YIL009W / FAA3

Long chain fatty acyl-CoA synthetase, activates imported fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL009W / FAA3

Click on Significant Values for Screen Details ID:SGTC_4|Compound:0960-0234|FD-Score:3.36|P-value:5.44E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:-6.66|P-value:8.88E-11 ID:SGTC_205|Compound:1486-1330|FD-Score:3.36|P-value:5.36E-4 ID:SGTC_247|Compound:mechlorethamine|FD-Score:3.70|P-value:1.61E-4 ID:SGTC_380|Compound:3970-0968|FD-Score:3.86|P-value:8.86E-5 ID:SGTC_425|Compound:3825-7017|FD-Score:4.05|P-value:4.24E-5 ID:SGTC_520|Compound:3584-0023|FD-Score:-4.24|P-value:2.59E-5 ID:SGTC_525|Compound:k781-2675|FD-Score:5.10|P-value:3.84E-7 ID:SGTC_613|Compound:3914-0030|FD-Score:-3.29|P-value:8.53E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:3.33|P-value:5.93E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:-13.50|P-value:7.91E-39 ID:SGTC_829|Compound:1635-0120|FD-Score:3.91|P-value:7.23E-5 ID:SGTC_888|Compound:0916-0002|FD-Score:3.21|P-value:9.03E-4 ID:SGTC_889|Compound:0919-1524|FD-Score:4.94|P-value:8.54E-7 ID:SGTC_911|Compound:3456-4043|FD-Score:3.53|P-value:3.03E-4 ID:SGTC_1018|Compound:4259-0013|FD-Score:3.60|P-value:2.33E-4 ID:SGTC_1166|Compound:k206-0078|FD-Score:3.71|P-value:1.54E-4 ID:SGTC_1264|Compound:0783-0040|FD-Score:-3.25|P-value:9.95E-4 ID:SGTC_1366|Compound:1683-0113|FD-Score:3.18|P-value:9.82E-4 ID:SGTC_1409|Compound:3909-8004|FD-Score:4.23|P-value:2.00E-5 ID:SGTC_1570|Compound:verbenone|FD-Score:3.75|P-value:1.36E-4 ID:SGTC_1590|Compound:st077108|FD-Score:4.83|P-value:1.39E-6 ID:SGTC_1668|Compound:st014914|FD-Score:3.30|P-value:6.65E-4 ID:SGTC_1714|Compound:st033236|FD-Score:3.62|P-value:2.14E-4 ID:SGTC_1735|Compound:st034310|FD-Score:3.68|P-value:1.73E-4 ID:SGTC_1770|Compound:st043884|FD-Score:4.50|P-value:6.36E-6 ID:SGTC_1862|Compound:st057513|FD-Score:3.91|P-value:7.36E-5 ID:SGTC_1875|Compound:nocodazole|FD-Score:3.18|P-value:9.85E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:3.40|P-value:4.68E-4 ID:SGTC_2008|Compound:4012253|FD-Score:4.24|P-value:1.91E-5 ID:SGTC_2090|Compound:5301565|FD-Score:-4.00|P-value:6.71E-5 ID:SGTC_2128|Compound:5255449|FD-Score:4.29|P-value:1.59E-5 ID:SGTC_2620|Compound:irigenin|FD-Score:3.32|P-value:6.15E-4 ID:SGTC_2624|Compound:nerol|FD-Score:-5.65|P-value:3.20E-8 ID:SGTC_2783|Compound:7738165|FD-Score:3.64|P-value:2.04E-4 ID:SGTC_2816|Compound:7982706|FD-Score:-3.46|P-value:4.86E-4 ID:SGTC_2839|Compound:9003951|FD-Score:6.50|P-value:1.54E-10 ID:SGTC_2843|Compound:9000894|FD-Score:4.72|P-value:2.36E-6 ID:SGTC_2941|Compound:9056145|FD-Score:3.77|P-value:1.25E-4 ID:SGTC_2945|Compound:9067681|FD-Score:-3.42|P-value:5.52E-4 ID:SGTC_2947|Compound:9072639|FD-Score:-4.23|P-value:2.73E-5 ID:SGTC_2993|Compound:9054257|FD-Score:3.74|P-value:1.39E-4 ID:SGTC_3332|Compound:9141069|FD-Score:3.63|P-value:2.12E-4 ID:SGTC_4|Compound:0960-0234|FD-Score:3.36|P-value:5.44E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:-6.66|P-value:8.88E-11 ID:SGTC_205|Compound:1486-1330|FD-Score:3.36|P-value:5.36E-4 ID:SGTC_247|Compound:mechlorethamine|FD-Score:3.70|P-value:1.61E-4 ID:SGTC_380|Compound:3970-0968|FD-Score:3.86|P-value:8.86E-5 ID:SGTC_425|Compound:3825-7017|FD-Score:4.05|P-value:4.24E-5 ID:SGTC_520|Compound:3584-0023|FD-Score:-4.24|P-value:2.59E-5 ID:SGTC_525|Compound:k781-2675|FD-Score:5.10|P-value:3.84E-7 ID:SGTC_613|Compound:3914-0030|FD-Score:-3.29|P-value:8.53E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:3.33|P-value:5.93E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:-13.50|P-value:7.91E-39 ID:SGTC_829|Compound:1635-0120|FD-Score:3.91|P-value:7.23E-5 ID:SGTC_888|Compound:0916-0002|FD-Score:3.21|P-value:9.03E-4 ID:SGTC_889|Compound:0919-1524|FD-Score:4.94|P-value:8.54E-7 ID:SGTC_911|Compound:3456-4043|FD-Score:3.53|P-value:3.03E-4 ID:SGTC_1018|Compound:4259-0013|FD-Score:3.60|P-value:2.33E-4 ID:SGTC_1166|Compound:k206-0078|FD-Score:3.71|P-value:1.54E-4 ID:SGTC_1264|Compound:0783-0040|FD-Score:-3.25|P-value:9.95E-4 ID:SGTC_1366|Compound:1683-0113|FD-Score:3.18|P-value:9.82E-4 ID:SGTC_1409|Compound:3909-8004|FD-Score:4.23|P-value:2.00E-5 ID:SGTC_1570|Compound:verbenone|FD-Score:3.75|P-value:1.36E-4 ID:SGTC_1590|Compound:st077108|FD-Score:4.83|P-value:1.39E-6 ID:SGTC_1668|Compound:st014914|FD-Score:3.30|P-value:6.65E-4 ID:SGTC_1714|Compound:st033236|FD-Score:3.62|P-value:2.14E-4 ID:SGTC_1735|Compound:st034310|FD-Score:3.68|P-value:1.73E-4 ID:SGTC_1770|Compound:st043884|FD-Score:4.50|P-value:6.36E-6 ID:SGTC_1862|Compound:st057513|FD-Score:3.91|P-value:7.36E-5 ID:SGTC_1875|Compound:nocodazole|FD-Score:3.18|P-value:9.85E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:3.40|P-value:4.68E-4 ID:SGTC_2008|Compound:4012253|FD-Score:4.24|P-value:1.91E-5 ID:SGTC_2090|Compound:5301565|FD-Score:-4.00|P-value:6.71E-5 ID:SGTC_2128|Compound:5255449|FD-Score:4.29|P-value:1.59E-5 ID:SGTC_2620|Compound:irigenin|FD-Score:3.32|P-value:6.15E-4 ID:SGTC_2624|Compound:nerol|FD-Score:-5.65|P-value:3.20E-8 ID:SGTC_2783|Compound:7738165|FD-Score:3.64|P-value:2.04E-4 ID:SGTC_2816|Compound:7982706|FD-Score:-3.46|P-value:4.86E-4 ID:SGTC_2839|Compound:9003951|FD-Score:6.50|P-value:1.54E-10 ID:SGTC_2843|Compound:9000894|FD-Score:4.72|P-value:2.36E-6 ID:SGTC_2941|Compound:9056145|FD-Score:3.77|P-value:1.25E-4 ID:SGTC_2945|Compound:9067681|FD-Score:-3.42|P-value:5.52E-4 ID:SGTC_2947|Compound:9072639|FD-Score:-4.23|P-value:2.73E-5 ID:SGTC_2993|Compound:9054257|FD-Score:3.74|P-value:1.39E-4 ID:SGTC_3332|Compound:9141069|FD-Score:3.63|P-value:2.12E-4

Top fitness defect scores for YIL009W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2839 9003951 6.50 26.0 µM 1.54E-10 2 3.93E-11
2 SGTC_525 k781-2675 5.10 26.7 µM 3.84E-7 redox potentiating 31 1.71E-7
3 SGTC_889 0919-1524 4.94 82.7 µM 8.54E-7 5 4.01E-7
4 SGTC_1590 st077108 4.83 57.8 µM 1.39E-6 2 6.76E-7
5 SGTC_2843 9000894 4.72 45.5 µM 2.36E-6 3 1.19E-6
6 SGTC_1770 st043884 4.50 66.3 µM 6.36E-6 8 3.42E-6
7 SGTC_2128 5255449 4.29 168.5 µM 1.59E-5 27 9.10E-6
8 SGTC_2008 4012253 4.24 172.0 µM 1.91E-5 18 1.11E-5
9 SGTC_1409 3909-8004 4.23 61.9 µM 2.00E-5 11 1.16E-5
10 SGTC_425 3825-7017 4.05 13.1 µM 4.24E-5 17 2.59E-5
11 SGTC_829 1635-0120 3.91 117.0 µM 7.23E-5 DNA damage response 42 4.57E-5
12 SGTC_1862 st057513 3.91 3.8 µM 7.36E-5 13 4.67E-5
13 SGTC_380 3970-0968 3.86 6.0 µM 8.86E-5 14 5.69E-5
14 SGTC_2941 9056145 3.77 11.2 µM 1.25E-4 22 8.22E-5
15 SGTC_1570 verbenone 3.75 133.0 µM 1.36E-4 21 9.00E-5
16 SGTC_2993 9054257 3.74 71.4 µM 1.39E-4 fatty acid desaturase (OLE1) 52 9.21E-5
17 SGTC_1166 k206-0078 3.71 225.0 µM 1.54E-4 25 1.02E-4
18 SGTC_247 mechlorethamine 3.70 29.7 µM 1.61E-4 DNA damage response 19 1.07E-4
19 SGTC_1735 st034310 3.68 56.8 µM 1.73E-4 Golgi 38 1.16E-4
20 SGTC_2783 7738165 3.64 71.4 µM 2.04E-4 39 1.38E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.316 1.11E-78 YHL045W_d YHL045W_d hom Putative protein of unknown function; not an essential gene
0.294 9.31E-68 YDL155W CLB3 hom B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation; relative distribution to the nucleus increases upon DNA replication stress
0.289 1.99E-65 YPL246C RBD2 hom Possible rhomboid protease, has similarity to eukaryotic rhomboid proteases including Pcp1p
0.285 8.58E-64 YML029W USA1 hom Scaffold subunit of the Hrd1p ubiquitin ligase that also promotes ligase oligomerization; involved in ER-associated protein degradation (ERAD); interacts with the U1 snRNP-specific protein, Snp1p
0.254 1.08E-50 YOR271C_p FSF1_p hom Putative protein, predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis
0.238 2.68E-44 YLR040C_p YLR040C_p hom Protein of unknown function; localizes to the cell wall; predicted to be a GPI-attached protein; upregulated by Mcm1p-Alpha1p transcription factor; partially overlaps the dubious ORF YLR041W; mRNA identified as translated by ribosome profiling data; YLR040C is not essential
0.234 5.38E-43 YLR317W_d YLR317W_d het Dubious open reading frame; may be part of a bicistronic transcript with NKP2/YLR315W; overlaps the verified ORF TAD3/YLR316C
0.228 6.72E-41 YGL114W_p YGL114W_p hom Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters
0.225 1.09E-39 YML025C YML6 het Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins
0.224 1.69E-39 YGL090W LIF1 hom Component of the DNA ligase IV complex that mediates nonhomologous end joining in DNA double-strand break repair; physically interacts with Dnl4p and Nej1p; homologous to mammalian XRCC4 protein
0.222 7.67E-39 YNL123W NMA111 hom Serine protease and general molecular chaperone; involved in response to heat stress and promotion of apoptosis; may contribute to lipid homeostasis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteases
0.206 1.73E-33 YDL022W GPD1 hom NAD-dependent glycerol-3-phosphate dehydrogenase; key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; homolog of Gpd2p; protein abundance increases in response to DNA replication stress; constitutively inactivated via phosphorylation by the protein kinases YPK1 and YPK2, dephosphorylation increases catalytic activity
0.196 2.45E-30 YLR034C SMF3 hom Putative divalent metal ion transporter involved in iron homeostasis; transcriptionally regulated by metal ions; member of the Nramp family of metal transport proteins; protein abundance increases in response to DNA replication stress
0.188 6.44E-28 YPL113C_p YPL113C_p hom Glyoxylate reductase; acts on glyoxylate and hydroxypyruvate substrates; YPL113C is not an essential gene
0.186 1.59E-27 YCR015C_p YCR015C_p hom Putative protein of unknown function; YCR015C is not an essential gene