YHR205W / SCH9

AGC family protein kinase; functional ortholog of mammalian S6 kinase; phosphorylated by Tor1p and required for TORC1-mediated regulation of ribosome biogenesis, translation initiation, and entry into G0 phase; involved in transactivation of osmostress-responsive genes; regulates G1 progression, cAPK activity and nitrogen activation of the FGM pathway; integrates nutrient signals and stress signals from sphingolipids to regulate lifespan

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR205W / SCH9

Click on Significant Values for Screen Details ID:SGTC_11|Compound:0438-0307|FD-Score:3.13|P-value:4.92E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:-3.40|P-value:2.39E-4 ID:SGTC_75|Compound:0159-0059|FD-Score:-3.46|P-value:1.89E-4 ID:SGTC_81|Compound:0411-0046|FD-Score:3.13|P-value:4.93E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:-3.30|P-value:3.46E-4 ID:SGTC_104|Compound:0074-0074|FD-Score:7.25|P-value:1.76E-14 ID:SGTC_108|Compound:0509-0257|FD-Score:9.30|P-value:1.47E-22 ID:SGTC_112|Compound:phenothiazine|FD-Score:-4.52|P-value:1.56E-6 ID:SGTC_115|Compound:0527-0192|FD-Score:11.10|P-value:1.84E-31 ID:SGTC_143|Compound:4032-1194|FD-Score:3.25|P-value:3.10E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:3.12|P-value:5.18E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:10.70|P-value:4.89E-29 ID:SGTC_159|Compound:3970-0959|FD-Score:5.79|P-value:6.98E-10 ID:SGTC_168|Compound:3970-0862|FD-Score:11.90|P-value:1.14E-35 ID:SGTC_187|Compound:1488-2104|FD-Score:4.07|P-value:9.67E-6 ID:SGTC_212|Compound:3807-4682|FD-Score:4.12|P-value:7.70E-6 ID:SGTC_214|Compound:4373-3496|FD-Score:8.20|P-value:5.29E-18 ID:SGTC_255|Compound:tunicamycin|FD-Score:3.13|P-value:4.95E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-5.57|P-value:4.43E-9 ID:SGTC_312|Compound:4092-0653|FD-Score:4.18|P-value:5.73E-6 ID:SGTC_356|Compound:1634-0012|FD-Score:4.87|P-value:1.66E-7 ID:SGTC_422|Compound:cantharidin|FD-Score:3.19|P-value:3.91E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.97|P-value:3.38E-10 ID:SGTC_502|Compound:l-744,832|FD-Score:3.79|P-value:3.43E-5 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:4.32|P-value:2.91E-6 ID:SGTC_513|Compound:4245-1575|FD-Score:-7.03|P-value:1.86E-13 ID:SGTC_514|Compound:4466-0038|FD-Score:-3.12|P-value:6.75E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:-3.04|P-value:8.98E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:6.62|P-value:2.16E-12 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.12|P-value:6.89E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:3.55|P-value:9.49E-5 ID:SGTC_580|Compound:1123-0028|FD-Score:2.94|P-value:9.79E-4 ID:SGTC_600|Compound:1495-0418|FD-Score:3.84|P-value:2.82E-5 ID:SGTC_625|Compound:k213-0058|FD-Score:6.20|P-value:4.29E-11 ID:SGTC_660|Compound:4031-1742|FD-Score:-3.51|P-value:1.54E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:5.36|P-value:9.98E-9 ID:SGTC_830|Compound:4076-0286|FD-Score:4.11|P-value:8.18E-6 ID:SGTC_938|Compound:3126-1755|FD-Score:4.04|P-value:1.11E-5 ID:SGTC_961|Compound:1252-1571|FD-Score:3.28|P-value:2.77E-4 ID:SGTC_997|Compound:3996-0078|FD-Score:3.66|P-value:6.14E-5 ID:SGTC_1002|Compound:4049-0206|FD-Score:4.95|P-value:1.06E-7 ID:SGTC_1059|Compound:3448-6867|FD-Score:4.41|P-value:1.87E-6 ID:SGTC_1472|Compound:k841-0093|FD-Score:3.43|P-value:1.54E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.87|P-value:2.46E-5 ID:SGTC_1712|Compound:st032288|FD-Score:6.40|P-value:1.10E-11 ID:SGTC_1768|Compound:st044301|FD-Score:3.29|P-value:2.71E-4 ID:SGTC_1830|Compound:st055982|FD-Score:3.51|P-value:1.14E-4 ID:SGTC_1834|Compound:st055981|FD-Score:3.27|P-value:2.95E-4 ID:SGTC_1840|Compound:st055363|FD-Score:-3.86|P-value:3.47E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.77|P-value:3.73E-5 ID:SGTC_1877|Compound:wortmannin|FD-Score:3.07|P-value:6.17E-4 ID:SGTC_1881|Compound:5652484|FD-Score:-3.18|P-value:5.44E-4 ID:SGTC_1893|Compound:st059353|FD-Score:3.83|P-value:2.95E-5 ID:SGTC_2028|Compound:5153890|FD-Score:-3.40|P-value:2.33E-4 ID:SGTC_2049|Compound:5262831|FD-Score:-3.74|P-value:5.88E-5 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.52|P-value:1.07E-4 ID:SGTC_2307|Compound:7538926|FD-Score:-3.02|P-value:9.75E-4 ID:SGTC_2460|Compound:5552655|FD-Score:-3.15|P-value:6.00E-4 ID:SGTC_2470|Compound:5664817|FD-Score:3.40|P-value:1.78E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:4.54|P-value:9.96E-7 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:4.68|P-value:4.60E-7 ID:SGTC_2653|Compound:dihydrofissinolide|FD-Score:3.74|P-value:4.22E-5 ID:SGTC_2662|Compound:daunorubicin|FD-Score:3.16|P-value:4.43E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:9.67|P-value:2.89E-24 ID:SGTC_2772|Compound:vinpocetine|FD-Score:3.97|P-value:1.58E-5 ID:SGTC_2812|Compound:7970281|FD-Score:-3.03|P-value:9.28E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-3.96|P-value:2.24E-5 ID:SGTC_3028|Compound:9087778|FD-Score:-3.11|P-value:6.96E-4 ID:SGTC_3031|Compound:9088762|FD-Score:4.16|P-value:6.42E-6 ID:SGTC_3146|Compound:9095609|FD-Score:-5.22|P-value:3.52E-8 ID:SGTC_3150|Compound:9097574|FD-Score:6.67|P-value:1.52E-12 ID:SGTC_3152|Compound:9099253|FD-Score:-3.27|P-value:3.95E-4 ID:SGTC_3190|Compound:9110366|FD-Score:4.02|P-value:1.21E-5 ID:SGTC_3194|Compound:9111903|FD-Score:4.69|P-value:4.45E-7 ID:SGTC_11|Compound:0438-0307|FD-Score:3.13|P-value:4.92E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:-3.40|P-value:2.39E-4 ID:SGTC_75|Compound:0159-0059|FD-Score:-3.46|P-value:1.89E-4 ID:SGTC_81|Compound:0411-0046|FD-Score:3.13|P-value:4.93E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:-3.30|P-value:3.46E-4 ID:SGTC_104|Compound:0074-0074|FD-Score:7.25|P-value:1.76E-14 ID:SGTC_108|Compound:0509-0257|FD-Score:9.30|P-value:1.47E-22 ID:SGTC_112|Compound:phenothiazine|FD-Score:-4.52|P-value:1.56E-6 ID:SGTC_115|Compound:0527-0192|FD-Score:11.10|P-value:1.84E-31 ID:SGTC_143|Compound:4032-1194|FD-Score:3.25|P-value:3.10E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:3.12|P-value:5.18E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:10.70|P-value:4.89E-29 ID:SGTC_159|Compound:3970-0959|FD-Score:5.79|P-value:6.98E-10 ID:SGTC_168|Compound:3970-0862|FD-Score:11.90|P-value:1.14E-35 ID:SGTC_187|Compound:1488-2104|FD-Score:4.07|P-value:9.67E-6 ID:SGTC_212|Compound:3807-4682|FD-Score:4.12|P-value:7.70E-6 ID:SGTC_214|Compound:4373-3496|FD-Score:8.20|P-value:5.29E-18 ID:SGTC_255|Compound:tunicamycin|FD-Score:3.13|P-value:4.95E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-5.57|P-value:4.43E-9 ID:SGTC_312|Compound:4092-0653|FD-Score:4.18|P-value:5.73E-6 ID:SGTC_356|Compound:1634-0012|FD-Score:4.87|P-value:1.66E-7 ID:SGTC_422|Compound:cantharidin|FD-Score:3.19|P-value:3.91E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.97|P-value:3.38E-10 ID:SGTC_502|Compound:l-744,832|FD-Score:3.79|P-value:3.43E-5 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:4.32|P-value:2.91E-6 ID:SGTC_513|Compound:4245-1575|FD-Score:-7.03|P-value:1.86E-13 ID:SGTC_514|Compound:4466-0038|FD-Score:-3.12|P-value:6.75E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:-3.04|P-value:8.98E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:6.62|P-value:2.16E-12 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.12|P-value:6.89E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:3.55|P-value:9.49E-5 ID:SGTC_580|Compound:1123-0028|FD-Score:2.94|P-value:9.79E-4 ID:SGTC_600|Compound:1495-0418|FD-Score:3.84|P-value:2.82E-5 ID:SGTC_625|Compound:k213-0058|FD-Score:6.20|P-value:4.29E-11 ID:SGTC_660|Compound:4031-1742|FD-Score:-3.51|P-value:1.54E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:5.36|P-value:9.98E-9 ID:SGTC_830|Compound:4076-0286|FD-Score:4.11|P-value:8.18E-6 ID:SGTC_938|Compound:3126-1755|FD-Score:4.04|P-value:1.11E-5 ID:SGTC_961|Compound:1252-1571|FD-Score:3.28|P-value:2.77E-4 ID:SGTC_997|Compound:3996-0078|FD-Score:3.66|P-value:6.14E-5 ID:SGTC_1002|Compound:4049-0206|FD-Score:4.95|P-value:1.06E-7 ID:SGTC_1059|Compound:3448-6867|FD-Score:4.41|P-value:1.87E-6 ID:SGTC_1472|Compound:k841-0093|FD-Score:3.43|P-value:1.54E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.87|P-value:2.46E-5 ID:SGTC_1712|Compound:st032288|FD-Score:6.40|P-value:1.10E-11 ID:SGTC_1768|Compound:st044301|FD-Score:3.29|P-value:2.71E-4 ID:SGTC_1830|Compound:st055982|FD-Score:3.51|P-value:1.14E-4 ID:SGTC_1834|Compound:st055981|FD-Score:3.27|P-value:2.95E-4 ID:SGTC_1840|Compound:st055363|FD-Score:-3.86|P-value:3.47E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.77|P-value:3.73E-5 ID:SGTC_1877|Compound:wortmannin|FD-Score:3.07|P-value:6.17E-4 ID:SGTC_1881|Compound:5652484|FD-Score:-3.18|P-value:5.44E-4 ID:SGTC_1893|Compound:st059353|FD-Score:3.83|P-value:2.95E-5 ID:SGTC_2028|Compound:5153890|FD-Score:-3.40|P-value:2.33E-4 ID:SGTC_2049|Compound:5262831|FD-Score:-3.74|P-value:5.88E-5 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.52|P-value:1.07E-4 ID:SGTC_2307|Compound:7538926|FD-Score:-3.02|P-value:9.75E-4 ID:SGTC_2460|Compound:5552655|FD-Score:-3.15|P-value:6.00E-4 ID:SGTC_2470|Compound:5664817|FD-Score:3.40|P-value:1.78E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:4.54|P-value:9.96E-7 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:4.68|P-value:4.60E-7 ID:SGTC_2653|Compound:dihydrofissinolide|FD-Score:3.74|P-value:4.22E-5 ID:SGTC_2662|Compound:daunorubicin|FD-Score:3.16|P-value:4.43E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:9.67|P-value:2.89E-24 ID:SGTC_2772|Compound:vinpocetine|FD-Score:3.97|P-value:1.58E-5 ID:SGTC_2812|Compound:7970281|FD-Score:-3.03|P-value:9.28E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-3.96|P-value:2.24E-5 ID:SGTC_3028|Compound:9087778|FD-Score:-3.11|P-value:6.96E-4 ID:SGTC_3031|Compound:9088762|FD-Score:4.16|P-value:6.42E-6 ID:SGTC_3146|Compound:9095609|FD-Score:-5.22|P-value:3.52E-8 ID:SGTC_3150|Compound:9097574|FD-Score:6.67|P-value:1.52E-12 ID:SGTC_3152|Compound:9099253|FD-Score:-3.27|P-value:3.95E-4 ID:SGTC_3190|Compound:9110366|FD-Score:4.02|P-value:1.21E-5 ID:SGTC_3194|Compound:9111903|FD-Score:4.69|P-value:4.45E-7

Top fitness defect scores for YHR205W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_168 3970-0862 11.90 530.5 µM 1.14E-35 7 5.93E-33
2 SGTC_115 0527-0192 11.10 112.0 µM 1.84E-31 3 4.52E-29
3 SGTC_150 3970-0969 10.70 77.2 µM 4.89E-29 2 7.80E-27
4 SGTC_2688 kanamycin b 9.67 96.7 µM 2.89E-24 calcium & mitochondrial duress 30 1.97E-22
5 SGTC_108 0509-0257 9.30 621.1 µM 1.47E-22 2 7.36E-21
6 SGTC_214 4373-3496 8.20 70.0 µM 5.29E-18 4 1.17E-16
7 SGTC_104 0074-0074 7.25 591.0 µM 1.76E-14 1 2.07E-13
8 SGTC_3150 9097574 6.67 49.5 µM 1.52E-12 2 1.26E-11
9 SGTC_528 3492-0019 6.62 172.0 µM 2.16E-12 calcium & mitochondrial duress 106 1.74E-11
10 SGTC_1712 st032288 6.40 53.4 µM 1.10E-11 calcium & mitochondrial duress 68 7.80E-11
11 SGTC_625 k213-0058 6.20 121.0 µM 4.29E-11 translation 29 2.74E-10
12 SGTC_159 3970-0959 5.79 50.0 µM 6.98E-10 28 3.58E-9
13 SGTC_800 3448-7362 5.36 155.0 µM 9.98E-9 translation 71 4.15E-8
14 SGTC_1002 4049-0206 4.95 172.0 µM 1.06E-7 10 3.65E-7
15 SGTC_356 1634-0012 4.87 32.5 µM 1.66E-7 10 5.52E-7
16 SGTC_3194 9111903 4.69 49.5 µM 4.45E-7 12 1.37E-6
17 SGTC_2497 7-hydroxyflavone 4.68 100.0 µM 4.60E-7 10 1.41E-6
18 SGTC_2489 cantharidin 4.54 73.4 µM 9.96E-7 cell wall signaling 28 2.88E-6
19 SGTC_1059 3448-6867 4.41 171.0 µM 1.87E-6 6 5.15E-6
20 SGTC_506 n9-isopropylolomoucine 4.32 153.0 µM 2.91E-6 10 7.74E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.450 4.25E-167 YFL033C RIM15 hom Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase
0.254 2.43E-50 YOL081W IRA2 hom GTPase-activating protein; negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions; similar to human neurofibromin; IRA2 has a paralog, IRA1, that arose from the whole genome duplication
0.236 1.55E-43 YDR475C JIP4 hom Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence
0.232 3.44E-42 YJL165C HAL5 hom Putative protein kinase; overexpression increases sodium and lithium tolerance, whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake, suggesting a role in regulation of Trk1p and/or Trk2p transporters; HAL5 has a paralog, KKQ8, that arose from the whole genome duplication
0.226 5.66E-40 YDR466W PKH3 hom Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant
0.223 6.56E-39 YJL101C GSH1 hom Gamma glutamylcysteine synthetase; catalyzes the first step in glutathione (GSH) biosynthesis; expression induced by oxidants, cadmium, and mercury; protein abundance increases in response to DNA replication stress
0.221 1.65E-38 YHR064C SSZ1 hom Hsp70 protein that interacts with Zuo1p (a DnaJ homolog) to form a ribosome-associated complex that binds the ribosome via the Zuo1p subunit; also involved in pleiotropic drug resistance via sequential activation of PDR1 and PDR5; binds ATP
0.213 9.44E-36 YNL246W VPS75 hom NAP family histone chaperone; binds to histones and Rtt109p, stimulating histone acetyltransferase activity; possesses nucleosome assembly activity in vitro; proposed role in vacuolar protein sorting and in double-strand break repair; protein abundance increases in response to DNA replication stress
0.212 2.85E-35 YDR467C_d YDR467C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.211 3.14E-35 YDR005C MAF1 hom Highly conserved negative regulator of RNA polymerase III; binds to the N-terminal domain of the Rpc160p subunit of Pol III to prevent closed-complex formation; localization and activity are regulated by phosphorylation, mediated by TORC1, protein kinase A, and Sch9p; localizes to cytoplasm during vegetative growth and translocates to the nucleus and nucleolus under stress conditions
0.208 3.76E-34 YDR359C EAF1 hom Component of the NuA4 histone acetyltransferase complex; acts as a platform for assembly of NuA4 subunits into the native complex; required for initiation of pre-meiotic DNA replication, likely due to its requirement for expression of IME1
0.203 1.93E-32 YGL250W RMR1 hom Protein required for meiotic recombination and gene conversion; null mutant displays reduced PIS1 expression and growth defects on non-fermentable carbon sources and minimal media; GFP-fusion protein localizes to both cytoplasm and nucleus
0.202 2.30E-32 YBL051C PIN4 hom Protein involved in G2/M phase progression and response to DNA damage, interacts with Rad53p; contains an RNA recognition motif, a nuclear localization signal, and several SQ/TQ cluster domains; hyperphosphorylated in response to DNA damage
0.195 4.14E-30 YML073C RPL6A hom Ribosomal 60S subunit protein L6A; N-terminally acetylated; binds 5.8S rRNA; homologous to mammalian ribosomal protein L6, no bacterial homolog; RPL6A has a paralog, RPL6B, that arose from the whole genome duplication
0.191 6.27E-29 YDR443C SSN2 hom Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for stable association of Srb10p-Srb11p kinase; essential for transcriptional regulation