YHR123W / EPT1

sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferase; not essential for viability; EPT1 has a paralog, CPT1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR123W / EPT1

Click on Significant Values for Screen Details ID:SGTC_57|Compound:miconazole|FD-Score:2.85|P-value:9.89E-4 ID:SGTC_79|Compound:0052-0007|FD-Score:-3.28|P-value:4.42E-4 ID:SGTC_347|Compound:4534-1311|FD-Score:-3.14|P-value:7.61E-4 ID:SGTC_561|Compound:1550-0330|FD-Score:2.87|P-value:9.31E-4 ID:SGTC_565|Compound:1418-0001|FD-Score:2.95|P-value:6.98E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:3.74|P-value:2.86E-5 ID:SGTC_836|Compound:0330-0104|FD-Score:4.14|P-value:4.54E-6 ID:SGTC_840|Compound:0245-0196|FD-Score:3.22|P-value:2.49E-4 ID:SGTC_909|Compound:3448-9333|FD-Score:-3.24|P-value:5.26E-4 ID:SGTC_912|Compound:3474-0017|FD-Score:-3.43|P-value:2.56E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:4.04|P-value:7.17E-6 ID:SGTC_1009|Compound:4106-0057|FD-Score:3.00|P-value:5.77E-4 ID:SGTC_1103|Compound:duloxetine|FD-Score:2.99|P-value:6.08E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:2.85|P-value:9.99E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:4.35|P-value:1.57E-6 ID:SGTC_1652|Compound:st011932|FD-Score:3.22|P-value:2.48E-4 ID:SGTC_1754|Compound:st042065|FD-Score:3.42|P-value:1.12E-4 ID:SGTC_1907|Compound:st060210|FD-Score:3.09|P-value:4.10E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.20|P-value:2.70E-4 ID:SGTC_1923|Compound:st058458|FD-Score:5.57|P-value:1.49E-9 ID:SGTC_1925|Compound:st057770|FD-Score:-3.16|P-value:7.04E-4 ID:SGTC_1927|Compound:st060202|FD-Score:3.99|P-value:8.94E-6 ID:SGTC_1935|Compound:st074532|FD-Score:4.22|P-value:2.96E-6 ID:SGTC_1987|Compound:st072290|FD-Score:3.15|P-value:3.25E-4 ID:SGTC_2066|Compound:5222451|FD-Score:4.19|P-value:3.48E-6 ID:SGTC_2075|Compound:5212009|FD-Score:3.13|P-value:3.57E-4 ID:SGTC_2108|Compound:5365811|FD-Score:3.22|P-value:2.47E-4 ID:SGTC_2205|Compound:7238770|FD-Score:3.01|P-value:5.62E-4 ID:SGTC_2331|Compound:7980721|FD-Score:3.03|P-value:5.14E-4 ID:SGTC_2362|Compound:9071156|FD-Score:2.93|P-value:7.48E-4 ID:SGTC_2466|Compound:5983409|FD-Score:3.56|P-value:6.30E-5 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-3.52|P-value:1.73E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:3.46|P-value:9.58E-5 ID:SGTC_2999|Compound:9069765|FD-Score:3.71|P-value:3.31E-5 ID:SGTC_57|Compound:miconazole|FD-Score:2.85|P-value:9.89E-4 ID:SGTC_79|Compound:0052-0007|FD-Score:-3.28|P-value:4.42E-4 ID:SGTC_347|Compound:4534-1311|FD-Score:-3.14|P-value:7.61E-4 ID:SGTC_561|Compound:1550-0330|FD-Score:2.87|P-value:9.31E-4 ID:SGTC_565|Compound:1418-0001|FD-Score:2.95|P-value:6.98E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:3.74|P-value:2.86E-5 ID:SGTC_836|Compound:0330-0104|FD-Score:4.14|P-value:4.54E-6 ID:SGTC_840|Compound:0245-0196|FD-Score:3.22|P-value:2.49E-4 ID:SGTC_909|Compound:3448-9333|FD-Score:-3.24|P-value:5.26E-4 ID:SGTC_912|Compound:3474-0017|FD-Score:-3.43|P-value:2.56E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:4.04|P-value:7.17E-6 ID:SGTC_1009|Compound:4106-0057|FD-Score:3.00|P-value:5.77E-4 ID:SGTC_1103|Compound:duloxetine|FD-Score:2.99|P-value:6.08E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:2.85|P-value:9.99E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:4.35|P-value:1.57E-6 ID:SGTC_1652|Compound:st011932|FD-Score:3.22|P-value:2.48E-4 ID:SGTC_1754|Compound:st042065|FD-Score:3.42|P-value:1.12E-4 ID:SGTC_1907|Compound:st060210|FD-Score:3.09|P-value:4.10E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.20|P-value:2.70E-4 ID:SGTC_1923|Compound:st058458|FD-Score:5.57|P-value:1.49E-9 ID:SGTC_1925|Compound:st057770|FD-Score:-3.16|P-value:7.04E-4 ID:SGTC_1927|Compound:st060202|FD-Score:3.99|P-value:8.94E-6 ID:SGTC_1935|Compound:st074532|FD-Score:4.22|P-value:2.96E-6 ID:SGTC_1987|Compound:st072290|FD-Score:3.15|P-value:3.25E-4 ID:SGTC_2066|Compound:5222451|FD-Score:4.19|P-value:3.48E-6 ID:SGTC_2075|Compound:5212009|FD-Score:3.13|P-value:3.57E-4 ID:SGTC_2108|Compound:5365811|FD-Score:3.22|P-value:2.47E-4 ID:SGTC_2205|Compound:7238770|FD-Score:3.01|P-value:5.62E-4 ID:SGTC_2331|Compound:7980721|FD-Score:3.03|P-value:5.14E-4 ID:SGTC_2362|Compound:9071156|FD-Score:2.93|P-value:7.48E-4 ID:SGTC_2466|Compound:5983409|FD-Score:3.56|P-value:6.30E-5 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-3.52|P-value:1.73E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:3.46|P-value:9.58E-5 ID:SGTC_2999|Compound:9069765|FD-Score:3.71|P-value:3.31E-5

Top fitness defect scores for YHR123W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1923 st058458 5.57 19.1 µM 1.49E-9 7 1.31E-8
2 SGTC_1246 0422-0085 4.35 105.0 µM 1.57E-6 18 6.81E-6
3 SGTC_1935 st074532 4.22 41.6 µM 2.96E-6 22 1.20E-5
4 SGTC_2066 5222451 4.19 176.0 µM 3.48E-6 heme biosynthesis & mitochondrial translocase 28 1.39E-5
5 SGTC_836 0330-0104 4.14 1.4 µM 4.54E-6 11 1.77E-5
6 SGTC_913 3487-1245 4.04 167.0 µM 7.17E-6 25 2.66E-5
7 SGTC_1927 st060202 3.99 13.8 µM 8.94E-6 16 3.24E-5
8 SGTC_769 0302-0231 3.74 76.0 µM 2.86E-5 48 9.18E-5
9 SGTC_2999 9069765 3.71 71.4 µM 3.31E-5 amide catabolism 36 1.04E-4
10 SGTC_2466 5983409 3.56 37.1 µM 6.30E-5 31 1.86E-4
11 SGTC_2594 a-mangostin 3.46 100.0 µM 9.58E-5 48 2.71E-4
12 SGTC_1754 st042065 3.42 16.1 µM 1.12E-4 NEO1-PIK1 230 3.12E-4
13 SGTC_2108 5365811 3.22 200.0 µM 2.47E-4 42 6.31E-4
14 SGTC_1652 st011932 3.22 78.0 µM 2.48E-4 RSC complex & mRNA processing 36 6.33E-4
15 SGTC_840 0245-0196 3.22 390.0 µM 2.49E-4 35 6.35E-4
16 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 3.20 70.1 µM 2.70E-4 65 6.83E-4
17 SGTC_1987 st072290 3.15 61.9 µM 3.25E-4 44 8.05E-4
18 SGTC_2075 5212009 3.13 200.0 µM 3.57E-4 36 8.77E-4
19 SGTC_1907 st060210 3.09 83.7 µM 4.10E-4 67 9.92E-4
20 SGTC_2331 7980721 3.03 200.0 µM 5.14E-4 73 0.00121

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.153 5.34E-19 YMR105C PGM2 hom Phosphoglucomutase; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism; functions as the acceptor for a Glc-phosphotransferase; protein abundance increases in response to DNA replication stress
0.127 1.58E-13 YDR210W_p YDR210W_p hom Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.124 6.46E-13 YIL069C RPS24B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S24, no bacterial homolog; RPS24B has a paralog, RPS24A, that arose from the whole genome duplication
0.116 1.84E-11 YPL085W SEC16 het COPII vesicle coat protein required for ER transport vesicle budding; Sec16p is bound to the periphery of ER membranes and may act to stabilize initial COPII complexes; interacts with Sec23p, Sec24p and Sec31p
0.113 5.33E-11 YBR264C YPT10 hom Rab family GTP-binding protein that contains the PEST signal sequence specific for proteolytic enzymes; may be involved in vesicular transport; overexpression leads to accumulation of Golgi-like cisternae with budding vesicles
0.109 2.23E-10 YHR188C GPI16 het Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-Tp homolog
0.108 3.62E-10 YOR230W WTM1 hom Transcriptional modulator involved in regulation of meiosis, silencing, and expression of RNR genes; required for nuclear localization of the ribonucleotide reductase small subunit Rnr2p and Rnr4p; contains WD repeats
0.099 9.63E-9 YMR115W MGR3 hom Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr1p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA
0.093 7.05E-8 YDR209C_d YDR209C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YDR210W.
0.090 2.02E-7 YLR081W GAL2 hom Galactose permease, required for utilization of galactose; also able to transport glucose
0.089 2.55E-7 YKR008W RSC4 het Component of the RSC chromatin remodeling complex; found in close proximity to nucleosomal DNA; displaced from the surface of nucleosomal DNA after chromatin remodeling; acetylated (K25) by Gcn5p, altering replication stress tolerance; contains tandem bromodomains that recognize histone H3 acetylated on K14 (H3K14ac) by Gcn5p
0.089 2.74E-7 YKL017C HCS1 hom Hexameric DNA polymerase alpha-associated DNA helicase A involved in lagging strand DNA synthesis; contains single-stranded DNA stimulated ATPase and dATPase activities; replication protein A stimulates helicase and ATPase activities
0.087 3.95E-7 YFL044C OTU1 hom Deubiquitylation enzyme that binds to the chaperone-ATPase Cdc48p; may contribute to regulation of protein degradation by deubiquitylating substrates that have been ubiquitylated by Ufd2p; member of the Ovarian Tumor (OTU) family; protein abundance increases in response to DNA replication stress
0.087 4.82E-7 YNL145W MFA2 hom Mating pheromone a-factor, made by a cells; interacts with alpha cells to induce cell cycle arrest and other responses leading to mating; biogenesis involves C-terminal modification, N-terminal proteolysis, and export; also encoded by MFA1
0.087 5.15E-7 YDL004W ATP16 het Delta subunit of the central stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated