YIL014W / MNT3

Alpha-1,3-mannosyltransferase, adds the fourth and fifth alpha-1,3-linked mannose residues to O-linked glycans during protein O-glycosylation

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL014W / MNT3

Click on Significant Values for Screen Details ID:SGTC_45|Compound:0kpi-0036|FD-Score:3.19|P-value:2.83E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:6.04|P-value:4.05E-11 ID:SGTC_75|Compound:0159-0059|FD-Score:2.86|P-value:9.93E-4 ID:SGTC_147|Compound:4466-0538|FD-Score:2.94|P-value:7.28E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:3.59|P-value:5.25E-5 ID:SGTC_177|Compound:1327-0068|FD-Score:-2.93|P-value:9.47E-4 ID:SGTC_183|Compound:3914-0051|FD-Score:3.60|P-value:4.98E-5 ID:SGTC_224|Compound:benfluorex|FD-Score:3.11|P-value:3.86E-4 ID:SGTC_296|Compound:1222-0039|FD-Score:3.24|P-value:2.30E-4 ID:SGTC_356|Compound:1634-0012|FD-Score:3.24|P-value:2.30E-4 ID:SGTC_519|Compound:k048-0011|FD-Score:2.89|P-value:8.96E-4 ID:SGTC_585|Compound:0kpi-0023|FD-Score:4.22|P-value:2.64E-6 ID:SGTC_951|Compound:1171-0579|FD-Score:3.76|P-value:2.49E-5 ID:SGTC_1084|Compound:voriconazole|FD-Score:4.56|P-value:4.53E-7 ID:SGTC_1092|Compound:toremifene|FD-Score:-2.92|P-value:9.90E-4 ID:SGTC_1101|Compound:ebselen|FD-Score:3.78|P-value:2.23E-5 ID:SGTC_1167|Compound:k781-0610|FD-Score:4.80|P-value:1.15E-7 ID:SGTC_1172|Compound:0370-0043|FD-Score:4.41|P-value:9.92E-7 ID:SGTC_1218|Compound:1348-1416|FD-Score:2.89|P-value:8.72E-4 ID:SGTC_1322|Compound:1348-1070|FD-Score:3.58|P-value:5.56E-5 ID:SGTC_1401|Compound:3807-4679|FD-Score:-3.39|P-value:1.61E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:3.20|P-value:2.72E-4 ID:SGTC_1673|Compound:st016611|FD-Score:3.99|P-value:8.39E-6 ID:SGTC_1809|Compound:st050081|FD-Score:-3.49|P-value:1.06E-4 ID:SGTC_1815|Compound:st051655|FD-Score:3.01|P-value:5.62E-4 ID:SGTC_1912|Compound:st060209|FD-Score:-3.18|P-value:3.82E-4 ID:SGTC_2007|Compound:4011539|FD-Score:-3.09|P-value:5.30E-4 ID:SGTC_2051|Compound:5263410|FD-Score:-3.02|P-value:6.93E-4 ID:SGTC_2104|Compound:5389443|FD-Score:-3.16|P-value:4.08E-4 ID:SGTC_2105|Compound:5350118|FD-Score:4.73|P-value:1.70E-7 ID:SGTC_2110|Compound:5483698|FD-Score:-6.48|P-value:2.62E-12 ID:SGTC_2119|Compound:5528445|FD-Score:3.90|P-value:1.28E-5 ID:SGTC_2229|Compound:7354935|FD-Score:3.06|P-value:4.69E-4 ID:SGTC_2483|Compound:5729050|FD-Score:3.97|P-value:9.01E-6 ID:SGTC_2490|Compound:carminic acid|FD-Score:3.25|P-value:2.19E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.11|P-value:3.92E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:3.35|P-value:1.50E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:-3.28|P-value:2.56E-4 ID:SGTC_2684|Compound:capsaicin|FD-Score:3.05|P-value:4.83E-4 ID:SGTC_2693|Compound:st077581|FD-Score:-3.94|P-value:1.43E-5 ID:SGTC_2750|Compound:bromebric acid|FD-Score:-3.82|P-value:2.54E-5 ID:SGTC_2757|Compound:clomiphene|FD-Score:-3.50|P-value:1.04E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:-4.35|P-value:1.90E-6 ID:SGTC_2937|Compound:9044753|FD-Score:5.00|P-value:3.57E-8 ID:SGTC_3041|Compound:9091929|FD-Score:3.61|P-value:4.92E-5 ID:SGTC_3095|Compound:9117207|FD-Score:2.97|P-value:6.51E-4 ID:SGTC_3103|Compound:9120822|FD-Score:3.65|P-value:4.07E-5 ID:SGTC_3146|Compound:9095609|FD-Score:4.68|P-value:2.27E-7 ID:SGTC_3147|Compound:9097027|FD-Score:3.54|P-value:6.74E-5 ID:SGTC_3157|Compound:9099274|FD-Score:5.14|P-value:1.54E-8 ID:SGTC_3227|Compound:9130768|FD-Score:3.52|P-value:7.29E-5 ID:SGTC_45|Compound:0kpi-0036|FD-Score:3.19|P-value:2.83E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:6.04|P-value:4.05E-11 ID:SGTC_75|Compound:0159-0059|FD-Score:2.86|P-value:9.93E-4 ID:SGTC_147|Compound:4466-0538|FD-Score:2.94|P-value:7.28E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:3.59|P-value:5.25E-5 ID:SGTC_177|Compound:1327-0068|FD-Score:-2.93|P-value:9.47E-4 ID:SGTC_183|Compound:3914-0051|FD-Score:3.60|P-value:4.98E-5 ID:SGTC_224|Compound:benfluorex|FD-Score:3.11|P-value:3.86E-4 ID:SGTC_296|Compound:1222-0039|FD-Score:3.24|P-value:2.30E-4 ID:SGTC_356|Compound:1634-0012|FD-Score:3.24|P-value:2.30E-4 ID:SGTC_519|Compound:k048-0011|FD-Score:2.89|P-value:8.96E-4 ID:SGTC_585|Compound:0kpi-0023|FD-Score:4.22|P-value:2.64E-6 ID:SGTC_951|Compound:1171-0579|FD-Score:3.76|P-value:2.49E-5 ID:SGTC_1084|Compound:voriconazole|FD-Score:4.56|P-value:4.53E-7 ID:SGTC_1092|Compound:toremifene|FD-Score:-2.92|P-value:9.90E-4 ID:SGTC_1101|Compound:ebselen|FD-Score:3.78|P-value:2.23E-5 ID:SGTC_1167|Compound:k781-0610|FD-Score:4.80|P-value:1.15E-7 ID:SGTC_1172|Compound:0370-0043|FD-Score:4.41|P-value:9.92E-7 ID:SGTC_1218|Compound:1348-1416|FD-Score:2.89|P-value:8.72E-4 ID:SGTC_1322|Compound:1348-1070|FD-Score:3.58|P-value:5.56E-5 ID:SGTC_1401|Compound:3807-4679|FD-Score:-3.39|P-value:1.61E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:3.20|P-value:2.72E-4 ID:SGTC_1673|Compound:st016611|FD-Score:3.99|P-value:8.39E-6 ID:SGTC_1809|Compound:st050081|FD-Score:-3.49|P-value:1.06E-4 ID:SGTC_1815|Compound:st051655|FD-Score:3.01|P-value:5.62E-4 ID:SGTC_1912|Compound:st060209|FD-Score:-3.18|P-value:3.82E-4 ID:SGTC_2007|Compound:4011539|FD-Score:-3.09|P-value:5.30E-4 ID:SGTC_2051|Compound:5263410|FD-Score:-3.02|P-value:6.93E-4 ID:SGTC_2104|Compound:5389443|FD-Score:-3.16|P-value:4.08E-4 ID:SGTC_2105|Compound:5350118|FD-Score:4.73|P-value:1.70E-7 ID:SGTC_2110|Compound:5483698|FD-Score:-6.48|P-value:2.62E-12 ID:SGTC_2119|Compound:5528445|FD-Score:3.90|P-value:1.28E-5 ID:SGTC_2229|Compound:7354935|FD-Score:3.06|P-value:4.69E-4 ID:SGTC_2483|Compound:5729050|FD-Score:3.97|P-value:9.01E-6 ID:SGTC_2490|Compound:carminic acid|FD-Score:3.25|P-value:2.19E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.11|P-value:3.92E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:3.35|P-value:1.50E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:-3.28|P-value:2.56E-4 ID:SGTC_2684|Compound:capsaicin|FD-Score:3.05|P-value:4.83E-4 ID:SGTC_2693|Compound:st077581|FD-Score:-3.94|P-value:1.43E-5 ID:SGTC_2750|Compound:bromebric acid|FD-Score:-3.82|P-value:2.54E-5 ID:SGTC_2757|Compound:clomiphene|FD-Score:-3.50|P-value:1.04E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:-4.35|P-value:1.90E-6 ID:SGTC_2937|Compound:9044753|FD-Score:5.00|P-value:3.57E-8 ID:SGTC_3041|Compound:9091929|FD-Score:3.61|P-value:4.92E-5 ID:SGTC_3095|Compound:9117207|FD-Score:2.97|P-value:6.51E-4 ID:SGTC_3103|Compound:9120822|FD-Score:3.65|P-value:4.07E-5 ID:SGTC_3146|Compound:9095609|FD-Score:4.68|P-value:2.27E-7 ID:SGTC_3147|Compound:9097027|FD-Score:3.54|P-value:6.74E-5 ID:SGTC_3157|Compound:9099274|FD-Score:5.14|P-value:1.54E-8 ID:SGTC_3227|Compound:9130768|FD-Score:3.52|P-value:7.29E-5

Top fitness defect scores for YIL014W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_50 0929-0078 6.04 56.4 µM 4.05E-11 24 7.70E-10
2 SGTC_3157 9099274 5.14 49.5 µM 1.54E-8 7 1.36E-7
3 SGTC_2937 9044753 5.00 11.3 µM 3.57E-8 60S ribosome export 14 2.84E-7
4 SGTC_1167 k781-0610 4.80 148.0 µM 1.15E-7 RNA processing & uracil transport 12 7.88E-7
5 SGTC_2105 5350118 4.73 200.0 µM 1.70E-7 13 1.11E-6
6 SGTC_3146 9095609 4.68 49.5 µM 2.27E-7 9 1.42E-6
7 SGTC_1084 voriconazole 4.56 435.0 nM 4.53E-7 azole & statin 17 2.60E-6
8 SGTC_1172 0370-0043 4.41 85.0 µM 9.92E-7 12 5.14E-6
9 SGTC_585 0kpi-0023 4.22 191.0 µM 2.64E-6 14 1.21E-5
10 SGTC_1673 st016611 3.99 27.3 µM 8.39E-6 44 3.31E-5
11 SGTC_2483 5729050 3.97 27.2 µM 9.01E-6 24 3.52E-5
12 SGTC_2119 5528445 3.90 120.6 µM 1.28E-5 20 4.78E-5
13 SGTC_1101 ebselen 3.78 5.3 µM 2.23E-5 31 7.77E-5
14 SGTC_951 1171-0579 3.76 82.7 µM 2.49E-5 cell wall 92 8.53E-5
15 SGTC_3103 9120822 3.65 49.5 µM 4.07E-5 20 1.31E-4
16 SGTC_3041 9091929 3.61 49.5 µM 4.92E-5 redox potentiating 30 1.55E-4
17 SGTC_183 3914-0051 3.60 30.6 µM 4.98E-5 60S ribosome export 32 1.56E-4
18 SGTC_151 3013-0144 3.59 2.3 µM 5.25E-5 iron homeostasis 42 1.64E-4
19 SGTC_1322 1348-1070 3.58 12.0 µM 5.56E-5 13 1.72E-4
20 SGTC_3147 9097027 3.54 49.5 µM 6.74E-5 36 2.04E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.135 3.90E-15 YNL106C INP52 hom Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.108 3.01E-10 YBR023C CHS3 hom Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan
0.106 8.11E-10 YBR134W_d YBR134W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.104 1.35E-9 YOL003C PFA4 hom Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
0.104 1.49E-9 YDR219C MFB1 hom Mitochondria-associated F-box protein involved in maintenance of normal mitochondrial morphology; interacts with Skp1p through the F-box motif; preferentially localizes to the mother cell during budding
0.101 3.96E-9 YGL178W MPT5 hom mRNA-binding protein of the PUF family; binds to the 3' UTR of specific mRNAs, including those involved in mating type switching, cell wall integrity, chronological lifespan, chromatin modification, and spindle pole body architecture; recruits the CCR4-NOT deadenylase complex to mRNAs along with Dhh1p and Dcp1p to promote deadenylation, decapping, and decay; also interacts with the Caf20p translational initiation repressor, affecting its mRNA target specificity
0.101 4.94E-9 YCR033W SNT1 hom Subunit of the Set3C deacetylase complex that interacts directly with the Set3C subunit, Sif2p; putative DNA-binding protein; mutant has increased aneuploidy tolerance
0.099 1.02E-8 YKL077W_p YKL077W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
0.094 5.12E-8 YML047C PRM6 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; regulated by Ste12p during mating; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family
0.092 1.03E-7 YOR042W CUE5 hom Protein containing a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.091 1.13E-7 YCR088W ABP1 hom Actin-binding protein of the cortical actin cytoskeleton, important for activation of the Arp2/3 complex that plays a key role actin in cytoskeleton organization; phosphorylation within its PRR (Proline-Rich Region), mediated by Cdc28p and Pho85p, protects Abp1p from proteolysis mediated by its own PEST sequences
0.090 1.61E-7 YNR005C_d YNR005C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.086 5.20E-7 YHR122W CIA2 het Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia1p and Met18p that directs Fe-S cluster incorporation into a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; ortholog of human FAM96B
0.085 8.30E-7 YJL099W CHS6 hom Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication
0.084 1.03E-6 YMR016C SOK2 hom Nuclear protein that negatively regulates pseudohyphal differentiation; plays a regulatory role in the cyclic AMP (cAMP)-dependent protein kinase (PKA) signal transduction pathway; SOK2 has a paralog, PHD1, that arose from the whole genome duplication