YHR197W / RIX1

Component of the Rix1 complex (Rix1p-Ipi1p-Ipi3p) and possibly pre-replicative complexes (pre-RCs); required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-RC formation and maintenance during DNA replication licensing; RIX1 is an essential gene

Zygosity: Heterozygous strain
fixedexpanded
Profile for YHR197W / RIX1

Click on Significant Values for Screen Details ID:SGTC_42|Compound:0133-0086|FD-Score:3.67|P-value:3.29E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:-5.75|P-value:3.11E-8 ID:SGTC_147|Compound:4466-0538|FD-Score:3.48|P-value:6.19E-4 ID:SGTC_272|Compound:doxorubicin|FD-Score:3.72|P-value:2.70E-4 ID:SGTC_338|Compound:4055-0136|FD-Score:3.45|P-value:6.86E-4 ID:SGTC_438|Compound:sphingosine|FD-Score:3.94|P-value:1.23E-4 ID:SGTC_529|Compound:4076-0302|FD-Score:3.71|P-value:2.79E-4 ID:SGTC_530|Compound:4358-1714|FD-Score:3.84|P-value:1.80E-4 ID:SGTC_585|Compound:0kpi-0023|FD-Score:-3.78|P-value:1.78E-4 ID:SGTC_596|Compound:1155-0152|FD-Score:3.86|P-value:1.66E-4 ID:SGTC_693|Compound:4161-2696|FD-Score:4.57|P-value:1.05E-5 ID:SGTC_696|Compound:1560-0013|FD-Score:7.39|P-value:2.70E-12 ID:SGTC_708|Compound:3448-5400|FD-Score:-3.78|P-value:1.83E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:4.88|P-value:2.72E-6 ID:SGTC_1051|Compound:3253-3903|FD-Score:-3.35|P-value:7.81E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:-4.00|P-value:7.93E-5 ID:SGTC_1232|Compound:0279-0259|FD-Score:-3.30|P-value:9.00E-4 ID:SGTC_1272|Compound:0839-0021|FD-Score:-5.41|P-value:1.72E-7 ID:SGTC_1523|Compound:st012844|FD-Score:3.62|P-value:3.92E-4 ID:SGTC_1723|Compound:st034307|FD-Score:-4.26|P-value:2.94E-5 ID:SGTC_1859|Compound:st055998|FD-Score:-3.67|P-value:2.70E-4 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:3.85|P-value:1.71E-4 ID:SGTC_1952|Compound:st077036|FD-Score:4.00|P-value:9.88E-5 ID:SGTC_2061|Compound:5245884|FD-Score:4.36|P-value:2.49E-5 ID:SGTC_2118|Compound:5526350|FD-Score:4.91|P-value:2.47E-6 ID:SGTC_2121|Compound:5257820|FD-Score:5.04|P-value:1.34E-6 ID:SGTC_2131|Compound:toluylene red|FD-Score:-3.69|P-value:2.51E-4 ID:SGTC_2145|Compound:5634607|FD-Score:5.30|P-value:3.99E-7 ID:SGTC_2308|Compound:7584454|FD-Score:-3.79|P-value:1.74E-4 ID:SGTC_2312|Compound:7706453|FD-Score:-4.10|P-value:5.47E-5 ID:SGTC_2349|Compound:9023730|FD-Score:-3.28|P-value:9.74E-4 ID:SGTC_2354|Compound:9060492|FD-Score:-3.56|P-value:3.87E-4 ID:SGTC_2432|Compound:5630864|FD-Score:4.37|P-value:2.41E-5 ID:SGTC_2433|Compound:5607874|FD-Score:3.68|P-value:3.12E-4 ID:SGTC_2464|Compound:5717415|FD-Score:3.87|P-value:1.61E-4 ID:SGTC_2468|Compound:5987765|FD-Score:4.54|P-value:1.20E-5 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:3.80|P-value:2.10E-4 ID:SGTC_2524|Compound:avocatin b|FD-Score:5.37|P-value:2.83E-7 ID:SGTC_2563|Compound:tomatine|FD-Score:-3.29|P-value:9.47E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:4.56|P-value:1.10E-5 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:-3.83|P-value:1.52E-4 ID:SGTC_2666|Compound:tannic acid|FD-Score:3.43|P-value:7.29E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:3.83|P-value:1.84E-4 ID:SGTC_2787|Compound:5284540|FD-Score:-3.81|P-value:1.63E-4 ID:SGTC_2831|Compound:7999036|FD-Score:3.46|P-value:6.56E-4 ID:SGTC_2997|Compound:9067075|FD-Score:4.56|P-value:1.12E-5 ID:SGTC_3049|Compound:9092223|FD-Score:3.40|P-value:8.07E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-9.25|P-value:1.86E-18 ID:SGTC_3139|Compound:9095020|FD-Score:3.61|P-value:3.99E-4 ID:SGTC_3150|Compound:9097574|FD-Score:3.34|P-value:9.80E-4 ID:SGTC_3238|Compound:9133470|FD-Score:3.35|P-value:9.36E-4 ID:SGTC_3257|Compound:9139206|FD-Score:4.69|P-value:6.38E-6 ID:SGTC_3278|Compound:9139605|FD-Score:3.77|P-value:2.33E-4 ID:SGTC_3324|Compound:9138759|FD-Score:-3.67|P-value:2.64E-4 ID:SGTC_3325|Compound:9138760|FD-Score:4.55|P-value:1.16E-5 ID:SGTC_3333|Compound:9141820|FD-Score:4.60|P-value:9.44E-6 ID:SGTC_42|Compound:0133-0086|FD-Score:3.67|P-value:3.29E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:-5.75|P-value:3.11E-8 ID:SGTC_147|Compound:4466-0538|FD-Score:3.48|P-value:6.19E-4 ID:SGTC_272|Compound:doxorubicin|FD-Score:3.72|P-value:2.70E-4 ID:SGTC_338|Compound:4055-0136|FD-Score:3.45|P-value:6.86E-4 ID:SGTC_438|Compound:sphingosine|FD-Score:3.94|P-value:1.23E-4 ID:SGTC_529|Compound:4076-0302|FD-Score:3.71|P-value:2.79E-4 ID:SGTC_530|Compound:4358-1714|FD-Score:3.84|P-value:1.80E-4 ID:SGTC_585|Compound:0kpi-0023|FD-Score:-3.78|P-value:1.78E-4 ID:SGTC_596|Compound:1155-0152|FD-Score:3.86|P-value:1.66E-4 ID:SGTC_693|Compound:4161-2696|FD-Score:4.57|P-value:1.05E-5 ID:SGTC_696|Compound:1560-0013|FD-Score:7.39|P-value:2.70E-12 ID:SGTC_708|Compound:3448-5400|FD-Score:-3.78|P-value:1.83E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:4.88|P-value:2.72E-6 ID:SGTC_1051|Compound:3253-3903|FD-Score:-3.35|P-value:7.81E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:-4.00|P-value:7.93E-5 ID:SGTC_1232|Compound:0279-0259|FD-Score:-3.30|P-value:9.00E-4 ID:SGTC_1272|Compound:0839-0021|FD-Score:-5.41|P-value:1.72E-7 ID:SGTC_1523|Compound:st012844|FD-Score:3.62|P-value:3.92E-4 ID:SGTC_1723|Compound:st034307|FD-Score:-4.26|P-value:2.94E-5 ID:SGTC_1859|Compound:st055998|FD-Score:-3.67|P-value:2.70E-4 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:3.85|P-value:1.71E-4 ID:SGTC_1952|Compound:st077036|FD-Score:4.00|P-value:9.88E-5 ID:SGTC_2061|Compound:5245884|FD-Score:4.36|P-value:2.49E-5 ID:SGTC_2118|Compound:5526350|FD-Score:4.91|P-value:2.47E-6 ID:SGTC_2121|Compound:5257820|FD-Score:5.04|P-value:1.34E-6 ID:SGTC_2131|Compound:toluylene red|FD-Score:-3.69|P-value:2.51E-4 ID:SGTC_2145|Compound:5634607|FD-Score:5.30|P-value:3.99E-7 ID:SGTC_2308|Compound:7584454|FD-Score:-3.79|P-value:1.74E-4 ID:SGTC_2312|Compound:7706453|FD-Score:-4.10|P-value:5.47E-5 ID:SGTC_2349|Compound:9023730|FD-Score:-3.28|P-value:9.74E-4 ID:SGTC_2354|Compound:9060492|FD-Score:-3.56|P-value:3.87E-4 ID:SGTC_2432|Compound:5630864|FD-Score:4.37|P-value:2.41E-5 ID:SGTC_2433|Compound:5607874|FD-Score:3.68|P-value:3.12E-4 ID:SGTC_2464|Compound:5717415|FD-Score:3.87|P-value:1.61E-4 ID:SGTC_2468|Compound:5987765|FD-Score:4.54|P-value:1.20E-5 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:3.80|P-value:2.10E-4 ID:SGTC_2524|Compound:avocatin b|FD-Score:5.37|P-value:2.83E-7 ID:SGTC_2563|Compound:tomatine|FD-Score:-3.29|P-value:9.47E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:4.56|P-value:1.10E-5 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:-3.83|P-value:1.52E-4 ID:SGTC_2666|Compound:tannic acid|FD-Score:3.43|P-value:7.29E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:3.83|P-value:1.84E-4 ID:SGTC_2787|Compound:5284540|FD-Score:-3.81|P-value:1.63E-4 ID:SGTC_2831|Compound:7999036|FD-Score:3.46|P-value:6.56E-4 ID:SGTC_2997|Compound:9067075|FD-Score:4.56|P-value:1.12E-5 ID:SGTC_3049|Compound:9092223|FD-Score:3.40|P-value:8.07E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-9.25|P-value:1.86E-18 ID:SGTC_3139|Compound:9095020|FD-Score:3.61|P-value:3.99E-4 ID:SGTC_3150|Compound:9097574|FD-Score:3.34|P-value:9.80E-4 ID:SGTC_3238|Compound:9133470|FD-Score:3.35|P-value:9.36E-4 ID:SGTC_3257|Compound:9139206|FD-Score:4.69|P-value:6.38E-6 ID:SGTC_3278|Compound:9139605|FD-Score:3.77|P-value:2.33E-4 ID:SGTC_3324|Compound:9138759|FD-Score:-3.67|P-value:2.64E-4 ID:SGTC_3325|Compound:9138760|FD-Score:4.55|P-value:1.16E-5 ID:SGTC_3333|Compound:9141820|FD-Score:4.60|P-value:9.44E-6

Top fitness defect scores for YHR197W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_696 1560-0013 7.39 611.0 µM 2.70E-12 2 7.26E-14 1.71
2 SGTC_2524 avocatin b 5.37 10.6 µM 2.83E-7 1 3.91E-8 2.44
3 SGTC_2145 5634607 5.30 200.0 µM 3.99E-7 1 5.79E-8 1.09
4 SGTC_2121 5257820 5.04 149.6 µM 1.34E-6 2 2.31E-7 0.47
5 SGTC_2118 5526350 4.91 200.0 µM 2.47E-6 2 4.64E-7 0.20
6 SGTC_1033 k072-0102 4.88 21.3 µM 2.72E-6 60S ribosome export 3 5.18E-7 0.42
7 SGTC_3257 9139206 4.69 33.0 µM 6.38E-6 3 1.37E-6 0.83
8 SGTC_3333 9141820 4.60 12.1 µM 9.44E-6 2 2.14E-6 0.58
9 SGTC_693 4161-2696 4.57 114.0 µM 1.05E-5 1 2.42E-6 0.30
10 SGTC_2630 antimycin a 4.56 100.0 µM 1.10E-5 mitochondrial processes 6 2.56E-6 0.17
11 SGTC_2997 9067075 4.56 71.4 µM 1.12E-5 unfolded protein response 16 2.59E-6 0.15
12 SGTC_3325 9138760 4.55 55.2 µM 1.16E-5 Golgi 2 2.71E-6 0.11
13 SGTC_2468 5987765 4.54 72.9 µM 1.20E-5 1 2.81E-6 0.43
14 SGTC_2432 5630864 4.37 12.2 µM 2.41E-5 3 6.23E-6 0.41
15 SGTC_2061 5245884 4.36 81.0 µM 2.49E-5 tubulin folding & SWR complex 4 6.48E-6 0.11
16 SGTC_1952 st077036 4.00 64.1 µM 9.88E-5 12 3.11E-5 0.02
17 SGTC_438 sphingosine 3.94 6.7 µM 1.23E-4 1 4.00E-5 0.35
18 SGTC_2464 5717415 3.87 7.7 µM 1.61E-4 2 5.43E-5 0.25
19 SGTC_596 1155-0152 3.86 116.0 µM 1.66E-4 TRP & mitochondrial translation 8 5.65E-5 0.09
20 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 3.85 14.9 µM 1.71E-4 5 5.82E-5 0.08

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.141 1.76E-16 YBR193C MED8 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
0.122 1.14E-12 YCR013C_d YCR013C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YCR013C and the overlapping essential gene PGK1 is reduced in a gcr1 null mutant
0.122 1.34E-12 YMR270C RRN9 het Protein involved in promoting high level transcription of rDNA, subunit of UAF (upstream activation factor) for RNA polymerase I
0.117 9.54E-12 YBL020W RFT1 het Essential integral membrane protein that is required for translocation of Man5GlcNac2-PP-Dol from the cytoplasmic side to the lumenal side of the ER membrane but is not the flippase; mutation is suppressed by expression of human p53 protein
0.105 1.06E-9 YNL161W CBK1 het Serine/threonine protein kinase of the the RAM signaling network; Ndr/LATS family member; binds regulatory subunit Mob2p; involved in regulation of cellular morphogenesis, polarized growth, and septum destruction; phosphorylation by Cbk1p regulates localization and activity of Ace2p transcription factor and Ssd1p translational repressor; Cbk1p activity is regulated by both phosphorylation and specific localization; relocalizes to cytoplasm upon DNA replication stress
0.104 1.43E-9 YKL083W_d YKL083W_d het Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified essential gene RRP14
0.101 4.63E-9 YDR498C SEC20 het Membrane glycoprotein v-SNARE involved in retrograde transport from the Golgi to the ER; required for N- and O-glycosylation in the Golgi but not in the ER; interacts with the Dsl1p complex through Tip20p
0.098 1.10E-8 YAR008W SEN34 het Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen34p contains the active site for tRNA 3' splice site cleavage and has similarity to Sen2p and to Archaeal tRNA splicing endonuclease
0.098 1.36E-8 YNL151C RPC31 het RNA polymerase III subunit C31
0.096 2.60E-8 YML098W TAF13 het TFIID subunit (19 kDa), involved in RNA polymerase II transcription initiation, similar to histone H4 with atypical histone fold motif of Spt3-like transcription factors
0.095 3.75E-8 YER126C NSA2 het Protein constituent of 66S pre-ribosomal particles, contributes to processing of the 27S pre-rRNA
0.094 4.82E-8 YDR294C DPL1 hom Dihydrosphingosine phosphate lyase, regulates intracellular levels of sphingolipid long-chain base phosphates (LCBPs), degrades phosphorylated long chain bases, prefers C16 dihydrosphingosine-l-phosphate as a substrate
0.092 1.01E-7 YDR082W STN1 het Telomere end-binding and capping protein, plays a key role with Pol12p in linking telomerase action with completion of lagging strand synthesis, and in a regulatory step required for telomere capping
0.092 1.03E-7 YDR373W FRQ1 het N-myristoylated calcium-binding protein that may have a role in intracellular signaling through its regulation of the phosphatidylinositol 4-kinase Pik1p; member of the recoverin/frequenin branch of the EF-hand superfamily
0.091 1.23E-7 YML046W PRP39 het U1 snRNP protein involved in splicing, contains multiple tetriatricopeptide repeats