YHR186C / KOG1

Subunit of TORC1, a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors

Zygosity: Heterozygous strain
fixedexpanded
Profile for YHR186C / KOG1

Click on Significant Values for Screen Details ID:SGTC_3|Compound:0833-0587|FD-Score:3.83|P-value:5.07E-5 ID:SGTC_17|Compound:0960-0276|FD-Score:5.55|P-value:8.61E-9 ID:SGTC_36|Compound:0335-0881|FD-Score:9.51|P-value:1.95E-22 ID:SGTC_46|Compound:0329-0187a|FD-Score:3.66|P-value:1.03E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:3.17|P-value:6.50E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:-3.62|P-value:1.05E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:4.17|P-value:1.12E-5 ID:SGTC_165|Compound:k038-0023|FD-Score:3.68|P-value:9.40E-5 ID:SGTC_207|Compound:4185-0010|FD-Score:4.24|P-value:8.14E-6 ID:SGTC_273|Compound:hydroxyurea|FD-Score:5.15|P-value:8.25E-8 ID:SGTC_294|Compound:k038-0071|FD-Score:3.37|P-value:3.10E-4 ID:SGTC_296|Compound:1222-0039|FD-Score:3.07|P-value:9.15E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:-3.43|P-value:2.28E-4 ID:SGTC_425|Compound:3825-7017|FD-Score:3.76|P-value:6.71E-5 ID:SGTC_648|Compound:0375-0473|FD-Score:4.05|P-value:1.93E-5 ID:SGTC_660|Compound:4031-1742|FD-Score:3.10|P-value:8.27E-4 ID:SGTC_703|Compound:3875-0075|FD-Score:3.33|P-value:3.60E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:3.99|P-value:2.55E-5 ID:SGTC_890|Compound:0929-0006|FD-Score:4.11|P-value:1.47E-5 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:3.19|P-value:6.10E-4 ID:SGTC_917|Compound:harmaline|FD-Score:3.26|P-value:4.62E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:5.60|P-value:6.10E-9 ID:SGTC_964|Compound:1287-0107|FD-Score:3.49|P-value:1.98E-4 ID:SGTC_981|Compound:1488-1094|FD-Score:3.37|P-value:3.19E-4 ID:SGTC_985|Compound:1493-0307|FD-Score:3.53|P-value:1.67E-4 ID:SGTC_988|Compound:1497-1057|FD-Score:3.15|P-value:6.92E-4 ID:SGTC_991|Compound:3996-0057|FD-Score:3.12|P-value:7.71E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:6.36|P-value:4.95E-11 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.22|P-value:5.35E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:-4.29|P-value:5.77E-6 ID:SGTC_1179|Compound:1021-1431|FD-Score:4.19|P-value:1.05E-5 ID:SGTC_1202|Compound:1988-0068|FD-Score:3.89|P-value:3.88E-5 ID:SGTC_1214|Compound:0358-0031|FD-Score:3.83|P-value:5.08E-5 ID:SGTC_1240|Compound:0356-0016|FD-Score:-3.80|P-value:5.16E-5 ID:SGTC_1261|Compound:0712-0010|FD-Score:3.10|P-value:8.32E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.08|P-value:8.95E-4 ID:SGTC_1308|Compound:1187-1617|FD-Score:3.16|P-value:6.81E-4 ID:SGTC_1339|Compound:1486-1321|FD-Score:4.05|P-value:1.92E-5 ID:SGTC_1386|Compound:3228-0095|FD-Score:3.44|P-value:2.38E-4 ID:SGTC_1432|Compound:4049-0298|FD-Score:3.11|P-value:8.15E-4 ID:SGTC_1489|Compound:4065-0444|FD-Score:4.85|P-value:4.07E-7 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:3.09|P-value:8.60E-4 ID:SGTC_1608|Compound:st001473|FD-Score:3.25|P-value:4.91E-4 ID:SGTC_1628|Compound:st004252|FD-Score:-3.98|P-value:2.38E-5 ID:SGTC_1647|Compound:st011722|FD-Score:-3.40|P-value:2.53E-4 ID:SGTC_1685|Compound:st024049|FD-Score:3.15|P-value:6.99E-4 ID:SGTC_1692|Compound:fluoroquinolonic acid|FD-Score:-3.09|P-value:7.72E-4 ID:SGTC_1695|Compound:st026914|FD-Score:3.39|P-value:2.92E-4 ID:SGTC_1700|Compound:st030840|FD-Score:3.70|P-value:8.64E-5 ID:SGTC_1722|Compound:st034304|FD-Score:-3.74|P-value:6.47E-5 ID:SGTC_1724|Compound:st037281|FD-Score:3.59|P-value:1.33E-4 ID:SGTC_1752|Compound:st044819|FD-Score:5.30|P-value:3.56E-8 ID:SGTC_1754|Compound:st042065|FD-Score:7.10|P-value:2.66E-13 ID:SGTC_1764|Compound:st044502|FD-Score:3.33|P-value:3.65E-4 ID:SGTC_1767|Compound:st044992|FD-Score:-3.50|P-value:1.74E-4 ID:SGTC_1781|Compound:st038725|FD-Score:4.98|P-value:2.05E-7 ID:SGTC_1789|Compound:tunicamycin|FD-Score:3.22|P-value:5.38E-4 ID:SGTC_1818|Compound:st052136|FD-Score:3.17|P-value:6.52E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:22.70|P-value:7.97E-119 ID:SGTC_1873|Compound:rapamycin|FD-Score:19.00|P-value:1.17E-83 ID:SGTC_1877|Compound:wortmannin|FD-Score:11.90|P-value:5.93E-34 ID:SGTC_1886|Compound:st057356|FD-Score:-3.49|P-value:1.78E-4 ID:SGTC_1896|Compound:st058441|FD-Score:-4.22|P-value:8.07E-6 ID:SGTC_1901|Compound:st060216|FD-Score:-4.41|P-value:3.32E-6 ID:SGTC_1902|Compound:st060212|FD-Score:-6.15|P-value:1.69E-10 ID:SGTC_1919|Compound:st067113|FD-Score:3.14|P-value:7.18E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:3.61|P-value:1.23E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.82|P-value:4.83E-7 ID:SGTC_2283|Compound:7944793|FD-Score:3.17|P-value:6.52E-4 ID:SGTC_2310|Compound:7668677|FD-Score:3.48|P-value:2.06E-4 ID:SGTC_2315|Compound:7733312|FD-Score:5.65|P-value:4.55E-9 ID:SGTC_2333|Compound:9017922|FD-Score:-3.34|P-value:3.14E-4 ID:SGTC_2485|Compound:5633444|FD-Score:3.74|P-value:7.42E-5 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:4.62|P-value:1.36E-6 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:-3.24|P-value:4.59E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:3.22|P-value:5.40E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:16.90|P-value:2.38E-66 ID:SGTC_2786|Compound:7743617|FD-Score:3.41|P-value:2.67E-4 ID:SGTC_2802|Compound:7925815|FD-Score:-5.26|P-value:3.89E-8 ID:SGTC_2957|Compound:9076800|FD-Score:-3.24|P-value:4.59E-4 ID:SGTC_3037|Compound:9091026|FD-Score:3.78|P-value:6.11E-5 ID:SGTC_3062|Compound:9077494|FD-Score:-7.40|P-value:2.07E-14 ID:SGTC_3072|Compound:9116419|FD-Score:3.60|P-value:1.27E-4 ID:SGTC_3078|Compound:9116413|FD-Score:3.17|P-value:6.59E-4 ID:SGTC_3083|Compound:9117465|FD-Score:3.61|P-value:1.26E-4 ID:SGTC_3152|Compound:9099253|FD-Score:6.35|P-value:5.50E-11 ID:SGTC_3295|Compound:9122362|FD-Score:3.09|P-value:8.47E-4 ID:SGTC_3|Compound:0833-0587|FD-Score:3.83|P-value:5.07E-5 ID:SGTC_17|Compound:0960-0276|FD-Score:5.55|P-value:8.61E-9 ID:SGTC_36|Compound:0335-0881|FD-Score:9.51|P-value:1.95E-22 ID:SGTC_46|Compound:0329-0187a|FD-Score:3.66|P-value:1.03E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:3.17|P-value:6.50E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:-3.62|P-value:1.05E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:4.17|P-value:1.12E-5 ID:SGTC_165|Compound:k038-0023|FD-Score:3.68|P-value:9.40E-5 ID:SGTC_207|Compound:4185-0010|FD-Score:4.24|P-value:8.14E-6 ID:SGTC_273|Compound:hydroxyurea|FD-Score:5.15|P-value:8.25E-8 ID:SGTC_294|Compound:k038-0071|FD-Score:3.37|P-value:3.10E-4 ID:SGTC_296|Compound:1222-0039|FD-Score:3.07|P-value:9.15E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:-3.43|P-value:2.28E-4 ID:SGTC_425|Compound:3825-7017|FD-Score:3.76|P-value:6.71E-5 ID:SGTC_648|Compound:0375-0473|FD-Score:4.05|P-value:1.93E-5 ID:SGTC_660|Compound:4031-1742|FD-Score:3.10|P-value:8.27E-4 ID:SGTC_703|Compound:3875-0075|FD-Score:3.33|P-value:3.60E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:3.99|P-value:2.55E-5 ID:SGTC_890|Compound:0929-0006|FD-Score:4.11|P-value:1.47E-5 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:3.19|P-value:6.10E-4 ID:SGTC_917|Compound:harmaline|FD-Score:3.26|P-value:4.62E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:5.60|P-value:6.10E-9 ID:SGTC_964|Compound:1287-0107|FD-Score:3.49|P-value:1.98E-4 ID:SGTC_981|Compound:1488-1094|FD-Score:3.37|P-value:3.19E-4 ID:SGTC_985|Compound:1493-0307|FD-Score:3.53|P-value:1.67E-4 ID:SGTC_988|Compound:1497-1057|FD-Score:3.15|P-value:6.92E-4 ID:SGTC_991|Compound:3996-0057|FD-Score:3.12|P-value:7.71E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:6.36|P-value:4.95E-11 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.22|P-value:5.35E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:-4.29|P-value:5.77E-6 ID:SGTC_1179|Compound:1021-1431|FD-Score:4.19|P-value:1.05E-5 ID:SGTC_1202|Compound:1988-0068|FD-Score:3.89|P-value:3.88E-5 ID:SGTC_1214|Compound:0358-0031|FD-Score:3.83|P-value:5.08E-5 ID:SGTC_1240|Compound:0356-0016|FD-Score:-3.80|P-value:5.16E-5 ID:SGTC_1261|Compound:0712-0010|FD-Score:3.10|P-value:8.32E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.08|P-value:8.95E-4 ID:SGTC_1308|Compound:1187-1617|FD-Score:3.16|P-value:6.81E-4 ID:SGTC_1339|Compound:1486-1321|FD-Score:4.05|P-value:1.92E-5 ID:SGTC_1386|Compound:3228-0095|FD-Score:3.44|P-value:2.38E-4 ID:SGTC_1432|Compound:4049-0298|FD-Score:3.11|P-value:8.15E-4 ID:SGTC_1489|Compound:4065-0444|FD-Score:4.85|P-value:4.07E-7 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:3.09|P-value:8.60E-4 ID:SGTC_1608|Compound:st001473|FD-Score:3.25|P-value:4.91E-4 ID:SGTC_1628|Compound:st004252|FD-Score:-3.98|P-value:2.38E-5 ID:SGTC_1647|Compound:st011722|FD-Score:-3.40|P-value:2.53E-4 ID:SGTC_1685|Compound:st024049|FD-Score:3.15|P-value:6.99E-4 ID:SGTC_1692|Compound:fluoroquinolonic acid|FD-Score:-3.09|P-value:7.72E-4 ID:SGTC_1695|Compound:st026914|FD-Score:3.39|P-value:2.92E-4 ID:SGTC_1700|Compound:st030840|FD-Score:3.70|P-value:8.64E-5 ID:SGTC_1722|Compound:st034304|FD-Score:-3.74|P-value:6.47E-5 ID:SGTC_1724|Compound:st037281|FD-Score:3.59|P-value:1.33E-4 ID:SGTC_1752|Compound:st044819|FD-Score:5.30|P-value:3.56E-8 ID:SGTC_1754|Compound:st042065|FD-Score:7.10|P-value:2.66E-13 ID:SGTC_1764|Compound:st044502|FD-Score:3.33|P-value:3.65E-4 ID:SGTC_1767|Compound:st044992|FD-Score:-3.50|P-value:1.74E-4 ID:SGTC_1781|Compound:st038725|FD-Score:4.98|P-value:2.05E-7 ID:SGTC_1789|Compound:tunicamycin|FD-Score:3.22|P-value:5.38E-4 ID:SGTC_1818|Compound:st052136|FD-Score:3.17|P-value:6.52E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:22.70|P-value:7.97E-119 ID:SGTC_1873|Compound:rapamycin|FD-Score:19.00|P-value:1.17E-83 ID:SGTC_1877|Compound:wortmannin|FD-Score:11.90|P-value:5.93E-34 ID:SGTC_1886|Compound:st057356|FD-Score:-3.49|P-value:1.78E-4 ID:SGTC_1896|Compound:st058441|FD-Score:-4.22|P-value:8.07E-6 ID:SGTC_1901|Compound:st060216|FD-Score:-4.41|P-value:3.32E-6 ID:SGTC_1902|Compound:st060212|FD-Score:-6.15|P-value:1.69E-10 ID:SGTC_1919|Compound:st067113|FD-Score:3.14|P-value:7.18E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:3.61|P-value:1.23E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.82|P-value:4.83E-7 ID:SGTC_2283|Compound:7944793|FD-Score:3.17|P-value:6.52E-4 ID:SGTC_2310|Compound:7668677|FD-Score:3.48|P-value:2.06E-4 ID:SGTC_2315|Compound:7733312|FD-Score:5.65|P-value:4.55E-9 ID:SGTC_2333|Compound:9017922|FD-Score:-3.34|P-value:3.14E-4 ID:SGTC_2485|Compound:5633444|FD-Score:3.74|P-value:7.42E-5 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:4.62|P-value:1.36E-6 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:-3.24|P-value:4.59E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:3.22|P-value:5.40E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:16.90|P-value:2.38E-66 ID:SGTC_2786|Compound:7743617|FD-Score:3.41|P-value:2.67E-4 ID:SGTC_2802|Compound:7925815|FD-Score:-5.26|P-value:3.89E-8 ID:SGTC_2957|Compound:9076800|FD-Score:-3.24|P-value:4.59E-4 ID:SGTC_3037|Compound:9091026|FD-Score:3.78|P-value:6.11E-5 ID:SGTC_3062|Compound:9077494|FD-Score:-7.40|P-value:2.07E-14 ID:SGTC_3072|Compound:9116419|FD-Score:3.60|P-value:1.27E-4 ID:SGTC_3078|Compound:9116413|FD-Score:3.17|P-value:6.59E-4 ID:SGTC_3083|Compound:9117465|FD-Score:3.61|P-value:1.26E-4 ID:SGTC_3152|Compound:9099253|FD-Score:6.35|P-value:5.50E-11 ID:SGTC_3295|Compound:9122362|FD-Score:3.09|P-value:8.47E-4

Top fitness defect scores for YHR186C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1844 rapamycin 22.70 4.0 nM 7.97E-119 1 1.16E-114 5.98
2 SGTC_1873 rapamycin 19.00 2.0 nM 1.17E-83 3 9.10E-81 6.77
3 SGTC_2679 rapamycin 16.90 1.0 nM 2.38E-66 2 4.41E-64 3.45
4 SGTC_1877 wortmannin 11.90 25.0 µM 5.93E-34 1 7.61E-33 4.37
5 SGTC_36 0335-0881 9.51 14.2 µM 1.95E-22 ubiquinone biosynthesis & proteasome 4 9.80E-22 0.60
6 SGTC_1754 st042065 7.10 16.1 µM 2.66E-13 NEO1-PIK1 10 6.42E-13 0.21
7 SGTC_999 4022-0066 6.36 22.7 µM 4.95E-11 Golgi 5 9.98E-11 1.77
8 SGTC_3152 9099253 6.35 49.5 µM 5.50E-11 NEO1-PIK1 11 1.11E-10 0.20
9 SGTC_2315 7733312 5.65 200.0 µM 4.55E-9 3 7.87E-9 0.53
10 SGTC_957 1187-1561 5.60 14.1 µM 6.10E-9 1 1.04E-8 0.55
11 SGTC_17 0960-0276 5.55 49.8 µM 8.61E-9 1 1.46E-8 0.55
12 SGTC_1752 st044819 5.30 83.0 µM 3.56E-8 3 5.75E-8 0.52
13 SGTC_273 hydroxyurea 5.15 18.1 mM 8.25E-8 heme biosynthesis & mitochondrial translocase 11 1.30E-7 0.07
14 SGTC_1781 st038725 4.98 66.3 µM 2.05E-7 NEO1 6 3.12E-7 0.10
15 SGTC_1489 4065-0444 4.85 182.0 µM 4.07E-7 1 6.06E-7 0.74
16 SGTC_2250 alverine citrate 4.82 130.0 µM 4.83E-7 24 7.16E-7 0.04
17 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 4.62 63.6 µM 1.36E-6 4 1.94E-6 0.13
18 SGTC_207 4185-0010 4.24 4.5 µM 8.14E-6 endomembrane recycling 14 1.10E-5 0.35
19 SGTC_1179 1021-1431 4.19 9.3 µM 1.05E-5 6 1.41E-5 0.58
20 SGTC_158 k038-0087 4.17 26.4 µM 1.12E-5 ubiquinone biosynthesis & proteasome 31 1.50E-5 0.16

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.565 2.74E-282 YJR066W TOR1 hom PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication
0.492 2.78E-204 YKL203C TOR2 het PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; TOR2 has a paralog, TOR1, that arose from the whole genome duplication
0.468 1.11E-182 YML121W GTR1 hom Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB
0.371 9.52E-110 YGR163W GTR2 hom Putative GTP binding protein that negatively regulates Ran/Tc4 GTPase cycle; activates transcription; subunit of EGO and GSE complexes; required for sorting of Gap1p; localizes to cytoplasm and to chromatin; homolog of human RagC and RagD
0.356 1.35E-100 YLR114C AVL9 hom Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.338 5.96E-90 YBR077C SLM4 hom Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; gene exhibits synthetic genetic interaction with MSS4
0.318 9.41E-80 YHR187W IKI1 hom Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; iki1 mutations confer resistance to the K. lactis toxin zymocin
0.299 2.73E-70 YKL110C KTI12 hom Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p
0.296 1.89E-68 YNL119W NCS2 hom Protein required for thiolation of the uridine at the wobble position of Lys(UUU) and Glu(UUC) tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae
0.292 5.06E-67 YKR007W MEH1 hom Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; loss results in a defect in vacuolar acidification
0.272 5.65E-58 YLR384C IKI3 hom Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD)
0.271 1.63E-57 YDR023W SES1 het Cytosolic seryl-tRNA synthetase, class II aminoacyl-tRNA synthetase that aminoacylates tRNA(Ser), displays tRNA-dependent amino acid recognition which enhances discrimination of the serine substrate, interacts with peroxin Pex21p
0.261 2.96E-53 YOR184W SER1 hom 3-phosphoserine aminotransferase; catalyzes the formation of phosphoserine from 3-phosphohydroxypyruvate, required for serine and glycine biosynthesis; regulated by the general control of amino acid biosynthesis mediated by Gcn4p; protein abundance increases in response to DNA replication stress
0.257 2.30E-51 YFL024C EPL1 het Subunit of NuA4, an essential histone H4/H2A acetyltransferase complex; conserved region at N-terminus is essential for interaction with the NPC (nucleosome core particle); required for autophagy; homologous to Drosophila Enhancer of Polycomb
0.254 1.98E-50 YNL147W LSM7 hom Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress