YHR110W / ERP5

Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR110W / ERP5

Click on Significant Values for Screen Details ID:SGTC_47|Compound:0149-0135|FD-Score:-3.23|P-value:8.50E-4 ID:SGTC_288|Compound:1315-0019|FD-Score:3.32|P-value:3.71E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:3.19|P-value:6.04E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:3.15|P-value:6.83E-4 ID:SGTC_653|Compound:0203-0016|FD-Score:6.23|P-value:1.85E-10 ID:SGTC_786|Compound:4544-0069|FD-Score:3.84|P-value:5.06E-5 ID:SGTC_808|Compound:0711-0032|FD-Score:3.16|P-value:6.65E-4 ID:SGTC_844|Compound:0330-0132|FD-Score:3.79|P-value:6.27E-5 ID:SGTC_852|Compound:0418-0143|FD-Score:4.82|P-value:5.73E-7 ID:SGTC_883|Compound:0850-0245|FD-Score:3.74|P-value:7.62E-5 ID:SGTC_990|Compound:3985-0011|FD-Score:-3.48|P-value:3.49E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:-5.81|P-value:5.81E-9 ID:SGTC_1004|Compound:4084-0029|FD-Score:4.06|P-value:1.98E-5 ID:SGTC_1039|Compound:k821-0043|FD-Score:5.45|P-value:1.99E-8 ID:SGTC_1092|Compound:toremifene|FD-Score:3.34|P-value:3.44E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:11.60|P-value:2.98E-31 ID:SGTC_1219|Compound:1469-0211|FD-Score:3.43|P-value:2.49E-4 ID:SGTC_1226|Compound:3909-7979|FD-Score:3.24|P-value:5.08E-4 ID:SGTC_1235|Compound:benzylparaben|FD-Score:3.47|P-value:2.14E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.91|P-value:3.83E-5 ID:SGTC_1261|Compound:0712-0010|FD-Score:3.92|P-value:3.57E-5 ID:SGTC_1340|Compound:1486-1359|FD-Score:3.98|P-value:2.87E-5 ID:SGTC_1442|Compound:4112-3290|FD-Score:-3.59|P-value:2.35E-4 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:-3.20|P-value:9.31E-4 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:3.28|P-value:4.39E-4 ID:SGTC_1613|Compound:st002381|FD-Score:-3.66|P-value:1.79E-4 ID:SGTC_1625|Compound:st003711|FD-Score:3.15|P-value:6.81E-4 ID:SGTC_1820|Compound:st053765|FD-Score:3.77|P-value:6.74E-5 ID:SGTC_1917|Compound:st066507|FD-Score:3.19|P-value:6.03E-4 ID:SGTC_2010|Compound:4012422|FD-Score:3.42|P-value:2.58E-4 ID:SGTC_2175|Compound:5807670|FD-Score:3.14|P-value:7.00E-4 ID:SGTC_2364|Compound:9055074|FD-Score:-3.45|P-value:3.99E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:3.45|P-value:2.33E-4 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.61|P-value:1.25E-4 ID:SGTC_2638|Compound:epoxomicin|FD-Score:3.41|P-value:2.67E-4 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:3.13|P-value:7.31E-4 ID:SGTC_2807|Compound:7945238|FD-Score:3.26|P-value:4.61E-4 ID:SGTC_2861|Compound:9024595|FD-Score:3.49|P-value:2.03E-4 ID:SGTC_2981|Compound:9013952|FD-Score:3.18|P-value:6.17E-4 ID:SGTC_3125|Compound:9127534|FD-Score:3.20|P-value:5.82E-4 ID:SGTC_3133|Compound:9127736|FD-Score:5.17|P-value:9.60E-8 ID:SGTC_3134|Compound:9127454|FD-Score:-4.52|P-value:5.00E-6 ID:SGTC_3284|Compound:9108171|FD-Score:3.06|P-value:9.30E-4 ID:SGTC_3354|Compound:9151612|FD-Score:4.08|P-value:1.83E-5 ID:SGTC_47|Compound:0149-0135|FD-Score:-3.23|P-value:8.50E-4 ID:SGTC_288|Compound:1315-0019|FD-Score:3.32|P-value:3.71E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:3.19|P-value:6.04E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:3.15|P-value:6.83E-4 ID:SGTC_653|Compound:0203-0016|FD-Score:6.23|P-value:1.85E-10 ID:SGTC_786|Compound:4544-0069|FD-Score:3.84|P-value:5.06E-5 ID:SGTC_808|Compound:0711-0032|FD-Score:3.16|P-value:6.65E-4 ID:SGTC_844|Compound:0330-0132|FD-Score:3.79|P-value:6.27E-5 ID:SGTC_852|Compound:0418-0143|FD-Score:4.82|P-value:5.73E-7 ID:SGTC_883|Compound:0850-0245|FD-Score:3.74|P-value:7.62E-5 ID:SGTC_990|Compound:3985-0011|FD-Score:-3.48|P-value:3.49E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:-5.81|P-value:5.81E-9 ID:SGTC_1004|Compound:4084-0029|FD-Score:4.06|P-value:1.98E-5 ID:SGTC_1039|Compound:k821-0043|FD-Score:5.45|P-value:1.99E-8 ID:SGTC_1092|Compound:toremifene|FD-Score:3.34|P-value:3.44E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:11.60|P-value:2.98E-31 ID:SGTC_1219|Compound:1469-0211|FD-Score:3.43|P-value:2.49E-4 ID:SGTC_1226|Compound:3909-7979|FD-Score:3.24|P-value:5.08E-4 ID:SGTC_1235|Compound:benzylparaben|FD-Score:3.47|P-value:2.14E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.91|P-value:3.83E-5 ID:SGTC_1261|Compound:0712-0010|FD-Score:3.92|P-value:3.57E-5 ID:SGTC_1340|Compound:1486-1359|FD-Score:3.98|P-value:2.87E-5 ID:SGTC_1442|Compound:4112-3290|FD-Score:-3.59|P-value:2.35E-4 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:-3.20|P-value:9.31E-4 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:3.28|P-value:4.39E-4 ID:SGTC_1613|Compound:st002381|FD-Score:-3.66|P-value:1.79E-4 ID:SGTC_1625|Compound:st003711|FD-Score:3.15|P-value:6.81E-4 ID:SGTC_1820|Compound:st053765|FD-Score:3.77|P-value:6.74E-5 ID:SGTC_1917|Compound:st066507|FD-Score:3.19|P-value:6.03E-4 ID:SGTC_2010|Compound:4012422|FD-Score:3.42|P-value:2.58E-4 ID:SGTC_2175|Compound:5807670|FD-Score:3.14|P-value:7.00E-4 ID:SGTC_2364|Compound:9055074|FD-Score:-3.45|P-value:3.99E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:3.45|P-value:2.33E-4 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.61|P-value:1.25E-4 ID:SGTC_2638|Compound:epoxomicin|FD-Score:3.41|P-value:2.67E-4 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:3.13|P-value:7.31E-4 ID:SGTC_2807|Compound:7945238|FD-Score:3.26|P-value:4.61E-4 ID:SGTC_2861|Compound:9024595|FD-Score:3.49|P-value:2.03E-4 ID:SGTC_2981|Compound:9013952|FD-Score:3.18|P-value:6.17E-4 ID:SGTC_3125|Compound:9127534|FD-Score:3.20|P-value:5.82E-4 ID:SGTC_3133|Compound:9127736|FD-Score:5.17|P-value:9.60E-8 ID:SGTC_3134|Compound:9127454|FD-Score:-4.52|P-value:5.00E-6 ID:SGTC_3284|Compound:9108171|FD-Score:3.06|P-value:9.30E-4 ID:SGTC_3354|Compound:9151612|FD-Score:4.08|P-value:1.83E-5

Top fitness defect scores for YHR110W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1129 3453-1384 11.60 223.0 µM 2.98E-31 1 2.96E-31
2 SGTC_653 0203-0016 6.23 55.2 µM 1.85E-10 3 2.28E-10
3 SGTC_1039 k821-0043 5.45 94.0 µM 1.99E-8 Golgi 7 2.46E-8
4 SGTC_3133 9127736 5.17 49.5 µM 9.60E-8 4 1.19E-7
5 SGTC_852 0418-0143 4.82 439.0 µM 5.73E-7 calcium & mitochondrial duress 43 7.06E-7
6 SGTC_3354 9151612 4.08 71.4 µM 1.83E-5 5 2.24E-5
7 SGTC_1004 4084-0029 4.06 199.0 µM 1.98E-5 13 2.42E-5
8 SGTC_1340 1486-1359 3.98 257.0 µM 2.87E-5 20 3.50E-5
9 SGTC_1261 0712-0010 3.92 12.7 µM 3.57E-5 RNA processing & uracil transport 23 4.34E-5
10 SGTC_1247 0448-0043 3.91 5.8 µM 3.83E-5 ERG2 46 4.66E-5
11 SGTC_786 4544-0069 3.84 423.0 µM 5.06E-5 37 6.14E-5
12 SGTC_844 0330-0132 3.79 15.3 µM 6.27E-5 17 7.61E-5
13 SGTC_1820 st053765 3.77 18.6 µM 6.74E-5 RPP1 & pyrimidine depletion 21 8.17E-5
14 SGTC_883 0850-0245 3.74 24.6 µM 7.62E-5 cell wall 37 9.24E-5
15 SGTC_2588 indole-3-carbinol 3.61 100.0 µM 1.25E-4 61 1.51E-4
16 SGTC_2861 9024595 3.49 19.5 µM 2.03E-4 6 2.45E-4
17 SGTC_1235 benzylparaben 3.47 21.5 µM 2.14E-4 23 2.58E-4
18 SGTC_2567 aureobasidin a 3.45 60.0 nM 2.33E-4 120 2.80E-4
19 SGTC_1219 1469-0211 3.43 33.1 µM 2.49E-4 26 3.00E-4
20 SGTC_2010 4012422 3.42 159.0 µM 2.58E-4 42 3.11E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.150 2.46E-18 YKR010C TOF2 hom Protein required for rDNA silencing and mitotic rDNA condensation; stimulates Cdc14p phosphatase activity and biphasic release to promote rDNA repeat segregation; required for condensin recruitment to the replication fork barrier site; TOF2 has a paralog, NET1, that arose from the whole genome duplication
0.133 9.16E-15 YLR363W-A YLR363W-A hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; relocalizes from nucleus to nucleolus upon DNA replication stress
0.131 2.66E-14 YLR276C DBP9 het DEAD-box protein required for 27S rRNA processing; exhibits DNA, RNA and DNA/RNA helicase activities; ATPase activity shows preference for DNA over RNA; DNA helicase activity abolished by mutation in RNA-binding domain
0.115 2.49E-11 YLR063W_p YLR063W_p hom Putative S-adenosylmethionine-dependent methyltransferase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR063W is not an essential gene
0.115 2.80E-11 YDR464W SPP41 het Protein involved in negative regulation of expression of spliceosome components PRP4 and PRP3
0.113 5.38E-11 YKL004W AUR1 het Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance
0.108 4.19E-10 YLR142W PUT1 hom Proline oxidase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source
0.104 1.45E-9 YDR412W RRP17 het Component of the pre-60S pre-ribosomal particle; required for cell viability under standard (aerobic) conditions but not under anaerobic conditions; exonuclease required for 5′ end processing of pre-60S ribosomal RNA
0.103 1.96E-9 YIL118W RHO3 het Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p
0.103 2.43E-9 YOR007C SGT2 hom Glutamine-rich cytoplasmic cochaperone; serves as a scaffold bringing together Get4, Get5p, and other TRC complex members that are required to mediate posttranslational insertion of tail-anchored proteins into the ER membrane; interacts with the prion domain of Sup35p; amyloid sensor; plays a role in targeting chaperones to prion aggregates; has similarity to human cochaperone SGT; forms cytoplasmic foci upon DNA replication stress
0.103 2.61E-9 YPL019C VTC3 hom Subunit of the vacuolar transporter chaperone (VTC) complex involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion
0.102 2.71E-9 YJR022W LSM8 het Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) that is part of spliceosomal U6 snRNP and is also implicated in processing of pre-tRNA, pre-snoRNA, and pre-rRNA
0.102 3.16E-9 YDL182W LYS20 hom Homocitrate synthase isozyme; catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; LYS20 has a paralog, LYS21, that arose from the whole genome duplication
0.101 4.61E-9 YIL163C_p YIL163C_p hom Protein of unknown function; mRNA identified as translated by ribosome profiling data
0.098 1.44E-8 YOR059C YOR059C hom Lipid particle protein of unknown function; contains a putative lipase serine active site; induced by transcription factor Rpn4p; protein abundance increases in response to DNA replication stress