HIPHOP chemogenomics database
YHR132C / ECM14 
Putative metalloprotease with similarity to the zinc carboxypeptidase family, required for normal cell wall assembly
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YHR132C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.107 | 4.89E-10 | YGR267C | FOL2 | het | GTP-cyclohydrolase I, catalyzes the first step in the folic acid biosynthetic pathway |
| 0.093 | 7.04E-8 | YOR074C | CDC21 | het | Thymidylate synthase, required for de novo biosynthesis of pyrimidine deoxyribonucleotides; expression is induced at G1/S |
| 0.091 | 1.30E-7 | YNR073C_p | YNR073C_p | hom | Putative mannitol dehydrogenase; identical in amino acid sequence to Dsf1p |
| 0.087 | 5.13E-7 | YKL112W | ABF1 | het | DNA binding protein with possible chromatin-reorganizing activity involved in transcriptional activation, gene silencing, and DNA replication and repair |
| 0.083 | 1.35E-6 | YGR261C | APL6 | hom | Beta3-like subunit of the yeast AP-3 complex; functions in transport of alkaline phosphatase to the vacuole via the alternate pathway; exists in both cytosolic and peripherally associated membrane-bound pools |
| 0.082 | 1.92E-6 | YDL085C-A_p | YDL085C-A_p | hom | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus |
| 0.079 | 4.99E-6 | YOR218C_d | YOR218C_d | het | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene RFC1/YOR217W |
| 0.078 | 5.91E-6 | YPR019W | MCM4 | het | Essential helicase component of heterohexameric MCM2-7 complexes which bind pre-replication complexes on DNA and melt DNA prior to replication; forms an Mcm4p-6p-7p subcomplex; shows nuclear accumulation in G1; homolog of S. pombe Cdc21p |
| 0.077 | 7.57E-6 | YDL219W | DTD1 | hom | D-Tyr-tRNA(Tyr) deacylase, functions in protein translation, may affect nonsense suppression via alteration of the protein synthesis machinery; ubiquitous among eukaryotes |
| 0.076 | 1.13E-5 | YFL046W_p | FMP32_p | hom | Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies |
| 0.075 | 1.36E-5 | YKR009C | FOX2 | hom | Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities |
| 0.072 | 3.35E-5 | YCL057W | PRD1 | hom | Zinc metalloendopeptidase; found in the cytoplasm and intermembrane space of mitochondria; with Cym1p, involved in degradation of mitochondrial proteins and of presequence peptides cleaved from imported proteins; protein abundance increases in response to DNA replication stress |
| 0.071 | 3.93E-5 | YDL043C | PRP11 | het | Subunit of the SF3a splicing factor complex, required for spliceosome assembly |
| 0.071 | 4.21E-5 | YGR259C_d | YGR259C_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF TNA1/YGR260W |
| 0.070 | 5.42E-5 | YHR178W | STB5 | hom | Transcription factor, involved in regulating multidrug resistance and oxidative stress response; forms a heterodimer with Pdr1p; contains a Zn(II)2Cys6 zinc finger domain that interacts with a pleiotropic drug resistance element in vitro |