HIPHOP chemogenomics database

YHR130C_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain

fixedexpanded
Profile for YHR130C / YHR130C

Click on Significant Values for Screen Details

Top fitness defect scores for YHR130C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_3212	9128307	7.14	49.5 µM	1.75E-12		8	4.60E-13
2	SGTC_449	xestospongin c	5.08	11.2 µM	3.81E-7	NEO1-PIK1	29	1.92E-7
3	SGTC_2587	piperic acid	4.54	92.2 µM	4.94E-6		12	2.85E-6
4	SGTC_1951	sophoraflavanone G	4.51	9.2 µM	5.68E-6	RNA processing & uracil transport	13	3.30E-6
5	SGTC_1377	2944-0135	4.21	198.0 µM	2.06E-5	calcium & mitochondrial duress	32	1.28E-5
6	SGTC_2939	9044578	3.91	71.4 µM	7.08E-5		40	4.69E-5
7	SGTC_1189	1431-2119	3.63	7.3 µM	2.02E-4		36	1.41E-4
8	SGTC_2777	climbazole	3.60	1.5 µM	2.25E-4	iron homeostasis	68	1.58E-4
9	SGTC_2783	7738165	3.59	71.4 µM	2.32E-4		42	1.63E-4
10	SGTC_1944	st076371	3.58	56.9 µM	2.47E-4		33	1.74E-4
11	SGTC_1641	st009299	3.44	47.1 µM	4.00E-4	mitochondrial processes	14	2.89E-4
12	SGTC_752	1896-0090	3.43	130.0 µM	4.19E-4	TSC3-RPN4	30	3.03E-4
13	SGTC_1840	st055363	3.38	71.0 µM	4.91E-4		27	3.59E-4
14	SGTC_376	3970-0862	3.35	59.1 µM	5.48E-4		39	4.03E-4
15	SGTC_1308	1187-1617	3.31	41.4 µM	6.41E-4	fatty acid desaturase (OLE1)	69	4.75E-4
16	SGTC_647	0140-0236	3.30	81.0 µM	6.46E-4		23	4.79E-4
17	SGTC_171	k064-0041	3.28	9.7 µM	6.91E-4	heme requiring	39	5.13E-4
18	SGTC_915	methyl methanesulfonate (MMS)	3.28	110.0 mM	7.01E-4	DNA damage response	68	5.21E-4
19	SGTC_2058	5236698	3.27	133.0 µM	7.26E-4		51	5.41E-4
20	SGTC_1839	st053978	3.22	48.0 µM	8.48E-4		38	6.37E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.201	6.84E-32	YHL003C	LAG1	hom	Ceramide synthase component; involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p; forms ER foci upon DNA replication stress
0.152	6.59E-19	YOR055W_d	YOR055W_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.151	1.22E-18	YPL167C	REV3	hom	Catalytic subunit of DNA polymerase zeta, involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair
0.121	1.70E-12	YEL018W	EAF5	hom	Esa1p-associated factor, non-essential subunit of the NuA4 acetyltransferase complex
0.116	1.93E-11	YMR239C	RNT1	het	Nuclear dsRNA-specific ribonuclease (RNase III); involved in rDNA transcription, rRNA processing and U2 snRNA 3' end formation by cleavage of a stem-loop structure at the 3' end of U2 snRNA; involved in polyadenylation-independent transcription termination; involved in the cell wall stress response, regulating the degradation of cell wall integrity and morphogenesis checkpoint genes
0.111	1.06E-10	YDL162C_d	YDL162C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps ENT1/YDL161W, a verified gene involved in endocytosis and actin cortical patch assembly
0.105	9.86E-10	YKL201C	MNN4	hom	Putative positive regulator of mannosylphosphate transferase Mnn6p; involved in mannosylphosphorylation of N-linked oligosaccharides; expression increases in late-logarithmic and stationary growth phases; MNN4 has a paralog, YJR061W, that arose from the whole genome duplication
0.103	2.37E-9	YGR274C	TAF1	het	TFIID subunit (145 kDa), involved in RNA polymerase II transcription initiation; possesses in vitro histone acetyltransferase activity but its role in vivo appears to be minor; involved in promoter binding and G1/S progression
0.097	1.60E-8	YJR107W_p	YJR107W_p	hom	Putative lipase
0.096	2.15E-8	YML069W	POB3	het	Subunit of the heterodimeric FACT complex (Spt16p-Pob3p); FACT associates with chromatin via interaction with Nhp6Ap and Nhp6Bp, and reorganizes nucleosomes to facilitate access to DNA by RNA and DNA polymerases; protein abundance increases in response to DNA replication stress
0.094	4.45E-8	YML067C	ERV41	hom	Protein localized to COPII-coated vesicles, forms a complex with Erv46p; involved in the membrane fusion stage of transport; has homology to human ERGIC2 (PTX1) protein
0.094	4.63E-8	YOR233W	KIN4	hom	Serine/threonine protein kinase; inhibits the mitotic exit network (MEN) when the spindle position checkpoint is activated; localized asymmetrically to mother cell cortex, spindle pole body and bud neck; KIN4 has a paralog, FRK1, that arose from the whole genome duplication
0.091	1.17E-7	YKR069W	MET1	hom	S-adenosyl-L-methionine uroporphyrinogen III transmethylase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis
0.088	3.50E-7	YOR155C	ISN1	hom	Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase, catalyzes the breakdown of IMP to inosine, does not show similarity to known 5'-nucleotidases from other organisms
0.087	5.07E-7	YKL075C_p	YKL075C_p	hom	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; proposed to be involved in resistance to streptozotocin and camptothecin