YHR191C / CTF8

Subunit of a complex with Ctf18p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR191C / CTF8

Click on Significant Values for Screen Details ID:SGTC_21|Compound:0849-0113|FD-Score:3.37|P-value:9.33E-4 ID:SGTC_174|Compound:3553-0389|FD-Score:3.47|P-value:6.65E-4 ID:SGTC_182|Compound:3448-4371|FD-Score:3.59|P-value:4.41E-4 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:3.53|P-value:5.56E-4 ID:SGTC_685|Compound:1278-0033|FD-Score:3.49|P-value:6.18E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:-3.92|P-value:4.98E-5 ID:SGTC_934|Compound:2950-0684|FD-Score:-3.32|P-value:4.47E-4 ID:SGTC_2258|Compound:7960471|FD-Score:3.52|P-value:5.62E-4 ID:SGTC_2337|Compound:9009472|FD-Score:3.52|P-value:5.71E-4 ID:SGTC_2393|Compound:9031399|FD-Score:-4.28|P-value:1.10E-5 ID:SGTC_2409|Compound:alverine citrate|FD-Score:-6.07|P-value:1.26E-9 ID:SGTC_2767|Compound:sibutramine|FD-Score:3.57|P-value:4.71E-4 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:-3.33|P-value:4.34E-4 ID:SGTC_2854|Compound:9024559|FD-Score:-4.14|P-value:2.01E-5 ID:SGTC_2885|Compound:9057732|FD-Score:-3.75|P-value:9.53E-5 ID:SGTC_2895|Compound:9054447|FD-Score:-3.60|P-value:1.66E-4 ID:SGTC_2927|Compound:9011802|FD-Score:3.55|P-value:5.14E-4 ID:SGTC_3026|Compound:9090633|FD-Score:3.68|P-value:3.28E-4 ID:SGTC_3100|Compound:9120536|FD-Score:-4.43|P-value:5.78E-6 ID:SGTC_3104|Compound:9120930|FD-Score:-3.26|P-value:5.66E-4 ID:SGTC_21|Compound:0849-0113|FD-Score:3.37|P-value:9.33E-4 ID:SGTC_174|Compound:3553-0389|FD-Score:3.47|P-value:6.65E-4 ID:SGTC_182|Compound:3448-4371|FD-Score:3.59|P-value:4.41E-4 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:3.53|P-value:5.56E-4 ID:SGTC_685|Compound:1278-0033|FD-Score:3.49|P-value:6.18E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:-3.92|P-value:4.98E-5 ID:SGTC_934|Compound:2950-0684|FD-Score:-3.32|P-value:4.47E-4 ID:SGTC_2258|Compound:7960471|FD-Score:3.52|P-value:5.62E-4 ID:SGTC_2337|Compound:9009472|FD-Score:3.52|P-value:5.71E-4 ID:SGTC_2393|Compound:9031399|FD-Score:-4.28|P-value:1.10E-5 ID:SGTC_2409|Compound:alverine citrate|FD-Score:-6.07|P-value:1.26E-9 ID:SGTC_2767|Compound:sibutramine|FD-Score:3.57|P-value:4.71E-4 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:-3.33|P-value:4.34E-4 ID:SGTC_2854|Compound:9024559|FD-Score:-4.14|P-value:2.01E-5 ID:SGTC_2885|Compound:9057732|FD-Score:-3.75|P-value:9.53E-5 ID:SGTC_2895|Compound:9054447|FD-Score:-3.60|P-value:1.66E-4 ID:SGTC_2927|Compound:9011802|FD-Score:3.55|P-value:5.14E-4 ID:SGTC_3026|Compound:9090633|FD-Score:3.68|P-value:3.28E-4 ID:SGTC_3100|Compound:9120536|FD-Score:-4.43|P-value:5.78E-6 ID:SGTC_3104|Compound:9120930|FD-Score:-3.26|P-value:5.66E-4

Top fitness defect scores for YHR191C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_3026 9090633 3.68 49.5 µM 3.28E-4 31 1.17E-4
2 SGTC_182 3448-4371 3.59 550.5 µM 4.41E-4 30 1.63E-4
3 SGTC_2767 sibutramine 3.57 71.5 µM 4.71E-4 30 1.75E-4
4 SGTC_2927 9011802 3.55 47.9 µM 5.14E-4 39 1.93E-4
5 SGTC_261 5-fluorouridine 3.53 15.4 µM 5.56E-4 exosome 24 2.11E-4
6 SGTC_2258 7960471 3.52 200.0 µM 5.62E-4 20 2.13E-4
7 SGTC_2337 9009472 3.52 200.0 µM 5.71E-4 49 2.17E-4
8 SGTC_685 1278-0033 3.49 54.9 µM 6.18E-4 60S ribosome export 39 2.37E-4
9 SGTC_174 3553-0389 3.47 74.3 µM 6.65E-4 33 2.57E-4
10 SGTC_21 0849-0113 3.37 23.0 µM 9.33E-4 52 3.76E-4
11 SGTC_1720 st037298 3.34 9.5 µM 0.00103 63 4.21E-4
12 SGTC_13 0199-0087 3.33 65.0 µM 0.00105 ERG2 21 4.29E-4
13 SGTC_2957 9076800 3.32 11.5 µM 0.00110 39 4.49E-4
14 SGTC_3068 9116768 3.32 49.5 µM 0.00110 38 4.51E-4
15 SGTC_1990 st072050 3.32 59.8 µM 0.00111 32 4.54E-4
16 SGTC_278 4092-0821 3.30 23.9 µM 0.00117 plasma membrane duress 72 4.83E-4
17 SGTC_2931 9014674 3.27 55.7 µM 0.00130 51 5.46E-4
18 SGTC_1733 st037357 3.26 54.9 µM 0.00133 60S ribosome export 73 5.56E-4
19 SGTC_2086 5274770 3.24 176.6 µM 0.00140 53 5.90E-4
20 SGTC_129 0088-0017 3.24 176.6 µM 0.00140 98 5.92E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.114 3.90E-11 YJL144W YJL144W hom Cytoplasmic hydrophilin essential in dessication-rehydration process; expression induced by osmotic stress, starvation and during stationary phase; protein abundance increases in response to DNA replication stress
0.110 2.00E-10 YML087C AIM33 hom Putative protein of unknown function, highly conserved across species; homolog of human CYB5R4; null mutant displays reduced frequency of mitochondrial genome loss; AIM33 has a paralog, PGA3, that arose from the whole genome duplication
0.090 2.07E-7 YIL143C SSL2 het Component of RNA polymerase transcription factor TFIIH holoenzyme; has DNA-dependent ATPase/helicase activity and is required, with Rad3p, for unwinding promoter DNA; interacts functionally with TFIIB and has roles in transcription start site selection and in gene looping to juxtapose initiation and termination regions; involved in DNA repair; homolog of human ERCC3
0.085 7.73E-7 YPR185W ATG13 hom Regulatory subunit of the Atg1p signaling complex; stimulates Atg1p kinase activity; required for vesicle formation during autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; involved in Atg9p, Atg23p, and Atg27p cycling
0.082 1.96E-6 YNR068C_p YNR068C_p hom Putative protein of unknown function; exhibits homology to C-terminal end of Bul1p; expressed as a readthrough product of BSC5, the readthrough locus being termed BUL3; the BUL3 readthrough product is involved in ubiquitin-mediated sorting of plasma membrane proteins and interacts with WW domains of Rsp5p in vitro, but in a functionally different way than the non-readthrough form
0.081 3.00E-6 YOR334W MRS2 hom Mitochondrial inner membrane Mg(2+) channel, required for maintenance of intramitochondrial Mg(2+) concentrations at the correct level to support splicing of group II introns
0.080 3.22E-6 YNL272C SEC2 het Guanyl-nucleotide exchange factor for the small G-protein Sec4p; essential for post-Golgi vesicle transport and for autophagy; associates with the exocyst, via exocyst subunit Sec15p, on secretory vesicles
0.079 4.86E-6 YPL272C_p YPL272C_p hom Putative protein of unknown function; gene expression induced in response to ketoconazole; YPL272C is not an essential gene
0.079 4.85E-6 YML038C YMD8 hom Putative nucleotide sugar transporter, has similarity to Vrg4p
0.076 1.09E-5 YJR032W CPR7 hom Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity
0.074 1.96E-5 YPR183W DPM1 het Dolichol phosphate mannose (Dol-P-Man) synthase of the ER membrane, catalyzes the formation of Dol-P-Man from Dol-P and GDP-Man; required for glycosyl phosphatidylinositol membrane anchoring, O mannosylation, and protein glycosylation
0.072 3.02E-5 YPR198W SGE1 hom Plasma membrane multidrug transporter of the major facilitator superfamily, acts as an extrusion permease; partial multicopy suppressor of gal11 mutations
0.071 3.42E-5 YBR149W ARA1 hom NADP+ dependent arabinose dehydrogenase, involved in carbohydrate metabolism; purified as homodimer; naturally occurs with a N-terminus degradation product
0.070 5.42E-5 YJL013C MAD3 hom Subunit of the spindle-assembly checkpoint complex, which delays anaphase onset in cells with defects in mitotic spindle assembly; pseudosubstrate inhibitor of APC(Cdc20), the anaphase promoting complex involved in securin (Pds1p) turnover
0.070 5.46E-5 YLR227C ADY4 hom Structural component of the meiotic outer plaque, which is a membrane-organizing center that assembles on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane