HIPHOP chemogenomics database

YHR156C / LIN1

Non-essential component of U5 snRNP; nuclear protein; physically interacts with Irr1p of cohesin complex; may link together proteins involved in chromosome segregation, mRNA splicing and DNA replication

Zygosity: Homozygous strain

fixedexpanded
Profile for YHR156C / LIN1

Click on Significant Values for Screen Details

Top fitness defect scores for YHR156C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2795	7780010	7.82	54.5 µM	2.81E-15		1	2.67E-15
2	SGTC_911	3456-4043	5.56	236.0 µM	1.41E-8	mitochondrial processes	6	1.35E-8
3	SGTC_2920	7982904	5.34	15.8 µM	4.82E-8		2	4.62E-8
4	SGTC_2083	5306046	5.18	65.9 µM	1.14E-7		5	1.09E-7
5	SGTC_1744	st037937	5.10	38.9 µM	1.80E-7		4	1.73E-7
6	SGTC_1723	st034307	4.99	2.5 µM	3.20E-7	mitochondrial processes	12	3.08E-7
7	SGTC_942	3253-1115	4.71	227.0 µM	1.28E-6		11	1.23E-6
8	SGTC_313	3474-0040	4.65	5.0 µM	1.69E-6	NEO1-PIK1	47	1.63E-6
9	SGTC_2699	st077704	4.57	54.6 µM	2.50E-6	endomembrane recycling	37	2.41E-6
10	SGTC_2908	7930301	4.34	100.0 µM	7.34E-6		16	7.09E-6
11	SGTC_3177	9107506	4.33	49.5 µM	7.66E-6	ERG2	6	7.39E-6
12	SGTC_3187	9109394	4.24	49.5 µM	1.18E-5	Golgi	15	1.14E-5
13	SGTC_1746	st038117	4.20	42.0 µM	1.36E-5		25	1.32E-5
14	SGTC_940	3232-1287	4.04	54.8 µM	2.80E-5	NEO1	37	2.71E-5
15	SGTC_2243	6634756	3.97	200.0 µM	3.78E-5		19	3.66E-5
16	SGTC_2800	7887935	3.92	81.8 µM	4.55E-5	RPP1 & pyrimidine depletion	35	4.40E-5
17	SGTC_702	1488-0190	3.76	94.0 µM	8.80E-5	amide catabolism	20	8.52E-5
18	SGTC_2467	5474540	3.72	200.0 µM	1.01E-4		22	9.81E-5
19	SGTC_2255	7941087	3.61	197.4 µM	1.55E-4		40	1.51E-4
20	SGTC_1340	1486-1359	3.60	257.0 µM	1.64E-4		33	1.59E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.152	1.05E-18	YBR032W_d	YBR032W_d	hom	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
0.111	1.16E-10	YPL123C	RNY1	hom	Vacuolar RNase of the T(2) family, relocalizes to the cytosol where it cleaves tRNAs upon oxidative or stationary phase stress; promotes apoptosis under stress conditions and this function is independent of its catalytic activity
0.108	3.10E-10	YHR152W	SPO12	hom	Nucleolar protein of unknown function, positive regulator of mitotic exit; involved in regulating release of Cdc14p from the nucleolus in early anaphase, may play similar role in meiosis
0.090	2.02E-7	YGL226C-A	OST5	hom	Zeta subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins
0.087	5.03E-7	YCR005C	CIT2	hom	Citrate synthase; catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors; CIT2 has a paralog, CIT1, that arose from the whole genome duplication
0.083	1.38E-6	YGR239C	PEX21	hom	Peroxin required for peroxisomal matrix protein targeting; acts on proteins containing the PTS2 targeting sequence; interacts with Pex7p; partially redundant with Pex18p; relative distribution to cytoplasmic foci increases upon DNA replication stress
0.083	1.41E-6	YOL104C	NDJ1	hom	Meiosis-specific telomere protein, required for bouquet formation, effective homolog pairing, ordered cross-over distribution, sister chromatid cohesion at meiotic telomeres, chromosomal segregation and telomere-led rapid prophase movement
0.082	1.82E-6	YER023W	PRO3	het	Delta 1-pyrroline-5-carboxylate reductase, catalyzes the last step in proline biosynthesis
0.075	1.25E-5	YNL326C	PFA3	hom	Palmitoyltransferase for Vac8p, required for vacuolar membrane fusion; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; autoacylates; required for vacuolar integrity under stress conditions
0.074	1.65E-5	YPR005C	HAL1	hom	Cytoplasmic protein involved in halotolerance; decreases intracellular Na+ (via Ena1p) and increases intracellular K+ by decreasing efflux; expression repressed by Ssn6p-Tup1p and Sko1p and induced by NaCl, KCl, and sorbitol through Gcn4p
0.074	1.93E-5	YBR220C_p	YBR220C_p	hom	Putative protein of unknown function; YBR220C is not an essential gene
0.073	2.06E-5	YMR215W	GAS3	hom	Low abundance, possibly inactive member of the GAS family of GPI-containing proteins; putative 1,3-beta-glucanosyltransferase with similarity to other GAS family members; localizes to the cell wall; mRNA induced during sporulation
0.073	2.08E-5	YKL053C-A	MDM35	hom	Mitochondrial intermembrane space protein; mutation affects mitochondrial distribution and morphology; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress
0.071	4.32E-5	YDL115C	IWR1	hom	RNA polymerase II transport factor, conserved from yeast to humans; also has a role in transporting RNA polymerase III into the nucleus; interacts with most of the RNAP II subunits; nucleo-cytoplasmic shuttling protein; deletion causes hypersensitivity to K1 killer toxin; protein increases in abundance and relocalizes from nucleus to cytoplasm upon DNA replication stress
0.070	4.87E-5	YBR229C	ROT2	hom	Glucosidase II catalytic subunit required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations