YHR158C / KEL1

Protein required for proper cell fusion and cell morphology; functions in a complex with Kel2p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR158C / KEL1

Click on Significant Values for Screen Details ID:SGTC_150|Compound:3970-0969|FD-Score:5.53|P-value:4.07E-8 ID:SGTC_396|Compound:dithiazanine|FD-Score:3.32|P-value:5.83E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:3.55|P-value:2.63E-4 ID:SGTC_533|Compound:1222-0222|FD-Score:4.67|P-value:2.84E-6 ID:SGTC_576|Compound:1073-0113|FD-Score:3.80|P-value:1.05E-4 ID:SGTC_593|Compound:1203-0218|FD-Score:-4.25|P-value:2.99E-5 ID:SGTC_596|Compound:1155-0152|FD-Score:4.06|P-value:3.86E-5 ID:SGTC_692|Compound:k241-0027|FD-Score:3.87|P-value:8.20E-5 ID:SGTC_849|Compound:0386-0493|FD-Score:3.99|P-value:5.11E-5 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:3.75|P-value:1.28E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:3.72|P-value:1.43E-4 ID:SGTC_1022|Compound:4477-0945|FD-Score:3.63|P-value:1.97E-4 ID:SGTC_1109|Compound:tnp00067|FD-Score:5.67|P-value:1.95E-8 ID:SGTC_1326|Compound:1431-2094|FD-Score:3.88|P-value:7.84E-5 ID:SGTC_1453|Compound:4237-0541|FD-Score:3.32|P-value:5.90E-4 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:3.61|P-value:2.12E-4 ID:SGTC_1574|Compound:spiramycin|FD-Score:-3.32|P-value:8.88E-4 ID:SGTC_1660|Compound:st012960|FD-Score:3.88|P-value:7.85E-5 ID:SGTC_1665|Compound:st014639|FD-Score:3.47|P-value:3.52E-4 ID:SGTC_1773|Compound:st048542|FD-Score:3.48|P-value:3.35E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:-5.35|P-value:1.99E-7 ID:SGTC_1908|Compound:st060353|FD-Score:3.89|P-value:7.43E-5 ID:SGTC_1932|Compound:st074806|FD-Score:3.53|P-value:2.82E-4 ID:SGTC_1937|Compound:st074714|FD-Score:-4.39|P-value:1.63E-5 ID:SGTC_2050|Compound:5263056|FD-Score:4.71|P-value:2.34E-6 ID:SGTC_2186|Compound:6124449|FD-Score:3.46|P-value:3.69E-4 ID:SGTC_2207|Compound:7258803|FD-Score:3.64|P-value:1.88E-4 ID:SGTC_2348|Compound:9022543|FD-Score:3.46|P-value:3.57E-4 ID:SGTC_2441|Compound:5730946|FD-Score:3.29|P-value:6.47E-4 ID:SGTC_2464|Compound:5717415|FD-Score:3.44|P-value:3.90E-4 ID:SGTC_2477|Compound:5967686|FD-Score:-4.25|P-value:2.98E-5 ID:SGTC_2487|Compound:5918373|FD-Score:3.32|P-value:5.95E-4 ID:SGTC_2488|Compound:5268135|FD-Score:8.11|P-value:2.20E-15 ID:SGTC_2605|Compound:digitonin|FD-Score:3.97|P-value:5.38E-5 ID:SGTC_2638|Compound:epoxomicin|FD-Score:4.10|P-value:3.22E-5 ID:SGTC_2678|Compound:equilin|FD-Score:3.55|P-value:2.64E-4 ID:SGTC_2941|Compound:9056145|FD-Score:4.62|P-value:3.52E-6 ID:SGTC_2944|Compound:9067346|FD-Score:5.34|P-value:1.10E-7 ID:SGTC_2982|Compound:9019404|FD-Score:3.97|P-value:5.52E-5 ID:SGTC_3074|Compound:9116018|FD-Score:-4.19|P-value:3.82E-5 ID:SGTC_3127|Compound:9126946|FD-Score:3.94|P-value:6.08E-5 ID:SGTC_3131|Compound:9127911|FD-Score:4.16|P-value:2.58E-5 ID:SGTC_3149|Compound:9097855|FD-Score:3.33|P-value:5.62E-4 ID:SGTC_3153|Compound:9100258|FD-Score:4.45|P-value:7.40E-6 ID:SGTC_3166|Compound:9102297|FD-Score:3.53|P-value:2.86E-4 ID:SGTC_3217|Compound:9129673|FD-Score:3.68|P-value:1.64E-4 ID:SGTC_3306|Compound:9127676|FD-Score:5.18|P-value:2.52E-7 ID:SGTC_3307|Compound:9126885|FD-Score:3.79|P-value:1.10E-4 ID:SGTC_3338|Compound:9144300|FD-Score:3.66|P-value:1.78E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:5.53|P-value:4.07E-8 ID:SGTC_396|Compound:dithiazanine|FD-Score:3.32|P-value:5.83E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:3.55|P-value:2.63E-4 ID:SGTC_533|Compound:1222-0222|FD-Score:4.67|P-value:2.84E-6 ID:SGTC_576|Compound:1073-0113|FD-Score:3.80|P-value:1.05E-4 ID:SGTC_593|Compound:1203-0218|FD-Score:-4.25|P-value:2.99E-5 ID:SGTC_596|Compound:1155-0152|FD-Score:4.06|P-value:3.86E-5 ID:SGTC_692|Compound:k241-0027|FD-Score:3.87|P-value:8.20E-5 ID:SGTC_849|Compound:0386-0493|FD-Score:3.99|P-value:5.11E-5 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:3.75|P-value:1.28E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:3.72|P-value:1.43E-4 ID:SGTC_1022|Compound:4477-0945|FD-Score:3.63|P-value:1.97E-4 ID:SGTC_1109|Compound:tnp00067|FD-Score:5.67|P-value:1.95E-8 ID:SGTC_1326|Compound:1431-2094|FD-Score:3.88|P-value:7.84E-5 ID:SGTC_1453|Compound:4237-0541|FD-Score:3.32|P-value:5.90E-4 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:3.61|P-value:2.12E-4 ID:SGTC_1574|Compound:spiramycin|FD-Score:-3.32|P-value:8.88E-4 ID:SGTC_1660|Compound:st012960|FD-Score:3.88|P-value:7.85E-5 ID:SGTC_1665|Compound:st014639|FD-Score:3.47|P-value:3.52E-4 ID:SGTC_1773|Compound:st048542|FD-Score:3.48|P-value:3.35E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:-5.35|P-value:1.99E-7 ID:SGTC_1908|Compound:st060353|FD-Score:3.89|P-value:7.43E-5 ID:SGTC_1932|Compound:st074806|FD-Score:3.53|P-value:2.82E-4 ID:SGTC_1937|Compound:st074714|FD-Score:-4.39|P-value:1.63E-5 ID:SGTC_2050|Compound:5263056|FD-Score:4.71|P-value:2.34E-6 ID:SGTC_2186|Compound:6124449|FD-Score:3.46|P-value:3.69E-4 ID:SGTC_2207|Compound:7258803|FD-Score:3.64|P-value:1.88E-4 ID:SGTC_2348|Compound:9022543|FD-Score:3.46|P-value:3.57E-4 ID:SGTC_2441|Compound:5730946|FD-Score:3.29|P-value:6.47E-4 ID:SGTC_2464|Compound:5717415|FD-Score:3.44|P-value:3.90E-4 ID:SGTC_2477|Compound:5967686|FD-Score:-4.25|P-value:2.98E-5 ID:SGTC_2487|Compound:5918373|FD-Score:3.32|P-value:5.95E-4 ID:SGTC_2488|Compound:5268135|FD-Score:8.11|P-value:2.20E-15 ID:SGTC_2605|Compound:digitonin|FD-Score:3.97|P-value:5.38E-5 ID:SGTC_2638|Compound:epoxomicin|FD-Score:4.10|P-value:3.22E-5 ID:SGTC_2678|Compound:equilin|FD-Score:3.55|P-value:2.64E-4 ID:SGTC_2941|Compound:9056145|FD-Score:4.62|P-value:3.52E-6 ID:SGTC_2944|Compound:9067346|FD-Score:5.34|P-value:1.10E-7 ID:SGTC_2982|Compound:9019404|FD-Score:3.97|P-value:5.52E-5 ID:SGTC_3074|Compound:9116018|FD-Score:-4.19|P-value:3.82E-5 ID:SGTC_3127|Compound:9126946|FD-Score:3.94|P-value:6.08E-5 ID:SGTC_3131|Compound:9127911|FD-Score:4.16|P-value:2.58E-5 ID:SGTC_3149|Compound:9097855|FD-Score:3.33|P-value:5.62E-4 ID:SGTC_3153|Compound:9100258|FD-Score:4.45|P-value:7.40E-6 ID:SGTC_3166|Compound:9102297|FD-Score:3.53|P-value:2.86E-4 ID:SGTC_3217|Compound:9129673|FD-Score:3.68|P-value:1.64E-4 ID:SGTC_3306|Compound:9127676|FD-Score:5.18|P-value:2.52E-7 ID:SGTC_3307|Compound:9126885|FD-Score:3.79|P-value:1.10E-4 ID:SGTC_3338|Compound:9144300|FD-Score:3.66|P-value:1.78E-4

Top fitness defect scores for YHR158C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2488 5268135 8.11 45.7 µM 2.20E-15 11 2.47E-16
2 SGTC_1109 tnp00067 5.67 928.3 nM 1.95E-8 2 7.33E-9
3 SGTC_150 3970-0969 5.53 77.2 µM 4.07E-8 27 1.61E-8
4 SGTC_2944 9067346 5.34 25.6 µM 1.10E-7 7 4.69E-8
5 SGTC_3306 9127676 5.18 59.8 µM 2.52E-7 8 1.14E-7
6 SGTC_2050 5263056 4.71 171.0 µM 2.34E-6 fatty acid desaturase (OLE1) 30 1.24E-6
7 SGTC_533 1222-0222 4.67 6.7 µM 2.84E-6 PDR1 17 1.53E-6
8 SGTC_2941 9056145 4.62 11.2 µM 3.52E-6 11 1.92E-6
9 SGTC_3153 9100258 4.45 49.5 µM 7.40E-6 11 4.25E-6
10 SGTC_3131 9127911 4.16 49.5 µM 2.58E-5 24 1.62E-5
11 SGTC_2638 epoxomicin 4.10 18.0 µM 3.22E-5 31 2.04E-5
12 SGTC_596 1155-0152 4.06 116.0 µM 3.86E-5 TRP & mitochondrial translation 34 2.48E-5
13 SGTC_849 0386-0493 3.99 241.0 µM 5.11E-5 18 3.35E-5
14 SGTC_2605 digitonin 3.97 300.0 nM 5.38E-5 28 3.53E-5
15 SGTC_2982 9019404 3.97 26.0 µM 5.52E-5 20 3.63E-5
16 SGTC_3127 9126946 3.94 49.5 µM 6.08E-5 ERG2 17 4.03E-5
17 SGTC_1908 st060353 3.89 56.5 µM 7.43E-5 RPP1 & pyrimidine depletion 38 4.99E-5
18 SGTC_1326 1431-2094 3.88 10.8 µM 7.84E-5 tubulin folding & SWR complex 38 5.28E-5
19 SGTC_1660 st012960 3.88 28.1 µM 7.85E-5 iron homeostasis 40 5.29E-5
20 SGTC_692 k241-0027 3.87 77.8 µM 8.20E-5 9 5.54E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.105 1.23E-9 YLR262C-A TMA7 hom Protein of unknown that associates with ribosomes; null mutant exhibits translation defects, altered polyribosome profiles, and resistance to the translation inhibitor anisomcyin; protein abundance increases in response to DNA replication stress
0.103 1.93E-9 YDL140C RPO21 het RNA polymerase II largest subunit B220, part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime
0.093 7.37E-8 YOR287C RRP36 het Component of 90S preribosomes; involved in early cleavages of the 35S pre-rRNA and in production of the 40S ribosomal subunit
0.090 1.99E-7 YPL159C PET20 hom Mitochondrial protein, required for respiratory growth under some conditions and for stability of the mitochondrial genome
0.085 9.30E-7 YMR213W CEF1 het Essential splicing factor; associated with Prp19p and the spliceosome, contains an N-terminal c-Myb DNA binding motif necessary for cell viability but not for Prp19p association, evolutionarily conserved and homologous to S. pombe Cdc5p
0.079 4.92E-6 YHR179W OYE2 hom Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN); responsible for geraniol reduction into citronellol during fermentation; homologous to Oye3p with different ligand binding and catalytic properties; may be involved in sterol metabolism, oxidative stress response, and programmed cell death; protein abundance increases in response to DNA replication stress
0.077 9.20E-6 YGR259C_d YGR259C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF TNA1/YGR260W
0.075 1.45E-5 YOR056C NOB1 het Protein involved in proteasomal and 40S ribosomal subunit biogenesis; required for cleavage of the 20S pre-rRNA to generate the mature 18S rRNA; cleavage is activated by Fun12p, a GTPase and translation initiation factor; relocalizes from nucleus to nucleolus upon DNA replication stress
0.073 2.07E-5 YPL027W SMA1 hom Protein of unknown function involved in the assembly of the prospore membrane during sporulation; interacts with Spo14p
0.072 2.89E-5 YKL193C SDS22 het Regulatory subunit of the type 1 protein phosphatase (PP1) Glc7p; whether it functions as a positive or negative regulator of Glc7p is controversial; involved in the regulation of Glc7p nuclear localization and function
0.070 5.07E-5 YNL204C SPS18 hom Protein of unknown function, contains a putative zinc-binding domain; expressed during sporulation
0.067 1.16E-4 YOL041C NOP12 hom Nucleolar protein involved in pre-25S rRNA processing and biogenesis of large 60S ribosomal subunit; contains an RNA recognition motif (RRM); binds to Ebp2; similar to Nop13p and Nsr1p
0.066 1.20E-4 YER093C TSC11 het Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p), a membrane-associated complex that regulates actin cytoskeletal dynamics during polarized growth and cell wall integrity; involved in sphingolipid metabolism; contains a RasGEFN domain
0.066 1.23E-4 YOL029C_p YOL029C_p hom Putative protein of unknown function; identified as interacting with Hsc82p and Hsp82p in high-throughput two-hybrid screens
0.066 1.24E-4 YNL058C_p YNL058C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YNL058C is not an essential gene