HIPHOP chemogenomics database
YIL013C / PDR11 
ATP-binding cassette (ABC) transporter, multidrug transporter involved in multiple drug resistance; mediates sterol uptake when sterol biosynthesis is compromised; regulated by Pdr1p; required for anaerobic growth
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YIL013C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.123 | 9.04E-13 | YLR351C | NIT3 | hom | Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member |
| 0.085 | 9.34E-7 | YML070W | DAK1 | hom | Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation |
| 0.082 | 1.97E-6 | YDR104C | SPO71 | hom | Meiosis-specific protein of unknown function, required for spore wall formation during sporulation, in particular for the proper size of the prospore membrane (PSM); interacts with SPO1; dispensable for both nuclear divisions during meiosis; contains two PH domains |
| 0.081 | 2.99E-6 | YEL068C_p | YEL068C_p | hom | Protein of unknown function; expressed at both mRNA and protein levels |
| 0.080 | 3.45E-6 | YDR282C_p | YDR282C_p | hom | Putative protein of unknown function; localizes to the inner mitochondrial membrane with the C terminus facing the intermembrane space; ortholog of human RMND1, mutation in which is implicated in infantile encephaloneuromyopathy and defective mitochondrial translation |
| 0.079 | 4.83E-6 | YKL091C | YKL091C | hom | Putative homolog of Sec14p, which is a phosphatidylinositol/phosphatidylcholine transfer protein involved in lipid metabolism; localizes to the nucleus; contains a CRAL/TRIO domain and binds several lipids in a large-scale study |
| 0.079 | 4.86E-6 | YMR194C-A_d | YMR194C-A_d | hom | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
| 0.078 | 6.73E-6 | YGR103W | NOP7 | het | Component of several different pre-ribosomal particles; forms a complex with Ytm1p and Erb1p that is required for maturation of the large ribosomal subunit; required for exit from G0 and the initiation of cell proliferation |
| 0.077 | 7.72E-6 | YPL085W | SEC16 | het | COPII vesicle coat protein required for ER transport vesicle budding; Sec16p is bound to the periphery of ER membranes and may act to stabilize initial COPII complexes; interacts with Sec23p, Sec24p and Sec31p |
| 0.077 | 8.03E-6 | YAL016C-B_d | YAL016C-B_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
| 0.075 | 1.49E-5 | YDR301W | CFT1 | het | RNA-binding subunit of the mRNA cleavage and polyadenylation factor; involved in poly(A) site recognition and required for both pre-mRNA cleavage and polyadenylation, 51% sequence similarity with mammalian AAUAA-binding subunit of CPSF |
| 0.074 | 1.73E-5 | YNL254C | RTC4 | hom | Protein of unknown function; null mutation suppresses cdc13-1 temperature sensitivity; (GFP)-fusion protein localizes to both the cytoplasm and the nucleus |
| 0.074 | 1.98E-5 | YOL031C | SIL1 | hom | Nucleotide exchange factor for the endoplasmic reticulum (ER) lumenal Hsp70 chaperone Kar2p, required for protein translocation into the ER; homolog of Yarrowia lipolytica SLS1; GrpE-like protein |
| 0.071 | 3.73E-5 | YOR310C | NOP58 | het | Protein involved in pre-rRNA processing, 18S rRNA synthesis, and snoRNA synthesis; component of the small subunit processome complex, which is required for processing of pre-18S rRNA |
| 0.070 | 5.44E-5 | YLR356W | ATG33 | hom | Mitochondrial mitophagy-specific protein; required primarily for mitophagy induced at the post-log phase; not required for other types of selective autophagy or macroautophagy; conserved within fungi, but not in higher eukaryotes |