YIL017C / VID28

GID Complex subunit, serves as adaptor for regulatory subunit Vid24p; protein involved in proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBPase); localized to the nucleus and the cytoplasm

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL017C / VID28

Click on Significant Values for Screen Details ID:SGTC_53|Compound:0973-0023|FD-Score:-3.43|P-value:7.59E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:3.39|P-value:6.57E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:6.13|P-value:3.68E-9 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.16|P-value:5.93E-5 ID:SGTC_467|Compound:ro 31-8220|FD-Score:4.04|P-value:6.55E-5 ID:SGTC_558|Compound:k064-0027|FD-Score:3.37|P-value:6.82E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:-3.38|P-value:9.14E-4 ID:SGTC_1153|Compound:4055-0057|FD-Score:3.62|P-value:2.99E-4 ID:SGTC_1155|Compound:4088-0394|FD-Score:3.53|P-value:4.14E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:3.35|P-value:7.36E-4 ID:SGTC_1333|Compound:1482-0047|FD-Score:-3.46|P-value:7.07E-4 ID:SGTC_1337|Compound:1486-1011|FD-Score:3.91|P-value:1.08E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:3.74|P-value:1.99E-4 ID:SGTC_1667|Compound:st014849|FD-Score:4.21|P-value:3.32E-5 ID:SGTC_1775|Compound:st081588|FD-Score:3.55|P-value:3.83E-4 ID:SGTC_1786|Compound:berberine|FD-Score:3.81|P-value:1.52E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.07|P-value:8.15E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:4.93|P-value:1.56E-6 ID:SGTC_1858|Compound:4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione|FD-Score:-3.37|P-value:9.22E-4 ID:SGTC_2337|Compound:9009472|FD-Score:-3.46|P-value:7.03E-4 ID:SGTC_2391|Compound:6285546|FD-Score:3.31|P-value:8.46E-4 ID:SGTC_2458|Compound:5808907|FD-Score:-4.50|P-value:1.52E-5 ID:SGTC_2477|Compound:5967686|FD-Score:3.72|P-value:2.11E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:4.15|P-value:4.35E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.30|P-value:8.69E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:-3.86|P-value:1.79E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:3.73|P-value:2.02E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:-6.65|P-value:3.27E-10 ID:SGTC_2950|Compound:9072895|FD-Score:3.89|P-value:1.13E-4 ID:SGTC_3034|Compound:9090421|FD-Score:-3.49|P-value:6.42E-4 ID:SGTC_3211|Compound:9128781|FD-Score:-4.83|P-value:3.75E-6 ID:SGTC_3349|Compound:9149703|FD-Score:5.44|P-value:1.41E-7 ID:SGTC_53|Compound:0973-0023|FD-Score:-3.43|P-value:7.59E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:3.39|P-value:6.57E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:6.13|P-value:3.68E-9 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.16|P-value:5.93E-5 ID:SGTC_467|Compound:ro 31-8220|FD-Score:4.04|P-value:6.55E-5 ID:SGTC_558|Compound:k064-0027|FD-Score:3.37|P-value:6.82E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:-3.38|P-value:9.14E-4 ID:SGTC_1153|Compound:4055-0057|FD-Score:3.62|P-value:2.99E-4 ID:SGTC_1155|Compound:4088-0394|FD-Score:3.53|P-value:4.14E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:3.35|P-value:7.36E-4 ID:SGTC_1333|Compound:1482-0047|FD-Score:-3.46|P-value:7.07E-4 ID:SGTC_1337|Compound:1486-1011|FD-Score:3.91|P-value:1.08E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:3.74|P-value:1.99E-4 ID:SGTC_1667|Compound:st014849|FD-Score:4.21|P-value:3.32E-5 ID:SGTC_1775|Compound:st081588|FD-Score:3.55|P-value:3.83E-4 ID:SGTC_1786|Compound:berberine|FD-Score:3.81|P-value:1.52E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.07|P-value:8.15E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:4.93|P-value:1.56E-6 ID:SGTC_1858|Compound:4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione|FD-Score:-3.37|P-value:9.22E-4 ID:SGTC_2337|Compound:9009472|FD-Score:-3.46|P-value:7.03E-4 ID:SGTC_2391|Compound:6285546|FD-Score:3.31|P-value:8.46E-4 ID:SGTC_2458|Compound:5808907|FD-Score:-4.50|P-value:1.52E-5 ID:SGTC_2477|Compound:5967686|FD-Score:3.72|P-value:2.11E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:4.15|P-value:4.35E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.30|P-value:8.69E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:-3.86|P-value:1.79E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:3.73|P-value:2.02E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:-6.65|P-value:3.27E-10 ID:SGTC_2950|Compound:9072895|FD-Score:3.89|P-value:1.13E-4 ID:SGTC_3034|Compound:9090421|FD-Score:-3.49|P-value:6.42E-4 ID:SGTC_3211|Compound:9128781|FD-Score:-4.83|P-value:3.75E-6 ID:SGTC_3349|Compound:9149703|FD-Score:5.44|P-value:1.41E-7

Top fitness defect scores for YIL017C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_451 chloral hydrate 6.13 100.0 µM 3.68E-9 15 4.36E-10
2 SGTC_3349 9149703 5.44 23.0 µM 1.41E-7 3 2.67E-8
3 SGTC_1844 rapamycin 4.93 4.0 nM 1.56E-6 117 4.02E-7
4 SGTC_1667 st014849 4.21 34.6 µM 3.32E-5 Golgi 6 1.25E-5
5 SGTC_2531 methyl deoxycholate 4.15 70.1 µM 4.35E-5 20 1.69E-5
6 SGTC_467 ro 31-8220 4.04 72.8 µM 6.55E-5 calcium & mitochondrial duress 74 2.68E-5
7 SGTC_1337 1486-1011 3.91 40.3 µM 1.08E-4 15 4.70E-5
8 SGTC_2950 9072895 3.89 21.5 µM 1.13E-4 41 4.92E-5
9 SGTC_1786 berberine 3.81 21.6 µM 1.52E-4 60S ribosome export 34 6.87E-5
10 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 3.74 54.9 µM 1.99E-4 redox potentiating 62 9.31E-5
11 SGTC_2679 rapamycin 3.73 1.0 nM 2.02E-4 161 9.47E-5
12 SGTC_2477 5967686 3.72 25.2 µM 2.11E-4 32 9.96E-5
13 SGTC_1153 4055-0057 3.62 267.0 µM 2.99E-4 38 1.47E-4
14 SGTC_1775 st081588 3.55 35.2 µM 3.83E-4 60S ribosome export 36 1.94E-4
15 SGTC_1155 4088-0394 3.53 48.2 µM 4.14E-4 47 2.11E-4
16 SGTC_58 0957-0393 3.39 9.0 µM 6.57E-4 cell wall 440 3.55E-4
17 SGTC_558 k064-0027 3.37 21.3 µM 6.82E-4 DNA damage response 50 3.69E-4
18 SGTC_1249 0481-0015 3.35 10.2 µM 7.36E-4 47 4.03E-4
19 SGTC_2391 6285546 3.31 200.0 µM 8.46E-4 40 4.70E-4
20 SGTC_2582 agaric acid 3.30 100.0 µM 8.69E-4 redox potentiating 389 4.85E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.184 5.99E-27 YKL203C TOR2 het PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; TOR2 has a paralog, TOR1, that arose from the whole genome duplication
0.180 5.67E-26 YJR066W TOR1 hom PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication
0.170 4.07E-23 YKR007W MEH1 hom Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; loss results in a defect in vacuolar acidification
0.168 1.00E-22 YHR036W BRL1 het Essential nuclear envelope integral membrane protein identified as a suppressor of a conditional mutation in the major karyopherin, CRM1; homologous to and interacts with Brr6p, a nuclear envelope protein involved in nuclear export
0.157 4.90E-20 YHR187W IKI1 hom Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; iki1 mutations confer resistance to the K. lactis toxin zymocin
0.154 2.68E-19 YNL119W NCS2 hom Protein required for thiolation of the uridine at the wobble position of Lys(UUU) and Glu(UUC) tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae
0.153 3.98E-19 YFR019W FAB1 hom 1-phosphatidylinositol-3-phosphate 5-kinase; vacuolar membrane kinase that generates phosphatidylinositol (3,5)P2, which is involved in vacuolar sorting and homeostasis
0.146 2.29E-17 YBR077C SLM4 hom Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; gene exhibits synthetic genetic interaction with MSS4
0.145 3.41E-17 YGR200C ELP2 hom Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; target of Kluyveromyces lactis zymocin
0.140 3.56E-16 YML121W GTR1 hom Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB
0.136 2.40E-15 YIL008W URM1 hom Ubiquitin-like protein involved in thiolation of cytoplasmic tRNAs; receives sulfur from the E1-like enzyme Uba4p and transfers it to tRNA; also functions as a protein tag with roles in nutrient sensing and oxidative stress response
0.136 2.69E-15 YHR186C KOG1 het Subunit of TORC1, a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors
0.135 3.72E-15 YDL160C DHH1 hom Cytoplasmic DExD/H-box helicase, stimulates mRNA decapping; coordinates distinct steps in mRNA function and decay, interacts with both the decapping and deadenylase complexes, may have a role in mRNA export and translation; C-terminus of Dhh1p interacts with Ngr1p and promotes POR1, but not EDC1 mRNA decay; forms cytoplasmic foci upon DNA replication stress
0.135 4.68E-15 YKL110C KTI12 hom Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p
0.130 3.55E-14 YKR035C_d OPI8_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene DID2/YKR035W-A