YIL009C-A / EST3

Component of the telomerase holoenzyme, involved in telomere replication

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL009C-A / EST3

Click on Significant Values for Screen Details ID:SGTC_69|Compound:0096-0274|FD-Score:5.53|P-value:7.10E-8 ID:SGTC_94|Compound:0334-0113|FD-Score:3.86|P-value:1.20E-4 ID:SGTC_174|Compound:3553-0389|FD-Score:4.66|P-value:4.64E-6 ID:SGTC_197|Compound:4544-0043|FD-Score:3.35|P-value:7.18E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:4.45|P-value:1.14E-5 ID:SGTC_666|Compound:0272-0154|FD-Score:3.86|P-value:1.17E-4 ID:SGTC_667|Compound:1498-1044|FD-Score:4.66|P-value:4.68E-6 ID:SGTC_875|Compound:0709-0210|FD-Score:-3.93|P-value:9.69E-5 ID:SGTC_952|Compound:1185-0122|FD-Score:4.11|P-value:4.51E-5 ID:SGTC_1255|Compound:0566-0045|FD-Score:-3.63|P-value:2.91E-4 ID:SGTC_1259|Compound:0671-0132|FD-Score:-3.40|P-value:6.24E-4 ID:SGTC_1265|Compound:0819-1001|FD-Score:5.71|P-value:2.75E-8 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:3.25|P-value:9.78E-4 ID:SGTC_1306|Compound:1185-0270|FD-Score:-3.41|P-value:6.08E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:3.31|P-value:8.18E-4 ID:SGTC_1469|Compound:k284-2957|FD-Score:3.47|P-value:4.84E-4 ID:SGTC_1479|Compound:0549-0158|FD-Score:4.78|P-value:2.74E-6 ID:SGTC_1489|Compound:4065-0444|FD-Score:3.60|P-value:3.08E-4 ID:SGTC_1497|Compound:4476-2978|FD-Score:3.35|P-value:7.09E-4 ID:SGTC_1501|Compound:4491-0275|FD-Score:-3.47|P-value:4.89E-4 ID:SGTC_1545|Compound:lovastatin|FD-Score:3.52|P-value:4.02E-4 ID:SGTC_1666|Compound:st014829|FD-Score:3.81|P-value:1.43E-4 ID:SGTC_1733|Compound:st037357|FD-Score:3.39|P-value:6.32E-4 ID:SGTC_1915|Compound:st067105|FD-Score:5.11|P-value:5.86E-7 ID:SGTC_2091|Compound:4-phenylthiadiazole|FD-Score:3.26|P-value:9.54E-4 ID:SGTC_2105|Compound:5350118|FD-Score:5.68|P-value:3.18E-8 ID:SGTC_2167|Compound:5876490|FD-Score:-3.42|P-value:5.81E-4 ID:SGTC_2288|Compound:7946289|FD-Score:-3.61|P-value:3.11E-4 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:3.50|P-value:4.28E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:-3.95|P-value:9.06E-5 ID:SGTC_2819|Compound:7996655|FD-Score:-4.17|P-value:3.80E-5 ID:SGTC_2911|Compound:7942208|FD-Score:3.29|P-value:8.75E-4 ID:SGTC_2945|Compound:9067681|FD-Score:7.63|P-value:2.02E-13 ID:SGTC_2950|Compound:9072895|FD-Score:5.09|P-value:6.52E-7 ID:SGTC_3052|Compound:9092717|FD-Score:3.34|P-value:7.27E-4 ID:SGTC_3094|Compound:9117742|FD-Score:3.71|P-value:2.10E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:5.53|P-value:7.10E-8 ID:SGTC_94|Compound:0334-0113|FD-Score:3.86|P-value:1.20E-4 ID:SGTC_174|Compound:3553-0389|FD-Score:4.66|P-value:4.64E-6 ID:SGTC_197|Compound:4544-0043|FD-Score:3.35|P-value:7.18E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:4.45|P-value:1.14E-5 ID:SGTC_666|Compound:0272-0154|FD-Score:3.86|P-value:1.17E-4 ID:SGTC_667|Compound:1498-1044|FD-Score:4.66|P-value:4.68E-6 ID:SGTC_875|Compound:0709-0210|FD-Score:-3.93|P-value:9.69E-5 ID:SGTC_952|Compound:1185-0122|FD-Score:4.11|P-value:4.51E-5 ID:SGTC_1255|Compound:0566-0045|FD-Score:-3.63|P-value:2.91E-4 ID:SGTC_1259|Compound:0671-0132|FD-Score:-3.40|P-value:6.24E-4 ID:SGTC_1265|Compound:0819-1001|FD-Score:5.71|P-value:2.75E-8 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:3.25|P-value:9.78E-4 ID:SGTC_1306|Compound:1185-0270|FD-Score:-3.41|P-value:6.08E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:3.31|P-value:8.18E-4 ID:SGTC_1469|Compound:k284-2957|FD-Score:3.47|P-value:4.84E-4 ID:SGTC_1479|Compound:0549-0158|FD-Score:4.78|P-value:2.74E-6 ID:SGTC_1489|Compound:4065-0444|FD-Score:3.60|P-value:3.08E-4 ID:SGTC_1497|Compound:4476-2978|FD-Score:3.35|P-value:7.09E-4 ID:SGTC_1501|Compound:4491-0275|FD-Score:-3.47|P-value:4.89E-4 ID:SGTC_1545|Compound:lovastatin|FD-Score:3.52|P-value:4.02E-4 ID:SGTC_1666|Compound:st014829|FD-Score:3.81|P-value:1.43E-4 ID:SGTC_1733|Compound:st037357|FD-Score:3.39|P-value:6.32E-4 ID:SGTC_1915|Compound:st067105|FD-Score:5.11|P-value:5.86E-7 ID:SGTC_2091|Compound:4-phenylthiadiazole|FD-Score:3.26|P-value:9.54E-4 ID:SGTC_2105|Compound:5350118|FD-Score:5.68|P-value:3.18E-8 ID:SGTC_2167|Compound:5876490|FD-Score:-3.42|P-value:5.81E-4 ID:SGTC_2288|Compound:7946289|FD-Score:-3.61|P-value:3.11E-4 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:3.50|P-value:4.28E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:-3.95|P-value:9.06E-5 ID:SGTC_2819|Compound:7996655|FD-Score:-4.17|P-value:3.80E-5 ID:SGTC_2911|Compound:7942208|FD-Score:3.29|P-value:8.75E-4 ID:SGTC_2945|Compound:9067681|FD-Score:7.63|P-value:2.02E-13 ID:SGTC_2950|Compound:9072895|FD-Score:5.09|P-value:6.52E-7 ID:SGTC_3052|Compound:9092717|FD-Score:3.34|P-value:7.27E-4 ID:SGTC_3094|Compound:9117742|FD-Score:3.71|P-value:2.10E-4

Top fitness defect scores for YIL009C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_2945 9067681 7.63 61.8 µM 2.02E-13 1 1.21E-14
2 SGTC_1265 0819-1001 5.71 68.8 µM 2.75E-8 3 5.59E-9
3 SGTC_2105 5350118 5.68 200.0 µM 3.18E-8 7 6.58E-9
4 SGTC_69 0096-0274 5.53 206.7 µM 7.10E-8 mitochondrial processes 12 1.59E-8
5 SGTC_1915 st067105 5.11 30.6 µM 5.86E-7 RNA pol III & RNase P/MRP 17 1.63E-7
6 SGTC_2950 9072895 5.09 21.5 µM 6.52E-7 14 1.84E-7
7 SGTC_1479 0549-0158 4.78 134.0 µM 2.74E-6 10 8.92E-7
8 SGTC_174 3553-0389 4.66 74.3 µM 4.64E-6 10 1.59E-6
9 SGTC_667 1498-1044 4.66 59.0 µM 4.68E-6 RPP1 & pyrimidine depletion 8 1.61E-6
10 SGTC_525 k781-2675 4.45 26.7 µM 1.14E-5 redox potentiating 38 4.27E-6
11 SGTC_952 1185-0122 4.11 232.0 µM 4.51E-5 16 1.95E-5
12 SGTC_666 0272-0154 3.86 136.0 µM 1.17E-4 cell wall 59 5.57E-5
13 SGTC_94 0334-0113 3.86 514.8 µM 1.20E-4 25 5.72E-5
14 SGTC_1666 st014829 3.81 29.0 µM 1.43E-4 calcium & mitochondrial duress 30 6.95E-5
15 SGTC_3094 9117742 3.71 49.5 µM 2.10E-4 28 1.06E-4
16 SGTC_1489 4065-0444 3.60 182.0 µM 3.08E-4 29 1.61E-4
17 SGTC_1545 lovastatin 3.52 49.4 µM 4.02E-4 38 2.16E-4
18 SGTC_2529 gangaleoidin 3.50 93.6 µM 4.28E-4 29 2.31E-4
19 SGTC_1469 k284-2957 3.47 126.0 µM 4.84E-4 21 2.65E-4
20 SGTC_1733 st037357 3.39 54.9 µM 6.32E-4 60S ribosome export 62 3.55E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.110 1.69E-10 YNL152W INN1 het Essential protein that associates with contractile actomyosin ring; required for ingression of the plasma membrane into the bud neck during cytokinesis; C2 domain, a membrane targeting module, is required for function; activates chitin synthase activity of Chs2p during cytokinesis
0.094 4.40E-8 YNR057C BIO4 hom Dethiobiotin synthetase, catalyzes the third step in the biotin biosynthesis pathway; BIO4 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis; expression appears to be repressed at low iron levels
0.093 6.51E-8 YDR225W HTA1 hom Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical subtypes (see also HTA2); DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p
0.085 8.19E-7 YLR386W VAC14 hom Protein involved in regulated synthesis of PtdIns(3,5)P(2), in control of trafficking of some proteins to the vacuole lumen via the MVB, and in maintenance of vacuole size and acidity; interacts with Fig4p; activator of Fab1p
0.083 1.58E-6 YBR271W EFM2 hom S-adenosylmethionine-dependent methyltransferase; methylates translation elongation factors EF2 (Eft1p and Eft2p) and EF3A (Yef3p); belongs to the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; predicted to be involved in ribosome biogenesis
0.082 2.01E-6 YGR232W NAS6 hom Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); ortholog of human oncoprotein gankyrin, which interacts with the Rb tumor suppressor and CDK4/6
0.081 2.82E-6 YER049W TPA1 hom Poly(rA)-binding protein involved in translation termination efficiency, mRNA poly(A) tail length and mRNA stability; interacts with Sup45p (eRF1), Sup35p (eRF3) and Pab1p; similar to prolyl 4-hydroxylases; binds Fe(III) and 2-oxoglutarate
0.076 1.13E-5 YJR093C FIP1 het Subunit of cleavage polyadenylation factor (CPF), interacts directly with poly(A) polymerase (Pap1p) to regulate its activity; bridging factor that links Pap1p and the CPF complex via Yth1p
0.076 1.19E-5 YJL170C ASG7 hom Protein that regulates signaling from a G protein beta subunit Ste4p and its relocalization within the cell; specific to a-cells and induced by alpha-factor
0.074 1.79E-5 YPR020W ATP20 hom Subunit g of the mitochondrial F1F0 ATP synthase; reversibly phosphorylated on two residues; unphosphorylated form is required for dimerization of the ATP synthase complex
0.074 1.93E-5 YKL103C APE1 hom Vacuolar aminopeptidase yscI; zinc metalloproteinase that belongs to the peptidase family M18; often used as a marker protein in studies of autophagy and cytosol to vacuole targeting (CVT) pathway; protein increases in abundance and relative distribution to cytoplasmic foci increases upon DNA replication stress
0.072 2.84E-5 YPL243W SRP68 het Core component of the signal recognition particle (SRP) complex; SRP complex functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress
0.072 3.19E-5 YOL013W-A_p YOL013W-A_p hom Putative protein of unknown function; identified by SAGE
0.069 7.01E-5 YDL152W_d YDL152W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SAS10/YDL153C, a component of the small ribosomal subunit processosome
0.069 7.09E-5 YBR087W RFC5 het Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon