YHR109W / CTM1

Cytochrome c lysine methyltransferase, trimethylates residue 72 of apo-cytochrome c (Cyc1p) in the cytosol; not required for normal respiratory growth

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR109W / CTM1

Click on Significant Values for Screen Details ID:SGTC_21|Compound:0849-0113|FD-Score:3.23|P-value:1.58E-4 ID:SGTC_61|Compound:0978-8327|FD-Score:3.34|P-value:9.52E-5 ID:SGTC_106|Compound:0092-0003|FD-Score:4.00|P-value:3.93E-6 ID:SGTC_192|Compound:3455-0609|FD-Score:3.26|P-value:1.35E-4 ID:SGTC_230|Compound:MPP+|FD-Score:3.14|P-value:2.32E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-2.96|P-value:4.89E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:2.86|P-value:7.01E-4 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:2.80|P-value:8.69E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:3.58|P-value:3.18E-5 ID:SGTC_723|Compound:4182-0001|FD-Score:-2.80|P-value:9.16E-4 ID:SGTC_786|Compound:4544-0069|FD-Score:3.28|P-value:1.24E-4 ID:SGTC_792|Compound:4534-1957|FD-Score:3.72|P-value:1.66E-5 ID:SGTC_890|Compound:0929-0006|FD-Score:2.82|P-value:8.32E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:10.70|P-value:3.90E-33 ID:SGTC_1030|Compound:k029-0042|FD-Score:3.24|P-value:1.47E-4 ID:SGTC_1040|Compound:k898-0338|FD-Score:-3.41|P-value:7.16E-5 ID:SGTC_1156|Compound:4092-0367|FD-Score:4.27|P-value:9.55E-7 ID:SGTC_1628|Compound:st004252|FD-Score:3.41|P-value:7.04E-5 ID:SGTC_1792|Compound:st045773|FD-Score:3.60|P-value:2.92E-5 ID:SGTC_1912|Compound:st060209|FD-Score:3.02|P-value:3.71E-4 ID:SGTC_1939|Compound:st074455|FD-Score:-4.50|P-value:2.59E-7 ID:SGTC_1940|Compound:st075990|FD-Score:3.43|P-value:6.37E-5 ID:SGTC_2288|Compound:7946289|FD-Score:3.43|P-value:6.51E-5 ID:SGTC_2345|Compound:9052315|FD-Score:3.57|P-value:3.41E-5 ID:SGTC_2400|Compound:5203494|FD-Score:3.09|P-value:2.84E-4 ID:SGTC_2428|Compound:5615643|FD-Score:3.15|P-value:2.21E-4 ID:SGTC_2475|Compound:5812728|FD-Score:2.91|P-value:5.85E-4 ID:SGTC_2508|Compound:celastrol|FD-Score:3.16|P-value:2.06E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:3.41|P-value:6.89E-5 ID:SGTC_2620|Compound:irigenin|FD-Score:-4.05|P-value:3.25E-6 ID:SGTC_2624|Compound:nerol|FD-Score:3.86|P-value:8.30E-6 ID:SGTC_2739|Compound:tacrine|FD-Score:3.13|P-value:2.33E-4 ID:SGTC_2767|Compound:sibutramine|FD-Score:3.75|P-value:1.43E-5 ID:SGTC_2769|Compound:toremifene|FD-Score:-3.59|P-value:3.14E-5 ID:SGTC_2820|Compound:7989630|FD-Score:-3.93|P-value:6.06E-6 ID:SGTC_2827|Compound:7993847|FD-Score:2.94|P-value:5.16E-4 ID:SGTC_2828|Compound:7998861|FD-Score:-7.50|P-value:3.02E-17 ID:SGTC_2832|Compound:7992762|FD-Score:3.06|P-value:3.22E-4 ID:SGTC_2873|Compound:9040596|FD-Score:-4.08|P-value:2.67E-6 ID:SGTC_2885|Compound:9057732|FD-Score:3.69|P-value:1.87E-5 ID:SGTC_2917|Compound:7979103|FD-Score:3.40|P-value:7.23E-5 ID:SGTC_2998|Compound:9066762|FD-Score:4.14|P-value:1.90E-6 ID:SGTC_3000|Compound:9075062|FD-Score:3.72|P-value:1.62E-5 ID:SGTC_3004|Compound:9076122|FD-Score:-2.82|P-value:8.49E-4 ID:SGTC_3013|Compound:9080133|FD-Score:5.04|P-value:9.29E-9 ID:SGTC_3087|Compound:9117406|FD-Score:3.09|P-value:2.79E-4 ID:SGTC_3113|Compound:9123498|FD-Score:3.51|P-value:4.56E-5 ID:SGTC_3308|Compound:9128332|FD-Score:-3.46|P-value:5.88E-5 ID:SGTC_3330|Compound:9141424|FD-Score:3.05|P-value:3.25E-4 ID:SGTC_21|Compound:0849-0113|FD-Score:3.23|P-value:1.58E-4 ID:SGTC_61|Compound:0978-8327|FD-Score:3.34|P-value:9.52E-5 ID:SGTC_106|Compound:0092-0003|FD-Score:4.00|P-value:3.93E-6 ID:SGTC_192|Compound:3455-0609|FD-Score:3.26|P-value:1.35E-4 ID:SGTC_230|Compound:MPP+|FD-Score:3.14|P-value:2.32E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-2.96|P-value:4.89E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:2.86|P-value:7.01E-4 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:2.80|P-value:8.69E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:3.58|P-value:3.18E-5 ID:SGTC_723|Compound:4182-0001|FD-Score:-2.80|P-value:9.16E-4 ID:SGTC_786|Compound:4544-0069|FD-Score:3.28|P-value:1.24E-4 ID:SGTC_792|Compound:4534-1957|FD-Score:3.72|P-value:1.66E-5 ID:SGTC_890|Compound:0929-0006|FD-Score:2.82|P-value:8.32E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:10.70|P-value:3.90E-33 ID:SGTC_1030|Compound:k029-0042|FD-Score:3.24|P-value:1.47E-4 ID:SGTC_1040|Compound:k898-0338|FD-Score:-3.41|P-value:7.16E-5 ID:SGTC_1156|Compound:4092-0367|FD-Score:4.27|P-value:9.55E-7 ID:SGTC_1628|Compound:st004252|FD-Score:3.41|P-value:7.04E-5 ID:SGTC_1792|Compound:st045773|FD-Score:3.60|P-value:2.92E-5 ID:SGTC_1912|Compound:st060209|FD-Score:3.02|P-value:3.71E-4 ID:SGTC_1939|Compound:st074455|FD-Score:-4.50|P-value:2.59E-7 ID:SGTC_1940|Compound:st075990|FD-Score:3.43|P-value:6.37E-5 ID:SGTC_2288|Compound:7946289|FD-Score:3.43|P-value:6.51E-5 ID:SGTC_2345|Compound:9052315|FD-Score:3.57|P-value:3.41E-5 ID:SGTC_2400|Compound:5203494|FD-Score:3.09|P-value:2.84E-4 ID:SGTC_2428|Compound:5615643|FD-Score:3.15|P-value:2.21E-4 ID:SGTC_2475|Compound:5812728|FD-Score:2.91|P-value:5.85E-4 ID:SGTC_2508|Compound:celastrol|FD-Score:3.16|P-value:2.06E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:3.41|P-value:6.89E-5 ID:SGTC_2620|Compound:irigenin|FD-Score:-4.05|P-value:3.25E-6 ID:SGTC_2624|Compound:nerol|FD-Score:3.86|P-value:8.30E-6 ID:SGTC_2739|Compound:tacrine|FD-Score:3.13|P-value:2.33E-4 ID:SGTC_2767|Compound:sibutramine|FD-Score:3.75|P-value:1.43E-5 ID:SGTC_2769|Compound:toremifene|FD-Score:-3.59|P-value:3.14E-5 ID:SGTC_2820|Compound:7989630|FD-Score:-3.93|P-value:6.06E-6 ID:SGTC_2827|Compound:7993847|FD-Score:2.94|P-value:5.16E-4 ID:SGTC_2828|Compound:7998861|FD-Score:-7.50|P-value:3.02E-17 ID:SGTC_2832|Compound:7992762|FD-Score:3.06|P-value:3.22E-4 ID:SGTC_2873|Compound:9040596|FD-Score:-4.08|P-value:2.67E-6 ID:SGTC_2885|Compound:9057732|FD-Score:3.69|P-value:1.87E-5 ID:SGTC_2917|Compound:7979103|FD-Score:3.40|P-value:7.23E-5 ID:SGTC_2998|Compound:9066762|FD-Score:4.14|P-value:1.90E-6 ID:SGTC_3000|Compound:9075062|FD-Score:3.72|P-value:1.62E-5 ID:SGTC_3004|Compound:9076122|FD-Score:-2.82|P-value:8.49E-4 ID:SGTC_3013|Compound:9080133|FD-Score:5.04|P-value:9.29E-9 ID:SGTC_3087|Compound:9117406|FD-Score:3.09|P-value:2.79E-4 ID:SGTC_3113|Compound:9123498|FD-Score:3.51|P-value:4.56E-5 ID:SGTC_3308|Compound:9128332|FD-Score:-3.46|P-value:5.88E-5 ID:SGTC_3330|Compound:9141424|FD-Score:3.05|P-value:3.25E-4

Top fitness defect scores for YHR109W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_996 3970-0799 10.70 1.8 µM 3.90E-33 12 5.27E-27
2 SGTC_3013 9080133 5.04 71.4 µM 9.29E-9 5 2.33E-7
3 SGTC_1156 4092-0367 4.27 4.9 µM 9.55E-7 13 9.91E-6
4 SGTC_2998 9066762 4.14 71.4 µM 1.90E-6 RPP1 & pyrimidine depletion 22 1.73E-5
5 SGTC_106 0092-0003 4.00 11.6 µM 3.93E-6 copper-dependent oxidative stress 16 3.12E-5
6 SGTC_2624 nerol 3.86 100.0 µM 8.30E-6 10 5.72E-5
7 SGTC_2767 sibutramine 3.75 71.5 µM 1.43E-5 24 8.91E-5
8 SGTC_3000 9075062 3.72 71.4 µM 1.62E-5 26 9.84E-5
9 SGTC_792 4534-1957 3.72 155.0 µM 1.66E-5 45 1.00E-4
10 SGTC_2885 9057732 3.69 52.0 µM 1.87E-5 17 1.10E-4
11 SGTC_1792 st045773 3.60 43.6 µM 2.92E-5 42 1.59E-4
12 SGTC_666 0272-0154 3.58 136.0 µM 3.18E-5 cell wall 70 1.70E-4
13 SGTC_2345 9052315 3.57 157.4 µM 3.41E-5 27 1.80E-4
14 SGTC_3113 9123498 3.51 49.5 µM 4.56E-5 22 2.28E-4
15 SGTC_1940 st075990 3.43 51.1 µM 6.37E-5 60S ribosome export 37 3.00E-4
16 SGTC_2288 7946289 3.43 167.3 µM 6.51E-5 47 3.05E-4
17 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 3.41 92.6 µM 6.89E-5 42 3.19E-4
18 SGTC_1628 st004252 3.41 77.7 µM 7.04E-5 39 3.25E-4
19 SGTC_2917 7979103 3.40 53.8 µM 7.23E-5 48 3.32E-4
20 SGTC_61 0978-8327 3.34 98.6 µM 9.52E-5 ergosterol biosynthesis 49 4.15E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.376 6.12E-113 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.299 3.37E-70 YDL099W BUG1 hom Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
0.286 2.94E-64 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.246 1.40E-47 YGL040C HEM2 het Aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus
0.243 1.98E-46 YGL222C EDC1 hom RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress
0.238 1.90E-44 YOR037W CYC2 hom Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
0.230 2.49E-41 YGL205W POX1 hom Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix
0.225 8.80E-40 YGR035C_p YGR035C_p hom Putative protein of unknown function, potential Cdc28p substrate; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance
0.220 4.62E-38 YDL186W_p YDL186W_p hom Putative protein of unknown function; YDL186W is not an essential gene
0.212 1.64E-35 YGL083W SCY1 hom Putative kinase, suppressor of GTPase mutant, similar to bovine rhodopsin kinase
0.210 6.48E-35 YGR050C_p YGR050C_p hom Protein of unknown function; mRNA identified as translated by ribosome profiling data
0.209 1.91E-34 YBR067C TIP1 hom Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins
0.208 5.72E-34 YNR033W ABZ1 hom Para-aminobenzoate (PABA) synthase; has similarity to Escherichia coli PABA synthase components PabA and PabB; required for the synthesis of para-aminobenzoic acid, an important intermediate for folate and ubiquinone Q biosynthesis; protein abundance increases in response to DNA replication stress
0.191 6.03E-29 YJR014W TMA22 hom Protein of unknown function; associates with ribosomes and has a putative RNA binding domain; interacts with Tma20p; similar to human GRAP and human DRP1, which interacts with human Tma20p homolog MCT-1; protein abundance increases in response to DNA replication stress
0.184 5.27E-27 YJL149W DAS1 hom Putative SCF ubiquitin ligase F-box protein; interacts physically with both Cdc53p and Skp1 and genetically with CDC34; similar to putative F-box protein YDR131C