YIL003W / CFD1

Highly conserved, iron-sulfur cluster binding protein localized in the cytoplasm; forms a complex with Nbp35p that is involved in iron-sulfur protein assembly in the cytosol

Zygosity: Heterozygous strain
fixedexpanded
Profile for YIL003W / CFD1

Click on Significant Values for Screen Details ID:SGTC_81|Compound:0411-0046|FD-Score:3.68|P-value:1.47E-5 ID:SGTC_104|Compound:0074-0074|FD-Score:3.31|P-value:7.97E-5 ID:SGTC_108|Compound:0509-0257|FD-Score:3.93|P-value:4.27E-6 ID:SGTC_116|Compound:0155-0182|FD-Score:-3.19|P-value:4.74E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:3.15|P-value:1.57E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:3.11|P-value:1.90E-4 ID:SGTC_156|Compound:3474-0145|FD-Score:-3.17|P-value:5.11E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:7.32|P-value:1.82E-16 ID:SGTC_168|Compound:3970-0862|FD-Score:3.16|P-value:1.51E-4 ID:SGTC_214|Compound:4373-3496|FD-Score:3.94|P-value:4.04E-6 ID:SGTC_301|Compound:4119-0100|FD-Score:2.87|P-value:4.88E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:3.36|P-value:6.30E-5 ID:SGTC_321|Compound:4534-3890|FD-Score:-3.34|P-value:2.61E-4 ID:SGTC_459|Compound:nigericin|FD-Score:3.51|P-value:3.31E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:4.69|P-value:6.53E-8 ID:SGTC_564|Compound:3555-0129|FD-Score:3.81|P-value:7.69E-6 ID:SGTC_574|Compound:1315-0397|FD-Score:-3.38|P-value:2.18E-4 ID:SGTC_745|Compound:0469-0705|FD-Score:2.78|P-value:6.90E-4 ID:SGTC_747|Compound:3448-8087|FD-Score:2.70|P-value:9.19E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:-3.46|P-value:1.56E-4 ID:SGTC_798|Compound:1287-0182|FD-Score:2.75|P-value:7.81E-4 ID:SGTC_847|Compound:0342-0274|FD-Score:3.16|P-value:1.52E-4 ID:SGTC_979|Compound:1426-2828|FD-Score:3.19|P-value:1.33E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:-3.00|P-value:9.48E-4 ID:SGTC_1025|Compound:k007-0731|FD-Score:-3.01|P-value:9.18E-4 ID:SGTC_1189|Compound:1431-2119|FD-Score:-5.13|P-value:2.96E-8 ID:SGTC_1197|Compound:1601-0112|FD-Score:-3.70|P-value:5.50E-5 ID:SGTC_1271|Compound:0832-2808|FD-Score:3.34|P-value:7.01E-5 ID:SGTC_1374|Compound:2889-5571|FD-Score:4.15|P-value:1.33E-6 ID:SGTC_1469|Compound:k284-2957|FD-Score:-6.26|P-value:1.38E-11 ID:SGTC_1648|Compound:st011736|FD-Score:-4.23|P-value:4.40E-6 ID:SGTC_1658|Compound:st012944|FD-Score:3.14|P-value:1.66E-4 ID:SGTC_1819|Compound:st053448|FD-Score:-4.00|P-value:1.38E-5 ID:SGTC_1825|Compound:st052143|FD-Score:3.35|P-value:6.55E-5 ID:SGTC_1982|Compound:st072467|FD-Score:2.72|P-value:8.67E-4 ID:SGTC_2024|Compound:5144227|FD-Score:3.21|P-value:1.23E-4 ID:SGTC_2064|Compound:5220758|FD-Score:4.18|P-value:1.17E-6 ID:SGTC_2237|Compound:6667747|FD-Score:2.84|P-value:5.53E-4 ID:SGTC_2246|Compound:7293507|FD-Score:2.77|P-value:7.07E-4 ID:SGTC_2329|Compound:6138490|FD-Score:5.52|P-value:3.15E-10 ID:SGTC_2403|Compound:6032726|FD-Score:-3.38|P-value:2.14E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.77|P-value:9.33E-6 ID:SGTC_2619|Compound:obliquin|FD-Score:3.34|P-value:7.14E-5 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:-3.14|P-value:5.62E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:4.96|P-value:1.20E-8 ID:SGTC_3210|Compound:9128157|FD-Score:-3.41|P-value:1.91E-4 ID:SGTC_3303|Compound:9125618|FD-Score:3.94|P-value:4.13E-6 ID:SGTC_81|Compound:0411-0046|FD-Score:3.68|P-value:1.47E-5 ID:SGTC_104|Compound:0074-0074|FD-Score:3.31|P-value:7.97E-5 ID:SGTC_108|Compound:0509-0257|FD-Score:3.93|P-value:4.27E-6 ID:SGTC_116|Compound:0155-0182|FD-Score:-3.19|P-value:4.74E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:3.15|P-value:1.57E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:3.11|P-value:1.90E-4 ID:SGTC_156|Compound:3474-0145|FD-Score:-3.17|P-value:5.11E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:7.32|P-value:1.82E-16 ID:SGTC_168|Compound:3970-0862|FD-Score:3.16|P-value:1.51E-4 ID:SGTC_214|Compound:4373-3496|FD-Score:3.94|P-value:4.04E-6 ID:SGTC_301|Compound:4119-0100|FD-Score:2.87|P-value:4.88E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:3.36|P-value:6.30E-5 ID:SGTC_321|Compound:4534-3890|FD-Score:-3.34|P-value:2.61E-4 ID:SGTC_459|Compound:nigericin|FD-Score:3.51|P-value:3.31E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:4.69|P-value:6.53E-8 ID:SGTC_564|Compound:3555-0129|FD-Score:3.81|P-value:7.69E-6 ID:SGTC_574|Compound:1315-0397|FD-Score:-3.38|P-value:2.18E-4 ID:SGTC_745|Compound:0469-0705|FD-Score:2.78|P-value:6.90E-4 ID:SGTC_747|Compound:3448-8087|FD-Score:2.70|P-value:9.19E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:-3.46|P-value:1.56E-4 ID:SGTC_798|Compound:1287-0182|FD-Score:2.75|P-value:7.81E-4 ID:SGTC_847|Compound:0342-0274|FD-Score:3.16|P-value:1.52E-4 ID:SGTC_979|Compound:1426-2828|FD-Score:3.19|P-value:1.33E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:-3.00|P-value:9.48E-4 ID:SGTC_1025|Compound:k007-0731|FD-Score:-3.01|P-value:9.18E-4 ID:SGTC_1189|Compound:1431-2119|FD-Score:-5.13|P-value:2.96E-8 ID:SGTC_1197|Compound:1601-0112|FD-Score:-3.70|P-value:5.50E-5 ID:SGTC_1271|Compound:0832-2808|FD-Score:3.34|P-value:7.01E-5 ID:SGTC_1374|Compound:2889-5571|FD-Score:4.15|P-value:1.33E-6 ID:SGTC_1469|Compound:k284-2957|FD-Score:-6.26|P-value:1.38E-11 ID:SGTC_1648|Compound:st011736|FD-Score:-4.23|P-value:4.40E-6 ID:SGTC_1658|Compound:st012944|FD-Score:3.14|P-value:1.66E-4 ID:SGTC_1819|Compound:st053448|FD-Score:-4.00|P-value:1.38E-5 ID:SGTC_1825|Compound:st052143|FD-Score:3.35|P-value:6.55E-5 ID:SGTC_1982|Compound:st072467|FD-Score:2.72|P-value:8.67E-4 ID:SGTC_2024|Compound:5144227|FD-Score:3.21|P-value:1.23E-4 ID:SGTC_2064|Compound:5220758|FD-Score:4.18|P-value:1.17E-6 ID:SGTC_2237|Compound:6667747|FD-Score:2.84|P-value:5.53E-4 ID:SGTC_2246|Compound:7293507|FD-Score:2.77|P-value:7.07E-4 ID:SGTC_2329|Compound:6138490|FD-Score:5.52|P-value:3.15E-10 ID:SGTC_2403|Compound:6032726|FD-Score:-3.38|P-value:2.14E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.77|P-value:9.33E-6 ID:SGTC_2619|Compound:obliquin|FD-Score:3.34|P-value:7.14E-5 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:-3.14|P-value:5.62E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:4.96|P-value:1.20E-8 ID:SGTC_3210|Compound:9128157|FD-Score:-3.41|P-value:1.91E-4 ID:SGTC_3303|Compound:9125618|FD-Score:3.94|P-value:4.13E-6

Top fitness defect scores for YIL003W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_163 1327-0036 7.32 7.5 µM 1.82E-16 26 1.23E-13 0.04
2 SGTC_2329 6138490 5.52 200.0 µM 3.15E-10 3 1.72E-8 0.48
3 SGTC_2651 1327-0036 4.96 5.0 µM 1.20E-8 40 3.44E-7 0.29
4 SGTC_513 4245-1575 4.69 41.7 µM 6.53E-8 unfolded protein response 21 1.38E-6 0.23
5 SGTC_2064 5220758 4.18 200.0 µM 1.17E-6 4 1.47E-5 0.16
6 SGTC_1374 2889-5571 4.15 141.0 µM 1.33E-6 RSC complex & mRNA processing 38 1.63E-5 0.10
7 SGTC_214 4373-3496 3.94 70.0 µM 4.04E-6 18 4.08E-5 0.06
8 SGTC_3303 9125618 3.94 40.6 µM 4.13E-6 9 4.15E-5 0.02
9 SGTC_108 0509-0257 3.93 621.1 µM 4.27E-6 14 4.26E-5 0.10
10 SGTC_564 3555-0129 3.81 330.0 µM 7.69E-6 4 6.90E-5 0.16
11 SGTC_2582 agaric acid 3.77 100.0 µM 9.33E-6 redox potentiating 36 8.08E-5 0.16
12 SGTC_81 0411-0046 3.68 10.0 µM 1.47E-5 42 1.17E-4 0.01
13 SGTC_459 nigericin 3.51 15.3 µM 3.31E-5 13 2.28E-4 0.19
14 SGTC_309 k408-0051 3.36 1.5 µM 6.30E-5 40 3.85E-4 0.01
15 SGTC_1825 st052143 3.35 62.6 µM 6.55E-5 10 3.97E-4 0.04
16 SGTC_1271 0832-2808 3.34 169.0 µM 7.01E-5 15 4.20E-4 0.07
17 SGTC_2619 obliquin 3.34 87.9 µM 7.14E-5 cell wall 39 4.26E-4 0.01
18 SGTC_104 0074-0074 3.31 591.0 µM 7.97E-5 26 4.67E-4 0.04
19 SGTC_2024 5144227 3.21 134.0 µM 1.23E-4 12 6.67E-4 0.02
20 SGTC_979 1426-2828 3.19 121.0 µM 1.33E-4 7 7.10E-4 0.13

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.322 6.02E-82 YIR008C PRI1 het Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
0.315 2.62E-78 YJR013W GPI14 het Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M
0.313 4.69E-77 YJL019W MPS3 het Nuclear envelope protein required for SPB insertion; initiation of SPB duplication and nuclear fusion; acetylation of Mps3p by Eco1p regulates its role in nuclear organization; localizes to the SPB half bridge and at telomeres during meiosis; required with Ndj1p and Csm4p for meiotic bouquet formation and telomere-led rapid prophase movement; N-terminal acetylated by Eco1p
0.280 1.19E-61 YIR012W SQT1 het Protein involved in 60S ribosomal subunit assembly or modification; contains multiple WD repeats; interacts with Qsr1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress
0.259 1.66E-52 YFL037W TUB2 het Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria
0.240 2.35E-45 YJL005W CYR1 het Adenylate cyclase, required for cAMP production and cAMP-dependent protein kinase signaling; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation
0.232 2.30E-42 YIL019W FAF1 het Protein required for pre-rRNA processing and 40S ribosomal subunit assembly
0.226 3.06E-40 YIL022W TIM44 het Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); tethers the import motor and regulatory factors (PAM complex) to the translocation channel (Tim23p-Tim17p core complex)
0.214 4.52E-36 YIL129C TAO3 het Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with protein kinase Cbk1p and also with Kic1p
0.205 3.11E-33 YIL046W MET30 het F-box protein containing five copies of the WD40 motif, controls cell cycle function, sulfur metabolism, and methionine biosynthesis as part of the ubiquitin ligase complex; interacts with and regulates Met4p, localizes within the nucleus
0.203 2.01E-32 YIL031W ULP2 het Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins, plays a role in chromosome cohesion at centromeric regions and recovery from checkpoint arrest induced by DNA damage or DNA replication defects; potential Cdc28p substrate
0.201 6.64E-32 YJR139C HOM6 hom Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase), dimeric enzyme that catalyzes the third step in the common pathway for methionine and threonine biosynthesis; enzyme has nucleotide-binding, dimerization and catalytic regions
0.198 4.79E-31 YGR193C PDX1 hom Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogenase (PDH) complex, plays a structural role in the complex by binding and positioning E3 to the dihydrolipoamide acetyltransferase (E2) core
0.193 2.24E-29 YER052C HOM3 hom Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.175 1.30E-24 YDR381W YRA1 het RNA binding protein required for export of poly(A)+ mRNA from the nucleus; proposed to couple mRNA export with 3' end processing via its interactions with Mex67p and Pcf11p; functionally redundant with Yra2p, another REF family member