HIPHOP chemogenomics database

YHR110W / ERP5

Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport

Zygosity: Homozygous strain

fixedexpanded
Profile for YHR110W / ERP5

Click on Significant Values for Screen Details

Top fitness defect scores for YHR110W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_1129	3453-1384	11.60	223.0 µM	2.98E-31		1	2.96E-31
2	SGTC_653	0203-0016	6.23	55.2 µM	1.85E-10		3	2.28E-10
3	SGTC_1039	k821-0043	5.45	94.0 µM	1.99E-8	Golgi	7	2.46E-8
4	SGTC_3133	9127736	5.17	49.5 µM	9.60E-8		4	1.19E-7
5	SGTC_852	0418-0143	4.82	439.0 µM	5.73E-7	calcium & mitochondrial duress	43	7.06E-7
6	SGTC_3354	9151612	4.08	71.4 µM	1.83E-5		5	2.24E-5
7	SGTC_1004	4084-0029	4.06	199.0 µM	1.98E-5		13	2.42E-5
8	SGTC_1340	1486-1359	3.98	257.0 µM	2.87E-5		20	3.50E-5
9	SGTC_1261	0712-0010	3.92	12.7 µM	3.57E-5	RNA processing & uracil transport	23	4.34E-5
10	SGTC_1247	0448-0043	3.91	5.8 µM	3.83E-5	ERG2	46	4.66E-5
11	SGTC_786	4544-0069	3.84	423.0 µM	5.06E-5		37	6.14E-5
12	SGTC_844	0330-0132	3.79	15.3 µM	6.27E-5		17	7.61E-5
13	SGTC_1820	st053765	3.77	18.6 µM	6.74E-5	RPP1 & pyrimidine depletion	21	8.17E-5
14	SGTC_883	0850-0245	3.74	24.6 µM	7.62E-5	cell wall	37	9.24E-5
15	SGTC_2588	indole-3-carbinol	3.61	100.0 µM	1.25E-4		61	1.51E-4
16	SGTC_2861	9024595	3.49	19.5 µM	2.03E-4		6	2.45E-4
17	SGTC_1235	benzylparaben	3.47	21.5 µM	2.14E-4		23	2.58E-4
18	SGTC_2567	aureobasidin a	3.45	60.0 nM	2.33E-4		120	2.80E-4
19	SGTC_1219	1469-0211	3.43	33.1 µM	2.49E-4		26	3.00E-4
20	SGTC_2010	4012422	3.42	159.0 µM	2.58E-4		42	3.11E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.150	2.46E-18	YKR010C	TOF2	hom	Protein required for rDNA silencing and mitotic rDNA condensation; stimulates Cdc14p phosphatase activity and biphasic release to promote rDNA repeat segregation; required for condensin recruitment to the replication fork barrier site; TOF2 has a paralog, NET1, that arose from the whole genome duplication
0.133	9.16E-15	YLR363W-A	YLR363W-A	hom	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; relocalizes from nucleus to nucleolus upon DNA replication stress
0.131	2.66E-14	YLR276C	DBP9	het	DEAD-box protein required for 27S rRNA processing; exhibits DNA, RNA and DNA/RNA helicase activities; ATPase activity shows preference for DNA over RNA; DNA helicase activity abolished by mutation in RNA-binding domain
0.115	2.49E-11	YLR063W_p	YLR063W_p	hom	Putative S-adenosylmethionine-dependent methyltransferase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR063W is not an essential gene
0.115	2.80E-11	YDR464W	SPP41	het	Protein involved in negative regulation of expression of spliceosome components PRP4 and PRP3
0.113	5.38E-11	YKL004W	AUR1	het	Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance
0.108	4.19E-10	YLR142W	PUT1	hom	Proline oxidase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source
0.104	1.45E-9	YDR412W	RRP17	het	Component of the pre-60S pre-ribosomal particle; required for cell viability under standard (aerobic) conditions but not under anaerobic conditions; exonuclease required for 5′ end processing of pre-60S ribosomal RNA
0.103	1.96E-9	YIL118W	RHO3	het	Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p
0.103	2.43E-9	YOR007C	SGT2	hom	Glutamine-rich cytoplasmic cochaperone; serves as a scaffold bringing together Get4, Get5p, and other TRC complex members that are required to mediate posttranslational insertion of tail-anchored proteins into the ER membrane; interacts with the prion domain of Sup35p; amyloid sensor; plays a role in targeting chaperones to prion aggregates; has similarity to human cochaperone SGT; forms cytoplasmic foci upon DNA replication stress
0.103	2.61E-9	YPL019C	VTC3	hom	Subunit of the vacuolar transporter chaperone (VTC) complex involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion
0.102	2.71E-9	YJR022W	LSM8	het	Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) that is part of spliceosomal U6 snRNP and is also implicated in processing of pre-tRNA, pre-snoRNA, and pre-rRNA
0.102	3.16E-9	YDL182W	LYS20	hom	Homocitrate synthase isozyme; catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; LYS20 has a paralog, LYS21, that arose from the whole genome duplication
0.101	4.61E-9	YIL163C_p	YIL163C_p	hom	Protein of unknown function; mRNA identified as translated by ribosome profiling data
0.098	1.44E-8	YOR059C	YOR059C	hom	Lipid particle protein of unknown function; contains a putative lipase serine active site; induced by transcription factor Rpn4p; protein abundance increases in response to DNA replication stress