YHR140W_p

Putative integral membrane protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR140W / YHR140W

Click on Significant Values for Screen Details ID:SGTC_102|Compound:gallobenzophenone|FD-Score:3.13|P-value:3.50E-4 ID:SGTC_117|Compound:lucigenin|FD-Score:3.75|P-value:2.49E-5 ID:SGTC_207|Compound:4185-0010|FD-Score:4.81|P-value:9.54E-8 ID:SGTC_259|Compound:usnic acid|FD-Score:2.87|P-value:9.21E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:3.71|P-value:2.90E-5 ID:SGTC_488|Compound:nitrendipine|FD-Score:3.48|P-value:8.28E-5 ID:SGTC_535|Compound:2293-4129|FD-Score:-2.96|P-value:7.30E-4 ID:SGTC_609|Compound:0986-0026|FD-Score:3.25|P-value:2.17E-4 ID:SGTC_685|Compound:1278-0033|FD-Score:3.76|P-value:2.38E-5 ID:SGTC_821|Compound:1114-0266|FD-Score:3.51|P-value:7.23E-5 ID:SGTC_882|Compound:0843-0131|FD-Score:4.57|P-value:3.79E-7 ID:SGTC_893|Compound:0958-0369|FD-Score:3.85|P-value:1.53E-5 ID:SGTC_895|Compound:0964-0006|FD-Score:2.94|P-value:7.26E-4 ID:SGTC_924|Compound:2046-0044|FD-Score:-3.02|P-value:5.82E-4 ID:SGTC_932|Compound:2857-0803|FD-Score:3.26|P-value:2.04E-4 ID:SGTC_949|Compound:1165-0505|FD-Score:3.60|P-value:4.91E-5 ID:SGTC_1045|Compound:1348-1485|FD-Score:-3.04|P-value:5.45E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.76|P-value:2.65E-5 ID:SGTC_1286|Compound:0929-0070|FD-Score:3.53|P-value:6.72E-5 ID:SGTC_1294|Compound:1000-1494|FD-Score:-3.06|P-value:5.06E-4 ID:SGTC_1315|Compound:1237-0019|FD-Score:5.45|P-value:1.82E-9 ID:SGTC_1602|Compound:st001878|FD-Score:4.47|P-value:6.59E-7 ID:SGTC_1611|Compound:st001856|FD-Score:3.52|P-value:6.93E-5 ID:SGTC_1613|Compound:st002381|FD-Score:2.88|P-value:9.04E-4 ID:SGTC_1616|Compound:st002734|FD-Score:3.98|P-value:8.09E-6 ID:SGTC_1620|Compound:st003704|FD-Score:3.22|P-value:2.45E-4 ID:SGTC_1761|Compound:st044296|FD-Score:-3.28|P-value:2.12E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:-3.43|P-value:1.13E-4 ID:SGTC_2549|Compound:cedrol|FD-Score:3.25|P-value:2.18E-4 ID:SGTC_2939|Compound:9044578|FD-Score:-2.92|P-value:8.62E-4 ID:SGTC_2971|Compound:9092186|FD-Score:3.95|P-value:9.56E-6 ID:SGTC_2975|Compound:9084847|FD-Score:-3.37|P-value:1.49E-4 ID:SGTC_3210|Compound:9128157|FD-Score:3.37|P-value:1.30E-4 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:3.13|P-value:3.50E-4 ID:SGTC_117|Compound:lucigenin|FD-Score:3.75|P-value:2.49E-5 ID:SGTC_207|Compound:4185-0010|FD-Score:4.81|P-value:9.54E-8 ID:SGTC_259|Compound:usnic acid|FD-Score:2.87|P-value:9.21E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:3.71|P-value:2.90E-5 ID:SGTC_488|Compound:nitrendipine|FD-Score:3.48|P-value:8.28E-5 ID:SGTC_535|Compound:2293-4129|FD-Score:-2.96|P-value:7.30E-4 ID:SGTC_609|Compound:0986-0026|FD-Score:3.25|P-value:2.17E-4 ID:SGTC_685|Compound:1278-0033|FD-Score:3.76|P-value:2.38E-5 ID:SGTC_821|Compound:1114-0266|FD-Score:3.51|P-value:7.23E-5 ID:SGTC_882|Compound:0843-0131|FD-Score:4.57|P-value:3.79E-7 ID:SGTC_893|Compound:0958-0369|FD-Score:3.85|P-value:1.53E-5 ID:SGTC_895|Compound:0964-0006|FD-Score:2.94|P-value:7.26E-4 ID:SGTC_924|Compound:2046-0044|FD-Score:-3.02|P-value:5.82E-4 ID:SGTC_932|Compound:2857-0803|FD-Score:3.26|P-value:2.04E-4 ID:SGTC_949|Compound:1165-0505|FD-Score:3.60|P-value:4.91E-5 ID:SGTC_1045|Compound:1348-1485|FD-Score:-3.04|P-value:5.45E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.76|P-value:2.65E-5 ID:SGTC_1286|Compound:0929-0070|FD-Score:3.53|P-value:6.72E-5 ID:SGTC_1294|Compound:1000-1494|FD-Score:-3.06|P-value:5.06E-4 ID:SGTC_1315|Compound:1237-0019|FD-Score:5.45|P-value:1.82E-9 ID:SGTC_1602|Compound:st001878|FD-Score:4.47|P-value:6.59E-7 ID:SGTC_1611|Compound:st001856|FD-Score:3.52|P-value:6.93E-5 ID:SGTC_1613|Compound:st002381|FD-Score:2.88|P-value:9.04E-4 ID:SGTC_1616|Compound:st002734|FD-Score:3.98|P-value:8.09E-6 ID:SGTC_1620|Compound:st003704|FD-Score:3.22|P-value:2.45E-4 ID:SGTC_1761|Compound:st044296|FD-Score:-3.28|P-value:2.12E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:-3.43|P-value:1.13E-4 ID:SGTC_2549|Compound:cedrol|FD-Score:3.25|P-value:2.18E-4 ID:SGTC_2939|Compound:9044578|FD-Score:-2.92|P-value:8.62E-4 ID:SGTC_2971|Compound:9092186|FD-Score:3.95|P-value:9.56E-6 ID:SGTC_2975|Compound:9084847|FD-Score:-3.37|P-value:1.49E-4 ID:SGTC_3210|Compound:9128157|FD-Score:3.37|P-value:1.30E-4

Top fitness defect scores for YHR140W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1315 1237-0019 5.45 3.7 µM 1.82E-9 3 2.46E-8
2 SGTC_207 4185-0010 4.81 4.5 µM 9.54E-8 endomembrane recycling 59 7.41E-7
3 SGTC_882 0843-0131 4.57 351.0 µM 3.79E-7 8 2.44E-6
4 SGTC_1602 st001878 4.47 87.6 µM 6.59E-7 12 3.92E-6
5 SGTC_1616 st002734 3.98 56.1 µM 8.09E-6 30 3.40E-5
6 SGTC_2971 9092186 3.95 9.9 µM 9.56E-6 ergosterol biosynthesis 33 3.93E-5
7 SGTC_893 0958-0369 3.85 48.9 µM 1.53E-5 26 5.91E-5
8 SGTC_685 1278-0033 3.76 54.9 µM 2.38E-5 60S ribosome export 26 8.64E-5
9 SGTC_117 lucigenin 3.75 22.1 µM 2.49E-5 redox potentiating 94 8.97E-5
10 SGTC_339 3091-4833 3.71 71.4 µM 2.90E-5 iron homeostasis 27 1.02E-4
11 SGTC_949 1165-0505 3.60 146.0 µM 4.91E-5 29 1.61E-4
12 SGTC_1286 0929-0070 3.53 131.0 µM 6.72E-5 28 2.12E-4
13 SGTC_1611 st001856 3.52 99.4 µM 6.93E-5 29 2.17E-4
14 SGTC_821 1114-0266 3.51 29.2 µM 7.23E-5 32 2.25E-4
15 SGTC_488 nitrendipine 3.48 139.0 µM 8.28E-5 62 2.53E-4
16 SGTC_3210 9128157 3.37 49.5 µM 1.30E-4 74 3.75E-4
17 SGTC_932 2857-0803 3.26 154.0 µM 2.04E-4 54 5.53E-4
18 SGTC_609 0986-0026 3.25 86.3 µM 2.17E-4 calcium & mitochondrial duress 59 5.83E-4
19 SGTC_2549 cedrol 3.25 20.9 µM 2.18E-4 32 5.86E-4
20 SGTC_1620 st003704 3.22 16.5 µM 2.45E-4 39 6.47E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.136 3.28E-15 YLR310C CDC25 het Membrane bound guanine nucleotide exchange factor (GEF or GDP-release factor); indirectly regulates adenylate cyclase through activation of Ras1p and Ras2p by stimulating the exchange of GDP for GTP; required for progression through G1
0.130 3.87E-14 YJR092W BUD4 hom Anillin-like protein involved in bud-site selection; required for the axial budding pattern; localizes with septins to the bud neck in mitosis and may constitute an axial landmark for the next round of budding; required for the formation and disassembly of the double septin ring structure, and generally for septin organization; in vivo substrate of Cdc28p/Clb2p
0.127 1.87E-13 YKL106C-A_p YKL106C-A_p hom Putative protein of unknown function; identified by homology to uncharacterized proteins in other fungi
0.124 4.52E-13 YER064C VHR2 hom Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.122 1.18E-12 YEL049W PAU2 hom Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
0.117 1.13E-11 YHL019C APM2 hom Protein of unknown function, homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport
0.110 1.94E-10 YDR499W LCD1 het Essential protein required for the DNA integrity checkpoint pathways; interacts physically with Mec1p; putative homolog of S. pombe Rad26 and human ATRIP; forms nuclear foci upon DNA replication stress
0.108 3.69E-10 YMR299C DYN3 hom Dynein light intermediate chain (LIC); localizes with dynein, null mutant is defective in nuclear migration
0.104 1.40E-9 YDR242W AMD2 hom Putative amidase
0.104 1.69E-9 YFL034W_p YFL034W_p hom Putative integral membrane protein that interacts with Rpp0p, which is a component of the ribosomal stalk
0.103 2.18E-9 YDL133C-A RPL41B hom Ribosomal 60S subunit protein L41B; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41, no bacterial homolog; RPL41B has a paralog, RPL41A, that arose from the whole genome duplication
0.102 2.95E-9 YLR170C APS1 hom Small subunit of the clathrin-associated adaptor complex AP-1, which is involved in protein sorting at the trans-Golgi network; homolog of the sigma subunit of the mammalian clathrin AP-1 complex
0.101 4.98E-9 YJL034W KAR2 het ATPase involved in protein import into the ER, also acts as a chaperone to mediate protein folding in the ER and may play a role in ER export of soluble proteins; regulates the unfolded protein response via interaction with Ire1p
0.099 7.91E-9 YOR298C-A MBF1 hom Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.098 1.13E-8 YLL051C FRE6 hom Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels