YHR116W / COX23

Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR116W / COX23

Click on Significant Values for Screen Details ID:SGTC_70|Compound:0141-0289|FD-Score:3.34|P-value:2.87E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:5.78|P-value:1.11E-9 ID:SGTC_176|Compound:1486-1328|FD-Score:-3.49|P-value:1.37E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:25.80|P-value:3.59E-158 ID:SGTC_359|Compound:0081-0058|FD-Score:-3.74|P-value:4.75E-5 ID:SGTC_375|Compound:3970-0961|FD-Score:-3.45|P-value:1.60E-4 ID:SGTC_376|Compound:3970-0862|FD-Score:3.80|P-value:4.29E-5 ID:SGTC_378|Compound:3970-0959|FD-Score:-4.47|P-value:1.59E-6 ID:SGTC_379|Compound:3970-0972|FD-Score:5.80|P-value:9.76E-10 ID:SGTC_386|Compound:1509-0011|FD-Score:23.40|P-value:8.34E-130 ID:SGTC_404|Compound:fumagillin|FD-Score:3.43|P-value:2.04E-4 ID:SGTC_417|Compound:st075190|FD-Score:3.09|P-value:7.07E-4 ID:SGTC_443|Compound:clozapine|FD-Score:3.86|P-value:3.30E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.46|P-value:1.66E-6 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:-3.22|P-value:3.83E-4 ID:SGTC_459|Compound:nigericin|FD-Score:3.17|P-value:5.33E-4 ID:SGTC_507|Compound:nimesulide|FD-Score:3.11|P-value:6.74E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:-3.39|P-value:2.00E-4 ID:SGTC_869|Compound:0564-0080|FD-Score:3.05|P-value:8.27E-4 ID:SGTC_936|Compound:3005-4620|FD-Score:3.74|P-value:5.69E-5 ID:SGTC_1153|Compound:4055-0057|FD-Score:4.21|P-value:6.91E-6 ID:SGTC_1180|Compound:1193-0155|FD-Score:-2.98|P-value:9.43E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:-3.05|P-value:7.28E-4 ID:SGTC_1339|Compound:1486-1321|FD-Score:-3.66|P-value:6.68E-5 ID:SGTC_1558|Compound:st069300|FD-Score:4.21|P-value:6.76E-6 ID:SGTC_1635|Compound:st007035|FD-Score:14.30|P-value:9.14E-50 ID:SGTC_1717|Compound:st033143|FD-Score:3.78|P-value:4.82E-5 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-4.69|P-value:5.28E-7 ID:SGTC_1787|Compound:fluconazole|FD-Score:-5.90|P-value:4.20E-10 ID:SGTC_1981|Compound:st071826|FD-Score:-3.95|P-value:1.93E-5 ID:SGTC_2130|Compound:NSC 7|FD-Score:4.80|P-value:3.43E-7 ID:SGTC_2258|Compound:7960471|FD-Score:-5.57|P-value:3.27E-9 ID:SGTC_2260|Compound:7964312|FD-Score:-4.69|P-value:5.18E-7 ID:SGTC_2345|Compound:9052315|FD-Score:-3.71|P-value:5.53E-5 ID:SGTC_2376|Compound:9072922|FD-Score:4.09|P-value:1.18E-5 ID:SGTC_2390|Compound:9097792|FD-Score:3.15|P-value:5.85E-4 ID:SGTC_2425|Compound:5628681|FD-Score:3.42|P-value:2.05E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:-3.56|P-value:1.02E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:-4.19|P-value:6.37E-6 ID:SGTC_2791|Compound:5663188|FD-Score:3.81|P-value:4.15E-5 ID:SGTC_2804|Compound:7954240|FD-Score:3.41|P-value:2.14E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-3.29|P-value:3.01E-4 ID:SGTC_2979|Compound:9012552|FD-Score:-3.47|P-value:1.47E-4 ID:SGTC_2984|Compound:9022109|FD-Score:-3.19|P-value:4.33E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:3.34|P-value:2.87E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:5.78|P-value:1.11E-9 ID:SGTC_176|Compound:1486-1328|FD-Score:-3.49|P-value:1.37E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:25.80|P-value:3.59E-158 ID:SGTC_359|Compound:0081-0058|FD-Score:-3.74|P-value:4.75E-5 ID:SGTC_375|Compound:3970-0961|FD-Score:-3.45|P-value:1.60E-4 ID:SGTC_376|Compound:3970-0862|FD-Score:3.80|P-value:4.29E-5 ID:SGTC_378|Compound:3970-0959|FD-Score:-4.47|P-value:1.59E-6 ID:SGTC_379|Compound:3970-0972|FD-Score:5.80|P-value:9.76E-10 ID:SGTC_386|Compound:1509-0011|FD-Score:23.40|P-value:8.34E-130 ID:SGTC_404|Compound:fumagillin|FD-Score:3.43|P-value:2.04E-4 ID:SGTC_417|Compound:st075190|FD-Score:3.09|P-value:7.07E-4 ID:SGTC_443|Compound:clozapine|FD-Score:3.86|P-value:3.30E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.46|P-value:1.66E-6 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:-3.22|P-value:3.83E-4 ID:SGTC_459|Compound:nigericin|FD-Score:3.17|P-value:5.33E-4 ID:SGTC_507|Compound:nimesulide|FD-Score:3.11|P-value:6.74E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:-3.39|P-value:2.00E-4 ID:SGTC_869|Compound:0564-0080|FD-Score:3.05|P-value:8.27E-4 ID:SGTC_936|Compound:3005-4620|FD-Score:3.74|P-value:5.69E-5 ID:SGTC_1153|Compound:4055-0057|FD-Score:4.21|P-value:6.91E-6 ID:SGTC_1180|Compound:1193-0155|FD-Score:-2.98|P-value:9.43E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:-3.05|P-value:7.28E-4 ID:SGTC_1339|Compound:1486-1321|FD-Score:-3.66|P-value:6.68E-5 ID:SGTC_1558|Compound:st069300|FD-Score:4.21|P-value:6.76E-6 ID:SGTC_1635|Compound:st007035|FD-Score:14.30|P-value:9.14E-50 ID:SGTC_1717|Compound:st033143|FD-Score:3.78|P-value:4.82E-5 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-4.69|P-value:5.28E-7 ID:SGTC_1787|Compound:fluconazole|FD-Score:-5.90|P-value:4.20E-10 ID:SGTC_1981|Compound:st071826|FD-Score:-3.95|P-value:1.93E-5 ID:SGTC_2130|Compound:NSC 7|FD-Score:4.80|P-value:3.43E-7 ID:SGTC_2258|Compound:7960471|FD-Score:-5.57|P-value:3.27E-9 ID:SGTC_2260|Compound:7964312|FD-Score:-4.69|P-value:5.18E-7 ID:SGTC_2345|Compound:9052315|FD-Score:-3.71|P-value:5.53E-5 ID:SGTC_2376|Compound:9072922|FD-Score:4.09|P-value:1.18E-5 ID:SGTC_2390|Compound:9097792|FD-Score:3.15|P-value:5.85E-4 ID:SGTC_2425|Compound:5628681|FD-Score:3.42|P-value:2.05E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:-3.56|P-value:1.02E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:-4.19|P-value:6.37E-6 ID:SGTC_2791|Compound:5663188|FD-Score:3.81|P-value:4.15E-5 ID:SGTC_2804|Compound:7954240|FD-Score:3.41|P-value:2.14E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-3.29|P-value:3.01E-4 ID:SGTC_2979|Compound:9012552|FD-Score:-3.47|P-value:1.47E-4 ID:SGTC_2984|Compound:9022109|FD-Score:-3.19|P-value:4.33E-4

Top fitness defect scores for YHR116W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 25.80 5.3 µM 3.59E-158 29 2.50E-147
2 SGTC_386 1509-0011 23.40 3.1 µM 8.34E-130 3 5.96E-121
3 SGTC_1635 st007035 14.30 42.4 µM 9.14E-50 45 1.69E-46
4 SGTC_379 3970-0972 5.80 5.9 µM 9.76E-10 tubulin folding & SWR complex 5 3.24E-9
5 SGTC_134 0269-0018 5.78 6.9 µM 1.11E-9 86 3.66E-9
6 SGTC_2130 NSC 7 4.80 2.5 µM 3.43E-7 copper-dependent oxidative stress 11 7.75E-7
7 SGTC_1558 st069300 4.21 45.6 µM 6.76E-6 8 1.26E-5
8 SGTC_1153 4055-0057 4.21 267.0 µM 6.91E-6 19 1.29E-5
9 SGTC_2376 9072922 4.09 81.3 µM 1.18E-5 24 2.12E-5
10 SGTC_443 clozapine 3.86 122.0 µM 3.30E-5 NEO1-PIK1 12 5.57E-5
11 SGTC_2791 5663188 3.81 71.4 µM 4.15E-5 RPP1 & pyrimidine depletion 23 6.89E-5
12 SGTC_376 3970-0862 3.80 59.1 µM 4.29E-5 24 7.11E-5
13 SGTC_1717 st033143 3.78 58.0 µM 4.82E-5 47 7.94E-5
14 SGTC_936 3005-4620 3.74 401.0 µM 5.69E-5 29 9.26E-5
15 SGTC_404 fumagillin 3.43 50.0 µM 2.04E-4 39 3.07E-4
16 SGTC_2425 5628681 3.42 7.8 µM 2.05E-4 47 3.07E-4
17 SGTC_2804 7954240 3.41 19.5 µM 2.14E-4 55 3.21E-4
18 SGTC_70 0141-0289 3.34 43.3 µM 2.87E-4 mitochondrial stress 230 4.23E-4
19 SGTC_459 nigericin 3.17 15.3 µM 5.33E-4 96 7.54E-4
20 SGTC_2390 9097792 3.15 176.6 µM 5.85E-4 42 8.24E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.780 0 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.749 0 YJL022W_d YJL022W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130
0.749 0 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.683 0 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.678 0 YPL132W COX11 hom Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
0.678 0 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.675 0 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.664 0 YJL062W-A COA3 hom Mitochondrial inner membrane protein that participates in regulation of COX1 translation, Cox1p stabilization, and cytochrome oxidase assembly
0.659 0 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.654 0 YOR065W CYT1 hom Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
0.650 0 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.649 0 YER058W PET117 hom Protein required for assembly of cytochrome c oxidase
0.646 0 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.646 0 YER141W COX15 hom Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase
0.646 0 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p