E-4
20 SGTC_1428 4049-0204 3.34 61.7 µM 3.36E-4 28 4.17E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.099 1.02E-8 YPR200C ARR2 hom Arsenate reductase required for arsenate resistance; converts arsenate to arsenite which can then be exported from cells by Arr3p
0.097 1.58E-8 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.094 5.17E-8 YLR193C UPS1 hom Phosphatidic acid transfer protein; plays a role in phospholipid metabolism by transporting phosphatidic acid from the outer to the inner mitochondrial membrane; localizes to the mitochondrial intermembrane space; null mutant has altered cardiolipin and phosphatidic acid levels; ortholog of human PRELI
0.093 6.55E-8 YNL150W_d YNL150W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; extensive overlap with PGA2/YNL149C, an uncharacterized gene with a proposed role in protein trafficking
0.090 1.51E-7 YLR398C SKI2 hom Ski complex component and putative RNA helicase, mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay
0.087 4.60E-7 YEL020C_p YEL020C_p hom Protein of unknown function with low sequence identity to Pdc1p; mRNA identified as translated by ribosome profiling data
0.084 1.09E-6 YPL267W ACM1 hom Pseudosubstrate inhibitor of the anaphase-promoting complex/cyclosome (APC/C), that suppresses APC/C [Cdh1]-mediated proteolysis of mitotic cyclins; associates with Cdh1p, Bmh1p and Bmh2p; cell cycle regulated protein
0.081 2.37E-6 YER030W CHZ1 hom Histone chaperone for Htz1p/H2A-H2B dimer; required for the stabilization of the Chz1p-Htz1-H2B complex; has overlapping function with Nap1p; null mutant displays weak sensitivity to MMS and benomyl; contains a highly conserved CHZ motif; protein abundance increases in response to DNA replication stress
0.081 2.64E-6 YKL017C HCS1 hom Hexameric DNA polymerase alpha-associated DNA helicase A involved in lagging strand DNA synthesis; contains single-stranded DNA stimulated ATPase and dATPase activities; replication protein A stimulates helicase and ATPase activities
0.078 6.56E-6 YOR346W REV1 hom Deoxycytidyl transferase; involved in repair of abasic sites and adducted guanines in damaged DNA by translesion synthesis (TLS); forms a complex with the subunits of DNA polymerase zeta, Rev3p and Rev7p; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.077 7.36E-6 YJR119C JHD2 hom JmjC domain family histone demethylase specific for H3-K4 (histone H3 Lys4); removes methyl groups specifically added by Set1p methyltransferase; protein levels regulated by Not4p (E3 ubiquitin ligase) polyubiquitin-mediated degradation
0.076 9.45E-6 YLR399C BDF1 hom Protein involved in transcription initiation at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf2p
0.076 1.18E-5 YGR019W UGA1 hom Gamma-aminobutyrate (GABA) transaminase; also known as 4-aminobutyrate aminotransferase; involved in the 4-aminobutyrate and glutamate degradation pathways; required for normal oxidative stress tolerance and nitrogen utilization; protein abundance increases in response to DNA replication stress
0.075 1.21E-5 YOR100C CRC1 hom Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation
0.075 1.37E-5 YJL157C FAR1 hom Cyclin-dependent kinase inhibitor; mediates cell cycle arrest in response to pheromone; also forms a complex with Cdc24p, Ste4p, and Ste18p that may specify the direction of polarized growth during mating; potential Cdc28p substrate; relocalizes from nucleus to cytoplasm upon DNA replication stress