HIPHOP chemogenomics database

YIL045W / PIG2

Putative type-1 protein phosphatase targeting subunit that tethers Glc7p type-1 protein phosphatase to Gsy2p glycogen synthase

Zygosity: Homozygous strain

fixedexpanded
Profile for YIL045W / PIG2

Click on Significant Values for Screen Details

Top fitness defect scores for YIL045W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2350	9023895	6.25	38.9 µM	8.18E-10	ergosterol biosynthesis	9	2.11E-10
2	SGTC_2237	6667747	5.89	47.2 µM	6.14E-9		5	1.88E-9
3	SGTC_2167	5876490	5.74	200.0 µM	1.40E-8		6	4.61E-9
4	SGTC_1324	1418-0026	4.98	34.4 µM	6.92E-7		3	3.15E-7
5	SGTC_2424	5537928	4.93	59.2 µM	9.01E-7		17	4.19E-7
6	SGTC_2651	1327-0036	4.86	5.0 µM	1.25E-6		116	5.95E-7
7	SGTC_2788	5282734	4.19	71.4 µM	2.31E-5		36	1.39E-5
8	SGTC_3002	9075603	4.18	71.4 µM	2.45E-5		16	1.48E-5
9	SGTC_2094	5332512	4.18	191.7 µM	2.45E-5		20	1.48E-5
10	SGTC_2831	7999036	4.12	19.5 µM	3.10E-5		39	1.91E-5
11	SGTC_2403	6032726	4.10	181.2 µM	3.35E-5		37	2.08E-5
12	SGTC_2803	7707263	4.00	71.4 µM	5.03E-5		29	3.22E-5
13	SGTC_1021	4476-0760	3.93	85.3 µM	6.45E-5		27	4.20E-5
14	SGTC_1492	4158-0558	3.90	28.5 µM	7.32E-5	60S ribosome export	16	4.82E-5
15	SGTC_25	0118-0223	3.82	35.7 µM	9.78E-5		18	6.58E-5
16	SGTC_2639	lactacystin	3.77	53.0 µM	1.21E-4		30	8.27E-5
17	SGTC_953	1188-0045	3.67	9.7 µM	1.73E-4	60S ribosome export	33	1.21E-4
18	SGTC_513	4245-1575	3.56	41.7 µM	2.59E-4	unfolded protein response	136	1.87E-4
19	SGTC_1893	st059353	3.56	36.1 µM	2.60E-4		35	1.88E-4
20	SGTC_1110	3-hydroxy-3'-methoxyflavone	3.48	1.2 µM	3.37E-4	iron homeostasis	66	2.48E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.110	1.92E-10	YIL046W	MET30	het	F-box protein containing five copies of the WD40 motif, controls cell cycle function, sulfur metabolism, and methionine biosynthesis as part of the ubiquitin ligase complex; interacts with and regulates Met4p, localizes within the nucleus
0.103	2.21E-9	YHR082C	KSP1	hom	Serine/threonine protein kinase; associates with TORC1 and likely involved in TOR signaling cascades; negative regulator of autophagy; nuclear translocation required for haploid filamentous growth; regulates filamentous growth induced nuclear translocation of Bcy1p, Fus3p, and Sks1p; overproduction causes allele-specific suppression of prp20-10; protein abundance increases in response to DNA replication stress
0.103	2.34E-9	YDL015C	TSC13	het	Enoyl reductase; catalyzes the last step in each cycle of very long chain fatty acid elongation; localizes to the ER, highly enriched in a structure marking nuclear-vacuolar junctions; coimmunoprecipitates with elongases Fen1p and Sur4p; protein increases in abundance and relative distribution to ER foci increases upon DNA replication stress
0.098	1.28E-8	YJL019W	MPS3	het	Nuclear envelope protein required for SPB insertion; initiation of SPB duplication and nuclear fusion; acetylation of Mps3p by Eco1p regulates its role in nuclear organization; localizes to the SPB half bridge and at telomeres during meiosis; required with Ndj1p and Csm4p for meiotic bouquet formation and telomere-led rapid prophase movement; N-terminal acetylated by Eco1p
0.097	1.63E-8	YIR008C	PRI1	het	Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
0.097	1.70E-8	YBR256C	RIB5	het	Riboflavin synthase; catalyzes the last step of the riboflavin biosynthesis pathway
0.095	3.47E-8	YFL037W	TUB2	het	Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria
0.093	5.76E-8	YJR039W_p	YJR039W_p	hom	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.092	8.55E-8	YIL019W	FAF1	het	Protein required for pre-rRNA processing and 40S ribosomal subunit assembly
0.092	8.69E-8	YDR419W	RAD30	hom	DNA polymerase eta, involved in translesion synthesis during post-replication repair; catalyzes the synthesis of DNA opposite cyclobutane pyrimidine dimers and other lesions; may also have a role in protection against mitochondrial mutagenesis; mutations in human pol eta are responsible for XPV
0.090	2.03E-7	YOR297C	TIM18	hom	Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; may mediate assembly or stability of the complex
0.089	2.25E-7	YJL005W	CYR1	het	Adenylate cyclase, required for cAMP production and cAMP-dependent protein kinase signaling; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation
0.089	2.67E-7	YGL073W	HSF1	het	Trimeric heat shock transcription factor, activates multiple genes in response to stresses that include hyperthermia; recognizes variable heat shock elements (HSEs) consisting of inverted NGAAN repeats; posttranslationally regulated
0.088	3.56E-7	YJR131W	MNS1	hom	Alpha-1,2-mannosidase involved in ER-associated protein degradation (ERAD); catalyzes the removal of one mannose residue from a glycosylated protein, converting the modification from Man9GlcNAc to Man8GlcNAc; catalyzes the last step in glycoprotein maturation in the ER and is critical for ER protein degradation
0.085	7.59E-7	YMR182W-A_p	YMR182W-A_p	hom	Putative protein of unknown function