YIL010W / DOT5

Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL010W / DOT5

Click on Significant Values for Screen Details ID:SGTC_65|Compound:0798-0905|FD-Score:5.86|P-value:5.83E-11 ID:SGTC_67|Compound:0335-0847|FD-Score:3.01|P-value:4.30E-4 ID:SGTC_144|Compound:4161-2749|FD-Score:-3.52|P-value:7.28E-5 ID:SGTC_145|Compound:3737-0113|FD-Score:-4.04|P-value:6.56E-6 ID:SGTC_306|Compound:1672-3436|FD-Score:-2.93|P-value:8.19E-4 ID:SGTC_394|Compound:menadione|FD-Score:2.89|P-value:6.81E-4 ID:SGTC_681|Compound:1642-0006|FD-Score:-3.04|P-value:5.36E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:3.05|P-value:3.64E-4 ID:SGTC_865|Compound:0488-0499|FD-Score:2.88|P-value:7.01E-4 ID:SGTC_959|Compound:1222-0044|FD-Score:3.12|P-value:2.80E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:-3.04|P-value:5.47E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-6.82|P-value:7.09E-14 ID:SGTC_1463|Compound:k081-0032|FD-Score:-5.19|P-value:9.40E-9 ID:SGTC_1717|Compound:st033143|FD-Score:5.44|P-value:1.07E-9 ID:SGTC_1997|Compound:st073024|FD-Score:3.08|P-value:3.19E-4 ID:SGTC_2125|Compound:5246583|FD-Score:3.28|P-value:1.40E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:2.79|P-value:9.79E-4 ID:SGTC_2293|Compound:7624732|FD-Score:-3.01|P-value:6.01E-4 ID:SGTC_2367|Compound:9070478|FD-Score:-3.07|P-value:4.79E-4 ID:SGTC_2430|Compound:5571206|FD-Score:2.99|P-value:4.64E-4 ID:SGTC_2487|Compound:5918373|FD-Score:2.94|P-value:5.61E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:3.32|P-value:1.19E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:-3.07|P-value:4.72E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:-8.65|P-value:2.72E-21 ID:SGTC_2802|Compound:7925815|FD-Score:-3.60|P-value:5.20E-5 ID:SGTC_2806|Compound:7952793|FD-Score:-3.97|P-value:9.01E-6 ID:SGTC_2815|Compound:7968870|FD-Score:-2.94|P-value:7.95E-4 ID:SGTC_2966|Compound:9084041|FD-Score:-4.22|P-value:2.54E-6 ID:SGTC_2979|Compound:9012552|FD-Score:-4.46|P-value:7.17E-7 ID:SGTC_2984|Compound:9022109|FD-Score:-3.29|P-value:1.94E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:5.86|P-value:5.83E-11 ID:SGTC_67|Compound:0335-0847|FD-Score:3.01|P-value:4.30E-4 ID:SGTC_144|Compound:4161-2749|FD-Score:-3.52|P-value:7.28E-5 ID:SGTC_145|Compound:3737-0113|FD-Score:-4.04|P-value:6.56E-6 ID:SGTC_306|Compound:1672-3436|FD-Score:-2.93|P-value:8.19E-4 ID:SGTC_394|Compound:menadione|FD-Score:2.89|P-value:6.81E-4 ID:SGTC_681|Compound:1642-0006|FD-Score:-3.04|P-value:5.36E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:3.05|P-value:3.64E-4 ID:SGTC_865|Compound:0488-0499|FD-Score:2.88|P-value:7.01E-4 ID:SGTC_959|Compound:1222-0044|FD-Score:3.12|P-value:2.80E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:-3.04|P-value:5.47E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-6.82|P-value:7.09E-14 ID:SGTC_1463|Compound:k081-0032|FD-Score:-5.19|P-value:9.40E-9 ID:SGTC_1717|Compound:st033143|FD-Score:5.44|P-value:1.07E-9 ID:SGTC_1997|Compound:st073024|FD-Score:3.08|P-value:3.19E-4 ID:SGTC_2125|Compound:5246583|FD-Score:3.28|P-value:1.40E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:2.79|P-value:9.79E-4 ID:SGTC_2293|Compound:7624732|FD-Score:-3.01|P-value:6.01E-4 ID:SGTC_2367|Compound:9070478|FD-Score:-3.07|P-value:4.79E-4 ID:SGTC_2430|Compound:5571206|FD-Score:2.99|P-value:4.64E-4 ID:SGTC_2487|Compound:5918373|FD-Score:2.94|P-value:5.61E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:3.32|P-value:1.19E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:-3.07|P-value:4.72E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:-8.65|P-value:2.72E-21 ID:SGTC_2802|Compound:7925815|FD-Score:-3.60|P-value:5.20E-5 ID:SGTC_2806|Compound:7952793|FD-Score:-3.97|P-value:9.01E-6 ID:SGTC_2815|Compound:7968870|FD-Score:-2.94|P-value:7.95E-4 ID:SGTC_2966|Compound:9084041|FD-Score:-4.22|P-value:2.54E-6 ID:SGTC_2979|Compound:9012552|FD-Score:-4.46|P-value:7.17E-7 ID:SGTC_2984|Compound:9022109|FD-Score:-3.29|P-value:1.94E-4

Top fitness defect scores for YIL010W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_65 0798-0905 5.86 35.0 µM 5.83E-11 calcium & mitochondrial duress 33 2.35E-9
2 SGTC_1717 st033143 5.44 58.0 µM 1.07E-9 18 2.67E-8
3 SGTC_2605 digitonin 3.32 300.0 nM 1.19E-4 57 4.49E-4
4 SGTC_2125 5246583 3.28 200.0 µM 1.40E-4 tubulin folding & SWR complex 78 5.14E-4
5 SGTC_959 1222-0044 3.12 107.0 µM 2.80E-4 54 9.18E-4
6 SGTC_1997 st073024 3.08 93.8 µM 3.19E-4 31 0.00102
7 SGTC_758 0868-0029 3.05 16.0 µM 3.64E-4 31 0.00114
8 SGTC_67 0335-0847 3.01 266.0 µM 4.30E-4 ubiquinone biosynthesis & proteasome 182 0.00132
9 SGTC_2430 5571206 2.99 200.0 µM 4.64E-4 103 0.00140
10 SGTC_2487 5918373 2.94 44.0 µM 5.61E-4 59 0.00164
11 SGTC_394 menadione 2.89 8.3 µM 6.81E-4 superoxide 75 0.00194
12 SGTC_865 0488-0499 2.88 301.0 µM 7.01E-4 55 0.00198
13 SGTC_2130 NSC 7 2.79 2.5 µM 9.79E-4 copper-dependent oxidative stress 113 0.00262
14 SGTC_1379 2144-0755 2.78 36.5 µM 0.00103 90 0.00273
15 SGTC_1642 st009582 2.74 77.7 µM 0.00120 RPP1 & pyrimidine depletion 75 0.00311
16 SGTC_1579 chlormadinone acetate 2.64 49.4 µM 0.00171 74 0.00419
17 SGTC_1798 st045719 2.60 61.0 µM 0.00193 68 0.00464
18 SGTC_883 0850-0245 2.59 24.6 µM 0.00199 cell wall 113 0.00476
19 SGTC_2918 7977171 2.59 22.1 µM 0.00201 96 0.00480
20 SGTC_907 3448-6986 2.58 75.5 µM 0.00206 120 0.00490

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.365 5.10E-106 YKL166C TPK3 hom cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk2p; localizes to P-bodies during stationary phase; TPK3 has a paralog, TPK1, that arose from the whole genome duplication
0.340 1.52E-91 YDR133C_d YDR133C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR134C
0.334 4.78E-88 YJR146W_p YJR146W_p hom Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps HMS2
0.316 1.57E-78 YDR312W SSF2 hom Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication
0.313 5.60E-77 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.296 1.07E-68 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.291 1.09E-66 YGR136W LSB1 hom Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein increases in abundance and forms nuclear foci in response to DNA replication stress
0.291 3.26E-66 YDL222C FMP45 hom Integral membrane protein localized to mitochondria (untagged protein); required for sporulation and maintaining sphingolipid content; has sequence similarity to SUR7 and YNL194C
0.286 9.09E-64 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.282 3.15E-62 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.280 1.71E-61 YDL176W YDL176W hom Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.278 1.15E-60 YLR179C YLR179C hom Protein of unknown function with similarity to Tfs1p; transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus
0.270 2.61E-57 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.260 3.81E-53 YDL157C_p YDL157C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.255 5.69E-51 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W