YIL019W / FAF1

Protein required for pre-rRNA processing and 40S ribosomal subunit assembly

Zygosity: Heterozygous strain
fixedexpanded
Profile for YIL019W / FAF1

Click on Significant Values for Screen Details ID:SGTC_163|Compound:1327-0036|FD-Score:6.05|P-value:1.25E-10 ID:SGTC_249|Compound:wiskostatin|FD-Score:3.51|P-value:1.16E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:4.55|P-value:9.10E-7 ID:SGTC_309|Compound:k408-0051|FD-Score:5.43|P-value:6.60E-9 ID:SGTC_435|Compound:c-PAF|FD-Score:3.74|P-value:4.37E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:3.36|P-value:2.11E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:3.06|P-value:6.41E-4 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:4.05|P-value:1.09E-5 ID:SGTC_550|Compound:4123-0385|FD-Score:-3.36|P-value:2.67E-4 ID:SGTC_559|Compound:1550-0661|FD-Score:3.02|P-value:7.49E-4 ID:SGTC_650|Compound:1328-0195|FD-Score:3.08|P-value:5.95E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-5.91|P-value:4.89E-10 ID:SGTC_839|Compound:0122-0028|FD-Score:3.38|P-value:1.95E-4 ID:SGTC_840|Compound:0245-0196|FD-Score:4.05|P-value:1.10E-5 ID:SGTC_919|Compound:tnp00227|FD-Score:3.26|P-value:3.02E-4 ID:SGTC_966|Compound:1300-0360|FD-Score:4.03|P-value:1.18E-5 ID:SGTC_994|Compound:3910-0338|FD-Score:3.56|P-value:9.22E-5 ID:SGTC_1009|Compound:4106-0057|FD-Score:2.97|P-value:8.86E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:3.55|P-value:9.79E-5 ID:SGTC_1350|Compound:1495-0454|FD-Score:3.57|P-value:8.82E-5 ID:SGTC_1509|Compound:1326-1131|FD-Score:3.12|P-value:5.17E-4 ID:SGTC_1522|Compound:st012842|FD-Score:2.95|P-value:9.46E-4 ID:SGTC_1895|Compound:st058434|FD-Score:3.66|P-value:6.18E-5 ID:SGTC_2004|Compound:4023728|FD-Score:2.96|P-value:9.33E-4 ID:SGTC_2015|Compound:5119600|FD-Score:3.40|P-value:1.81E-4 ID:SGTC_2084|Compound:5306078|FD-Score:3.39|P-value:1.85E-4 ID:SGTC_2262|Compound:9014885|FD-Score:2.97|P-value:8.84E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:-5.63|P-value:2.88E-9 ID:SGTC_2414|Compound:st077232|FD-Score:-4.00|P-value:1.80E-5 ID:SGTC_2419|Compound:paclitaxel|FD-Score:-10.10|P-value:3.58E-26 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:-3.14|P-value:6.03E-4 ID:SGTC_2437|Compound:5741531|FD-Score:-3.14|P-value:6.11E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.40|P-value:7.76E-9 ID:SGTC_2593|Compound:nobiletin|FD-Score:-3.19|P-value:5.15E-4 ID:SGTC_2629|Compound:bisabolol|FD-Score:3.12|P-value:5.12E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:12.20|P-value:2.03E-37 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.76|P-value:3.10E-7 ID:SGTC_2700|Compound:st077718|FD-Score:3.11|P-value:5.32E-4 ID:SGTC_3006|Compound:9075424|FD-Score:-4.44|P-value:2.29E-6 ID:SGTC_3017|Compound:9080681|FD-Score:4.20|P-value:5.31E-6 ID:SGTC_3152|Compound:9099253|FD-Score:-3.29|P-value:3.46E-4 ID:SGTC_3180|Compound:9109287|FD-Score:3.38|P-value:1.94E-4 ID:SGTC_3243|Compound:9134147|FD-Score:3.06|P-value:6.58E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:6.05|P-value:1.25E-10 ID:SGTC_249|Compound:wiskostatin|FD-Score:3.51|P-value:1.16E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:4.55|P-value:9.10E-7 ID:SGTC_309|Compound:k408-0051|FD-Score:5.43|P-value:6.60E-9 ID:SGTC_435|Compound:c-PAF|FD-Score:3.74|P-value:4.37E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:3.36|P-value:2.11E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:3.06|P-value:6.41E-4 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:4.05|P-value:1.09E-5 ID:SGTC_550|Compound:4123-0385|FD-Score:-3.36|P-value:2.67E-4 ID:SGTC_559|Compound:1550-0661|FD-Score:3.02|P-value:7.49E-4 ID:SGTC_650|Compound:1328-0195|FD-Score:3.08|P-value:5.95E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-5.91|P-value:4.89E-10 ID:SGTC_839|Compound:0122-0028|FD-Score:3.38|P-value:1.95E-4 ID:SGTC_840|Compound:0245-0196|FD-Score:4.05|P-value:1.10E-5 ID:SGTC_919|Compound:tnp00227|FD-Score:3.26|P-value:3.02E-4 ID:SGTC_966|Compound:1300-0360|FD-Score:4.03|P-value:1.18E-5 ID:SGTC_994|Compound:3910-0338|FD-Score:3.56|P-value:9.22E-5 ID:SGTC_1009|Compound:4106-0057|FD-Score:2.97|P-value:8.86E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:3.55|P-value:9.79E-5 ID:SGTC_1350|Compound:1495-0454|FD-Score:3.57|P-value:8.82E-5 ID:SGTC_1509|Compound:1326-1131|FD-Score:3.12|P-value:5.17E-4 ID:SGTC_1522|Compound:st012842|FD-Score:2.95|P-value:9.46E-4 ID:SGTC_1895|Compound:st058434|FD-Score:3.66|P-value:6.18E-5 ID:SGTC_2004|Compound:4023728|FD-Score:2.96|P-value:9.33E-4 ID:SGTC_2015|Compound:5119600|FD-Score:3.40|P-value:1.81E-4 ID:SGTC_2084|Compound:5306078|FD-Score:3.39|P-value:1.85E-4 ID:SGTC_2262|Compound:9014885|FD-Score:2.97|P-value:8.84E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:-5.63|P-value:2.88E-9 ID:SGTC_2414|Compound:st077232|FD-Score:-4.00|P-value:1.80E-5 ID:SGTC_2419|Compound:paclitaxel|FD-Score:-10.10|P-value:3.58E-26 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:-3.14|P-value:6.03E-4 ID:SGTC_2437|Compound:5741531|FD-Score:-3.14|P-value:6.11E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.40|P-value:7.76E-9 ID:SGTC_2593|Compound:nobiletin|FD-Score:-3.19|P-value:5.15E-4 ID:SGTC_2629|Compound:bisabolol|FD-Score:3.12|P-value:5.12E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:12.20|P-value:2.03E-37 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.76|P-value:3.10E-7 ID:SGTC_2700|Compound:st077718|FD-Score:3.11|P-value:5.32E-4 ID:SGTC_3006|Compound:9075424|FD-Score:-4.44|P-value:2.29E-6 ID:SGTC_3017|Compound:9080681|FD-Score:4.20|P-value:5.31E-6 ID:SGTC_3152|Compound:9099253|FD-Score:-3.29|P-value:3.46E-4 ID:SGTC_3180|Compound:9109287|FD-Score:3.38|P-value:1.94E-4 ID:SGTC_3243|Compound:9134147|FD-Score:3.06|P-value:6.58E-4

Top fitness defect scores for YIL019W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2651 1327-0036 12.20 5.0 µM 2.03E-37 10 1.49E-34 0.30
2 SGTC_163 1327-0036 6.05 7.5 µM 1.25E-10 32 7.30E-10 0.01
3 SGTC_309 k408-0051 5.43 1.5 µM 6.60E-9 12 2.81E-8 0.24
4 SGTC_2582 agaric acid 5.40 100.0 µM 7.76E-9 redox potentiating 20 3.26E-8 0.18
5 SGTC_2688 kanamycin b 4.76 96.7 µM 3.10E-7 calcium & mitochondrial duress 7 9.71E-7 0.04
6 SGTC_266 formosanin C 4.55 406.0 nM 9.10E-7 sphingolipid biosynthesis & PDR1 18 2.62E-6 0.01
7 SGTC_3017 9080681 4.20 49.5 µM 5.31E-6 1 1.33E-5 0.72
8 SGTC_546 peri-Naphthalide 4.05 147.0 µM 1.09E-5 DNA damage response 24 2.57E-5 0.08
9 SGTC_840 0245-0196 4.05 390.0 µM 1.10E-5 3 2.60E-5 0.51
10 SGTC_966 1300-0360 4.03 30.2 µM 1.18E-5 heme requiring 16 2.78E-5 0.12
11 SGTC_435 c-PAF 3.74 6.7 µM 4.37E-5 16 9.25E-5 0.28
12 SGTC_1895 st058434 3.66 18.3 µM 6.18E-5 6 1.27E-4 0.05
13 SGTC_1350 1495-0454 3.57 146.0 µM 8.82E-5 4 1.77E-4 0.19
14 SGTC_994 3910-0338 3.56 138.0 µM 9.22E-5 calcium & mitochondrial duress 20 1.84E-4 0.06
15 SGTC_1246 0422-0085 3.55 105.0 µM 9.79E-5 13 1.94E-4 0.21
16 SGTC_249 wiskostatin 3.51 11.2 µM 1.16E-4 4 2.27E-4 0.16
17 SGTC_2015 5119600 3.40 184.0 µM 1.81E-4 12 3.42E-4 0.04
18 SGTC_2084 5306078 3.39 60.6 µM 1.85E-4 8 3.49E-4 0.03
19 SGTC_3180 9109287 3.38 49.5 µM 1.94E-4 15 3.65E-4 0.05
20 SGTC_839 0122-0028 3.38 230.0 µM 1.95E-4 RSC complex & mRNA processing 47 3.66E-4 0.00

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.401 1.36E-129 YJL019W MPS3 het Nuclear envelope protein required for SPB insertion; initiation of SPB duplication and nuclear fusion; acetylation of Mps3p by Eco1p regulates its role in nuclear organization; localizes to the SPB half bridge and at telomeres during meiosis; required with Ndj1p and Csm4p for meiotic bouquet formation and telomere-led rapid prophase movement; N-terminal acetylated by Eco1p
0.385 3.44E-119 YIR008C PRI1 het Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
0.383 7.65E-118 YIR012W SQT1 het Protein involved in 60S ribosomal subunit assembly or modification; contains multiple WD repeats; interacts with Qsr1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress
0.375 1.95E-112 YJL005W CYR1 het Adenylate cyclase, required for cAMP production and cAMP-dependent protein kinase signaling; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation
0.367 1.01E-107 YFL037W TUB2 het Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria
0.361 1.24E-103 YJR013W GPI14 het Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M
0.355 1.88E-100 YIL129C TAO3 het Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with protein kinase Cbk1p and also with Kic1p
0.325 3.32E-83 YIL046W MET30 het F-box protein containing five copies of the WD40 motif, controls cell cycle function, sulfur metabolism, and methionine biosynthesis as part of the ubiquitin ligase complex; interacts with and regulates Met4p, localizes within the nucleus
0.313 4.60E-77 YIL022W TIM44 het Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); tethers the import motor and regulatory factors (PAM complex) to the translocation channel (Tim23p-Tim17p core complex)
0.289 1.34E-65 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.271 1.50E-57 YIL031W ULP2 het Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins, plays a role in chromosome cohesion at centromeric regions and recovery from checkpoint arrest induced by DNA damage or DNA replication defects; potential Cdc28p substrate
0.259 1.53E-52 YIL135C VHS2 hom Cytoplasmic protein of unknown function; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; similar to Mlf3p
0.252 6.70E-50 YJL013C MAD3 hom Subunit of the spindle-assembly checkpoint complex, which delays anaphase onset in cells with defects in mitotic spindle assembly; pseudosubstrate inhibitor of APC(Cdc20), the anaphase promoting complex involved in securin (Pds1p) turnover
0.232 2.30E-42 YIL003W CFD1 het Highly conserved, iron-sulfur cluster binding protein localized in the cytoplasm; forms a complex with Nbp35p that is involved in iron-sulfur protein assembly in the cytosol
0.226 3.07E-40 YIL107C PFK26 hom 6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate; has negligible fructose-2,6-bisphosphatase activity; transcriptional regulation involves protein kinase A