YHR202W_p

Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole, while HA-tagged protein is found in the soluble fraction, suggesting cytoplasmic localization

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR202W / YHR202W

Click on Significant Values for Screen Details ID:SGTC_48|Compound:0382-0018|FD-Score:3.25|P-value:5.80E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:6.59|P-value:2.32E-11 ID:SGTC_379|Compound:3970-0972|FD-Score:3.39|P-value:3.48E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:3.42|P-value:3.13E-4 ID:SGTC_539|Compound:4859-0462|FD-Score:3.41|P-value:3.28E-4 ID:SGTC_549|Compound:1661-1316|FD-Score:3.36|P-value:3.88E-4 ID:SGTC_656|Compound:4090-1979|FD-Score:3.33|P-value:4.39E-4 ID:SGTC_661|Compound:1304-0007|FD-Score:3.33|P-value:4.39E-4 ID:SGTC_667|Compound:1498-1044|FD-Score:3.13|P-value:8.89E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:6.91|P-value:2.51E-12 ID:SGTC_827|Compound:3253-0474|FD-Score:3.51|P-value:2.31E-4 ID:SGTC_835|Compound:0312-0010|FD-Score:4.24|P-value:1.12E-5 ID:SGTC_895|Compound:0964-0006|FD-Score:3.28|P-value:5.22E-4 ID:SGTC_976|Compound:1348-1067|FD-Score:4.91|P-value:4.54E-7 ID:SGTC_988|Compound:1497-1057|FD-Score:-3.49|P-value:2.42E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:3.98|P-value:3.50E-5 ID:SGTC_1017|Compound:4239-0030|FD-Score:4.29|P-value:9.23E-6 ID:SGTC_1020|Compound:4335-0961|FD-Score:6.68|P-value:1.24E-11 ID:SGTC_1052|Compound:3253-3998|FD-Score:3.40|P-value:3.36E-4 ID:SGTC_1117|Compound:retinoic acid|FD-Score:3.18|P-value:7.56E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:-3.34|P-value:4.22E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:4.05|P-value:2.55E-5 ID:SGTC_1167|Compound:k781-0610|FD-Score:5.26|P-value:7.37E-8 ID:SGTC_1221|Compound:2958-7315|FD-Score:4.86|P-value:6.08E-7 ID:SGTC_1245|Compound:0418-0076|FD-Score:5.55|P-value:1.45E-8 ID:SGTC_1395|Compound:3486-0190|FD-Score:3.38|P-value:3.68E-4 ID:SGTC_1433|Compound:4060-0023|FD-Score:3.32|P-value:4.52E-4 ID:SGTC_1482|Compound:3346-2049|FD-Score:3.77|P-value:8.44E-5 ID:SGTC_1489|Compound:4065-0444|FD-Score:3.35|P-value:4.06E-4 ID:SGTC_1683|Compound:st010134|FD-Score:3.18|P-value:7.42E-4 ID:SGTC_1770|Compound:st043884|FD-Score:3.14|P-value:8.63E-4 ID:SGTC_1777|Compound:st045864|FD-Score:3.18|P-value:7.50E-4 ID:SGTC_1780|Compound:st038448|FD-Score:4.61|P-value:2.04E-6 ID:SGTC_1804|Compound:st050076|FD-Score:4.64|P-value:1.81E-6 ID:SGTC_1819|Compound:st053448|FD-Score:3.75|P-value:9.14E-5 ID:SGTC_1824|Compound:st053723|FD-Score:-3.14|P-value:8.27E-4 ID:SGTC_1900|Compound:st060200|FD-Score:3.29|P-value:5.08E-4 ID:SGTC_1943|Compound:st076331|FD-Score:5.10|P-value:1.71E-7 ID:SGTC_1962|Compound:st076595|FD-Score:3.67|P-value:1.23E-4 ID:SGTC_2016|Compound:5121758|FD-Score:3.68|P-value:1.16E-4 ID:SGTC_2039|Compound:Aminomethylbenzodioxan|FD-Score:3.36|P-value:3.98E-4 ID:SGTC_2099|Compound:5377090|FD-Score:4.14|P-value:1.80E-5 ID:SGTC_2137|Compound:5261020|FD-Score:5.06|P-value:2.16E-7 ID:SGTC_2146|Compound:5545642|FD-Score:5.21|P-value:9.84E-8 ID:SGTC_2229|Compound:7354935|FD-Score:5.25|P-value:7.72E-8 ID:SGTC_2352|Compound:9027995|FD-Score:5.39|P-value:3.67E-8 ID:SGTC_2354|Compound:9060492|FD-Score:3.10|P-value:9.94E-4 ID:SGTC_2601|Compound:securinine|FD-Score:3.13|P-value:8.94E-4 ID:SGTC_2618|Compound:avocadyne|FD-Score:3.54|P-value:2.04E-4 ID:SGTC_2809|Compound:7964133|FD-Score:7.36|P-value:9.49E-14 ID:SGTC_2815|Compound:7968870|FD-Score:3.72|P-value:1.02E-4 ID:SGTC_2857|Compound:9024691|FD-Score:4.25|P-value:1.07E-5 ID:SGTC_2864|Compound:9034755|FD-Score:3.45|P-value:2.87E-4 ID:SGTC_2895|Compound:9054447|FD-Score:3.58|P-value:1.73E-4 ID:SGTC_2924|Compound:9010168|FD-Score:-4.03|P-value:2.73E-5 ID:SGTC_2957|Compound:9076800|FD-Score:3.85|P-value:6.00E-5 ID:SGTC_48|Compound:0382-0018|FD-Score:3.25|P-value:5.80E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:6.59|P-value:2.32E-11 ID:SGTC_379|Compound:3970-0972|FD-Score:3.39|P-value:3.48E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:3.42|P-value:3.13E-4 ID:SGTC_539|Compound:4859-0462|FD-Score:3.41|P-value:3.28E-4 ID:SGTC_549|Compound:1661-1316|FD-Score:3.36|P-value:3.88E-4 ID:SGTC_656|Compound:4090-1979|FD-Score:3.33|P-value:4.39E-4 ID:SGTC_661|Compound:1304-0007|FD-Score:3.33|P-value:4.39E-4 ID:SGTC_667|Compound:1498-1044|FD-Score:3.13|P-value:8.89E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:6.91|P-value:2.51E-12 ID:SGTC_827|Compound:3253-0474|FD-Score:3.51|P-value:2.31E-4 ID:SGTC_835|Compound:0312-0010|FD-Score:4.24|P-value:1.12E-5 ID:SGTC_895|Compound:0964-0006|FD-Score:3.28|P-value:5.22E-4 ID:SGTC_976|Compound:1348-1067|FD-Score:4.91|P-value:4.54E-7 ID:SGTC_988|Compound:1497-1057|FD-Score:-3.49|P-value:2.42E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:3.98|P-value:3.50E-5 ID:SGTC_1017|Compound:4239-0030|FD-Score:4.29|P-value:9.23E-6 ID:SGTC_1020|Compound:4335-0961|FD-Score:6.68|P-value:1.24E-11 ID:SGTC_1052|Compound:3253-3998|FD-Score:3.40|P-value:3.36E-4 ID:SGTC_1117|Compound:retinoic acid|FD-Score:3.18|P-value:7.56E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:-3.34|P-value:4.22E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:4.05|P-value:2.55E-5 ID:SGTC_1167|Compound:k781-0610|FD-Score:5.26|P-value:7.37E-8 ID:SGTC_1221|Compound:2958-7315|FD-Score:4.86|P-value:6.08E-7 ID:SGTC_1245|Compound:0418-0076|FD-Score:5.55|P-value:1.45E-8 ID:SGTC_1395|Compound:3486-0190|FD-Score:3.38|P-value:3.68E-4 ID:SGTC_1433|Compound:4060-0023|FD-Score:3.32|P-value:4.52E-4 ID:SGTC_1482|Compound:3346-2049|FD-Score:3.77|P-value:8.44E-5 ID:SGTC_1489|Compound:4065-0444|FD-Score:3.35|P-value:4.06E-4 ID:SGTC_1683|Compound:st010134|FD-Score:3.18|P-value:7.42E-4 ID:SGTC_1770|Compound:st043884|FD-Score:3.14|P-value:8.63E-4 ID:SGTC_1777|Compound:st045864|FD-Score:3.18|P-value:7.50E-4 ID:SGTC_1780|Compound:st038448|FD-Score:4.61|P-value:2.04E-6 ID:SGTC_1804|Compound:st050076|FD-Score:4.64|P-value:1.81E-6 ID:SGTC_1819|Compound:st053448|FD-Score:3.75|P-value:9.14E-5 ID:SGTC_1824|Compound:st053723|FD-Score:-3.14|P-value:8.27E-4 ID:SGTC_1900|Compound:st060200|FD-Score:3.29|P-value:5.08E-4 ID:SGTC_1943|Compound:st076331|FD-Score:5.10|P-value:1.71E-7 ID:SGTC_1962|Compound:st076595|FD-Score:3.67|P-value:1.23E-4 ID:SGTC_2016|Compound:5121758|FD-Score:3.68|P-value:1.16E-4 ID:SGTC_2039|Compound:Aminomethylbenzodioxan|FD-Score:3.36|P-value:3.98E-4 ID:SGTC_2099|Compound:5377090|FD-Score:4.14|P-value:1.80E-5 ID:SGTC_2137|Compound:5261020|FD-Score:5.06|P-value:2.16E-7 ID:SGTC_2146|Compound:5545642|FD-Score:5.21|P-value:9.84E-8 ID:SGTC_2229|Compound:7354935|FD-Score:5.25|P-value:7.72E-8 ID:SGTC_2352|Compound:9027995|FD-Score:5.39|P-value:3.67E-8 ID:SGTC_2354|Compound:9060492|FD-Score:3.10|P-value:9.94E-4 ID:SGTC_2601|Compound:securinine|FD-Score:3.13|P-value:8.94E-4 ID:SGTC_2618|Compound:avocadyne|FD-Score:3.54|P-value:2.04E-4 ID:SGTC_2809|Compound:7964133|FD-Score:7.36|P-value:9.49E-14 ID:SGTC_2815|Compound:7968870|FD-Score:3.72|P-value:1.02E-4 ID:SGTC_2857|Compound:9024691|FD-Score:4.25|P-value:1.07E-5 ID:SGTC_2864|Compound:9034755|FD-Score:3.45|P-value:2.87E-4 ID:SGTC_2895|Compound:9054447|FD-Score:3.58|P-value:1.73E-4 ID:SGTC_2924|Compound:9010168|FD-Score:-4.03|P-value:2.73E-5 ID:SGTC_2957|Compound:9076800|FD-Score:3.85|P-value:6.00E-5

Top fitness defect scores for YHR202W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2809 7964133 7.36 13.0 µM 9.49E-14 60S ribosome export 3 9.16E-14
2 SGTC_696 1560-0013 6.91 611.0 µM 2.51E-12 4 2.43E-12
3 SGTC_1020 4335-0961 6.68 93.3 µM 1.24E-11 1 1.20E-11
4 SGTC_168 3970-0862 6.59 530.5 µM 2.32E-11 34 2.25E-11
5 SGTC_1245 0418-0076 5.55 17.2 µM 1.45E-8 ERG2 8 1.41E-8
6 SGTC_2352 9027995 5.39 87.8 µM 3.67E-8 tubulin folding & SWR complex 14 3.59E-8
7 SGTC_1167 k781-0610 5.26 148.0 µM 7.37E-8 RNA processing & uracil transport 7 7.21E-8
8 SGTC_2229 7354935 5.25 190.0 µM 7.72E-8 RSC complex & mRNA processing 3 7.55E-8
9 SGTC_2146 5545642 5.21 200.0 µM 9.84E-8 5 9.63E-8
10 SGTC_1943 st076331 5.10 65.2 µM 1.71E-7 5 1.68E-7
11 SGTC_2137 5261020 5.06 140.0 µM 2.16E-7 20 2.11E-7
12 SGTC_976 1348-1067 4.91 47.6 µM 4.54E-7 60S ribosome export 12 4.45E-7
13 SGTC_1221 2958-7315 4.86 257.0 µM 6.08E-7 10 5.96E-7
14 SGTC_1804 st050076 4.64 49.1 µM 1.81E-6 6 1.78E-6
15 SGTC_1780 st038448 4.61 24.5 µM 2.04E-6 iron homeostasis 4 2.01E-6
16 SGTC_1017 4239-0030 4.29 168.0 µM 9.23E-6 17 9.08E-6
17 SGTC_2857 9024691 4.25 58.4 µM 1.07E-5 16 1.05E-5
18 SGTC_835 0312-0010 4.24 67.2 µM 1.12E-5 8 1.10E-5
19 SGTC_2099 5377090 4.14 177.4 µM 1.80E-5 17 1.77E-5
20 SGTC_1136 pergolide 4.05 1.1 µM 2.55E-5 35 2.51E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.110 1.94E-10 YJL101C GSH1 hom Gamma glutamylcysteine synthetase; catalyzes the first step in glutathione (GSH) biosynthesis; expression induced by oxidants, cadmium, and mercury; protein abundance increases in response to DNA replication stress
0.103 2.03E-9 YDR002W YRB1 het Ran GTPase binding protein; involved in nuclear protein import and RNA export, ubiquitin-mediated protein degradation during the cell cycle; shuttles between the nucleus and cytoplasm; is essential; homolog of human RanBP1
0.094 5.05E-8 YDL108W KIN28 het Serine/threonine protein kinase, subunit of the transcription factor TFIIH; involved in transcription initiation at RNA polymerase II promoters
0.091 1.28E-7 YOR305W RRG7 hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); YOR305W is not an essential gene
0.087 3.87E-7 YBR290W BSD2 hom Heavy metal ion homeostasis protein, facilitates trafficking of Smf1p and Smf2p metal transporters to the vacuole where they are degraded, controls metal ion transport, prevents metal hyperaccumulation, functions in copper detoxification
0.084 1.16E-6 YGR224W AZR1 hom Plasma membrane transporter of the major facilitator superfamily, involved in resistance to azole drugs such as ketoconazole and fluconazole
0.081 2.38E-6 YHR157W REC104 hom Protein involved in early stages of meiotic recombination; required for meiotic crossing over; forms a complex with Rec102p and Spo11p necessary during the initiation of recombination
0.080 3.37E-6 YFL033C RIM15 hom Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase
0.079 4.70E-6 YDR005C MAF1 hom Highly conserved negative regulator of RNA polymerase III; binds to the N-terminal domain of the Rpc160p subunit of Pol III to prevent closed-complex formation; localization and activity are regulated by phosphorylation, mediated by TORC1, protein kinase A, and Sch9p; localizes to cytoplasm during vegetative growth and translocates to the nucleus and nucleolus under stress conditions
0.079 4.75E-6 YOL075C_p YOL075C_p hom Putative ABC transporter
0.077 8.92E-6 YJR032W CPR7 hom Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity
0.075 1.41E-5 YLR223C IFH1 het Coactivator that regulates transcription of ribosomal protein (RP) genes; recruited to RP gene promoters during optimal growth conditions via Fhl1p; subunit of CURI, a complex that coordinates RP production and pre-rRNA processing
0.074 1.97E-5 YLR002C NOC3 het Component of a nuclear complex with Noc2p and pre-replicative complexes; the Noc2p-Noc3p complex binds to 66S ribosomal precursors to mediate their maturation and intranuclear transport; binds to chromatin at active replication origins, and is required for pre-RC formation and maintenance during DNA replication licensing
0.073 2.14E-5 YPR069C SPE3 hom Spermidine synthase, involved in biosynthesis of spermidine and also in biosynthesis of pantothenic acid; spermidine is required for growth of wild-type cells
0.073 2.35E-5 YOR269W PAC1 hom Involved in nuclear migration, part of the dynein/dynactin pathway; targets dynein to microtubule tips, which is necessary for sliding of microtubules along bud cortex; serves at interface between dynein's ATPase site and its microtubule binding stalk, causing individual dynein motors to remain attached to microtubules for long periods; synthetic lethal with bni1; homolog of human LIS1, mutations in which cause the severe brain disorder lissencephaly