YHR155W / YSP1

Mitochondrial protein; potential role in promoting mitochondrial fragmentation during programmed cell death in response to high levels of alpha-factor mating pheromone or the drug amiodarone; YSP1 has a paralog, SIP3, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR155W / YSP1

Click on Significant Values for Screen Details ID:SGTC_59|Compound:0330-0160|FD-Score:5.36|P-value:2.34E-7 ID:SGTC_64|Compound:000l-0018|FD-Score:3.33|P-value:8.74E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:-3.65|P-value:2.69E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:6.38|P-value:9.69E-10 ID:SGTC_69|Compound:0096-0274|FD-Score:-4.26|P-value:2.78E-5 ID:SGTC_70|Compound:0141-0289|FD-Score:17.90|P-value:2.64E-64 ID:SGTC_108|Compound:0509-0257|FD-Score:4.14|P-value:4.92E-5 ID:SGTC_119|Compound:0121-0043|FD-Score:4.25|P-value:3.28E-5 ID:SGTC_134|Compound:0269-0018|FD-Score:5.30|P-value:3.11E-7 ID:SGTC_143|Compound:4032-1194|FD-Score:4.46|P-value:1.37E-5 ID:SGTC_149|Compound:3970-0822|FD-Score:8.09|P-value:1.33E-14 ID:SGTC_163|Compound:1327-0036|FD-Score:6.99|P-value:2.33E-11 ID:SGTC_168|Compound:3970-0862|FD-Score:5.74|P-value:3.36E-8 ID:SGTC_176|Compound:1486-1328|FD-Score:-3.61|P-value:3.11E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:6.06|P-value:5.85E-9 ID:SGTC_214|Compound:4373-3496|FD-Score:4.67|P-value:5.53E-6 ID:SGTC_233|Compound:rapamycin|FD-Score:4.10|P-value:5.81E-5 ID:SGTC_266|Compound:formosanin C|FD-Score:5.79|P-value:2.50E-8 ID:SGTC_272|Compound:doxorubicin|FD-Score:3.31|P-value:9.45E-4 ID:SGTC_305|Compound:1682-2595|FD-Score:3.76|P-value:2.05E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:15.30|P-value:2.78E-47 ID:SGTC_435|Compound:c-PAF|FD-Score:16.00|P-value:2.03E-51 ID:SGTC_439|Compound:amiodarone|FD-Score:7.03|P-value:1.89E-11 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:7.40|P-value:1.59E-12 ID:SGTC_455|Compound:paf C-16|FD-Score:15.60|P-value:5.16E-49 ID:SGTC_470|Compound:aa-861|FD-Score:3.56|P-value:4.16E-4 ID:SGTC_493|Compound:zm226600|FD-Score:3.82|P-value:1.64E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:5.68|P-value:4.64E-8 ID:SGTC_543|Compound:3844-1095|FD-Score:3.86|P-value:1.43E-4 ID:SGTC_599|Compound:1935-0052|FD-Score:3.33|P-value:8.77E-4 ID:SGTC_639|Compound:0833-0042|FD-Score:5.04|P-value:1.08E-6 ID:SGTC_666|Compound:0272-0154|FD-Score:3.41|P-value:6.84E-4 ID:SGTC_683|Compound:panaxydol|FD-Score:3.41|P-value:6.88E-4 ID:SGTC_744|Compound:1594-0068|FD-Score:3.46|P-value:5.74E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:3.44|P-value:6.08E-4 ID:SGTC_804|Compound:1595-0054|FD-Score:4.09|P-value:6.10E-5 ID:SGTC_819|Compound:1013-0258|FD-Score:5.59|P-value:7.42E-8 ID:SGTC_887|Compound:0885-0007|FD-Score:3.58|P-value:3.80E-4 ID:SGTC_1041|Compound:0206-0046|FD-Score:7.39|P-value:1.76E-12 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:3.90|P-value:1.24E-4 ID:SGTC_1113|Compound:artemisinin|FD-Score:3.48|P-value:5.36E-4 ID:SGTC_1123|Compound:mangostin|FD-Score:9.25|P-value:1.55E-18 ID:SGTC_1174|Compound:0739-0097|FD-Score:3.64|P-value:3.09E-4 ID:SGTC_1189|Compound:1431-2119|FD-Score:3.85|P-value:1.51E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:-3.75|P-value:1.95E-4 ID:SGTC_1277|Compound:0873-0036|FD-Score:4.38|P-value:1.92E-5 ID:SGTC_1326|Compound:1431-2094|FD-Score:3.41|P-value:6.89E-4 ID:SGTC_1356|Compound:1502-0781|FD-Score:3.84|P-value:1.56E-4 ID:SGTC_1396|Compound:3511-0007|FD-Score:5.30|P-value:3.06E-7 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:3.43|P-value:6.39E-4 ID:SGTC_1600|Compound:coumarin 106|FD-Score:4.55|P-value:9.32E-6 ID:SGTC_1679|Compound:4130-1276|FD-Score:5.37|P-value:2.21E-7 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.40|P-value:6.30E-4 ID:SGTC_1845|Compound:st056753|FD-Score:3.53|P-value:4.50E-4 ID:SGTC_1855|Compound:st056195|FD-Score:3.66|P-value:2.97E-4 ID:SGTC_1892|Compound:st058411|FD-Score:3.80|P-value:1.76E-4 ID:SGTC_1922|Compound:5578187|FD-Score:4.78|P-value:3.54E-6 ID:SGTC_1930|Compound:st074634|FD-Score:3.90|P-value:1.23E-4 ID:SGTC_1941|Compound:st076221|FD-Score:6.99|P-value:2.37E-11 ID:SGTC_2020|Compound:4017018|FD-Score:3.58|P-value:3.88E-4 ID:SGTC_2043|Compound:5101342|FD-Score:3.68|P-value:2.69E-4 ID:SGTC_2068|Compound:5226020|FD-Score:4.21|P-value:3.87E-5 ID:SGTC_2069|Compound:5228469|FD-Score:3.40|P-value:6.95E-4 ID:SGTC_2077|Compound:5212015|FD-Score:-4.07|P-value:5.86E-5 ID:SGTC_2207|Compound:7258803|FD-Score:3.42|P-value:6.61E-4 ID:SGTC_2245|Compound:6637752|FD-Score:5.66|P-value:5.07E-8 ID:SGTC_2259|Compound:7964009|FD-Score:3.83|P-value:1.59E-4 ID:SGTC_2347|Compound:9049783|FD-Score:-3.37|P-value:7.01E-4 ID:SGTC_2351|Compound:9026858|FD-Score:4.60|P-value:7.76E-6 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:-3.47|P-value:5.09E-4 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:3.47|P-value:5.52E-4 ID:SGTC_2556|Compound:citropten|FD-Score:3.54|P-value:4.45E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:12.30|P-value:3.16E-31 ID:SGTC_2584|Compound:androsterone|FD-Score:3.44|P-value:6.26E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:-3.69|P-value:2.41E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:5.03|P-value:1.13E-6 ID:SGTC_2651|Compound:1327-0036|FD-Score:5.18|P-value:5.41E-7 ID:SGTC_2652|Compound:actinonin|FD-Score:4.44|P-value:1.52E-5 ID:SGTC_2797|Compound:7859098|FD-Score:4.74|P-value:4.19E-6 ID:SGTC_2882|Compound:9058044|FD-Score:3.49|P-value:5.22E-4 ID:SGTC_2890|Compound:9046729|FD-Score:-3.34|P-value:7.77E-4 ID:SGTC_2893|Compound:9048488|FD-Score:3.92|P-value:1.13E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.59|P-value:3.43E-4 ID:SGTC_2954|Compound:9074818|FD-Score:10.60|P-value:5.57E-24 ID:SGTC_2955|Compound:9076254|FD-Score:3.85|P-value:1.50E-4 ID:SGTC_2956|Compound:9076196|FD-Score:-4.54|P-value:8.86E-6 ID:SGTC_2959|Compound:9079155|FD-Score:11.40|P-value:4.32E-27 ID:SGTC_2980|Compound:9014342|FD-Score:3.72|P-value:2.37E-4 ID:SGTC_3019|Compound:9081971|FD-Score:-3.27|P-value:9.74E-4 ID:SGTC_3038|Compound:9091290|FD-Score:3.52|P-value:4.80E-4 ID:SGTC_3136|Compound:9095672|FD-Score:-3.84|P-value:1.40E-4 ID:SGTC_3143|Compound:9086658|FD-Score:7.32|P-value:2.69E-12 ID:SGTC_3209|Compound:9113616|FD-Score:4.47|P-value:1.35E-5 ID:SGTC_3306|Compound:9127676|FD-Score:4.32|P-value:2.43E-5 ID:SGTC_59|Compound:0330-0160|FD-Score:5.36|P-value:2.34E-7 ID:SGTC_64|Compound:000l-0018|FD-Score:3.33|P-value:8.74E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:-3.65|P-value:2.69E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:6.38|P-value:9.69E-10 ID:SGTC_69|Compound:0096-0274|FD-Score:-4.26|P-value:2.78E-5 ID:SGTC_70|Compound:0141-0289|FD-Score:17.90|P-value:2.64E-64 ID:SGTC_108|Compound:0509-0257|FD-Score:4.14|P-value:4.92E-5 ID:SGTC_119|Compound:0121-0043|FD-Score:4.25|P-value:3.28E-5 ID:SGTC_134|Compound:0269-0018|FD-Score:5.30|P-value:3.11E-7 ID:SGTC_143|Compound:4032-1194|FD-Score:4.46|P-value:1.37E-5 ID:SGTC_149|Compound:3970-0822|FD-Score:8.09|P-value:1.33E-14 ID:SGTC_163|Compound:1327-0036|FD-Score:6.99|P-value:2.33E-11 ID:SGTC_168|Compound:3970-0862|FD-Score:5.74|P-value:3.36E-8 ID:SGTC_176|Compound:1486-1328|FD-Score:-3.61|P-value:3.11E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:6.06|P-value:5.85E-9 ID:SGTC_214|Compound:4373-3496|FD-Score:4.67|P-value:5.53E-6 ID:SGTC_233|Compound:rapamycin|FD-Score:4.10|P-value:5.81E-5 ID:SGTC_266|Compound:formosanin C|FD-Score:5.79|P-value:2.50E-8 ID:SGTC_272|Compound:doxorubicin|FD-Score:3.31|P-value:9.45E-4 ID:SGTC_305|Compound:1682-2595|FD-Score:3.76|P-value:2.05E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:15.30|P-value:2.78E-47 ID:SGTC_435|Compound:c-PAF|FD-Score:16.00|P-value:2.03E-51 ID:SGTC_439|Compound:amiodarone|FD-Score:7.03|P-value:1.89E-11 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:7.40|P-value:1.59E-12 ID:SGTC_455|Compound:paf C-16|FD-Score:15.60|P-value:5.16E-49 ID:SGTC_470|Compound:aa-861|FD-Score:3.56|P-value:4.16E-4 ID:SGTC_493|Compound:zm226600|FD-Score:3.82|P-value:1.64E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:5.68|P-value:4.64E-8 ID:SGTC_543|Compound:3844-1095|FD-Score:3.86|P-value:1.43E-4 ID:SGTC_599|Compound:1935-0052|FD-Score:3.33|P-value:8.77E-4 ID:SGTC_639|Compound:0833-0042|FD-Score:5.04|P-value:1.08E-6 ID:SGTC_666|Compound:0272-0154|FD-Score:3.41|P-value:6.84E-4 ID:SGTC_683|Compound:panaxydol|FD-Score:3.41|P-value:6.88E-4 ID:SGTC_744|Compound:1594-0068|FD-Score:3.46|P-value:5.74E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:3.44|P-value:6.08E-4 ID:SGTC_804|Compound:1595-0054|FD-Score:4.09|P-value:6.10E-5 ID:SGTC_819|Compound:1013-0258|FD-Score:5.59|P-value:7.42E-8 ID:SGTC_887|Compound:0885-0007|FD-Score:3.58|P-value:3.80E-4 ID:SGTC_1041|Compound:0206-0046|FD-Score:7.39|P-value:1.76E-12 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:3.90|P-value:1.24E-4 ID:SGTC_1113|Compound:artemisinin|FD-Score:3.48|P-value:5.36E-4 ID:SGTC_1123|Compound:mangostin|FD-Score:9.25|P-value:1.55E-18 ID:SGTC_1174|Compound:0739-0097|FD-Score:3.64|P-value:3.09E-4 ID:SGTC_1189|Compound:1431-2119|FD-Score:3.85|P-value:1.51E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:-3.75|P-value:1.95E-4 ID:SGTC_1277|Compound:0873-0036|FD-Score:4.38|P-value:1.92E-5 ID:SGTC_1326|Compound:1431-2094|FD-Score:3.41|P-value:6.89E-4 ID:SGTC_1356|Compound:1502-0781|FD-Score:3.84|P-value:1.56E-4 ID:SGTC_1396|Compound:3511-0007|FD-Score:5.30|P-value:3.06E-7 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:3.43|P-value:6.39E-4 ID:SGTC_1600|Compound:coumarin 106|FD-Score:4.55|P-value:9.32E-6 ID:SGTC_1679|Compound:4130-1276|FD-Score:5.37|P-value:2.21E-7 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.40|P-value:6.30E-4 ID:SGTC_1845|Compound:st056753|FD-Score:3.53|P-value:4.50E-4 ID:SGTC_1855|Compound:st056195|FD-Score:3.66|P-value:2.97E-4 ID:SGTC_1892|Compound:st058411|FD-Score:3.80|P-value:1.76E-4 ID:SGTC_1922|Compound:5578187|FD-Score:4.78|P-value:3.54E-6 ID:SGTC_1930|Compound:st074634|FD-Score:3.90|P-value:1.23E-4 ID:SGTC_1941|Compound:st076221|FD-Score:6.99|P-value:2.37E-11 ID:SGTC_2020|Compound:4017018|FD-Score:3.58|P-value:3.88E-4 ID:SGTC_2043|Compound:5101342|FD-Score:3.68|P-value:2.69E-4 ID:SGTC_2068|Compound:5226020|FD-Score:4.21|P-value:3.87E-5 ID:SGTC_2069|Compound:5228469|FD-Score:3.40|P-value:6.95E-4 ID:SGTC_2077|Compound:5212015|FD-Score:-4.07|P-value:5.86E-5 ID:SGTC_2207|Compound:7258803|FD-Score:3.42|P-value:6.61E-4 ID:SGTC_2245|Compound:6637752|FD-Score:5.66|P-value:5.07E-8 ID:SGTC_2259|Compound:7964009|FD-Score:3.83|P-value:1.59E-4 ID:SGTC_2347|Compound:9049783|FD-Score:-3.37|P-value:7.01E-4 ID:SGTC_2351|Compound:9026858|FD-Score:4.60|P-value:7.76E-6 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:-3.47|P-value:5.09E-4 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:3.47|P-value:5.52E-4 ID:SGTC_2556|Compound:citropten|FD-Score:3.54|P-value:4.45E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:12.30|P-value:3.16E-31 ID:SGTC_2584|Compound:androsterone|FD-Score:3.44|P-value:6.26E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:-3.69|P-value:2.41E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:5.03|P-value:1.13E-6 ID:SGTC_2651|Compound:1327-0036|FD-Score:5.18|P-value:5.41E-7 ID:SGTC_2652|Compound:actinonin|FD-Score:4.44|P-value:1.52E-5 ID:SGTC_2797|Compound:7859098|FD-Score:4.74|P-value:4.19E-6 ID:SGTC_2882|Compound:9058044|FD-Score:3.49|P-value:5.22E-4 ID:SGTC_2890|Compound:9046729|FD-Score:-3.34|P-value:7.77E-4 ID:SGTC_2893|Compound:9048488|FD-Score:3.92|P-value:1.13E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.59|P-value:3.43E-4 ID:SGTC_2954|Compound:9074818|FD-Score:10.60|P-value:5.57E-24 ID:SGTC_2955|Compound:9076254|FD-Score:3.85|P-value:1.50E-4 ID:SGTC_2956|Compound:9076196|FD-Score:-4.54|P-value:8.86E-6 ID:SGTC_2959|Compound:9079155|FD-Score:11.40|P-value:4.32E-27 ID:SGTC_2980|Compound:9014342|FD-Score:3.72|P-value:2.37E-4 ID:SGTC_3019|Compound:9081971|FD-Score:-3.27|P-value:9.74E-4 ID:SGTC_3038|Compound:9091290|FD-Score:3.52|P-value:4.80E-4 ID:SGTC_3136|Compound:9095672|FD-Score:-3.84|P-value:1.40E-4 ID:SGTC_3143|Compound:9086658|FD-Score:7.32|P-value:2.69E-12 ID:SGTC_3209|Compound:9113616|FD-Score:4.47|P-value:1.35E-5 ID:SGTC_3306|Compound:9127676|FD-Score:4.32|P-value:2.43E-5

Top fitness defect scores for YHR155W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_70 0141-0289 17.90 43.3 µM 2.64E-64 mitochondrial stress 6 3.95E-72
2 SGTC_435 c-PAF 16.00 6.7 µM 2.03E-51 1 1.22E-57
3 SGTC_455 paf C-16 15.60 10.0 µM 5.16E-49 1 6.19E-55
4 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 15.30 8.0 µM 2.78E-47 1 5.47E-53
5 SGTC_2582 agaric acid 12.30 100.0 µM 3.16E-31 redox potentiating 37 6.23E-35
6 SGTC_2959 9079155 11.40 11.0 µM 4.32E-27 1 2.78E-30
7 SGTC_2954 9074818 10.60 52.7 µM 5.57E-24 1 8.74E-27
8 SGTC_1123 mangostin 9.25 811.3 nM 1.55E-18 mitochondrial response to ROS 3 1.16E-20
9 SGTC_149 3970-0822 8.09 46.1 µM 1.33E-14 tubulin folding & SWR complex 16 3.06E-16
10 SGTC_453 enantio-paf c16 7.40 10.0 µM 1.59E-12 19 6.62E-14
11 SGTC_1041 0206-0046 7.39 107.0 µM 1.76E-12 9 7.41E-14
12 SGTC_3143 9086658 7.32 49.5 µM 2.69E-12 2 1.20E-13
13 SGTC_439 amiodarone 7.03 34.4 µM 1.89E-11 NEO1-PIK1 29 1.07E-12
14 SGTC_163 1327-0036 6.99 7.5 µM 2.33E-11 27 1.35E-12
15 SGTC_1941 st076221 6.99 61.8 µM 2.37E-11 sphingolipid biosynthesis & PDR1 27 1.38E-12
16 SGTC_67 0335-0847 6.38 266.0 µM 9.69E-10 ubiquinone biosynthesis & proteasome 60 8.91E-11
17 SGTC_184 1494-0393 6.06 24.7 µM 5.85E-9 17 6.72E-10
18 SGTC_266 formosanin C 5.79 406.0 nM 2.50E-8 sphingolipid biosynthesis & PDR1 31 3.44E-9
19 SGTC_168 3970-0862 5.74 530.5 µM 3.36E-8 49 4.78E-9
20 SGTC_513 4245-1575 5.68 41.7 µM 4.64E-8 unfolded protein response 57 6.87E-9

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.385 6.65E-119 YNL257C SIP3 hom Transcription cofactor; acts through interaction with DNA-bound Snf1p; C-terminal region has a putative leucine zipper motif; potential Cdc28p substrate; SIP3 has a paralog, YSP1, that arose from the whole genome duplication
0.346 3.63E-95 YJL005W CYR1 het Adenylate cyclase, required for cAMP production and cAMP-dependent protein kinase signaling; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation
0.270 4.95E-57 YIR012W SQT1 het Protein involved in 60S ribosomal subunit assembly or modification; contains multiple WD repeats; interacts with Qsr1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress
0.236 1.12E-43 YIL046W MET30 het F-box protein containing five copies of the WD40 motif, controls cell cycle function, sulfur metabolism, and methionine biosynthesis as part of the ubiquitin ligase complex; interacts with and regulates Met4p, localizes within the nucleus
0.233 1.63E-42 YIL129C TAO3 het Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with protein kinase Cbk1p and also with Kic1p
0.231 4.78E-42 YDR414C ERD1 hom Predicted membrane protein required for the retention of lumenal endoplasmic reticulum proteins; mutants secrete the endogenous ER protein, BiP (Kar2p)
0.231 6.98E-42 YDL002C NHP10 hom Protein related to mammalian high mobility group proteins; preferentially binds DNA ends, protecting them from exonucleatic cleavage; likely component of the chromatin-remodeling complex INO80 complex; proposed to be involved in DNA repair
0.217 3.49E-37 YIR008C PRI1 het Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
0.213 1.31E-35 YEL042W GDA1 hom Guanosine diphosphatase located in the Golgi, involved in the transport of GDP-mannose into the Golgi lumen by converting GDP to GMP after mannose is transferred its substrate
0.203 1.23E-32 YMR102C_p YMR102C_p hom Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene
0.200 1.02E-31 YDR326C YSP2 hom Protein involved in programmed cell death; mutant shows resistance to cell death induced by amiodarone or intracellular acidification; YSP2 has a paralog, YHR080C, that arose from the whole genome duplication
0.196 1.56E-30 YJR013W GPI14 het Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M
0.193 2.11E-29 YDR435C PPM1 hom Carboxyl methyltransferase, methylates the C terminus of the protein phosphatase 2A catalytic subunit (Pph21p or Pph22p), which is important for complex formation with regulatory subunits
0.192 3.77E-29 YNL027W CRZ1 hom Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress
0.190 1.07E-28 YDL210W UGA4 hom Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane