YIL024C_p

Putative protein of unknown function; non-essential gene; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL024C / YIL024C

Click on Significant Values for Screen Details ID:SGTC_271|Compound:rotenone|FD-Score:-3.04|P-value:5.77E-4 ID:SGTC_308|Compound:4092-1169|FD-Score:3.31|P-value:2.28E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:3.70|P-value:4.46E-5 ID:SGTC_372|Compound:0155-0182|FD-Score:4.50|P-value:9.26E-7 ID:SGTC_431|Compound:k089-0097|FD-Score:4.44|P-value:1.24E-6 ID:SGTC_592|Compound:k241-0073|FD-Score:3.94|P-value:1.47E-5 ID:SGTC_685|Compound:1278-0033|FD-Score:3.30|P-value:2.41E-4 ID:SGTC_779|Compound:1360-0071|FD-Score:4.66|P-value:3.87E-7 ID:SGTC_807|Compound:1315-0151|FD-Score:2.95|P-value:9.15E-4 ID:SGTC_840|Compound:0245-0196|FD-Score:3.64|P-value:5.85E-5 ID:SGTC_841|Compound:0251-0215|FD-Score:3.01|P-value:7.33E-4 ID:SGTC_857|Compound:0438-0306|FD-Score:-3.70|P-value:3.85E-5 ID:SGTC_1082|Compound:camptothecin|FD-Score:-4.01|P-value:9.10E-6 ID:SGTC_1299|Compound:1079-1439|FD-Score:4.54|P-value:7.45E-7 ID:SGTC_1499|Compound:4480-0877|FD-Score:4.10|P-value:7.14E-6 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:4.13|P-value:5.88E-6 ID:SGTC_1562|Compound:morin hydrate|FD-Score:3.18|P-value:3.84E-4 ID:SGTC_1625|Compound:st003711|FD-Score:3.20|P-value:3.58E-4 ID:SGTC_1637|Compound:st007924|FD-Score:3.58|P-value:7.59E-5 ID:SGTC_1731|Compound:st035964|FD-Score:2.93|P-value:9.64E-4 ID:SGTC_1804|Compound:st050076|FD-Score:-3.99|P-value:1.01E-5 ID:SGTC_2066|Compound:5222451|FD-Score:3.17|P-value:4.01E-4 ID:SGTC_2119|Compound:5528445|FD-Score:3.68|P-value:4.84E-5 ID:SGTC_2149|Compound:5554786|FD-Score:-3.16|P-value:3.71E-4 ID:SGTC_2190|Compound:6049624|FD-Score:3.25|P-value:2.86E-4 ID:SGTC_2413|Compound:inermin|FD-Score:3.72|P-value:4.03E-5 ID:SGTC_2607|Compound:solasodine|FD-Score:4.01|P-value:1.08E-5 ID:SGTC_2611|Compound:pyromycin|FD-Score:3.01|P-value:7.20E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:3.19|P-value:3.63E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:3.79|P-value:2.99E-5 ID:SGTC_2643|Compound:anethole|FD-Score:3.92|P-value:1.64E-5 ID:SGTC_2846|Compound:9008642|FD-Score:3.14|P-value:4.46E-4 ID:SGTC_2849|Compound:9019321|FD-Score:-4.49|P-value:8.12E-7 ID:SGTC_2944|Compound:9067346|FD-Score:-2.89|P-value:9.81E-4 ID:SGTC_2968|Compound:9090663|FD-Score:4.00|P-value:1.14E-5 ID:SGTC_2975|Compound:9084847|FD-Score:-3.08|P-value:4.90E-4 ID:SGTC_2998|Compound:9066762|FD-Score:3.09|P-value:5.45E-4 ID:SGTC_3187|Compound:9109394|FD-Score:4.02|P-value:1.05E-5 ID:SGTC_3189|Compound:9110682|FD-Score:3.75|P-value:3.57E-5 ID:SGTC_3203|Compound:9113543|FD-Score:4.67|P-value:3.78E-7 ID:SGTC_3210|Compound:9128157|FD-Score:4.00|P-value:1.12E-5 ID:SGTC_3211|Compound:9128781|FD-Score:3.87|P-value:2.04E-5 ID:SGTC_3253|Compound:9135987|FD-Score:-3.02|P-value:6.22E-4 ID:SGTC_3264|Compound:9137442|FD-Score:-3.19|P-value:3.31E-4 ID:SGTC_3278|Compound:9139605|FD-Score:-2.99|P-value:6.85E-4 ID:SGTC_3295|Compound:9122362|FD-Score:3.35|P-value:1.96E-4 ID:SGTC_3296|Compound:9122258|FD-Score:3.02|P-value:6.94E-4 ID:SGTC_271|Compound:rotenone|FD-Score:-3.04|P-value:5.77E-4 ID:SGTC_308|Compound:4092-1169|FD-Score:3.31|P-value:2.28E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:3.70|P-value:4.46E-5 ID:SGTC_372|Compound:0155-0182|FD-Score:4.50|P-value:9.26E-7 ID:SGTC_431|Compound:k089-0097|FD-Score:4.44|P-value:1.24E-6 ID:SGTC_592|Compound:k241-0073|FD-Score:3.94|P-value:1.47E-5 ID:SGTC_685|Compound:1278-0033|FD-Score:3.30|P-value:2.41E-4 ID:SGTC_779|Compound:1360-0071|FD-Score:4.66|P-value:3.87E-7 ID:SGTC_807|Compound:1315-0151|FD-Score:2.95|P-value:9.15E-4 ID:SGTC_840|Compound:0245-0196|FD-Score:3.64|P-value:5.85E-5 ID:SGTC_841|Compound:0251-0215|FD-Score:3.01|P-value:7.33E-4 ID:SGTC_857|Compound:0438-0306|FD-Score:-3.70|P-value:3.85E-5 ID:SGTC_1082|Compound:camptothecin|FD-Score:-4.01|P-value:9.10E-6 ID:SGTC_1299|Compound:1079-1439|FD-Score:4.54|P-value:7.45E-7 ID:SGTC_1499|Compound:4480-0877|FD-Score:4.10|P-value:7.14E-6 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:4.13|P-value:5.88E-6 ID:SGTC_1562|Compound:morin hydrate|FD-Score:3.18|P-value:3.84E-4 ID:SGTC_1625|Compound:st003711|FD-Score:3.20|P-value:3.58E-4 ID:SGTC_1637|Compound:st007924|FD-Score:3.58|P-value:7.59E-5 ID:SGTC_1731|Compound:st035964|FD-Score:2.93|P-value:9.64E-4 ID:SGTC_1804|Compound:st050076|FD-Score:-3.99|P-value:1.01E-5 ID:SGTC_2066|Compound:5222451|FD-Score:3.17|P-value:4.01E-4 ID:SGTC_2119|Compound:5528445|FD-Score:3.68|P-value:4.84E-5 ID:SGTC_2149|Compound:5554786|FD-Score:-3.16|P-value:3.71E-4 ID:SGTC_2190|Compound:6049624|FD-Score:3.25|P-value:2.86E-4 ID:SGTC_2413|Compound:inermin|FD-Score:3.72|P-value:4.03E-5 ID:SGTC_2607|Compound:solasodine|FD-Score:4.01|P-value:1.08E-5 ID:SGTC_2611|Compound:pyromycin|FD-Score:3.01|P-value:7.20E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:3.19|P-value:3.63E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:3.79|P-value:2.99E-5 ID:SGTC_2643|Compound:anethole|FD-Score:3.92|P-value:1.64E-5 ID:SGTC_2846|Compound:9008642|FD-Score:3.14|P-value:4.46E-4 ID:SGTC_2849|Compound:9019321|FD-Score:-4.49|P-value:8.12E-7 ID:SGTC_2944|Compound:9067346|FD-Score:-2.89|P-value:9.81E-4 ID:SGTC_2968|Compound:9090663|FD-Score:4.00|P-value:1.14E-5 ID:SGTC_2975|Compound:9084847|FD-Score:-3.08|P-value:4.90E-4 ID:SGTC_2998|Compound:9066762|FD-Score:3.09|P-value:5.45E-4 ID:SGTC_3187|Compound:9109394|FD-Score:4.02|P-value:1.05E-5 ID:SGTC_3189|Compound:9110682|FD-Score:3.75|P-value:3.57E-5 ID:SGTC_3203|Compound:9113543|FD-Score:4.67|P-value:3.78E-7 ID:SGTC_3210|Compound:9128157|FD-Score:4.00|P-value:1.12E-5 ID:SGTC_3211|Compound:9128781|FD-Score:3.87|P-value:2.04E-5 ID:SGTC_3253|Compound:9135987|FD-Score:-3.02|P-value:6.22E-4 ID:SGTC_3264|Compound:9137442|FD-Score:-3.19|P-value:3.31E-4 ID:SGTC_3278|Compound:9139605|FD-Score:-2.99|P-value:6.85E-4 ID:SGTC_3295|Compound:9122362|FD-Score:3.35|P-value:1.96E-4 ID:SGTC_3296|Compound:9122258|FD-Score:3.02|P-value:6.94E-4

Top fitness defect scores for YIL024C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3203 9113543 4.67 49.5 µM 3.78E-7 16 1.54E-6
2 SGTC_779 1360-0071 4.66 233.0 µM 3.87E-7 fatty acid desaturase (OLE1) 15 1.57E-6
3 SGTC_1299 1079-1439 4.54 3.7 µM 7.45E-7 TSC3-RPN4 5 2.82E-6
4 SGTC_372 0155-0182 4.50 15.9 µM 9.26E-7 mitochondrial response to ROS 20 3.42E-6
5 SGTC_431 k089-0097 4.44 107.0 µM 1.24E-6 iron homeostasis 23 4.42E-6
6 SGTC_1557 sumaresinolic acid 4.13 42.3 µM 5.88E-6 15 1.78E-5
7 SGTC_1499 4480-0877 4.10 67.3 µM 7.14E-6 4 2.11E-5
8 SGTC_3187 9109394 4.02 49.5 µM 1.05E-5 Golgi 19 2.97E-5
9 SGTC_2607 solasodine 4.01 47.4 µM 1.08E-5 58 3.05E-5
10 SGTC_3210 9128157 4.00 49.5 µM 1.12E-5 46 3.15E-5
11 SGTC_2968 9090663 4.00 33.4 µM 1.14E-5 28 3.19E-5
12 SGTC_592 k241-0073 3.94 46.5 µM 1.47E-5 22 4.03E-5
13 SGTC_2643 anethole 3.92 100.0 µM 1.64E-5 16 4.42E-5
14 SGTC_3211 9128781 3.87 49.5 µM 2.04E-5 63 5.38E-5
15 SGTC_2640 pentamidine 3.79 10.4 µM 2.99E-5 mitochondrial processes 38 7.57E-5
16 SGTC_3189 9110682 3.75 49.5 µM 3.57E-5 44 8.88E-5
17 SGTC_2413 inermin 3.72 26.1 µM 4.03E-5 63 9.89E-5
18 SGTC_358 0075-0058 3.70 9.4 µM 4.46E-5 75 1.08E-4
19 SGTC_2119 5528445 3.68 120.6 µM 4.84E-5 29 1.16E-4
20 SGTC_840 0245-0196 3.64 390.0 µM 5.85E-5 17 1.38E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.137 1.30E-15 YGR173W RBG2 hom Protein with a role in translation; forms a complex with Gir2p; has similarity to mammalian developmentally regulated GTP-binding protein
0.131 2.48E-14 YLL055W YCT1 hom High-affinity cysteine-specific transporter with similarity to the Dal5p family of transporters; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YCT1 is not an essential gene
0.120 2.54E-12 YFL038C YPT1 het Rab family GTPase, involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p)
0.116 1.50E-11 YMR059W SEN15 het Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p
0.116 1.56E-11 YPR121W THI22 hom Protein with similarity to hydroxymethylpyrimidine phosphate kinases; member of a gene family with THI20 and THI21; not required for thiamine biosynthesis
0.110 1.64E-10 YLL017W YLL017W hom Non-essential Ras guanine nucleotide exchange factor (GEF); localized to the membrane; expressed in poor nutrient conditions and on nonfermentable carbon sources; contains a stop codon in S288C, full-length gene includes YLL016W; SDC25 has a paralog, CDC25, that arose from the whole genome duplication
0.107 4.29E-10 YGR122C-A_d YGR122C-A_d hom Dubious open reading frame unlikely to encode a functional protein, similar to YLR334C and YOL106W
0.099 9.76E-9 YLR285W NNT1 hom S-adenosylmethionine-dependent methyltransferase; has a role in rDNA silencing and in lifespan determination
0.098 1.18E-8 YGR112W SHY1 hom Mitochondrial inner membrane protein required for assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes; similar to human SURF1 involved in Leigh Syndrome
0.092 8.36E-8 YOR098C NUP1 het FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; possible karyopherin release factor that accelerates release of karyopherin-cargo complexes after transport across NPC; both NUP1 and NUP60 are homologous to human NUP153
0.092 8.61E-8 YLR237W THI7 hom Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia
0.091 1.33E-7 YMR096W SNZ1 hom Protein involved in vitamin B6 biosynthesis; member of a stationary phase-induced gene family; coregulated with SNO1; interacts with Sno1p and with Yhr198p, perhaps as a multiprotein complex containing other Snz and Sno proteins
0.091 1.51E-7 YKL020C SPT23 hom ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Mga2p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting
0.089 2.72E-7 YGL097W SRM1 het Nucleotide exchange factor for Gsp1p, localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; suppressor of the pheromone response pathway; potentially phosphorylated by Cdc28p
0.088 3.72E-7 YIL137C TMA108 hom Protein that associates with ribosomes and is involved in ribosome biogenesis; putative metalloprotease