YIL013C / PDR11

ATP-binding cassette (ABC) transporter, multidrug transporter involved in multiple drug resistance; mediates sterol uptake when sterol biosynthesis is compromised; regulated by Pdr1p; required for anaerobic growth

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL013C / PDR11

Click on Significant Values for Screen Details ID:SGTC_9|Compound:0092-0002|FD-Score:3.23|P-value:6.95E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:-4.01|P-value:3.40E-5 ID:SGTC_301|Compound:4119-0100|FD-Score:3.90|P-value:5.63E-5 ID:SGTC_418|Compound:lividomycin a|FD-Score:-3.31|P-value:4.90E-4 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:3.52|P-value:2.50E-4 ID:SGTC_744|Compound:1594-0068|FD-Score:3.32|P-value:5.09E-4 ID:SGTC_792|Compound:4534-1957|FD-Score:-4.18|P-value:1.64E-5 ID:SGTC_913|Compound:3487-1245|FD-Score:4.28|P-value:1.11E-5 ID:SGTC_981|Compound:1488-1094|FD-Score:4.04|P-value:3.15E-5 ID:SGTC_988|Compound:1497-1057|FD-Score:3.69|P-value:1.28E-4 ID:SGTC_993|Compound:3909-8757|FD-Score:3.85|P-value:6.88E-5 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:3.44|P-value:3.31E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:3.84|P-value:7.11E-5 ID:SGTC_1354|Compound:1498-1681|FD-Score:4.94|P-value:5.07E-7 ID:SGTC_1359|Compound:1582-0056|FD-Score:4.15|P-value:2.02E-5 ID:SGTC_1362|Compound:1611-0397|FD-Score:4.50|P-value:4.14E-6 ID:SGTC_1368|Compound:1852-0141|FD-Score:4.25|P-value:1.26E-5 ID:SGTC_1674|Compound:st016616|FD-Score:3.43|P-value:3.40E-4 ID:SGTC_1748|Compound:st037455|FD-Score:4.27|P-value:1.18E-5 ID:SGTC_1833|Compound:st055984|FD-Score:3.35|P-value:4.62E-4 ID:SGTC_1991|Compound:st073000|FD-Score:3.21|P-value:7.58E-4 ID:SGTC_2050|Compound:5263056|FD-Score:3.30|P-value:5.54E-4 ID:SGTC_2074|Compound:5212007|FD-Score:3.86|P-value:6.56E-5 ID:SGTC_2083|Compound:5306046|FD-Score:4.09|P-value:2.61E-5 ID:SGTC_2128|Compound:5255449|FD-Score:4.40|P-value:6.61E-6 ID:SGTC_2281|Compound:7943571|FD-Score:3.22|P-value:7.32E-4 ID:SGTC_2288|Compound:7946289|FD-Score:3.16|P-value:8.83E-4 ID:SGTC_2292|Compound:7671323|FD-Score:-3.95|P-value:4.31E-5 ID:SGTC_2334|Compound:9017922|FD-Score:-3.18|P-value:7.79E-4 ID:SGTC_2341|Compound:7987486|FD-Score:3.75|P-value:1.05E-4 ID:SGTC_2373|Compound:9071805|FD-Score:4.37|P-value:7.40E-6 ID:SGTC_2377|Compound:9073351|FD-Score:3.29|P-value:5.67E-4 ID:SGTC_2385|Compound:9074692|FD-Score:5.01|P-value:3.44E-7 ID:SGTC_2432|Compound:5630864|FD-Score:4.55|P-value:3.23E-6 ID:SGTC_2601|Compound:securinine|FD-Score:3.66|P-value:1.43E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:-3.23|P-value:6.53E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:-3.36|P-value:4.14E-4 ID:SGTC_2799|Compound:7812892|FD-Score:6.61|P-value:2.87E-11 ID:SGTC_2821|Compound:7996764|FD-Score:-3.12|P-value:9.55E-4 ID:SGTC_2822|Compound:7994718|FD-Score:3.35|P-value:4.56E-4 ID:SGTC_2823|Compound:7987624|FD-Score:6.58|P-value:3.49E-11 ID:SGTC_2824|Compound:7998404|FD-Score:-3.13|P-value:9.06E-4 ID:SGTC_2837|Compound:9008476|FD-Score:3.57|P-value:2.05E-4 ID:SGTC_2865|Compound:9030313|FD-Score:3.57|P-value:2.06E-4 ID:SGTC_2871|Compound:9038510|FD-Score:3.78|P-value:9.17E-5 ID:SGTC_2902|Compound:5787006|FD-Score:-3.28|P-value:5.53E-4 ID:SGTC_2919|Compound:7978188|FD-Score:4.35|P-value:8.22E-6 ID:SGTC_3065|Compound:9113888|FD-Score:3.84|P-value:7.14E-5 ID:SGTC_3272|Compound:9137413|FD-Score:3.75|P-value:1.01E-4 ID:SGTC_3284|Compound:9108171|FD-Score:-4.24|P-value:1.23E-5 ID:SGTC_9|Compound:0092-0002|FD-Score:3.23|P-value:6.95E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:-4.01|P-value:3.40E-5 ID:SGTC_301|Compound:4119-0100|FD-Score:3.90|P-value:5.63E-5 ID:SGTC_418|Compound:lividomycin a|FD-Score:-3.31|P-value:4.90E-4 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:3.52|P-value:2.50E-4 ID:SGTC_744|Compound:1594-0068|FD-Score:3.32|P-value:5.09E-4 ID:SGTC_792|Compound:4534-1957|FD-Score:-4.18|P-value:1.64E-5 ID:SGTC_913|Compound:3487-1245|FD-Score:4.28|P-value:1.11E-5 ID:SGTC_981|Compound:1488-1094|FD-Score:4.04|P-value:3.15E-5 ID:SGTC_988|Compound:1497-1057|FD-Score:3.69|P-value:1.28E-4 ID:SGTC_993|Compound:3909-8757|FD-Score:3.85|P-value:6.88E-5 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:3.44|P-value:3.31E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:3.84|P-value:7.11E-5 ID:SGTC_1354|Compound:1498-1681|FD-Score:4.94|P-value:5.07E-7 ID:SGTC_1359|Compound:1582-0056|FD-Score:4.15|P-value:2.02E-5 ID:SGTC_1362|Compound:1611-0397|FD-Score:4.50|P-value:4.14E-6 ID:SGTC_1368|Compound:1852-0141|FD-Score:4.25|P-value:1.26E-5 ID:SGTC_1674|Compound:st016616|FD-Score:3.43|P-value:3.40E-4 ID:SGTC_1748|Compound:st037455|FD-Score:4.27|P-value:1.18E-5 ID:SGTC_1833|Compound:st055984|FD-Score:3.35|P-value:4.62E-4 ID:SGTC_1991|Compound:st073000|FD-Score:3.21|P-value:7.58E-4 ID:SGTC_2050|Compound:5263056|FD-Score:3.30|P-value:5.54E-4 ID:SGTC_2074|Compound:5212007|FD-Score:3.86|P-value:6.56E-5 ID:SGTC_2083|Compound:5306046|FD-Score:4.09|P-value:2.61E-5 ID:SGTC_2128|Compound:5255449|FD-Score:4.40|P-value:6.61E-6 ID:SGTC_2281|Compound:7943571|FD-Score:3.22|P-value:7.32E-4 ID:SGTC_2288|Compound:7946289|FD-Score:3.16|P-value:8.83E-4 ID:SGTC_2292|Compound:7671323|FD-Score:-3.95|P-value:4.31E-5 ID:SGTC_2334|Compound:9017922|FD-Score:-3.18|P-value:7.79E-4 ID:SGTC_2341|Compound:7987486|FD-Score:3.75|P-value:1.05E-4 ID:SGTC_2373|Compound:9071805|FD-Score:4.37|P-value:7.40E-6 ID:SGTC_2377|Compound:9073351|FD-Score:3.29|P-value:5.67E-4 ID:SGTC_2385|Compound:9074692|FD-Score:5.01|P-value:3.44E-7 ID:SGTC_2432|Compound:5630864|FD-Score:4.55|P-value:3.23E-6 ID:SGTC_2601|Compound:securinine|FD-Score:3.66|P-value:1.43E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:-3.23|P-value:6.53E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:-3.36|P-value:4.14E-4 ID:SGTC_2799|Compound:7812892|FD-Score:6.61|P-value:2.87E-11 ID:SGTC_2821|Compound:7996764|FD-Score:-3.12|P-value:9.55E-4 ID:SGTC_2822|Compound:7994718|FD-Score:3.35|P-value:4.56E-4 ID:SGTC_2823|Compound:7987624|FD-Score:6.58|P-value:3.49E-11 ID:SGTC_2824|Compound:7998404|FD-Score:-3.13|P-value:9.06E-4 ID:SGTC_2837|Compound:9008476|FD-Score:3.57|P-value:2.05E-4 ID:SGTC_2865|Compound:9030313|FD-Score:3.57|P-value:2.06E-4 ID:SGTC_2871|Compound:9038510|FD-Score:3.78|P-value:9.17E-5 ID:SGTC_2902|Compound:5787006|FD-Score:-3.28|P-value:5.53E-4 ID:SGTC_2919|Compound:7978188|FD-Score:4.35|P-value:8.22E-6 ID:SGTC_3065|Compound:9113888|FD-Score:3.84|P-value:7.14E-5 ID:SGTC_3272|Compound:9137413|FD-Score:3.75|P-value:1.01E-4 ID:SGTC_3284|Compound:9108171|FD-Score:-4.24|P-value:1.23E-5

Top fitness defect scores for YIL013C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2799 7812892 6.61 81.8 µM 2.87E-11 superoxide 7 1.91E-11
2 SGTC_2823 7987624 6.58 58.4 µM 3.49E-11 2 2.33E-11
3 SGTC_2385 9074692 5.01 200.0 µM 3.44E-7 20 2.68E-7
4 SGTC_1354 1498-1681 4.94 81.0 µM 5.07E-7 6 3.98E-7
5 SGTC_2432 5630864 4.55 12.2 µM 3.23E-6 13 2.62E-6
6 SGTC_1362 1611-0397 4.50 101.0 µM 4.14E-6 9 3.36E-6
7 SGTC_2128 5255449 4.40 168.5 µM 6.61E-6 23 5.42E-6
8 SGTC_2373 9071805 4.37 200.0 µM 7.40E-6 7 6.08E-6
9 SGTC_2919 7978188 4.35 46.4 µM 8.22E-6 13 6.77E-6
10 SGTC_913 3487-1245 4.28 167.0 µM 1.11E-5 19 9.21E-6
11 SGTC_1748 st037455 4.27 53.6 µM 1.18E-5 23 9.78E-6
12 SGTC_1368 1852-0141 4.25 284.0 µM 1.26E-5 ERG2 33 1.05E-5
13 SGTC_1359 1582-0056 4.15 520.0 nM 2.02E-5 15 1.69E-5
14 SGTC_2083 5306046 4.09 65.9 µM 2.61E-5 24 2.19E-5
15 SGTC_981 1488-1094 4.04 54.9 µM 3.15E-5 21 2.65E-5
16 SGTC_301 4119-0100 3.90 24.5 µM 5.63E-5 NEO1 84 4.79E-5
17 SGTC_2074 5212007 3.86 75.4 µM 6.56E-5 14 5.59E-5
18 SGTC_993 3909-8757 3.85 62.7 µM 6.88E-5 29 5.87E-5
19 SGTC_1214 0358-0031 3.84 63.7 µM 7.11E-5 22 6.07E-5
20 SGTC_3065 9113888 3.84 49.5 µM 7.14E-5 25 6.09E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.123 9.04E-13 YLR351C NIT3 hom Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member
0.085 9.34E-7 YML070W DAK1 hom Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation
0.082 1.97E-6 YDR104C SPO71 hom Meiosis-specific protein of unknown function, required for spore wall formation during sporulation, in particular for the proper size of the prospore membrane (PSM); interacts with SPO1; dispensable for both nuclear divisions during meiosis; contains two PH domains
0.081 2.99E-6 YEL068C_p YEL068C_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.080 3.45E-6 YDR282C_p YDR282C_p hom Putative protein of unknown function; localizes to the inner mitochondrial membrane with the C terminus facing the intermembrane space; ortholog of human RMND1, mutation in which is implicated in infantile encephaloneuromyopathy and defective mitochondrial translation
0.079 4.83E-6 YKL091C YKL091C hom Putative homolog of Sec14p, which is a phosphatidylinositol/phosphatidylcholine transfer protein involved in lipid metabolism; localizes to the nucleus; contains a CRAL/TRIO domain and binds several lipids in a large-scale study
0.079 4.86E-6 YMR194C-A_d YMR194C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.078 6.73E-6 YGR103W NOP7 het Component of several different pre-ribosomal particles; forms a complex with Ytm1p and Erb1p that is required for maturation of the large ribosomal subunit; required for exit from G0 and the initiation of cell proliferation
0.077 7.72E-6 YPL085W SEC16 het COPII vesicle coat protein required for ER transport vesicle budding; Sec16p is bound to the periphery of ER membranes and may act to stabilize initial COPII complexes; interacts with Sec23p, Sec24p and Sec31p
0.077 8.03E-6 YAL016C-B_d YAL016C-B_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.075 1.49E-5 YDR301W CFT1 het RNA-binding subunit of the mRNA cleavage and polyadenylation factor; involved in poly(A) site recognition and required for both pre-mRNA cleavage and polyadenylation, 51% sequence similarity with mammalian AAUAA-binding subunit of CPSF
0.074 1.73E-5 YNL254C RTC4 hom Protein of unknown function; null mutation suppresses cdc13-1 temperature sensitivity; (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
0.074 1.98E-5 YOL031C SIL1 hom Nucleotide exchange factor for the endoplasmic reticulum (ER) lumenal Hsp70 chaperone Kar2p, required for protein translocation into the ER; homolog of Yarrowia lipolytica SLS1; GrpE-like protein
0.071 3.73E-5 YOR310C NOP58 het Protein involved in pre-rRNA processing, 18S rRNA synthesis, and snoRNA synthesis; component of the small subunit processome complex, which is required for processing of pre-18S rRNA
0.070 5.44E-5 YLR356W ATG33 hom Mitochondrial mitophagy-specific protein; required primarily for mitophagy induced at the post-log phase; not required for other types of selective autophagy or macroautophagy; conserved within fungi, but not in higher eukaryotes