YIL032C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL032C / YIL032C

Click on Significant Values for Screen Details ID:SGTC_128|Compound:0906-2981|FD-Score:5.65|P-value:4.94E-8 ID:SGTC_131|Compound:0141-0277|FD-Score:9.09|P-value:5.28E-18 ID:SGTC_142|Compound:0335-0849|FD-Score:-4.56|P-value:8.10E-6 ID:SGTC_145|Compound:3737-0113|FD-Score:6.85|P-value:5.30E-11 ID:SGTC_149|Compound:3970-0822|FD-Score:-4.26|P-value:2.86E-5 ID:SGTC_158|Compound:k038-0087|FD-Score:-3.90|P-value:1.13E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:-3.49|P-value:4.89E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:5.36|P-value:2.15E-7 ID:SGTC_259|Compound:usnic acid|FD-Score:3.33|P-value:8.43E-4 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:-3.42|P-value:6.08E-4 ID:SGTC_332|Compound:4112-0506|FD-Score:-3.64|P-value:2.87E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:-4.22|P-value:3.41E-5 ID:SGTC_360|Compound:0957-0399|FD-Score:9.08|P-value:5.72E-18 ID:SGTC_364|Compound:0083-0097|FD-Score:-11.60|P-value:3.11E-28 ID:SGTC_365|Compound:0121-0052|FD-Score:-4.13|P-value:4.75E-5 ID:SGTC_427|Compound:1354-0053|FD-Score:3.32|P-value:8.72E-4 ID:SGTC_547|Compound:1120-0019|FD-Score:4.24|P-value:3.28E-5 ID:SGTC_551|Compound:k048-0028|FD-Score:3.85|P-value:1.41E-4 ID:SGTC_555|Compound:4296-0685|FD-Score:-5.12|P-value:6.71E-7 ID:SGTC_879|Compound:0831-1030|FD-Score:-3.52|P-value:4.44E-4 ID:SGTC_891|Compound:0929-0073|FD-Score:3.33|P-value:8.60E-4 ID:SGTC_895|Compound:0964-0006|FD-Score:3.55|P-value:4.07E-4 ID:SGTC_896|Compound:0964-0007|FD-Score:3.44|P-value:6.02E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:3.96|P-value:9.37E-5 ID:SGTC_906|Compound:1165-0455|FD-Score:-3.97|P-value:8.74E-5 ID:SGTC_994|Compound:3910-0338|FD-Score:3.45|P-value:5.81E-4 ID:SGTC_1034|Compound:k072-0165|FD-Score:-3.37|P-value:7.17E-4 ID:SGTC_1042|Compound:0350-0096|FD-Score:-3.97|P-value:8.72E-5 ID:SGTC_1178|Compound:0988-0033|FD-Score:3.40|P-value:6.76E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:5.30|P-value:2.94E-7 ID:SGTC_1378|Compound:2093-0007|FD-Score:-3.62|P-value:3.10E-4 ID:SGTC_1379|Compound:2144-0755|FD-Score:3.80|P-value:1.71E-4 ID:SGTC_1445|Compound:4239-0156|FD-Score:3.44|P-value:6.01E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:3.35|P-value:7.90E-4 ID:SGTC_2398|Compound:5228213|FD-Score:3.42|P-value:6.44E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:3.97|P-value:9.16E-5 ID:SGTC_2409|Compound:alverine citrate|FD-Score:-5.38|P-value:1.86E-7 ID:SGTC_2433|Compound:5607874|FD-Score:-3.57|P-value:3.65E-4 ID:SGTC_2628|Compound:lathosterol|FD-Score:4.30|P-value:2.58E-5 ID:SGTC_2814|Compound:7977482|FD-Score:4.40|P-value:1.70E-5 ID:SGTC_2931|Compound:9014674|FD-Score:-3.58|P-value:3.60E-4 ID:SGTC_2939|Compound:9044578|FD-Score:-4.13|P-value:4.72E-5 ID:SGTC_3205|Compound:9113483|FD-Score:3.96|P-value:9.54E-5 ID:SGTC_128|Compound:0906-2981|FD-Score:5.65|P-value:4.94E-8 ID:SGTC_131|Compound:0141-0277|FD-Score:9.09|P-value:5.28E-18 ID:SGTC_142|Compound:0335-0849|FD-Score:-4.56|P-value:8.10E-6 ID:SGTC_145|Compound:3737-0113|FD-Score:6.85|P-value:5.30E-11 ID:SGTC_149|Compound:3970-0822|FD-Score:-4.26|P-value:2.86E-5 ID:SGTC_158|Compound:k038-0087|FD-Score:-3.90|P-value:1.13E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:-3.49|P-value:4.89E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:5.36|P-value:2.15E-7 ID:SGTC_259|Compound:usnic acid|FD-Score:3.33|P-value:8.43E-4 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:-3.42|P-value:6.08E-4 ID:SGTC_332|Compound:4112-0506|FD-Score:-3.64|P-value:2.87E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:-4.22|P-value:3.41E-5 ID:SGTC_360|Compound:0957-0399|FD-Score:9.08|P-value:5.72E-18 ID:SGTC_364|Compound:0083-0097|FD-Score:-11.60|P-value:3.11E-28 ID:SGTC_365|Compound:0121-0052|FD-Score:-4.13|P-value:4.75E-5 ID:SGTC_427|Compound:1354-0053|FD-Score:3.32|P-value:8.72E-4 ID:SGTC_547|Compound:1120-0019|FD-Score:4.24|P-value:3.28E-5 ID:SGTC_551|Compound:k048-0028|FD-Score:3.85|P-value:1.41E-4 ID:SGTC_555|Compound:4296-0685|FD-Score:-5.12|P-value:6.71E-7 ID:SGTC_879|Compound:0831-1030|FD-Score:-3.52|P-value:4.44E-4 ID:SGTC_891|Compound:0929-0073|FD-Score:3.33|P-value:8.60E-4 ID:SGTC_895|Compound:0964-0006|FD-Score:3.55|P-value:4.07E-4 ID:SGTC_896|Compound:0964-0007|FD-Score:3.44|P-value:6.02E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:3.96|P-value:9.37E-5 ID:SGTC_906|Compound:1165-0455|FD-Score:-3.97|P-value:8.74E-5 ID:SGTC_994|Compound:3910-0338|FD-Score:3.45|P-value:5.81E-4 ID:SGTC_1034|Compound:k072-0165|FD-Score:-3.37|P-value:7.17E-4 ID:SGTC_1042|Compound:0350-0096|FD-Score:-3.97|P-value:8.72E-5 ID:SGTC_1178|Compound:0988-0033|FD-Score:3.40|P-value:6.76E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:5.30|P-value:2.94E-7 ID:SGTC_1378|Compound:2093-0007|FD-Score:-3.62|P-value:3.10E-4 ID:SGTC_1379|Compound:2144-0755|FD-Score:3.80|P-value:1.71E-4 ID:SGTC_1445|Compound:4239-0156|FD-Score:3.44|P-value:6.01E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:3.35|P-value:7.90E-4 ID:SGTC_2398|Compound:5228213|FD-Score:3.42|P-value:6.44E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:3.97|P-value:9.16E-5 ID:SGTC_2409|Compound:alverine citrate|FD-Score:-5.38|P-value:1.86E-7 ID:SGTC_2433|Compound:5607874|FD-Score:-3.57|P-value:3.65E-4 ID:SGTC_2628|Compound:lathosterol|FD-Score:4.30|P-value:2.58E-5 ID:SGTC_2814|Compound:7977482|FD-Score:4.40|P-value:1.70E-5 ID:SGTC_2931|Compound:9014674|FD-Score:-3.58|P-value:3.60E-4 ID:SGTC_2939|Compound:9044578|FD-Score:-4.13|P-value:4.72E-5 ID:SGTC_3205|Compound:9113483|FD-Score:3.96|P-value:9.54E-5

Top fitness defect scores for YIL032C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_131 0141-0277 9.09 33.9 µM 5.28E-18 1 5.15E-20
2 SGTC_360 0957-0399 9.08 1.0 µM 5.72E-18 cell wall 6 5.63E-20
3 SGTC_145 3737-0113 6.85 38.4 µM 5.30E-11 DNA intercalators 16 3.69E-12
4 SGTC_128 0906-2981 5.65 13.4 µM 4.94E-8 2 7.87E-9
5 SGTC_184 1494-0393 5.36 24.7 µM 2.15E-7 23 4.10E-8
6 SGTC_1377 2944-0135 5.30 198.0 µM 2.94E-7 calcium & mitochondrial duress 15 5.80E-8
7 SGTC_2814 7977482 4.40 43.0 µM 1.70E-5 37 5.45E-6
8 SGTC_2628 lathosterol 4.30 100.0 µM 2.58E-5 23 8.70E-6
9 SGTC_547 1120-0019 4.24 610.0 nM 3.28E-5 azole & statin 25 1.14E-5
10 SGTC_2407 paclitaxel 3.97 400.0 µM 9.16E-5 35 3.59E-5
11 SGTC_902 1120-0002 3.96 2.1 µM 9.37E-5 azole & statin 47 3.68E-5
12 SGTC_3205 9113483 3.96 49.5 µM 9.54E-5 28 3.76E-5
13 SGTC_551 k048-0028 3.85 34.9 µM 1.41E-4 18 5.83E-5
14 SGTC_1379 2144-0755 3.80 36.5 µM 1.71E-4 30 7.22E-5
15 SGTC_895 0964-0006 3.55 13.7 µM 4.07E-4 24 1.90E-4
16 SGTC_994 3910-0338 3.45 138.0 µM 5.81E-4 calcium & mitochondrial duress 70 2.83E-4
17 SGTC_1445 4239-0156 3.44 97.7 µM 6.01E-4 48 2.93E-4
18 SGTC_896 0964-0007 3.44 44.5 µM 6.02E-4 20 2.94E-4
19 SGTC_2398 5228213 3.42 48.8 µM 6.44E-4 iron homeostasis 65 3.17E-4
20 SGTC_1178 0988-0033 3.40 191.0 µM 6.76E-4 51 3.34E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.215 2.18E-36 YHR149C SKG6 hom Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p
0.159 1.68E-20 YPL035C_d YPL035C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YPL034W; YPL035C is not an essential gene
0.151 1.93E-18 YEL017C-A PMP2 hom Proteolipid associated with plasma membrane H(+)-ATPase (Pma1p); regulates plasma membrane H(+)-ATPase activity; protein abundance increases in response to DNA replication stress; PMP2 has a paralog, PMP1, that arose from the whole genome duplication
0.134 6.74E-15 YHL010C ETP1 hom Putative protein of unknown function that is required for growth on ethanol; contains a zinc finger region and has homology to human BRAP2, which is a cytoplasmic protein that binds nuclear localization sequences
0.120 2.77E-12 YEL064C AVT2 hom Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
0.116 1.58E-11 YPL262W FUM1 hom Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial distribution determined by the N-terminal targeting sequence, protein conformation, and status of glyoxylate shunt; phosphorylated in mitochondria
0.113 5.38E-11 YGL002W ERP6 hom Member of the p24 family involved in ER to Golgi transport; similar to Emp24p and Erv25p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; ERP6 has a paralog, ERP1, that arose from the whole genome duplication
0.113 6.24E-11 YNR004W_p SWM2_p hom Putative protein of unknown function; haploid disruptant exhibits cold-sensitive growth and elongated buds
0.111 1.33E-10 YBL008W-A_p YBL008W-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.108 4.04E-10 YNL085W MKT1 hom Protein that forms a complex with Pbp1p; complex may mediate posttranscriptional regulation of HO; involved in propagation of M2 dsRNA satellite of L-A virus; allelic variation affects mitochondrial genome stability, drug resistance, and more; forms cytoplasmic foci upon DNA replication stress
0.107 5.04E-10 YJR149W_p YJR149W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.105 1.16E-9 YPL211W NIP7 het Nucleolar protein required for 60S ribosome subunit biogenesis, constituent of 66S pre-ribosomal particles; physically interacts with Nop8p and the exosome subunit Rrp43p
0.104 2.07E-9 YDR029W_d YDR029W_d hom Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data
0.103 2.58E-9 YOR077W RTS2 het Basic zinc-finger protein, similar to human and mouse Kin17 proteins which are chromatin-associated proteins involved in UV response and DNA replication
0.102 2.73E-9 YPL052W OAZ1 hom Regulator of ornithine decarboxylase (Spe1p), antizyme that binds to Spe1p to stimulate ubiquitin-independent degradation by the proteasome; binding of polyamines to nascent Oaz1p during translation stimulates +1 ribosomal frameshifting, allowing translation of full-length Oaz1p