HIPHOP chemogenomics database
YHR181W / SVP26 
Integral membrane protein of the early Golgi apparatus and endoplasmic reticulum, involved in COP II vesicle transport; may also function to promote retention of proteins in the early Golgi compartment
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YHR181W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.125 | 3.59E-13 | YEL003W | GIM4 | hom | Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it |
| 0.114 | 3.45E-11 | YDR360W_d | OPI7_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene VID21/YDR359C. |
| 0.112 | 6.77E-11 | YDL140C | RPO21 | het | RNA polymerase II largest subunit B220, part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime |
| 0.108 | 3.73E-10 | YLL013C | PUF3 | hom | Protein of the mitochondrial outer surface, links the Arp2/3 complex with the mitochore during anterograde mitochondrial movement; also binds to and promotes degradation of mRNAs for select nuclear-encoded mitochondrial proteins |
| 0.102 | 2.68E-9 | YFR035C_p | YFR035C_p | hom | Putative protein of unknown function, deletion mutant exhibits synthetic phenotype with alpha-synuclein |
| 0.097 | 1.76E-8 | YPL111W | CAR1 | hom | Arginase, responsible for arginine degradation, expression responds to both induction by arginine and nitrogen catabolite repression; disruption enhances freeze tolerance |
| 0.095 | 3.05E-8 | YML021C | UNG1 | hom | Uracil-DNA glycosylase, required for repair of uracil in DNA formed by spontaneous cytosine deamination, not required for strand-specific mismatch repair, cell-cycle regulated, expressed in late G1, localizes to mitochondria and nucleus |
| 0.092 | 1.08E-7 | YHR137W | ARO9 | hom | Aromatic aminotransferase II, catalyzes the first step of tryptophan, phenylalanine, and tyrosine catabolism |
| 0.088 | 3.40E-7 | YPL194W | DDC1 | hom | DNA damage checkpoint protein; part of a PCNA-like complex required for DNA damage response, required for pachytene checkpoint to inhibit cell cycle in response to unrepaired recombination intermediates; potential Cdc28p substrate; forms nuclear foci upon DNA replication stress |
| 0.086 | 5.89E-7 | YMR299C | DYN3 | hom | Dynein light intermediate chain (LIC); localizes with dynein, null mutant is defective in nuclear migration |
| 0.086 | 5.98E-7 | YOR316C | COT1 | hom | Vacuolar transporter that mediates zinc transport into the vacuole; overexpression confers resistance to cobalt and rhodium; protein abundance increases in response to DNA replication stress; COT1 has a paralog, ZRC1, that arose from the whole genome duplication |
| 0.084 | 1.09E-6 | YHL037C_d | YHL037C_d | hom | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
| 0.083 | 1.39E-6 | YDR483W | KRE2 | hom | Alpha1,2-mannosyltransferase of the Golgi; involved in protein mannosylation; KRE2 has a paralog, KTR6, that arose from the whole genome duplication |
| 0.081 | 2.41E-6 | YFL012W_p | YFL012W_p | hom | Putative protein of unknown function; transcribed during sporulation; null mutant exhibits increased resistance to rapamycin |
| 0.077 | 7.81E-6 | YGL140C_p | YGL140C_p | hom | Putative protein of unknown function; non-essential gene; contains multiple predicted transmembrane domains |