HIPHOP chemogenomics database

YIL039W / TED1

Conserved phosphoesterase domain-containing protein that acts together with Emp24p/Erv25p in cargo exit from the ER; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)

Zygosity: Homozygous strain

fixedexpanded
Profile for YIL039W / TED1

Click on Significant Values for Screen Details

Top fitness defect scores for YIL039W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_625	k213-0058	9.79	121.0 µM	7.77E-18	translation	4	6.11E-23
2	SGTC_451	chloral hydrate	9.77	100.0 µM	8.86E-18		3	7.26E-23
3	SGTC_1354	1498-1681	8.94	81.0 µM	3.68E-15		1	1.99E-19
4	SGTC_2011	4012611	7.73	177.0 µM	8.86E-12	mitochondrial processes	4	5.45E-15
5	SGTC_525	k781-2675	7.04	26.7 µM	4.64E-10	redox potentiating	17	9.79E-13
6	SGTC_104	0074-0074	6.81	591.0 µM	1.61E-9		2	5.00E-12
7	SGTC_2004	4023728	6.72	41.9 µM	2.60E-9		4	9.37E-12
8	SGTC_3026	9090633	6.41	49.5 µM	1.24E-8		2	7.27E-11
9	SGTC_830	4076-0286	6.37	57.8 µM	1.51E-8	translation	10	9.42E-11
10	SGTC_935	2996-0153	6.22	430.0 µM	3.25E-8	PDR1	5	2.56E-10
11	SGTC_800	3448-7362	6.01	155.0 µM	8.83E-8	translation	49	9.48E-10
12	SGTC_381	3461-2219	5.84	42.7 µM	1.89E-7	copper-dependent oxidative stress	3	2.57E-9
13	SGTC_1785	bathophenanthroline	5.59	24.0 µM	5.90E-7	heme requiring	15	1.14E-8
14	SGTC_3141	9094609	5.58	49.5 µM	6.09E-7	iron homeostasis	10	1.19E-8
15	SGTC_2601	securinine	5.38	100.0 µM	1.49E-6		8	3.81E-8
16	SGTC_2017	5132927	5.33	60.6 µM	1.83E-6		7	4.98E-8
17	SGTC_2422	chlorphenesin carbamate	5.30	384.2 µM	2.02E-6		9	5.69E-8
18	SGTC_576	1073-0113	5.22	22.7 µM	2.81E-6	redox potentiating	31	8.75E-8
19	SGTC_2307	7538926	5.18	6.3 µM	3.33E-6		15	1.09E-7
20	SGTC_3	0833-0587	5.14	95.6 µM	3.93E-6	redox potentiating	12	1.36E-7

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.217	5.85E-37	YNL268W	LYP1	hom	Lysine permease; one of three amino acid permeases (Alp1p, Can1p, Lyp1p) responsible for uptake of cationic amino acids
0.192	2.58E-29	YOL100W	PKH2	hom	Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh1p
0.185	3.15E-27	YPL208W	RKM1	hom	SET-domain lysine-N-methyltransferase, catalyzes the formation of dimethyllysine residues on the large ribsomal subunit proteins L23a (Rpl23Ap and Rpl23Bp) and L18 (Rps18Ap and Rps18Bp)
0.171	2.09E-23	YBR162C	TOS1	hom	Covalently-bound cell wall protein of unknown function; identified as a cell cycle regulated SBF target gene; deletion mutants are highly resistant to treatment with beta-1,3-glucanase; has sequence similarity to YJL171C
0.171	2.36E-23	YDR516C	EMI2	hom	Non-essential protein of unknown function; required for transcriptional induction of the early meiotic-specific transcription factor IME1; required for sporulation; expression regulated by glucose-repression transcription factors Mig1/2p; EMI2 has a paralog, GLK1, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.170	4.47E-23	YGL251C	HFM1	hom	Meiosis specific DNA helicase involved in the conversion of double-stranded breaks to later recombination intermediates and in crossover control; catalyzes the unwinding of Holliday junctions; has ssDNA and dsDNA stimulated ATPase activity
0.169	8.25E-23	YGL236C	MTO1	hom	Mitochondrial protein, forms a heterodimer complex with Mss1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; required for respiration in paromomycin-resistant 15S rRNA mutants
0.160	1.22E-20	YGL167C	PMR1	hom	High affinity Ca2+/Mn2+ P-type ATPase required for Ca2+ and Mn2+ transport into Golgi; involved in Ca2+ dependent protein sorting and processing; mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey disease
0.139	7.25E-16	YGL168W	HUR1	hom	Protein of unknown function; reported null mutant phenotype of hydroxyurea sensitivity may be due to effects on overlapping PMR1 gene
0.133	1.26E-14	YDR281C	PHM6	hom	Protein of unknown function, expression is regulated by phosphate levels
0.121	1.97E-12	YOR305W	RRG7	hom	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); YOR305W is not an essential gene
0.119	3.89E-12	YOR085W	OST3	hom	Gamma subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins
0.116	1.45E-11	YIR021W-A_p	YIR021W-A_p	hom	Putative protein of unknown function; identified by expression profiling and mass spectrometry
0.116	1.87E-11	YAL058W	CNE1	hom	Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeast
0.108	3.12E-10	YIL038C	NOT3	hom	Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation