YHR130C_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR130C / YHR130C

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:3.19|P-value:9.57E-4 ID:SGTC_171|Compound:k064-0041|FD-Score:3.28|P-value:6.91E-4 ID:SGTC_376|Compound:3970-0862|FD-Score:3.35|P-value:5.48E-4 ID:SGTC_449|Compound:xestospongin c|FD-Score:5.08|P-value:3.81E-7 ID:SGTC_577|Compound:r071-0003|FD-Score:-3.61|P-value:2.22E-4 ID:SGTC_647|Compound:0140-0236|FD-Score:3.30|P-value:6.46E-4 ID:SGTC_752|Compound:1896-0090|FD-Score:3.43|P-value:4.19E-4 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:3.28|P-value:7.01E-4 ID:SGTC_1189|Compound:1431-2119|FD-Score:3.63|P-value:2.02E-4 ID:SGTC_1308|Compound:1187-1617|FD-Score:3.31|P-value:6.41E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:4.21|P-value:2.06E-5 ID:SGTC_1641|Compound:st009299|FD-Score:3.44|P-value:4.00E-4 ID:SGTC_1826|Compound:st055655|FD-Score:3.21|P-value:8.70E-4 ID:SGTC_1839|Compound:st053978|FD-Score:3.22|P-value:8.48E-4 ID:SGTC_1840|Compound:st055363|FD-Score:3.38|P-value:4.91E-4 ID:SGTC_1944|Compound:st076371|FD-Score:3.58|P-value:2.47E-4 ID:SGTC_1948|Compound:st076329|FD-Score:-3.34|P-value:5.75E-4 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:4.51|P-value:5.68E-6 ID:SGTC_2058|Compound:5236698|FD-Score:3.27|P-value:7.26E-4 ID:SGTC_2587|Compound:piperic acid|FD-Score:4.54|P-value:4.94E-6 ID:SGTC_2605|Compound:digitonin|FD-Score:-3.46|P-value:3.78E-4 ID:SGTC_2608|Compound:thymoquinone|FD-Score:-3.84|P-value:9.21E-5 ID:SGTC_2777|Compound:climbazole|FD-Score:3.60|P-value:2.25E-4 ID:SGTC_2783|Compound:7738165|FD-Score:3.59|P-value:2.32E-4 ID:SGTC_2939|Compound:9044578|FD-Score:3.91|P-value:7.08E-5 ID:SGTC_2955|Compound:9076254|FD-Score:-3.30|P-value:6.56E-4 ID:SGTC_2981|Compound:9013952|FD-Score:-3.39|P-value:4.80E-4 ID:SGTC_3205|Compound:9113483|FD-Score:-3.74|P-value:1.37E-4 ID:SGTC_3212|Compound:9128307|FD-Score:7.14|P-value:1.75E-12 ID:SGTC_3351|Compound:9150312|FD-Score:-4.46|P-value:7.27E-6 ID:SGTC_6|Compound:0844-0013|FD-Score:3.19|P-value:9.57E-4 ID:SGTC_171|Compound:k064-0041|FD-Score:3.28|P-value:6.91E-4 ID:SGTC_376|Compound:3970-0862|FD-Score:3.35|P-value:5.48E-4 ID:SGTC_449|Compound:xestospongin c|FD-Score:5.08|P-value:3.81E-7 ID:SGTC_577|Compound:r071-0003|FD-Score:-3.61|P-value:2.22E-4 ID:SGTC_647|Compound:0140-0236|FD-Score:3.30|P-value:6.46E-4 ID:SGTC_752|Compound:1896-0090|FD-Score:3.43|P-value:4.19E-4 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:3.28|P-value:7.01E-4 ID:SGTC_1189|Compound:1431-2119|FD-Score:3.63|P-value:2.02E-4 ID:SGTC_1308|Compound:1187-1617|FD-Score:3.31|P-value:6.41E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:4.21|P-value:2.06E-5 ID:SGTC_1641|Compound:st009299|FD-Score:3.44|P-value:4.00E-4 ID:SGTC_1826|Compound:st055655|FD-Score:3.21|P-value:8.70E-4 ID:SGTC_1839|Compound:st053978|FD-Score:3.22|P-value:8.48E-4 ID:SGTC_1840|Compound:st055363|FD-Score:3.38|P-value:4.91E-4 ID:SGTC_1944|Compound:st076371|FD-Score:3.58|P-value:2.47E-4 ID:SGTC_1948|Compound:st076329|FD-Score:-3.34|P-value:5.75E-4 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:4.51|P-value:5.68E-6 ID:SGTC_2058|Compound:5236698|FD-Score:3.27|P-value:7.26E-4 ID:SGTC_2587|Compound:piperic acid|FD-Score:4.54|P-value:4.94E-6 ID:SGTC_2605|Compound:digitonin|FD-Score:-3.46|P-value:3.78E-4 ID:SGTC_2608|Compound:thymoquinone|FD-Score:-3.84|P-value:9.21E-5 ID:SGTC_2777|Compound:climbazole|FD-Score:3.60|P-value:2.25E-4 ID:SGTC_2783|Compound:7738165|FD-Score:3.59|P-value:2.32E-4 ID:SGTC_2939|Compound:9044578|FD-Score:3.91|P-value:7.08E-5 ID:SGTC_2955|Compound:9076254|FD-Score:-3.30|P-value:6.56E-4 ID:SGTC_2981|Compound:9013952|FD-Score:-3.39|P-value:4.80E-4 ID:SGTC_3205|Compound:9113483|FD-Score:-3.74|P-value:1.37E-4 ID:SGTC_3212|Compound:9128307|FD-Score:7.14|P-value:1.75E-12 ID:SGTC_3351|Compound:9150312|FD-Score:-4.46|P-value:7.27E-6

Top fitness defect scores for YHR130C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3212 9128307 7.14 49.5 µM 1.75E-12 8 4.60E-13
2 SGTC_449 xestospongin c 5.08 11.2 µM 3.81E-7 NEO1-PIK1 29 1.92E-7
3 SGTC_2587 piperic acid 4.54 92.2 µM 4.94E-6 12 2.85E-6
4 SGTC_1951 sophoraflavanone G 4.51 9.2 µM 5.68E-6 RNA processing & uracil transport 13 3.30E-6
5 SGTC_1377 2944-0135 4.21 198.0 µM 2.06E-5 calcium & mitochondrial duress 32 1.28E-5
6 SGTC_2939 9044578 3.91 71.4 µM 7.08E-5 40 4.69E-5
7 SGTC_1189 1431-2119 3.63 7.3 µM 2.02E-4 36 1.41E-4
8 SGTC_2777 climbazole 3.60 1.5 µM 2.25E-4 iron homeostasis 68 1.58E-4
9 SGTC_2783 7738165 3.59 71.4 µM 2.32E-4 42 1.63E-4
10 SGTC_1944 st076371 3.58 56.9 µM 2.47E-4 33 1.74E-4
11 SGTC_1641 st009299 3.44 47.1 µM 4.00E-4 mitochondrial processes 14 2.89E-4
12 SGTC_752 1896-0090 3.43 130.0 µM 4.19E-4 TSC3-RPN4 30 3.03E-4
13 SGTC_1840 st055363 3.38 71.0 µM 4.91E-4 27 3.59E-4
14 SGTC_376 3970-0862 3.35 59.1 µM 5.48E-4 39 4.03E-4
15 SGTC_1308 1187-1617 3.31 41.4 µM 6.41E-4 fatty acid desaturase (OLE1) 69 4.75E-4
16 SGTC_647 0140-0236 3.30 81.0 µM 6.46E-4 23 4.79E-4
17 SGTC_171 k064-0041 3.28 9.7 µM 6.91E-4 heme requiring 39 5.13E-4
18 SGTC_915 methyl methanesulfonate (MMS) 3.28 110.0 mM 7.01E-4 DNA damage response 68 5.21E-4
19 SGTC_2058 5236698 3.27 133.0 µM 7.26E-4 51 5.41E-4
20 SGTC_1839 st053978 3.22 48.0 µM 8.48E-4 38 6.37E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.201 6.84E-32 YHL003C LAG1 hom Ceramide synthase component; involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p; forms ER foci upon DNA replication stress
0.152 6.59E-19 YOR055W_d YOR055W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.151 1.22E-18 YPL167C REV3 hom Catalytic subunit of DNA polymerase zeta, involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair
0.121 1.70E-12 YEL018W EAF5 hom Esa1p-associated factor, non-essential subunit of the NuA4 acetyltransferase complex
0.116 1.93E-11 YMR239C RNT1 het Nuclear dsRNA-specific ribonuclease (RNase III); involved in rDNA transcription, rRNA processing and U2 snRNA 3' end formation by cleavage of a stem-loop structure at the 3' end of U2 snRNA; involved in polyadenylation-independent transcription termination; involved in the cell wall stress response, regulating the degradation of cell wall integrity and morphogenesis checkpoint genes
0.111 1.06E-10 YDL162C_d YDL162C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps ENT1/YDL161W, a verified gene involved in endocytosis and actin cortical patch assembly
0.105 9.86E-10 YKL201C MNN4 hom Putative positive regulator of mannosylphosphate transferase Mnn6p; involved in mannosylphosphorylation of N-linked oligosaccharides; expression increases in late-logarithmic and stationary growth phases; MNN4 has a paralog, YJR061W, that arose from the whole genome duplication
0.103 2.37E-9 YGR274C TAF1 het TFIID subunit (145 kDa), involved in RNA polymerase II transcription initiation; possesses in vitro histone acetyltransferase activity but its role in vivo appears to be minor; involved in promoter binding and G1/S progression
0.097 1.60E-8 YJR107W_p YJR107W_p hom Putative lipase
0.096 2.15E-8 YML069W POB3 het Subunit of the heterodimeric FACT complex (Spt16p-Pob3p); FACT associates with chromatin via interaction with Nhp6Ap and Nhp6Bp, and reorganizes nucleosomes to facilitate access to DNA by RNA and DNA polymerases; protein abundance increases in response to DNA replication stress
0.094 4.45E-8 YML067C ERV41 hom Protein localized to COPII-coated vesicles, forms a complex with Erv46p; involved in the membrane fusion stage of transport; has homology to human ERGIC2 (PTX1) protein
0.094 4.63E-8 YOR233W KIN4 hom Serine/threonine protein kinase; inhibits the mitotic exit network (MEN) when the spindle position checkpoint is activated; localized asymmetrically to mother cell cortex, spindle pole body and bud neck; KIN4 has a paralog, FRK1, that arose from the whole genome duplication
0.091 1.17E-7 YKR069W MET1 hom S-adenosyl-L-methionine uroporphyrinogen III transmethylase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis
0.088 3.50E-7 YOR155C ISN1 hom Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase, catalyzes the breakdown of IMP to inosine, does not show similarity to known 5'-nucleotidases from other organisms
0.087 5.07E-7 YKL075C_p YKL075C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; proposed to be involved in resistance to streptozotocin and camptothecin