HIPHOP chemogenomics database

YHR106W / TRR2

Mitochondrial thioredoxin reductase; involved in protection against oxidative stress, required with Glr1p to maintain the redox state of Trx3p; contains active-site motif (CAVC) present in prokaryotic orthologs; binds NADPH and FAD; TRR2 has a paralog, TRR1, that arose from the whole genome duplication

Zygosity: Homozygous strain

fixedexpanded
Profile for YHR106W / TRR2

Click on Significant Values for Screen Details

Top fitness defect scores for YHR106W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2754	granisetron	5.58	64.0 µM	2.57E-9		10	1.20E-8
2	SGTC_3217	9129673	5.07	49.5 µM	5.28E-8		9	2.01E-7
3	SGTC_354	2783-3500	5.06	4.9 µM	5.65E-8	cell wall	30	2.14E-7
4	SGTC_1576	erythromycin ethylsuccinate	4.99	23.2 µM	8.04E-8		8	2.97E-7
5	SGTC_1912	st060209	4.48	90.8 µM	1.20E-6		27	3.67E-6
6	SGTC_2819	7996655	4.42	46.4 µM	1.63E-6		12	4.88E-6
7	SGTC_1705	st027868	4.31	56.3 µM	2.83E-6		4	8.15E-6
8	SGTC_403	arphamenine a	4.30	50.0 µM	2.91E-6	60S ribosome export	12	8.38E-6
9	SGTC_1363	1636-0063	4.20	10.4 µM	4.82E-6	Golgi	21	1.34E-5
10	SGTC_2664	lyso-paf C-16	4.19	73.5 µM	4.94E-6		7	1.37E-5
11	SGTC_1430	4049-0248	4.05	69.1 µM	9.51E-6		17	2.51E-5
12	SGTC_2083	5306046	3.85	65.9 µM	2.38E-5		31	5.89E-5
13	SGTC_655	k060-0012	3.82	42.0 µM	2.67E-5		12	6.56E-5
14	SGTC_2767	sibutramine	3.69	71.5 µM	4.86E-5		28	1.14E-4
15	SGTC_1565	sinapyl alcohol	3.52	95.1 µM	9.68E-5		43	2.16E-4
16	SGTC_1861	st057647	3.50	17.4 µM	1.07E-4		37	2.37E-4
17	SGTC_2328	6201408	3.48	200.0 µM	1.15E-4		35	2.54E-4
18	SGTC_639	0833-0042	3.43	114.0 µM	1.38E-4		66	3.00E-4
19	SGTC_1939	st074455	3.39	53.6 µM	1.60E-4		48	3.45E-4
20	SGTC_2415	st077333	3.39	57.7 µM	1.62E-4		78	3.49E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.142	1.65E-16	YDL149W	ATG9	hom	Transmembrane protein involved in forming Cvt and autophagic vesicles; cycles between the phagophore assembly site (PAS) and other cytosolic punctate structures, not found in autophagosomes; may be involved in membrane delivery to the PAS
0.123	8.09E-13	YOR087W	YVC1	hom	Vacuolar cation channel, mediates release of Ca(2+) from the vacuole in response to hyperosmotic shock
0.122	1.07E-12	YNR003C	RPC34	het	RNA polymerase III subunit C34; interacts with TFIIIB70 and is a key determinant in pol III recruitment by the preinitiation complex
0.101	4.22E-9	YNL312W	RFA2	het	Subunit of heterotrimeric Replication Protein A (RPA); RPA is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination; protein abundance increases in response to DNA replication stress
0.096	2.83E-8	YHL040C	ARN1	hom	ARN family transporter for siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophores; protein increases in abundance and relocalizes to the vacuole upon DNA replication stress
0.095	3.62E-8	YMR247C	RKR1	hom	RING domain E3 ubiquitin ligase; involved in the ubiquitin-mediated degradation of non-stop proteins; functional connections to chromatin modification; nuclear protein that also co-localizes with ribosomes; homolog of mouse Listerin, whose mutation has been reported to cause neurodegeneration in mice
0.094	4.64E-8	YMR182C	RGM1	hom	Putative zinc finger DNA binding transcription factor; contains two N-terminal C2H2 zinc fingers and C-terminal proline rich domain; overproduction impairs cell growth and induces expression of genes involved in monosaccharide catabolism and aldehyde metabolism; regulates expression of of Y-prime telomeric elements and subtelomeric COS genes; RGM1 has a paralog, USV1, that arose from the whole genome duplication
0.093	7.62E-8	YIL147C	SLN1	het	Histidine kinase osmosensor that regulates a MAP kinase cascade; transmembrane protein with an intracellular kinase domain that signals to Ypd1p and Ssk1p, thereby forming a phosphorelay system similar to bacterial two-component regulators
0.090	1.83E-7	YNR056C	BIO5	hom	Putative transmembrane protein involved in the biotin biosynthesis pathway; responsible for uptake of 7-keto 8-aminopelargonic acid; BIO5 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis
0.090	2.02E-7	YDL236W	PHO13	hom	Alkaline phosphatase specific for p-nitrophenyl phosphate; also has protein phosphatase activity
0.089	2.39E-7	YIL119C	RPI1	hom	Transcription factor with allelic differences between S288C and Sigma1278b; mediates fermentation stress tolerance by modulating cell wall integrity; overexpression suppresses heat shock sensitivity of wild-type RAS2 overexpression and also suppresses cell lysis defect of mpk1 mutation; allele from S288c can confer fMAPK pathway independent transcription of FLO11; S288C and Sigma1278b alleles differ in number of tandem repeats within ORF
0.088	3.07E-7	YJR147W	HMS2	hom	Protein with similarity to heat shock transcription factors; overexpression suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant; HMS2 has a paralog, SKN7, that arose from the whole genome duplication
0.086	7.01E-7	YHR193C	EGD2	hom	Alpha subunit of the heteromeric nascent polypeptide-associated complex (NAC) involved in protein sorting and translocation, associated with cytoplasmic ribosomes
0.084	1.20E-6	YIL114C	POR2	hom	Putative mitochondrial porin (voltage-dependent anion channel); not required for mitochondrial membrane permeability or mitochondrial osmotic stability; POR2 has a paralog, POR1, that arose from the whole genome duplication
0.083	1.30E-6	YPL001W	HAT1	hom	Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex that uses the cofactor acetyl coenzyme A, to acetylate free nuclear and cytoplasmic histone H4; involved in telomeric silencing and DNA double-strand break repair