YHR181W / SVP26

Integral membrane protein of the early Golgi apparatus and endoplasmic reticulum, involved in COP II vesicle transport; may also function to promote retention of proteins in the early Golgi compartment

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR181W / SVP26

Click on Significant Values for Screen Details ID:SGTC_26|Compound:0302-0163|FD-Score:3.26|P-value:9.32E-4 ID:SGTC_41|Compound:0478-0632|FD-Score:3.77|P-value:1.61E-4 ID:SGTC_117|Compound:lucigenin|FD-Score:7.99|P-value:2.28E-14 ID:SGTC_122|Compound:0236-0016|FD-Score:3.95|P-value:8.49E-5 ID:SGTC_343|Compound:4130-2827|FD-Score:-3.57|P-value:5.19E-4 ID:SGTC_459|Compound:nigericin|FD-Score:3.73|P-value:1.87E-4 ID:SGTC_646|Compound:4092-0839|FD-Score:-4.00|P-value:1.12E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:3.54|P-value:3.67E-4 ID:SGTC_692|Compound:k241-0027|FD-Score:5.37|P-value:1.74E-7 ID:SGTC_747|Compound:3448-8087|FD-Score:3.43|P-value:5.24E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:-3.58|P-value:4.89E-4 ID:SGTC_810|Compound:3825-7150|FD-Score:3.32|P-value:7.66E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:-3.53|P-value:5.92E-4 ID:SGTC_1112|Compound:tnp00069|FD-Score:-4.30|P-value:3.58E-5 ID:SGTC_1265|Compound:0819-1001|FD-Score:4.41|P-value:1.35E-5 ID:SGTC_1295|Compound:1013-0063|FD-Score:4.24|P-value:2.70E-5 ID:SGTC_1473|Compound:k844-0725|FD-Score:4.47|P-value:1.07E-5 ID:SGTC_1483|Compound:3453-0561|FD-Score:4.11|P-value:4.54E-5 ID:SGTC_1514|Compound:1189-1591|FD-Score:3.61|P-value:2.84E-4 ID:SGTC_1746|Compound:st038117|FD-Score:4.21|P-value:3.08E-5 ID:SGTC_1916|Compound:st067606|FD-Score:4.38|P-value:1.58E-5 ID:SGTC_1939|Compound:st074455|FD-Score:3.39|P-value:5.97E-4 ID:SGTC_2246|Compound:7293507|FD-Score:5.39|P-value:1.60E-7 ID:SGTC_2348|Compound:9022543|FD-Score:3.49|P-value:4.25E-4 ID:SGTC_2389|Compound:9091542|FD-Score:3.26|P-value:9.29E-4 ID:SGTC_2450|Compound:5739737|FD-Score:4.13|P-value:4.29E-5 ID:SGTC_2474|Compound:5321570|FD-Score:3.43|P-value:5.31E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:-3.89|P-value:1.67E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.65|P-value:2.47E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:-3.67|P-value:3.69E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:3.69|P-value:2.18E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:3.74|P-value:1.79E-4 ID:SGTC_2773|Compound:thioridazine|FD-Score:5.77|P-value:2.32E-8 ID:SGTC_2902|Compound:5787006|FD-Score:5.13|P-value:5.72E-7 ID:SGTC_2906|Compound:7926292|FD-Score:4.25|P-value:2.61E-5 ID:SGTC_2916|Compound:7875993|FD-Score:5.04|P-value:8.56E-7 ID:SGTC_3010|Compound:9080089|FD-Score:3.47|P-value:4.64E-4 ID:SGTC_3040|Compound:9091894|FD-Score:4.85|P-value:2.10E-6 ID:SGTC_3188|Compound:9110789|FD-Score:3.25|P-value:9.59E-4 ID:SGTC_3296|Compound:9122258|FD-Score:-3.48|P-value:6.97E-4 ID:SGTC_3302|Compound:9125395|FD-Score:3.44|P-value:5.07E-4 ID:SGTC_3307|Compound:9126885|FD-Score:6.81|P-value:5.82E-11 ID:SGTC_3308|Compound:9128332|FD-Score:3.43|P-value:5.37E-4 ID:SGTC_3326|Compound:9140064|FD-Score:5.13|P-value:5.72E-7 ID:SGTC_26|Compound:0302-0163|FD-Score:3.26|P-value:9.32E-4 ID:SGTC_41|Compound:0478-0632|FD-Score:3.77|P-value:1.61E-4 ID:SGTC_117|Compound:lucigenin|FD-Score:7.99|P-value:2.28E-14 ID:SGTC_122|Compound:0236-0016|FD-Score:3.95|P-value:8.49E-5 ID:SGTC_343|Compound:4130-2827|FD-Score:-3.57|P-value:5.19E-4 ID:SGTC_459|Compound:nigericin|FD-Score:3.73|P-value:1.87E-4 ID:SGTC_646|Compound:4092-0839|FD-Score:-4.00|P-value:1.12E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:3.54|P-value:3.67E-4 ID:SGTC_692|Compound:k241-0027|FD-Score:5.37|P-value:1.74E-7 ID:SGTC_747|Compound:3448-8087|FD-Score:3.43|P-value:5.24E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:-3.58|P-value:4.89E-4 ID:SGTC_810|Compound:3825-7150|FD-Score:3.32|P-value:7.66E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:-3.53|P-value:5.92E-4 ID:SGTC_1112|Compound:tnp00069|FD-Score:-4.30|P-value:3.58E-5 ID:SGTC_1265|Compound:0819-1001|FD-Score:4.41|P-value:1.35E-5 ID:SGTC_1295|Compound:1013-0063|FD-Score:4.24|P-value:2.70E-5 ID:SGTC_1473|Compound:k844-0725|FD-Score:4.47|P-value:1.07E-5 ID:SGTC_1483|Compound:3453-0561|FD-Score:4.11|P-value:4.54E-5 ID:SGTC_1514|Compound:1189-1591|FD-Score:3.61|P-value:2.84E-4 ID:SGTC_1746|Compound:st038117|FD-Score:4.21|P-value:3.08E-5 ID:SGTC_1916|Compound:st067606|FD-Score:4.38|P-value:1.58E-5 ID:SGTC_1939|Compound:st074455|FD-Score:3.39|P-value:5.97E-4 ID:SGTC_2246|Compound:7293507|FD-Score:5.39|P-value:1.60E-7 ID:SGTC_2348|Compound:9022543|FD-Score:3.49|P-value:4.25E-4 ID:SGTC_2389|Compound:9091542|FD-Score:3.26|P-value:9.29E-4 ID:SGTC_2450|Compound:5739737|FD-Score:4.13|P-value:4.29E-5 ID:SGTC_2474|Compound:5321570|FD-Score:3.43|P-value:5.31E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:-3.89|P-value:1.67E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.65|P-value:2.47E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:-3.67|P-value:3.69E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:3.69|P-value:2.18E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:3.74|P-value:1.79E-4 ID:SGTC_2773|Compound:thioridazine|FD-Score:5.77|P-value:2.32E-8 ID:SGTC_2902|Compound:5787006|FD-Score:5.13|P-value:5.72E-7 ID:SGTC_2906|Compound:7926292|FD-Score:4.25|P-value:2.61E-5 ID:SGTC_2916|Compound:7875993|FD-Score:5.04|P-value:8.56E-7 ID:SGTC_3010|Compound:9080089|FD-Score:3.47|P-value:4.64E-4 ID:SGTC_3040|Compound:9091894|FD-Score:4.85|P-value:2.10E-6 ID:SGTC_3188|Compound:9110789|FD-Score:3.25|P-value:9.59E-4 ID:SGTC_3296|Compound:9122258|FD-Score:-3.48|P-value:6.97E-4 ID:SGTC_3302|Compound:9125395|FD-Score:3.44|P-value:5.07E-4 ID:SGTC_3307|Compound:9126885|FD-Score:6.81|P-value:5.82E-11 ID:SGTC_3308|Compound:9128332|FD-Score:3.43|P-value:5.37E-4 ID:SGTC_3326|Compound:9140064|FD-Score:5.13|P-value:5.72E-7

Top fitness defect scores for YHR181W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_117 lucigenin 7.99 22.1 µM 2.28E-14 redox potentiating 16 6.95E-16
2 SGTC_3307 9126885 6.81 69.3 µM 5.82E-11 3 4.80E-12
3 SGTC_2773 thioridazine 5.77 9.1 µM 2.32E-8 2 4.04E-9
4 SGTC_2246 7293507 5.39 91.6 µM 1.60E-7 15 3.52E-8
5 SGTC_692 k241-0027 5.37 77.8 µM 1.74E-7 3 3.87E-8
6 SGTC_2902 5787006 5.13 60.5 µM 5.72E-7 Golgi 9 1.47E-7
7 SGTC_3326 9140064 5.13 16.4 µM 5.72E-7 10 1.47E-7
8 SGTC_2916 7875993 5.04 68.8 µM 8.56E-7 8 2.31E-7
9 SGTC_3040 9091894 4.85 49.5 µM 2.10E-6 DNA intercalators 11 6.31E-7
10 SGTC_1473 k844-0725 4.47 134.0 µM 1.07E-5 5 3.90E-6
11 SGTC_1265 0819-1001 4.41 68.8 µM 1.35E-5 15 5.07E-6
12 SGTC_1916 st067606 4.38 49.2 µM 1.58E-5 23 6.04E-6
13 SGTC_2906 7926292 4.25 26.4 µM 2.61E-5 18 1.06E-5
14 SGTC_1295 1013-0063 4.24 9.8 µM 2.70E-5 4 1.10E-5
15 SGTC_1746 st038117 4.21 42.0 µM 3.08E-5 24 1.27E-5
16 SGTC_2450 5739737 4.13 12.9 µM 4.29E-5 22 1.84E-5
17 SGTC_1483 3453-0561 4.11 55.9 µM 4.54E-5 19 1.96E-5
18 SGTC_122 0236-0016 3.95 402.4 µM 8.49E-5 RNA processing & uracil transport 32 3.94E-5
19 SGTC_41 0478-0632 3.77 82.6 µM 1.61E-4 36 8.05E-5
20 SGTC_2766 oltipraz 3.74 83.9 µM 1.79E-4 heme requiring 30 9.03E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.125 3.59E-13 YEL003W GIM4 hom Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it
0.114 3.45E-11 YDR360W_d OPI7_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene VID21/YDR359C.
0.112 6.77E-11 YDL140C RPO21 het RNA polymerase II largest subunit B220, part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime
0.108 3.73E-10 YLL013C PUF3 hom Protein of the mitochondrial outer surface, links the Arp2/3 complex with the mitochore during anterograde mitochondrial movement; also binds to and promotes degradation of mRNAs for select nuclear-encoded mitochondrial proteins
0.102 2.68E-9 YFR035C_p YFR035C_p hom Putative protein of unknown function, deletion mutant exhibits synthetic phenotype with alpha-synuclein
0.097 1.76E-8 YPL111W CAR1 hom Arginase, responsible for arginine degradation, expression responds to both induction by arginine and nitrogen catabolite repression; disruption enhances freeze tolerance
0.095 3.05E-8 YML021C UNG1 hom Uracil-DNA glycosylase, required for repair of uracil in DNA formed by spontaneous cytosine deamination, not required for strand-specific mismatch repair, cell-cycle regulated, expressed in late G1, localizes to mitochondria and nucleus
0.092 1.08E-7 YHR137W ARO9 hom Aromatic aminotransferase II, catalyzes the first step of tryptophan, phenylalanine, and tyrosine catabolism
0.088 3.40E-7 YPL194W DDC1 hom DNA damage checkpoint protein; part of a PCNA-like complex required for DNA damage response, required for pachytene checkpoint to inhibit cell cycle in response to unrepaired recombination intermediates; potential Cdc28p substrate; forms nuclear foci upon DNA replication stress
0.086 5.89E-7 YMR299C DYN3 hom Dynein light intermediate chain (LIC); localizes with dynein, null mutant is defective in nuclear migration
0.086 5.98E-7 YOR316C COT1 hom Vacuolar transporter that mediates zinc transport into the vacuole; overexpression confers resistance to cobalt and rhodium; protein abundance increases in response to DNA replication stress; COT1 has a paralog, ZRC1, that arose from the whole genome duplication
0.084 1.09E-6 YHL037C_d YHL037C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.083 1.39E-6 YDR483W KRE2 hom Alpha1,2-mannosyltransferase of the Golgi; involved in protein mannosylation; KRE2 has a paralog, KTR6, that arose from the whole genome duplication
0.081 2.41E-6 YFL012W_p YFL012W_p hom Putative protein of unknown function; transcribed during sporulation; null mutant exhibits increased resistance to rapamycin
0.077 7.81E-6 YGL140C_p YGL140C_p hom Putative protein of unknown function; non-essential gene; contains multiple predicted transmembrane domains