HIPHOP chemogenomics database

YHR155W / YSP1

Mitochondrial protein; potential role in promoting mitochondrial fragmentation during programmed cell death in response to high levels of alpha-factor mating pheromone or the drug amiodarone; YSP1 has a paralog, SIP3, that arose from the whole genome duplication

Zygosity: Homozygous strain

fixedexpanded
Profile for YHR155W / YSP1

Click on Significant Values for Screen Details

Top fitness defect scores for YHR155W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_70	0141-0289	17.90	43.3 µM	2.64E-64	mitochondrial stress	6	3.95E-72
2	SGTC_435	c-PAF	16.00	6.7 µM	2.03E-51		1	1.22E-57
3	SGTC_455	paf C-16	15.60	10.0 µM	5.16E-49		1	6.19E-55
4	SGTC_434	1-hexadecyl-2-methylglycero-3 PC	15.30	8.0 µM	2.78E-47		1	5.47E-53
5	SGTC_2582	agaric acid	12.30	100.0 µM	3.16E-31	redox potentiating	37	6.23E-35
6	SGTC_2959	9079155	11.40	11.0 µM	4.32E-27		1	2.78E-30
7	SGTC_2954	9074818	10.60	52.7 µM	5.57E-24		1	8.74E-27
8	SGTC_1123	mangostin	9.25	811.3 nM	1.55E-18	mitochondrial response to ROS	3	1.16E-20
9	SGTC_149	3970-0822	8.09	46.1 µM	1.33E-14	tubulin folding & SWR complex	16	3.06E-16
10	SGTC_453	enantio-paf c16	7.40	10.0 µM	1.59E-12		19	6.62E-14
11	SGTC_1041	0206-0046	7.39	107.0 µM	1.76E-12		9	7.41E-14
12	SGTC_3143	9086658	7.32	49.5 µM	2.69E-12		2	1.20E-13
13	SGTC_439	amiodarone	7.03	34.4 µM	1.89E-11	NEO1-PIK1	29	1.07E-12
14	SGTC_163	1327-0036	6.99	7.5 µM	2.33E-11		27	1.35E-12
15	SGTC_1941	st076221	6.99	61.8 µM	2.37E-11	sphingolipid biosynthesis & PDR1	27	1.38E-12
16	SGTC_67	0335-0847	6.38	266.0 µM	9.69E-10	ubiquinone biosynthesis & proteasome	60	8.91E-11
17	SGTC_184	1494-0393	6.06	24.7 µM	5.85E-9		17	6.72E-10
18	SGTC_266	formosanin C	5.79	406.0 nM	2.50E-8	sphingolipid biosynthesis & PDR1	31	3.44E-9
19	SGTC_168	3970-0862	5.74	530.5 µM	3.36E-8		49	4.78E-9
20	SGTC_513	4245-1575	5.68	41.7 µM	4.64E-8	unfolded protein response	57	6.87E-9

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.385	6.65E-119	YNL257C	SIP3	hom	Transcription cofactor; acts through interaction with DNA-bound Snf1p; C-terminal region has a putative leucine zipper motif; potential Cdc28p substrate; SIP3 has a paralog, YSP1, that arose from the whole genome duplication
0.346	3.63E-95	YJL005W	CYR1	het	Adenylate cyclase, required for cAMP production and cAMP-dependent protein kinase signaling; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation
0.270	4.95E-57	YIR012W	SQT1	het	Protein involved in 60S ribosomal subunit assembly or modification; contains multiple WD repeats; interacts with Qsr1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress
0.236	1.12E-43	YIL046W	MET30	het	F-box protein containing five copies of the WD40 motif, controls cell cycle function, sulfur metabolism, and methionine biosynthesis as part of the ubiquitin ligase complex; interacts with and regulates Met4p, localizes within the nucleus
0.233	1.63E-42	YIL129C	TAO3	het	Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with protein kinase Cbk1p and also with Kic1p
0.231	4.78E-42	YDR414C	ERD1	hom	Predicted membrane protein required for the retention of lumenal endoplasmic reticulum proteins; mutants secrete the endogenous ER protein, BiP (Kar2p)
0.231	6.98E-42	YDL002C	NHP10	hom	Protein related to mammalian high mobility group proteins; preferentially binds DNA ends, protecting them from exonucleatic cleavage; likely component of the chromatin-remodeling complex INO80 complex; proposed to be involved in DNA repair
0.217	3.49E-37	YIR008C	PRI1	het	Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
0.213	1.31E-35	YEL042W	GDA1	hom	Guanosine diphosphatase located in the Golgi, involved in the transport of GDP-mannose into the Golgi lumen by converting GDP to GMP after mannose is transferred its substrate
0.203	1.23E-32	YMR102C_p	YMR102C_p	hom	Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene
0.200	1.02E-31	YDR326C	YSP2	hom	Protein involved in programmed cell death; mutant shows resistance to cell death induced by amiodarone or intracellular acidification; YSP2 has a paralog, YHR080C, that arose from the whole genome duplication
0.196	1.56E-30	YJR013W	GPI14	het	Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M
0.193	2.11E-29	YDR435C	PPM1	hom	Carboxyl methyltransferase, methylates the C terminus of the protein phosphatase 2A catalytic subunit (Pph21p or Pph22p), which is important for complex formation with regulatory subunits
0.192	3.77E-29	YNL027W	CRZ1	hom	Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress
0.190	1.07E-28	YDL210W	UGA4	hom	Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane