YHR166C / CDC23

Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition

Zygosity: Heterozygous strain
fixedexpanded
Profile for YHR166C / CDC23

Click on Significant Values for Screen Details ID:SGTC_70|Compound:0141-0289|FD-Score:5.55|P-value:1.45E-9 ID:SGTC_73|Compound:0327-0325|FD-Score:-5.20|P-value:1.32E-8 ID:SGTC_78|Compound:0336-0123|FD-Score:3.56|P-value:6.89E-5 ID:SGTC_116|Compound:0155-0182|FD-Score:-5.06|P-value:2.99E-8 ID:SGTC_141|Compound:0443-0274|FD-Score:-8.87|P-value:1.13E-21 ID:SGTC_150|Compound:3970-0969|FD-Score:3.35|P-value:1.71E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:2.99|P-value:7.04E-4 ID:SGTC_189|Compound:3970-0742|FD-Score:8.37|P-value:1.67E-19 ID:SGTC_190|Compound:3970-0790|FD-Score:4.93|P-value:6.75E-8 ID:SGTC_197|Compound:4544-0043|FD-Score:-3.51|P-value:8.46E-5 ID:SGTC_205|Compound:1486-1330|FD-Score:-3.03|P-value:5.88E-4 ID:SGTC_214|Compound:4373-3496|FD-Score:7.82|P-value:3.03E-17 ID:SGTC_305|Compound:1682-2595|FD-Score:3.69|P-value:3.98E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.36|P-value:1.62E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:-3.56|P-value:6.97E-5 ID:SGTC_405|Compound:ebelactone b|FD-Score:-3.20|P-value:3.04E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:5.21|P-value:1.21E-8 ID:SGTC_440|Compound:fluspirilene|FD-Score:3.04|P-value:5.71E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.26|P-value:2.65E-6 ID:SGTC_639|Compound:0833-0042|FD-Score:3.31|P-value:1.98E-4 ID:SGTC_650|Compound:1328-0195|FD-Score:3.51|P-value:8.80E-5 ID:SGTC_682|Compound:0kpi-0099|FD-Score:5.69|P-value:5.76E-10 ID:SGTC_733|Compound:4069-0007|FD-Score:-4.29|P-value:2.18E-6 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.51|P-value:8.58E-5 ID:SGTC_762|Compound:1165-0429|FD-Score:5.00|P-value:4.33E-8 ID:SGTC_778|Compound:3456-2434|FD-Score:-4.15|P-value:4.48E-6 ID:SGTC_847|Compound:0342-0274|FD-Score:2.97|P-value:7.42E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:-3.10|P-value:4.42E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:3.51|P-value:8.82E-5 ID:SGTC_987|Compound:1497-1013|FD-Score:3.47|P-value:1.04E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:-7.56|P-value:2.97E-16 ID:SGTC_1039|Compound:k821-0043|FD-Score:3.16|P-value:3.66E-4 ID:SGTC_1041|Compound:0206-0046|FD-Score:4.23|P-value:3.05E-6 ID:SGTC_1043|Compound:0916-0009|FD-Score:3.34|P-value:1.77E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.54|P-value:7.43E-5 ID:SGTC_1123|Compound:mangostin|FD-Score:-3.67|P-value:4.27E-5 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.71|P-value:3.59E-5 ID:SGTC_1191|Compound:1487-1166|FD-Score:3.28|P-value:2.25E-4 ID:SGTC_1330|Compound:1469-0054|FD-Score:4.67|P-value:2.86E-7 ID:SGTC_1333|Compound:1482-0047|FD-Score:4.77|P-value:1.66E-7 ID:SGTC_1350|Compound:1495-0454|FD-Score:3.24|P-value:2.60E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:-5.89|P-value:1.42E-10 ID:SGTC_1365|Compound:1672-3266|FD-Score:3.93|P-value:1.30E-5 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.00|P-value:6.63E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:-3.44|P-value:1.14E-4 ID:SGTC_1571|Compound:st070080|FD-Score:-2.89|P-value:9.99E-4 ID:SGTC_1573|Compound:oleylamine|FD-Score:-2.89|P-value:9.92E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:2.89|P-value:9.98E-4 ID:SGTC_1712|Compound:st032288|FD-Score:-3.09|P-value:4.62E-4 ID:SGTC_1740|Compound:st038286|FD-Score:-2.91|P-value:9.29E-4 ID:SGTC_1745|Compound:st081495|FD-Score:4.33|P-value:1.85E-6 ID:SGTC_1755|Compound:st041960|FD-Score:2.91|P-value:9.43E-4 ID:SGTC_1983|Compound:st071813|FD-Score:3.17|P-value:3.55E-4 ID:SGTC_1996|Compound:st072960|FD-Score:3.63|P-value:5.06E-5 ID:SGTC_1998|Compound:st075797|FD-Score:-3.18|P-value:3.27E-4 ID:SGTC_2076|Compound:5212012|FD-Score:3.53|P-value:8.01E-5 ID:SGTC_2124|Compound:5246320|FD-Score:3.51|P-value:8.51E-5 ID:SGTC_2130|Compound:NSC 7|FD-Score:2.92|P-value:9.09E-4 ID:SGTC_2199|Compound:6590217|FD-Score:-2.98|P-value:7.17E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:-3.77|P-value:2.64E-5 ID:SGTC_2257|Compound:7960413|FD-Score:-3.24|P-value:2.58E-4 ID:SGTC_2282|Compound:7944268|FD-Score:-2.99|P-value:6.79E-4 ID:SGTC_2283|Compound:7944793|FD-Score:-3.70|P-value:3.77E-5 ID:SGTC_2284|Compound:7945075|FD-Score:4.04|P-value:7.78E-6 ID:SGTC_2307|Compound:7538926|FD-Score:-3.45|P-value:1.08E-4 ID:SGTC_2367|Compound:9070478|FD-Score:3.86|P-value:1.85E-5 ID:SGTC_2411|Compound:st077133|FD-Score:3.20|P-value:3.08E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:3.74|P-value:3.19E-5 ID:SGTC_2687|Compound:chenodiol|FD-Score:-4.01|P-value:8.62E-6 ID:SGTC_2851|Compound:9015922|FD-Score:2.97|P-value:7.55E-4 ID:SGTC_2934|Compound:9036370|FD-Score:3.23|P-value:2.71E-4 ID:SGTC_2937|Compound:9044753|FD-Score:-3.48|P-value:9.78E-5 ID:SGTC_2965|Compound:9082772|FD-Score:-4.63|P-value:3.63E-7 ID:SGTC_3062|Compound:9077494|FD-Score:-3.67|P-value:4.23E-5 ID:SGTC_70|Compound:0141-0289|FD-Score:5.55|P-value:1.45E-9 ID:SGTC_73|Compound:0327-0325|FD-Score:-5.20|P-value:1.32E-8 ID:SGTC_78|Compound:0336-0123|FD-Score:3.56|P-value:6.89E-5 ID:SGTC_116|Compound:0155-0182|FD-Score:-5.06|P-value:2.99E-8 ID:SGTC_141|Compound:0443-0274|FD-Score:-8.87|P-value:1.13E-21 ID:SGTC_150|Compound:3970-0969|FD-Score:3.35|P-value:1.71E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:2.99|P-value:7.04E-4 ID:SGTC_189|Compound:3970-0742|FD-Score:8.37|P-value:1.67E-19 ID:SGTC_190|Compound:3970-0790|FD-Score:4.93|P-value:6.75E-8 ID:SGTC_197|Compound:4544-0043|FD-Score:-3.51|P-value:8.46E-5 ID:SGTC_205|Compound:1486-1330|FD-Score:-3.03|P-value:5.88E-4 ID:SGTC_214|Compound:4373-3496|FD-Score:7.82|P-value:3.03E-17 ID:SGTC_305|Compound:1682-2595|FD-Score:3.69|P-value:3.98E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.36|P-value:1.62E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:-3.56|P-value:6.97E-5 ID:SGTC_405|Compound:ebelactone b|FD-Score:-3.20|P-value:3.04E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:5.21|P-value:1.21E-8 ID:SGTC_440|Compound:fluspirilene|FD-Score:3.04|P-value:5.71E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.26|P-value:2.65E-6 ID:SGTC_639|Compound:0833-0042|FD-Score:3.31|P-value:1.98E-4 ID:SGTC_650|Compound:1328-0195|FD-Score:3.51|P-value:8.80E-5 ID:SGTC_682|Compound:0kpi-0099|FD-Score:5.69|P-value:5.76E-10 ID:SGTC_733|Compound:4069-0007|FD-Score:-4.29|P-value:2.18E-6 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.51|P-value:8.58E-5 ID:SGTC_762|Compound:1165-0429|FD-Score:5.00|P-value:4.33E-8 ID:SGTC_778|Compound:3456-2434|FD-Score:-4.15|P-value:4.48E-6 ID:SGTC_847|Compound:0342-0274|FD-Score:2.97|P-value:7.42E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:-3.10|P-value:4.42E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:3.51|P-value:8.82E-5 ID:SGTC_987|Compound:1497-1013|FD-Score:3.47|P-value:1.04E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:-7.56|P-value:2.97E-16 ID:SGTC_1039|Compound:k821-0043|FD-Score:3.16|P-value:3.66E-4 ID:SGTC_1041|Compound:0206-0046|FD-Score:4.23|P-value:3.05E-6 ID:SGTC_1043|Compound:0916-0009|FD-Score:3.34|P-value:1.77E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.54|P-value:7.43E-5 ID:SGTC_1123|Compound:mangostin|FD-Score:-3.67|P-value:4.27E-5 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.71|P-value:3.59E-5 ID:SGTC_1191|Compound:1487-1166|FD-Score:3.28|P-value:2.25E-4 ID:SGTC_1330|Compound:1469-0054|FD-Score:4.67|P-value:2.86E-7 ID:SGTC_1333|Compound:1482-0047|FD-Score:4.77|P-value:1.66E-7 ID:SGTC_1350|Compound:1495-0454|FD-Score:3.24|P-value:2.60E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:-5.89|P-value:1.42E-10 ID:SGTC_1365|Compound:1672-3266|FD-Score:3.93|P-value:1.30E-5 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.00|P-value:6.63E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:-3.44|P-value:1.14E-4 ID:SGTC_1571|Compound:st070080|FD-Score:-2.89|P-value:9.99E-4 ID:SGTC_1573|Compound:oleylamine|FD-Score:-2.89|P-value:9.92E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:2.89|P-value:9.98E-4 ID:SGTC_1712|Compound:st032288|FD-Score:-3.09|P-value:4.62E-4 ID:SGTC_1740|Compound:st038286|FD-Score:-2.91|P-value:9.29E-4 ID:SGTC_1745|Compound:st081495|FD-Score:4.33|P-value:1.85E-6 ID:SGTC_1755|Compound:st041960|FD-Score:2.91|P-value:9.43E-4 ID:SGTC_1983|Compound:st071813|FD-Score:3.17|P-value:3.55E-4 ID:SGTC_1996|Compound:st072960|FD-Score:3.63|P-value:5.06E-5 ID:SGTC_1998|Compound:st075797|FD-Score:-3.18|P-value:3.27E-4 ID:SGTC_2076|Compound:5212012|FD-Score:3.53|P-value:8.01E-5 ID:SGTC_2124|Compound:5246320|FD-Score:3.51|P-value:8.51E-5 ID:SGTC_2130|Compound:NSC 7|FD-Score:2.92|P-value:9.09E-4 ID:SGTC_2199|Compound:6590217|FD-Score:-2.98|P-value:7.17E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:-3.77|P-value:2.64E-5 ID:SGTC_2257|Compound:7960413|FD-Score:-3.24|P-value:2.58E-4 ID:SGTC_2282|Compound:7944268|FD-Score:-2.99|P-value:6.79E-4 ID:SGTC_2283|Compound:7944793|FD-Score:-3.70|P-value:3.77E-5 ID:SGTC_2284|Compound:7945075|FD-Score:4.04|P-value:7.78E-6 ID:SGTC_2307|Compound:7538926|FD-Score:-3.45|P-value:1.08E-4 ID:SGTC_2367|Compound:9070478|FD-Score:3.86|P-value:1.85E-5 ID:SGTC_2411|Compound:st077133|FD-Score:3.20|P-value:3.08E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:3.74|P-value:3.19E-5 ID:SGTC_2687|Compound:chenodiol|FD-Score:-4.01|P-value:8.62E-6 ID:SGTC_2851|Compound:9015922|FD-Score:2.97|P-value:7.55E-4 ID:SGTC_2934|Compound:9036370|FD-Score:3.23|P-value:2.71E-4 ID:SGTC_2937|Compound:9044753|FD-Score:-3.48|P-value:9.78E-5 ID:SGTC_2965|Compound:9082772|FD-Score:-4.63|P-value:3.63E-7 ID:SGTC_3062|Compound:9077494|FD-Score:-3.67|P-value:4.23E-5

Top fitness defect scores for YHR166C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_189 3970-0742 8.37 2.1 µM 1.67E-19 1 2.87E-17 4.50
2 SGTC_214 4373-3496 7.82 70.0 µM 3.03E-17 3 2.71E-15 0.62
3 SGTC_682 0kpi-0099 5.69 17.0 µM 5.76E-10 16 6.38E-9 0.27
4 SGTC_70 0141-0289 5.55 43.3 µM 1.45E-9 mitochondrial stress 11 1.43E-8 0.58
5 SGTC_435 c-PAF 5.21 6.7 µM 1.21E-8 10 9.22E-8 0.30
6 SGTC_762 1165-0429 5.00 115.0 µM 4.33E-8 TSC3-RPN4 2 2.82E-7 0.90
7 SGTC_190 3970-0790 4.93 3.7 µM 6.75E-8 1 4.16E-7 1.44
8 SGTC_1333 1482-0047 4.77 286.0 µM 1.66E-7 3 9.17E-7 0.35
9 SGTC_1330 1469-0054 4.67 61.8 µM 2.86E-7 iron homeostasis 4 1.48E-6 0.50
10 SGTC_1745 st081495 4.33 74.0 µM 1.85E-6 RNA processing & uracil transport 27 7.60E-6 0.02
11 SGTC_453 enantio-paf c16 4.26 10.0 µM 2.65E-6 20 1.04E-5 0.26
12 SGTC_1041 0206-0046 4.23 107.0 µM 3.05E-6 5 1.18E-5 0.19
13 SGTC_2284 7945075 4.04 39.2 µM 7.78E-6 mitochondrial processes 1 2.69E-5 0.54
14 SGTC_1365 1672-3266 3.93 55.4 µM 1.30E-5 5 4.22E-5 0.06
15 SGTC_2367 9070478 3.86 135.4 µM 1.85E-5 cell wall 11 5.74E-5 0.24
16 SGTC_2567 aureobasidin a 3.74 60.0 nM 3.19E-5 48 9.29E-5 0.01
17 SGTC_1125 tnp00248 3.71 1.3 µM 3.59E-5 13 1.03E-4 0.19
18 SGTC_305 1682-2595 3.69 20.8 µM 3.98E-5 RNA processing & uracil transport 11 1.13E-4 0.11
19 SGTC_1996 st072960 3.63 66.8 µM 5.06E-5 5 1.39E-4 0.29
20 SGTC_78 0336-0123 3.56 156.8 µM 6.89E-5 9 1.83E-4 0.07

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.270 4.14E-57 YDR478W SNM1 het Subunit of RNase MRP, which cleaves pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; binds to the NME1 RNA subunit of RNase MRP
0.247 8.83E-48 YDL060W TSR1 het Protein required for processing of 20S pre-rRNA in the cytoplasm; associates with pre-40S ribosomal particles; inhibits the premature association of 60S subunits with assembling 40S subunits in the cytoplasm; similar to Bms1p; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.237 3.69E-44 YOR159C SME1 het Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm E
0.233 1.18E-42 YDL007W RPT2 het One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for normal peptide hydrolysis by the core 20S particle
0.201 5.31E-32 YNL161W CBK1 het Serine/threonine protein kinase of the the RAM signaling network; Ndr/LATS family member; binds regulatory subunit Mob2p; involved in regulation of cellular morphogenesis, polarized growth, and septum destruction; phosphorylation by Cbk1p regulates localization and activity of Ace2p transcription factor and Ssd1p translational repressor; Cbk1p activity is regulated by both phosphorylation and specific localization; relocalizes to cytoplasm upon DNA replication stress
0.199 2.60E-31 YER171W RAD3 het 5' to 3' DNA helicase; involved in nucleotide excision repair and transcription; subunit of RNA polII initiation factor TFIIH and of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPD protein; mutant has aneuploidy tolerance; protein abundance increases in response to DNA replication stress
0.193 2.24E-29 YIL083C CAB2 het Probable phosphopantothenoylcysteine synthetase (PPCS), which catalyzes the second step of coenzyme A biosynthesis from pantothenate; null mutant lethality is complemented by E. coli coaBC (encoding a bifunctional enzyme with PPCS activity)
0.179 1.34E-25 YBL004W UTP20 het Component of the small-subunit (SSU) processome, which is involved in the biogenesis of the 18S rRNA
0.178 2.78E-25 YIL022W TIM44 het Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); tethers the import motor and regulatory factors (PAM complex) to the translocation channel (Tim23p-Tim17p core complex)
0.177 4.99E-25 YLR117C CLF1 het Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; homolog of Drosophila crooked neck protein; interacts with U1 snRNP proteins
0.175 1.35E-24 YDR088C SLU7 het RNA splicing factor, required for ATP-independent portion of 2nd catalytic step of spliceosomal RNA splicing; interacts with Prp18p; contains zinc knuckle domain
0.173 6.27E-24 YDR499W LCD1 het Essential protein required for the DNA integrity checkpoint pathways; interacts physically with Mec1p; putative homolog of S. pombe Rad26 and human ATRIP; forms nuclear foci upon DNA replication stress
0.172 1.27E-23 YJL143W TIM17 het Essential subunit of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); with Tim23p, contributes to the architecture and function of the import channel; may link the import motor to the core TIM23 complex
0.160 8.96E-21 YIL147C SLN1 het Histidine kinase osmosensor that regulates a MAP kinase cascade; transmembrane protein with an intracellular kinase domain that signals to Ypd1p and Ssk1p, thereby forming a phosphorelay system similar to bacterial two-component regulators
0.148 6.68E-18 YER013W PRP22 het DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase, associates with lariat intermediates before the second catalytic step of splicing; mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes